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LOGD/LOGP
experts in Measuring physicochemical properties Fast For most projects, data is returned within 5 business days or less. Flexible Use our standard experimental protocol or customize your own. Affordable Multiple options are available for a wide variety of budgets. EXPERTS IN ANALYTICAL CHEMISTRY Analiza, Inc. is a leading contract research organization dedicated to discovering,COMPANY OVERVIEW
Company Overview. Analiza, Inc. is a leading contract research organization dedicated to discovering, developing, and commercializing new technologies for the life sciences. Analiza provides integrated solutions to key applications in the pharmaceutical, biotechnology and diagnostics industries. Since 1997, Analiza has pioneered uniqueCONTACT - ANALIZA
Contact Us Interested in receiving more information about our services? info@analiza.com (216) 432-9050 3615 Superior Ave. #4407BCleveland, OH 44114 PHYSICOCHEMICAL PROPERTIES It is critical to obtain experimental physicochemical property data in early drug discovery. Because these properties significantly influence ADME properties and guide decision-making about which drug candidates to pursue, it is important that physicochemical property measurements be affordable, reliable, and readily available. Analiza has adapted, improved, and automated gold-standardFAQ - ANALIZA
What is the best way to ship my samples? FOR DMSO STOCKS: The best shipping practice is to send the samples in a 96-well plate frozen on dry ice. The samples should be secured with a heat seal. Sticky seals are not recommended, as they can easily peel away from the sample plate. Sending the FAQ Read More »CAREERS - ANALIZA
Careers. Analiza extends the in-house physicochemical and ADME profiling capabilities of our clients by adapting gold standard methods for compatibility with early drug discovery. Our focus is providing fast, accurate, and affordable results to our clients in the fast-paced pharmaceutical and biotech industries. SOLUBILITY - ANALIZA Solubility (µM) Whether you’re tight on budget, time, or internal capacity, Analiza offers a solubility assay to meet your needs. We use only miniaturized, gold- standard shake-flask assays with quantitation by LC-MS, LC-UV or chemiluminscent nitrogen detection (CLND) to IN-VITRO ADME PROPERTIES ADME properties are critical to assess during lead selection because they influence a drug’s bioavailability and efficacy. Conducting in-vitro studies is a rapid and cost-effective way to prioritize compounds and predict the success of downstream in-vivo ADME studies. Because solubility issues can affect the reliability of in-vitro data, our assays have been optimized to deliver data for aPAMPA - ANALIZA
The PAMPA assay generates consistent, reproducible data over a range of permeability values. To avoid non-specific binding, we’ve incorporated Corning Gentest TM pre-coated PAMPA plates into our workflow. Unlike traditional PAMPA formulations, these plates are comprised of an oil-lipid-oil trilayer, offering a shortened path forcompound
ANALIZA.COM
analiza.com
ANALYTICAL CHEMISTRY SERVICES FOR EARLY DRUG DISCOVERYCAREERSCONTACTPKACHEMICAL STABILITYMINIATURIZED SHAKE-FLASKLOGD/LOGP
experts in Measuring physicochemical properties Fast For most projects, data is returned within 5 business days or less. Flexible Use our standard experimental protocol or customize your own. Affordable Multiple options are available for a wide variety of budgets. EXPERTS IN ANALYTICAL CHEMISTRY Analiza, Inc. is a leading contract research organization dedicated to discovering,COMPANY OVERVIEW
Company Overview. Analiza, Inc. is a leading contract research organization dedicated to discovering, developing, and commercializing new technologies for the life sciences. Analiza provides integrated solutions to key applications in the pharmaceutical, biotechnology and diagnostics industries. Since 1997, Analiza has pioneered uniqueCONTACT - ANALIZA
Contact Us Interested in receiving more information about our services? info@analiza.com (216) 432-9050 3615 Superior Ave. #4407BCleveland, OH 44114 PHYSICOCHEMICAL PROPERTIES It is critical to obtain experimental physicochemical property data in early drug discovery. Because these properties significantly influence ADME properties and guide decision-making about which drug candidates to pursue, it is important that physicochemical property measurements be affordable, reliable, and readily available. Analiza has adapted, improved, and automated gold-standardFAQ - ANALIZA
What is the best way to ship my samples? FOR DMSO STOCKS: The best shipping practice is to send the samples in a 96-well plate frozen on dry ice. The samples should be secured with a heat seal. Sticky seals are not recommended, as they can easily peel away from the sample plate. Sending the FAQ Read More »CAREERS - ANALIZA
Careers. Analiza extends the in-house physicochemical and ADME profiling capabilities of our clients by adapting gold standard methods for compatibility with early drug discovery. Our focus is providing fast, accurate, and affordable results to our clients in the fast-paced pharmaceutical and biotech industries. SOLUBILITY - ANALIZA Solubility (µM) Whether you’re tight on budget, time, or internal capacity, Analiza offers a solubility assay to meet your needs. We use only miniaturized, gold- standard shake-flask assays with quantitation by LC-MS, LC-UV or chemiluminscent nitrogen detection (CLND) to IN-VITRO ADME PROPERTIES ADME properties are critical to assess during lead selection because they influence a drug’s bioavailability and efficacy. Conducting in-vitro studies is a rapid and cost-effective way to prioritize compounds and predict the success of downstream in-vivo ADME studies. Because solubility issues can affect the reliability of in-vitro data, our assays have been optimized to deliver data for aPAMPA - ANALIZA
The PAMPA assay generates consistent, reproducible data over a range of permeability values. To avoid non-specific binding, we’ve incorporated Corning Gentest TM pre-coated PAMPA plates into our workflow. Unlike traditional PAMPA formulations, these plates are comprised of an oil-lipid-oil trilayer, offering a shortened path forcompound
ANALIZA.COM
analiza.com
ASSAYS ARCHIVE
Timelines and budgets are tight, so we’ve coupled high resolution accurate mass Q-TOF microsomal stability with HPLC to help you do morewith less.
SOLUBILITY - ANALIZA Solubility (µM) Whether you’re tight on budget, time, or internal capacity, Analiza offers a solubility assay to meet your needs. We use only miniaturized, gold- standard shake-flask assays with quantitation by LC-MS, LC-UV or chemiluminscent nitrogen detection (CLND) toBLOG - ANALIZA 2.0
Subscribe to our mailing list! First Name. Last Name IN-VITRO ADME PROPERTIES ADME properties are critical to assess during lead selection because they influence a drug’s bioavailability and efficacy. Conducting in-vitro studies is a rapid and cost-effective way to prioritize compounds and predict the success of downstream in-vivo ADME studies. Because solubility issues can affect the reliability of in-vitro data, our assays have been optimized to deliver data for a MICROSOMAL STABILITY Timelines and budgets are tight, so we’ve coupled high resolution accurate mass Q-TOF microsomal stability with HPLC to help you do more with less. Full-scan data is acquired, from which narrow window extracted ion chromatograms are generated, producing quantitative data equivalent to that obtained by HPLC/MS/MS without the time-consuming process of developing distinct, MS methods for eachCHEMICAL STABILITY
Highly unstable compounds can lead to ambiguous in vitro biological data and may not be suitable candidates for development. Our automated short-term chemical stability assay mimics the short gastrointestinal transit time and in vitro biology conditions, delivering stability-pHprofiles in
PLASMA STABILITY
Assay Information. Poor plasma stability can lead to rapid clearance, short half-lives, and poor in vivo performance. Pharmacokinetic (PK) studies are especially challenging for these compounds as they continue to degrade even after blood is sampled from the study animal, leading to ambiguous PK data. In the case of prodrugs and antedrugs SINGLE BUILDERS ARCHIVE Home Events Single Builder Home Events Single Builder Home Events Single Builder Home Events Single Builder Home Events Single Builder Home Events Single Builder Home KATE.FAVRE, AUTHOR AT ANALIZA Share on email Email Share on linkedin Share Solubility is a critical physicochemical property to measure in drug discovery. The data can be used to guide lead optimization, troubleshoot erratic bioassay results, and identify potential downstream liabilities such as insufficient solubility for bioassays orANALIZA.COM
analiza.com
ANALYTICAL CHEMISTRY SERVICES FOR EARLY DRUG DISCOVERYSERVICESCAREERSCONTACTPKACHEMICAL STABILITYMINIATURIZED SHAKE-FLASK LOGD/LOGP experts in Measuring physicochemical properties Fast For most projects, data is returned within 5 business days or less. Flexible Use our standard experimental protocol or customize your own. Affordable Multiple options are available for a wide variety of budgets. EXPERTS IN ANALYTICAL CHEMISTRY Analiza, Inc. is a leading contract research organization dedicated to discovering,COMPANY OVERVIEW
Company Overview. Analiza, Inc. is a leading contract research organization dedicated to discovering, developing, and commercializing new technologies for the life sciences. Analiza provides integrated solutions to key applications in the pharmaceutical, biotechnology and diagnostics industries. Since 1997, Analiza has pioneered unique CUSTOM ANALYTICAL SERVICES Analiza offers comprehensive custom analytical services for non-GLP studies, with over 3,000 square feet of dedicated laboratory space equipped with HPLC, UPLC, LC-QTOFMS, plate readers, and a team of specialized applications chemists. Whether your team requires state-of-the-art instrumentation, a team of expert scientists, or extra capacity to support discovery and early development projectsCONTACT - ANALIZA
Contact Us Interested in receiving more information about our services? info@analiza.com (216) 432-9050 3615 Superior Ave. #4407BCleveland, OH 44114CAREERS - ANALIZA
Careers. Analiza extends the in-house physicochemical and ADME profiling capabilities of our clients by adapting gold standard methods for compatibility with early drug discovery. Our focus is providing fast, accurate, and affordable results to our clients in the fast-paced pharmaceutical and biotech industries. PHYSICOCHEMICAL PROPERTIES It is critical to obtain experimental physicochemical property data in early drug discovery. Because these properties significantly influence ADME properties and guide decision-making about which drug candidates to pursue, it is important that physicochemical property measurements be affordable, reliable, and readily available. Analiza has adapted, improved, and automated gold-standardFAQ - ANALIZA
What is the best way to ship my samples? FOR DMSO STOCKS: The best shipping practice is to send the samples in a 96-well plate frozen on dry ice. The samples should be secured with a heat seal. Sticky seals are not recommended, as they can easily peel away from the sample plate. Sending the FAQ Read More »PKA - ANALIZA
Assay Information. We scaled back the compound requirements to deliver accurate pKa data from just 30 μL of 10mM DMSO stock solution, because we understand that you cannot spare mLs of material for a single measurement during the discovery phase. We also understand that the timescale for discovery options is measured in hours not days orweeks
PAMPA - ANALIZA
The PAMPA assay generates consistent, reproducible data over a range of permeability values. To avoid non-specific binding, we’ve incorporated Corning Gentest TM pre-coated PAMPA plates into our workflow. Unlike traditional PAMPA formulations, these plates are comprised of an oil-lipid-oil trilayer, offering a shortened path forcompound
MICROSOMAL STABILITY Timelines and budgets are tight, so we’ve coupled high resolution accurate mass Q-TOF microsomal stability with HPLC to help you do more with less. Full-scan data is acquired, from which narrow window extracted ion chromatograms are generated, producing quantitative data equivalent to that obtained by HPLC/MS/MS without the time-consuming process of developing distinct, MS methods for each ANALYTICAL CHEMISTRY SERVICES FOR EARLY DRUG DISCOVERYSERVICESCAREERSCONTACTPKACHEMICAL STABILITYMINIATURIZED SHAKE-FLASK LOGD/LOGP experts in Measuring physicochemical properties Fast For most projects, data is returned within 5 business days or less. Flexible Use our standard experimental protocol or customize your own. Affordable Multiple options are available for a wide variety of budgets. EXPERTS IN ANALYTICAL CHEMISTRY Analiza, Inc. is a leading contract research organization dedicated to discovering,COMPANY OVERVIEW
Company Overview. Analiza, Inc. is a leading contract research organization dedicated to discovering, developing, and commercializing new technologies for the life sciences. Analiza provides integrated solutions to key applications in the pharmaceutical, biotechnology and diagnostics industries. Since 1997, Analiza has pioneered unique CUSTOM ANALYTICAL SERVICES Analiza offers comprehensive custom analytical services for non-GLP studies, with over 3,000 square feet of dedicated laboratory space equipped with HPLC, UPLC, LC-QTOFMS, plate readers, and a team of specialized applications chemists. Whether your team requires state-of-the-art instrumentation, a team of expert scientists, or extra capacity to support discovery and early development projectsCONTACT - ANALIZA
Contact Us Interested in receiving more information about our services? info@analiza.com (216) 432-9050 3615 Superior Ave. #4407BCleveland, OH 44114CAREERS - ANALIZA
Careers. Analiza extends the in-house physicochemical and ADME profiling capabilities of our clients by adapting gold standard methods for compatibility with early drug discovery. Our focus is providing fast, accurate, and affordable results to our clients in the fast-paced pharmaceutical and biotech industries. PHYSICOCHEMICAL PROPERTIES It is critical to obtain experimental physicochemical property data in early drug discovery. Because these properties significantly influence ADME properties and guide decision-making about which drug candidates to pursue, it is important that physicochemical property measurements be affordable, reliable, and readily available. Analiza has adapted, improved, and automated gold-standardFAQ - ANALIZA
What is the best way to ship my samples? FOR DMSO STOCKS: The best shipping practice is to send the samples in a 96-well plate frozen on dry ice. The samples should be secured with a heat seal. Sticky seals are not recommended, as they can easily peel away from the sample plate. Sending the FAQ Read More »PKA - ANALIZA
Assay Information. We scaled back the compound requirements to deliver accurate pKa data from just 30 μL of 10mM DMSO stock solution, because we understand that you cannot spare mLs of material for a single measurement during the discovery phase. We also understand that the timescale for discovery options is measured in hours not days orweeks
PAMPA - ANALIZA
The PAMPA assay generates consistent, reproducible data over a range of permeability values. To avoid non-specific binding, we’ve incorporated Corning Gentest TM pre-coated PAMPA plates into our workflow. Unlike traditional PAMPA formulations, these plates are comprised of an oil-lipid-oil trilayer, offering a shortened path forcompound
MICROSOMAL STABILITY Timelines and budgets are tight, so we’ve coupled high resolution accurate mass Q-TOF microsomal stability with HPLC to help you do more with less. Full-scan data is acquired, from which narrow window extracted ion chromatograms are generated, producing quantitative data equivalent to that obtained by HPLC/MS/MS without the time-consuming process of developing distinct, MS methods for eachASSAYS ARCHIVE
Timelines and budgets are tight, so we’ve coupled high resolution accurate mass Q-TOF microsomal stability with HPLC to help you do morewith less.
IN-VITRO ADME PROPERTIES ADME properties are critical to assess during lead selection because they influence a drug’s bioavailability and efficacy. Conducting in-vitro studies is a rapid and cost-effective way to prioritize compounds and predict the success of downstream in-vivo ADME studies. Because solubility issues can affect the reliability of in-vitro data, our assays have been optimized to deliver data for a SOLUBILITY - ANALIZA Solubility (µM) Whether you’re tight on budget, time, or internal capacity, Analiza offers a solubility assay to meet your needs. We use only miniaturized, gold- standard shake-flask assays with quantitation by LC-MS, LC-UV or chemiluminscent nitrogen detection (CLND) toPAMPA - ANALIZA
The PAMPA assay generates consistent, reproducible data over a range of permeability values. To avoid non-specific binding, we’ve incorporated Corning Gentest TM pre-coated PAMPA plates into our workflow. Unlike traditional PAMPA formulations, these plates are comprised of an oil-lipid-oil trilayer, offering a shortened path forcompound
ALPHALOGD - ANALIZA
Whether you’re tight on budget, time, or internal capacity, Analiza offers a logD assay to meet your needs—especially if you’re breaking into new chemical space. To meet the short timelines and scarce compound availability associated with discovery operations, we now offer a sophisticated HPLC-based alternative to the shake-flaskmethod
SERVICES | ANALIZA, INC. Analiza, Inc. 3615 Superior Ave #4407b. Cleveland, OH 44114 (216)432-9050
BLOG - ANALIZA 2.0
Subscribe to our mailing list! First Name. Last NameWWW.ANALIZA.COM
www.analiza.com
ANALIZA.COM
analiza.com
PLASMA STABILITY
Assay Information. Poor plasma stability can lead to rapid clearance, short half-lives, and poor in vivo performance. Pharmacokinetic (PK) studies are especially challenging for these compounds as they continue to degrade even after blood is sampled from the study animal, leading to ambiguous PK data. In the case of prodrugs and antedrugs ANALYTICAL CHEMISTRY SERVICES FOR EARLY DRUG DISCOVERYSERVICESCAREERSCONTACTPKACHEMICAL STABILITYMINIATURIZED SHAKE-FLASK LOGD/LOGP experts in Measuring physicochemical properties Fast For most projects, data is returned within 5 business days or less. Flexible Use our standard experimental protocol or customize your own. Affordable Multiple options are available for a wide variety of budgets. EXPERTS IN ANALYTICAL CHEMISTRY Analiza, Inc. is a leading contract research organization dedicated to discovering,COMPANY OVERVIEW
Company Overview. Analiza, Inc. is a leading contract research organization dedicated to discovering, developing, and commercializing new technologies for the life sciences. Analiza provides integrated solutions to key applications in the pharmaceutical, biotechnology and diagnostics industries. Since 1997, Analiza has pioneered unique CUSTOM ANALYTICAL SERVICES Analiza offers comprehensive custom analytical services for non-GLP studies, with over 3,000 square feet of dedicated laboratory space equipped with HPLC, UPLC, LC-QTOFMS, plate readers, and a team of specialized applications chemists. Whether your team requires state-of-the-art instrumentation, a team of expert scientists, or extra capacity to support discovery and early development projectsCONTACT - ANALIZA
Contact Us Interested in receiving more information about our services? info@analiza.com (216) 432-9050 3615 Superior Ave. #4407BCleveland, OH 44114CAREERS - ANALIZA
Careers. Analiza extends the in-house physicochemical and ADME profiling capabilities of our clients by adapting gold standard methods for compatibility with early drug discovery. Our focus is providing fast, accurate, and affordable results to our clients in the fast-paced pharmaceutical and biotech industries. PHYSICOCHEMICAL PROPERTIES It is critical to obtain experimental physicochemical property data in early drug discovery. Because these properties significantly influence ADME properties and guide decision-making about which drug candidates to pursue, it is important that physicochemical property measurements be affordable, reliable, and readily available. Analiza has adapted, improved, and automated gold-standardFAQ - ANALIZA
What is the best way to ship my samples? FOR DMSO STOCKS: The best shipping practice is to send the samples in a 96-well plate frozen on dry ice. The samples should be secured with a heat seal. Sticky seals are not recommended, as they can easily peel away from the sample plate. Sending the FAQ Read More »PKA - ANALIZA
Assay Information. We scaled back the compound requirements to deliver accurate pKa data from just 30 μL of 10mM DMSO stock solution, because we understand that you cannot spare mLs of material for a single measurement during the discovery phase. We also understand that the timescale for discovery options is measured in hours not days orweeks
PAMPA - ANALIZA
The PAMPA assay generates consistent, reproducible data over a range of permeability values. To avoid non-specific binding, we’ve incorporated Corning Gentest TM pre-coated PAMPA plates into our workflow. Unlike traditional PAMPA formulations, these plates are comprised of an oil-lipid-oil trilayer, offering a shortened path forcompound
MICROSOMAL STABILITY Timelines and budgets are tight, so we’ve coupled high resolution accurate mass Q-TOF microsomal stability with HPLC to help you do more with less. Full-scan data is acquired, from which narrow window extracted ion chromatograms are generated, producing quantitative data equivalent to that obtained by HPLC/MS/MS without the time-consuming process of developing distinct, MS methods for each ANALYTICAL CHEMISTRY SERVICES FOR EARLY DRUG DISCOVERYSERVICESCAREERSCONTACTPKACHEMICAL STABILITYMINIATURIZED SHAKE-FLASK LOGD/LOGP experts in Measuring physicochemical properties Fast For most projects, data is returned within 5 business days or less. Flexible Use our standard experimental protocol or customize your own. Affordable Multiple options are available for a wide variety of budgets. EXPERTS IN ANALYTICAL CHEMISTRY Analiza, Inc. is a leading contract research organization dedicated to discovering,COMPANY OVERVIEW
Company Overview. Analiza, Inc. is a leading contract research organization dedicated to discovering, developing, and commercializing new technologies for the life sciences. Analiza provides integrated solutions to key applications in the pharmaceutical, biotechnology and diagnostics industries. Since 1997, Analiza has pioneered unique CUSTOM ANALYTICAL SERVICES Analiza offers comprehensive custom analytical services for non-GLP studies, with over 3,000 square feet of dedicated laboratory space equipped with HPLC, UPLC, LC-QTOFMS, plate readers, and a team of specialized applications chemists. Whether your team requires state-of-the-art instrumentation, a team of expert scientists, or extra capacity to support discovery and early development projectsCONTACT - ANALIZA
Contact Us Interested in receiving more information about our services? info@analiza.com (216) 432-9050 3615 Superior Ave. #4407BCleveland, OH 44114CAREERS - ANALIZA
Careers. Analiza extends the in-house physicochemical and ADME profiling capabilities of our clients by adapting gold standard methods for compatibility with early drug discovery. Our focus is providing fast, accurate, and affordable results to our clients in the fast-paced pharmaceutical and biotech industries. PHYSICOCHEMICAL PROPERTIES It is critical to obtain experimental physicochemical property data in early drug discovery. Because these properties significantly influence ADME properties and guide decision-making about which drug candidates to pursue, it is important that physicochemical property measurements be affordable, reliable, and readily available. Analiza has adapted, improved, and automated gold-standardFAQ - ANALIZA
What is the best way to ship my samples? FOR DMSO STOCKS: The best shipping practice is to send the samples in a 96-well plate frozen on dry ice. The samples should be secured with a heat seal. Sticky seals are not recommended, as they can easily peel away from the sample plate. Sending the FAQ Read More »PKA - ANALIZA
Assay Information. We scaled back the compound requirements to deliver accurate pKa data from just 30 μL of 10mM DMSO stock solution, because we understand that you cannot spare mLs of material for a single measurement during the discovery phase. We also understand that the timescale for discovery options is measured in hours not days orweeks
PAMPA - ANALIZA
The PAMPA assay generates consistent, reproducible data over a range of permeability values. To avoid non-specific binding, we’ve incorporated Corning Gentest TM pre-coated PAMPA plates into our workflow. Unlike traditional PAMPA formulations, these plates are comprised of an oil-lipid-oil trilayer, offering a shortened path forcompound
MICROSOMAL STABILITY Timelines and budgets are tight, so we’ve coupled high resolution accurate mass Q-TOF microsomal stability with HPLC to help you do more with less. Full-scan data is acquired, from which narrow window extracted ion chromatograms are generated, producing quantitative data equivalent to that obtained by HPLC/MS/MS without the time-consuming process of developing distinct, MS methods for eachASSAYS ARCHIVE
Timelines and budgets are tight, so we’ve coupled high resolution accurate mass Q-TOF microsomal stability with HPLC to help you do morewith less.
IN-VITRO ADME PROPERTIES ADME properties are critical to assess during lead selection because they influence a drug’s bioavailability and efficacy. Conducting in-vitro studies is a rapid and cost-effective way to prioritize compounds and predict the success of downstream in-vivo ADME studies. Because solubility issues can affect the reliability of in-vitro data, our assays have been optimized to deliver data for a SOLUBILITY - ANALIZA Solubility (µM) Whether you’re tight on budget, time, or internal capacity, Analiza offers a solubility assay to meet your needs. We use only miniaturized, gold- standard shake-flask assays with quantitation by LC-MS, LC-UV or chemiluminscent nitrogen detection (CLND) toPAMPA - ANALIZA
The PAMPA assay generates consistent, reproducible data over a range of permeability values. To avoid non-specific binding, we’ve incorporated Corning Gentest TM pre-coated PAMPA plates into our workflow. Unlike traditional PAMPA formulations, these plates are comprised of an oil-lipid-oil trilayer, offering a shortened path forcompound
ALPHALOGD - ANALIZA
Whether you’re tight on budget, time, or internal capacity, Analiza offers a logD assay to meet your needs—especially if you’re breaking into new chemical space. To meet the short timelines and scarce compound availability associated with discovery operations, we now offer a sophisticated HPLC-based alternative to the shake-flaskmethod
SERVICES | ANALIZA, INC. Analiza, Inc. 3615 Superior Ave #4407b. Cleveland, OH 44114 (216)432-9050
BLOG - ANALIZA 2.0
Subscribe to our mailing list! First Name. Last NameWWW.ANALIZA.COM
www.analiza.com
ANALIZA.COM
analiza.com
PLASMA STABILITY
Assay Information. Poor plasma stability can lead to rapid clearance, short half-lives, and poor in vivo performance. Pharmacokinetic (PK) studies are especially challenging for these compounds as they continue to degrade even after blood is sampled from the study animal, leading to ambiguous PK data. In the case of prodrugs and antedrugs ANALYTICAL CHEMISTRY SERVICES FOR EARLY DRUG DISCOVERYSERVICESCAREERSCONTACTPKAMINIATURIZED SHAKE-FLASK LOGD/LOGPXRD-CRYSTALLINITY ASSESSMENT experts in Measuring physicochemical properties Fast For most projects, data is returned within 5 business days or less. Flexible Use our standard experimental protocol or customize your own. Affordable Multiple options are available for a wide variety of budgets. EXPERTS IN ANALYTICAL CHEMISTRY Analiza, Inc. is a leading contract research organization dedicated to discovering,COMPANY OVERVIEW
Company Overview. Analiza, Inc. is a leading contract research organization dedicated to discovering, developing, and commercializing new technologies for the life sciences. Analiza provides integrated solutions to key applications in the pharmaceutical, biotechnology and diagnostics industries. Since 1997, Analiza has pioneered unique CUSTOM ANALYTICAL SERVICES Analiza offers comprehensive custom analytical services for non-GLP studies, with over 3,000 square feet of dedicated laboratory space equipped with HPLC, UPLC, LC-QTOFMS, plate readers, and a team of specialized applications chemists. Whether your team requires state-of-the-art instrumentation, a team of expert scientists, or extra capacity to support discovery and early development projectsCONTACT - ANALIZA
Contact Us Interested in receiving more information about our services? info@analiza.com (216) 432-9050 3615 Superior Ave. #4407BCleveland, OH 44114CAREERS - ANALIZA
Careers. Analiza extends the in-house physicochemical and ADME profiling capabilities of our clients by adapting gold standard methods for compatibility with early drug discovery. Our focus is providing fast, accurate, and affordable results to our clients in the fast-paced pharmaceutical and biotech industries. PHYSICOCHEMICAL PROPERTIES It is critical to obtain experimental physicochemical property data in early drug discovery. Because these properties significantly influence ADME properties and guide decision-making about which drug candidates to pursue, it is important that physicochemical property measurements be affordable, reliable, and readily available. Analiza has adapted, improved, and automated gold-standardFAQ - ANALIZA
What is the best way to ship my samples? FOR DMSO STOCKS: The best shipping practice is to send the samples in a 96-well plate frozen on dry ice. The samples should be secured with a heat seal. Sticky seals are not recommended, as they can easily peel away from the sample plate. Sending the FAQ Read More »PKA - ANALIZA
Assay Information. We scaled back the compound requirements to deliver accurate pKa data from just 30 μL of 10mM DMSO stock solution, because we understand that you cannot spare mLs of material for a single measurement during the discovery phase. We also understand that the timescale for discovery options is measured in hours not days orweeks
PAMPA - ANALIZA
The PAMPA assay generates consistent, reproducible data over a range of permeability values. To avoid non-specific binding, we’ve incorporated Corning Gentest TM pre-coated PAMPA plates into our workflow. Unlike traditional PAMPA formulations, these plates are comprised of an oil-lipid-oil trilayer, offering a shortened path forcompound
MICROSOMAL STABILITY Timelines and budgets are tight, so we’ve coupled high resolution accurate mass Q-TOF microsomal stability with HPLC to help you do more with less. Full-scan data is acquired, from which narrow window extracted ion chromatograms are generated, producing quantitative data equivalent to that obtained by HPLC/MS/MS without the time-consuming process of developing distinct, MS methods for each ANALYTICAL CHEMISTRY SERVICES FOR EARLY DRUG DISCOVERYSERVICESCAREERSCONTACTPKAMINIATURIZED SHAKE-FLASK LOGD/LOGPXRD-CRYSTALLINITY ASSESSMENT experts in Measuring physicochemical properties Fast For most projects, data is returned within 5 business days or less. Flexible Use our standard experimental protocol or customize your own. Affordable Multiple options are available for a wide variety of budgets. EXPERTS IN ANALYTICAL CHEMISTRY Analiza, Inc. is a leading contract research organization dedicated to discovering,COMPANY OVERVIEW
Company Overview. Analiza, Inc. is a leading contract research organization dedicated to discovering, developing, and commercializing new technologies for the life sciences. Analiza provides integrated solutions to key applications in the pharmaceutical, biotechnology and diagnostics industries. Since 1997, Analiza has pioneered unique CUSTOM ANALYTICAL SERVICES Analiza offers comprehensive custom analytical services for non-GLP studies, with over 3,000 square feet of dedicated laboratory space equipped with HPLC, UPLC, LC-QTOFMS, plate readers, and a team of specialized applications chemists. Whether your team requires state-of-the-art instrumentation, a team of expert scientists, or extra capacity to support discovery and early development projectsCONTACT - ANALIZA
Contact Us Interested in receiving more information about our services? info@analiza.com (216) 432-9050 3615 Superior Ave. #4407BCleveland, OH 44114CAREERS - ANALIZA
Careers. Analiza extends the in-house physicochemical and ADME profiling capabilities of our clients by adapting gold standard methods for compatibility with early drug discovery. Our focus is providing fast, accurate, and affordable results to our clients in the fast-paced pharmaceutical and biotech industries. PHYSICOCHEMICAL PROPERTIES It is critical to obtain experimental physicochemical property data in early drug discovery. Because these properties significantly influence ADME properties and guide decision-making about which drug candidates to pursue, it is important that physicochemical property measurements be affordable, reliable, and readily available. Analiza has adapted, improved, and automated gold-standardFAQ - ANALIZA
What is the best way to ship my samples? FOR DMSO STOCKS: The best shipping practice is to send the samples in a 96-well plate frozen on dry ice. The samples should be secured with a heat seal. Sticky seals are not recommended, as they can easily peel away from the sample plate. Sending the FAQ Read More »PKA - ANALIZA
Assay Information. We scaled back the compound requirements to deliver accurate pKa data from just 30 μL of 10mM DMSO stock solution, because we understand that you cannot spare mLs of material for a single measurement during the discovery phase. We also understand that the timescale for discovery options is measured in hours not days orweeks
PAMPA - ANALIZA
The PAMPA assay generates consistent, reproducible data over a range of permeability values. To avoid non-specific binding, we’ve incorporated Corning Gentest TM pre-coated PAMPA plates into our workflow. Unlike traditional PAMPA formulations, these plates are comprised of an oil-lipid-oil trilayer, offering a shortened path forcompound
MICROSOMAL STABILITY Timelines and budgets are tight, so we’ve coupled high resolution accurate mass Q-TOF microsomal stability with HPLC to help you do more with less. Full-scan data is acquired, from which narrow window extracted ion chromatograms are generated, producing quantitative data equivalent to that obtained by HPLC/MS/MS without the time-consuming process of developing distinct, MS methods for eachASSAYS ARCHIVE
Timelines and budgets are tight, so we’ve coupled high resolution accurate mass Q-TOF microsomal stability with HPLC to help you do morewith less.
IN-VITRO ADME PROPERTIES ADME properties are critical to assess during lead selection because they influence a drug’s bioavailability and efficacy. Conducting in-vitro studies is a rapid and cost-effective way to prioritize compounds and predict the success of downstream in-vivo ADME studies. Because solubility issues can affect the reliability of in-vitro data, our assays have been optimized to deliver data for a SOLUBILITY - ANALIZA Solubility (µM) Whether you’re tight on budget, time, or internal capacity, Analiza offers a solubility assay to meet your needs. We use only miniaturized, gold- standard shake-flask assays with quantitation by LC-MS, LC-UV or chemiluminscent nitrogen detection (CLND) toPAMPA - ANALIZA
The PAMPA assay generates consistent, reproducible data over a range of permeability values. To avoid non-specific binding, we’ve incorporated Corning Gentest TM pre-coated PAMPA plates into our workflow. Unlike traditional PAMPA formulations, these plates are comprised of an oil-lipid-oil trilayer, offering a shortened path forcompound
ALPHALOGD - ANALIZA
Whether you’re tight on budget, time, or internal capacity, Analiza offers a logD assay to meet your needs—especially if you’re breaking into new chemical space. To meet the short timelines and scarce compound availability associated with discovery operations, we now offer a sophisticated HPLC-based alternative to the shake-flaskmethod
SERVICES | ANALIZA, INC. Analiza, Inc. 3615 Superior Ave #4407b. Cleveland, OH 44114 (216)432-9050
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PLASMA STABILITY
Assay Information. Poor plasma stability can lead to rapid clearance, short half-lives, and poor in vivo performance. Pharmacokinetic (PK) studies are especially challenging for these compounds as they continue to degrade even after blood is sampled from the study animal, leading to ambiguous PK data. In the case of prodrugs and antedrugs ANALYTICAL CHEMISTRY SERVICES FOR EARLY DRUG DISCOVERYSERVICESCAREERSCONTACTPKAMINIATURIZED SHAKE-FLASK LOGD/LOGPXRD-CRYSTALLINITY ASSESSMENT experts in Measuring physicochemical properties Fast For most projects, data is returned within 5 business days or less. Flexible Use our standard experimental protocol or customize your own. Affordable Multiple options are available for a wide variety of budgets. EXPERTS IN ANALYTICAL CHEMISTRY Analiza, Inc. is a leading contract research organization dedicated to discovering,COMPANY OVERVIEW
Company Overview. Analiza, Inc. is a leading contract research organization dedicated to discovering, developing, and commercializing new technologies for the life sciences. Analiza provides integrated solutions to key applications in the pharmaceutical, biotechnology and diagnostics industries. Since 1997, Analiza has pioneered unique CUSTOM ANALYTICAL SERVICES Analiza offers comprehensive custom analytical services for non-GLP studies, with over 3,000 square feet of dedicated laboratory space equipped with HPLC, UPLC, LC-QTOFMS, plate readers, and a team of specialized applications chemists. Whether your team requires state-of-the-art instrumentation, a team of expert scientists, or extra capacity to support discovery and early development projectsCONTACT - ANALIZA
Contact Us Interested in receiving more information about our services? info@analiza.com (216) 432-9050 3615 Superior Ave. #4407BCleveland, OH 44114CAREERS - ANALIZA
Careers. Analiza extends the in-house physicochemical and ADME profiling capabilities of our clients by adapting gold standard methods for compatibility with early drug discovery. Our focus is providing fast, accurate, and affordable results to our clients in the fast-paced pharmaceutical and biotech industries. PHYSICOCHEMICAL PROPERTIES It is critical to obtain experimental physicochemical property data in early drug discovery. Because these properties significantly influence ADME properties and guide decision-making about which drug candidates to pursue, it is important that physicochemical property measurements be affordable, reliable, and readily available. Analiza has adapted, improved, and automated gold-standardFAQ - ANALIZA
What is the best way to ship my samples? FOR DMSO STOCKS: The best shipping practice is to send the samples in a 96-well plate frozen on dry ice. The samples should be secured with a heat seal. Sticky seals are not recommended, as they can easily peel away from the sample plate. Sending the FAQ Read More »PKA - ANALIZA
Assay Information. We scaled back the compound requirements to deliver accurate pKa data from just 30 μL of 10mM DMSO stock solution, because we understand that you cannot spare mLs of material for a single measurement during the discovery phase. We also understand that the timescale for discovery options is measured in hours not days orweeks
PAMPA - ANALIZA
The PAMPA assay generates consistent, reproducible data over a range of permeability values. To avoid non-specific binding, we’ve incorporated Corning Gentest TM pre-coated PAMPA plates into our workflow. Unlike traditional PAMPA formulations, these plates are comprised of an oil-lipid-oil trilayer, offering a shortened path forcompound
MICROSOMAL STABILITY Timelines and budgets are tight, so we’ve coupled high resolution accurate mass Q-TOF microsomal stability with HPLC to help you do more with less. Full-scan data is acquired, from which narrow window extracted ion chromatograms are generated, producing quantitative data equivalent to that obtained by HPLC/MS/MS without the time-consuming process of developing distinct, MS methods for each ANALYTICAL CHEMISTRY SERVICES FOR EARLY DRUG DISCOVERYSERVICESCAREERSCONTACTPKAMINIATURIZED SHAKE-FLASK LOGD/LOGPXRD-CRYSTALLINITY ASSESSMENT experts in Measuring physicochemical properties Fast For most projects, data is returned within 5 business days or less. Flexible Use our standard experimental protocol or customize your own. Affordable Multiple options are available for a wide variety of budgets. EXPERTS IN ANALYTICAL CHEMISTRY Analiza, Inc. is a leading contract research organization dedicated to discovering,COMPANY OVERVIEW
Company Overview. Analiza, Inc. is a leading contract research organization dedicated to discovering, developing, and commercializing new technologies for the life sciences. Analiza provides integrated solutions to key applications in the pharmaceutical, biotechnology and diagnostics industries. Since 1997, Analiza has pioneered unique CUSTOM ANALYTICAL SERVICES Analiza offers comprehensive custom analytical services for non-GLP studies, with over 3,000 square feet of dedicated laboratory space equipped with HPLC, UPLC, LC-QTOFMS, plate readers, and a team of specialized applications chemists. Whether your team requires state-of-the-art instrumentation, a team of expert scientists, or extra capacity to support discovery and early development projectsCONTACT - ANALIZA
Contact Us Interested in receiving more information about our services? info@analiza.com (216) 432-9050 3615 Superior Ave. #4407BCleveland, OH 44114CAREERS - ANALIZA
Careers. Analiza extends the in-house physicochemical and ADME profiling capabilities of our clients by adapting gold standard methods for compatibility with early drug discovery. Our focus is providing fast, accurate, and affordable results to our clients in the fast-paced pharmaceutical and biotech industries. PHYSICOCHEMICAL PROPERTIES It is critical to obtain experimental physicochemical property data in early drug discovery. Because these properties significantly influence ADME properties and guide decision-making about which drug candidates to pursue, it is important that physicochemical property measurements be affordable, reliable, and readily available. Analiza has adapted, improved, and automated gold-standardFAQ - ANALIZA
What is the best way to ship my samples? FOR DMSO STOCKS: The best shipping practice is to send the samples in a 96-well plate frozen on dry ice. The samples should be secured with a heat seal. Sticky seals are not recommended, as they can easily peel away from the sample plate. Sending the FAQ Read More »PKA - ANALIZA
Assay Information. We scaled back the compound requirements to deliver accurate pKa data from just 30 μL of 10mM DMSO stock solution, because we understand that you cannot spare mLs of material for a single measurement during the discovery phase. We also understand that the timescale for discovery options is measured in hours not days orweeks
PAMPA - ANALIZA
The PAMPA assay generates consistent, reproducible data over a range of permeability values. To avoid non-specific binding, we’ve incorporated Corning Gentest TM pre-coated PAMPA plates into our workflow. Unlike traditional PAMPA formulations, these plates are comprised of an oil-lipid-oil trilayer, offering a shortened path forcompound
MICROSOMAL STABILITY Timelines and budgets are tight, so we’ve coupled high resolution accurate mass Q-TOF microsomal stability with HPLC to help you do more with less. Full-scan data is acquired, from which narrow window extracted ion chromatograms are generated, producing quantitative data equivalent to that obtained by HPLC/MS/MS without the time-consuming process of developing distinct, MS methods for eachASSAYS ARCHIVE
Timelines and budgets are tight, so we’ve coupled high resolution accurate mass Q-TOF microsomal stability with HPLC to help you do morewith less.
IN-VITRO ADME PROPERTIES ADME properties are critical to assess during lead selection because they influence a drug’s bioavailability and efficacy. Conducting in-vitro studies is a rapid and cost-effective way to prioritize compounds and predict the success of downstream in-vivo ADME studies. Because solubility issues can affect the reliability of in-vitro data, our assays have been optimized to deliver data for a SOLUBILITY - ANALIZA Solubility (µM) Whether you’re tight on budget, time, or internal capacity, Analiza offers a solubility assay to meet your needs. We use only miniaturized, gold- standard shake-flask assays with quantitation by LC-MS, LC-UV or chemiluminscent nitrogen detection (CLND) toPAMPA - ANALIZA
The PAMPA assay generates consistent, reproducible data over a range of permeability values. To avoid non-specific binding, we’ve incorporated Corning Gentest TM pre-coated PAMPA plates into our workflow. Unlike traditional PAMPA formulations, these plates are comprised of an oil-lipid-oil trilayer, offering a shortened path forcompound
ALPHALOGD - ANALIZA
Whether you’re tight on budget, time, or internal capacity, Analiza offers a logD assay to meet your needs—especially if you’re breaking into new chemical space. To meet the short timelines and scarce compound availability associated with discovery operations, we now offer a sophisticated HPLC-based alternative to the shake-flaskmethod
SERVICES | ANALIZA, INC. Analiza, Inc. 3615 Superior Ave #4407b. Cleveland, OH 44114 (216)432-9050
BLOG - ANALIZA 2.0
Subscribe to our mailing list! First Name. Last NameWWW.ANALIZA.COM
www.analiza.com
ANALIZA.COM
analiza.com
PLASMA STABILITY
Assay Information. Poor plasma stability can lead to rapid clearance, short half-lives, and poor in vivo performance. Pharmacokinetic (PK) studies are especially challenging for these compounds as they continue to degrade even after blood is sampled from the study animal, leading to ambiguous PK data. In the case of prodrugs and antedrugs__
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ADME PROPERTY SCREENING From permeability, drug absorption, and transport to drug metabolism our services can be tailored to support your ADME/Tox needs.read more__
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