Are you over 18 and want to see adult content?
More Annotations
VIABUY prepaid credit card with online account
Are you over 18 and want to see adult content?
Александр Афанасьев — LiveJournal
Are you over 18 and want to see adult content?
Sewing machines, embroidery machines, vacuum cleaners, small appliances - AllBrands.com
Are you over 18 and want to see adult content?
Создать логотип онлайн бесплатно! Для компании, Instagram, VK, FB!
Are you over 18 and want to see adult content?
Nie wieder Diäten – Nie wieder Diäten
Are you over 18 and want to see adult content?
Favourite Annotations
A complete backup of https://dotti.com.au
Are you over 18 and want to see adult content?
A complete backup of https://ravensoftware.com
Are you over 18 and want to see adult content?
A complete backup of https://cayxanh.us
Are you over 18 and want to see adult content?
A complete backup of https://atheer.om
Are you over 18 and want to see adult content?
A complete backup of https://washington-report.org
Are you over 18 and want to see adult content?
A complete backup of https://glamnetic.com
Are you over 18 and want to see adult content?
A complete backup of https://usgovernmentmanual.gov
Are you over 18 and want to see adult content?
A complete backup of https://foodstandards.gov.au
Are you over 18 and want to see adult content?
A complete backup of https://ballet-de-marseille.com
Are you over 18 and want to see adult content?
A complete backup of https://genf20.com
Are you over 18 and want to see adult content?
A complete backup of https://upsc.gov.in
Are you over 18 and want to see adult content?
A complete backup of https://hildalsolis.org
Are you over 18 and want to see adult content?
Text
relate these to
THE REPUTATION OF AGING IN ANCIENT AND CURRENT MYTHOLOGY The reputation of aging in our culture is generally not a good one. Facts about aging are often misperceived. Aging is usually ignored, viewed in a context of resignation, or felt to be irrelevant until it is imminent. Diseases and accidents are seen to be the main causes of death even though those diseases and accidents are ones of old age. PQQ – ACTIVATOR OF PGC-1ALPHA, SIRT3 AND MITOCHONDRIAL By Vince Giuliano Minor update July 12, 2013. Pyrroloquinoline quinone (PQQ), a redox cofactor available as a dietary supplement, appears to have at least three central biological effects with powerful downstream health and longevity consequences: it stimulates the generation of PGC1-alpha, results in expression of SIRT3, and induces mitochondrial biogenesis.AMPK AND LONGEVITY
AMPK acts as an energy sensor of the cell and works as a key regulator of mitochondrial biogenesis. AMPK activity has been shown to decrease with age, which may contribute to decreased mitochondrial biogenesis and function with aging. The 2008 publication Mitochondrial biogenesis and healthy aging identifies yet-another theory of aging: that AGING, HEALTH AND DISEASE PART 2 OF INTERVENTIONS THAT REDUCE ALL CAUSE MORTALITY by James P Watson and Vince Giuliano. There is a community of self-experimenters who are taking the drug Metformin, not because they are diabetic or prediabetic, the FDA-approved reasons for prescribing the drug, but rather because they believe it probably has an impact in promoting general health and retarding aging().In fact, it is probably the pharmaceutical most used for this purpose. TRANSPOSABLE DNA ELEMENTS Transposable DNA elements – Part 1: basics and importance. Posted on 12. November 2015 by Vince Giuliano. This is the first blog entry in a three-part series concerned with transposable DNA entries (TEs). It focuses on basics of what TEs are, why they are important for us who are concerned with health and aging, and briefly outlines what NIACIN OR NIACINAMIDE SUPPLEMENTATION €“ GOOD OR BAD IDEA Niacin also assists in antioxidant and detoxification functions, and the production of sex and adrenal hormones. Vitamin B3 (niacin, niacinamide, nicotinic acid) lowers cholesterol by preventing its buildup in the liver and arteries. Niacin moves fat from tissues for fat metabolism, burning it YGC MORE ON YOUNGING1.0 By Vince Giuliano. Methuselah –Methuselah lived 969 years according to Genesis 5:27, the oldest person who ever lived. Image source I believe the previous blog entry YGB YOUNGING1.0 – THE EMERGING AGING REVERSAL STRATEGY may well turn out to be the most important one published in this blog so far. In that blog entry, Steve Buss and I described some key elements of a strategy for age ANTI-INFLAMMATORY HERBAL LIPOSOMAL PROPARATIONS … By Vince Giuliano Frequent Frequent readers of this blog know that I have invented a dietary supplement for the control of chronic inflammation, an important hallmark of aging disabilities. The purpose of this blog entry is Continue reading → VINCE GIULIANO, AUTHOR AT AGINGSCIENCES™ January 2021 by Vince Giuliano. This gallery contains 4 photos . I expand on the hypothesized scientific basis for YOUNGING1.0, which is the reversal of global H3K27 histone methylation via JMJD2/JMJD3. I go deeper into the biology and processes of histone methylation – andrelate these to
THE REPUTATION OF AGING IN ANCIENT AND CURRENT MYTHOLOGY The reputation of aging in our culture is generally not a good one. Facts about aging are often misperceived. Aging is usually ignored, viewed in a context of resignation, or felt to be irrelevant until it is imminent. Diseases and accidents are seen to be the main causes of death even though those diseases and accidents are ones of old age. PQQ – ACTIVATOR OF PGC-1ALPHA, SIRT3 AND MITOCHONDRIAL By Vince Giuliano Minor update July 12, 2013. Pyrroloquinoline quinone (PQQ), a redox cofactor available as a dietary supplement, appears to have at least three central biological effects with powerful downstream health and longevity consequences: it stimulates the generation of PGC1-alpha, results in expression of SIRT3, and induces mitochondrial biogenesis.AMPK AND LONGEVITY
AMPK acts as an energy sensor of the cell and works as a key regulator of mitochondrial biogenesis. AMPK activity has been shown to decrease with age, which may contribute to decreased mitochondrial biogenesis and function with aging. The 2008 publication Mitochondrial biogenesis and healthy aging identifies yet-another theory of aging: that AGING, HEALTH AND DISEASE PART 2 OF INTERVENTIONS THAT REDUCE ALL CAUSE MORTALITY by James P Watson and Vince Giuliano. There is a community of self-experimenters who are taking the drug Metformin, not because they are diabetic or prediabetic, the FDA-approved reasons for prescribing the drug, but rather because they believe it probably has an impact in promoting general health and retarding aging().In fact, it is probably the pharmaceutical most used for this purpose. TRANSPOSABLE DNA ELEMENTS Transposable DNA elements – Part 1: basics and importance. Posted on 12. November 2015 by Vince Giuliano. This is the first blog entry in a three-part series concerned with transposable DNA entries (TEs). It focuses on basics of what TEs are, why they are important for us who are concerned with health and aging, and briefly outlines what NIACIN OR NIACINAMIDE SUPPLEMENTATION €“ GOOD OR BAD IDEA Niacin also assists in antioxidant and detoxification functions, and the production of sex and adrenal hormones. Vitamin B3 (niacin, niacinamide, nicotinic acid) lowers cholesterol by preventing its buildup in the liver and arteries. Niacin moves fat from tissues for fat metabolism, burning itAGINGSCIENCES™
this gallery contains 5 photos.. review of scientific aspects related to neuroinflammation: reactive oxygen species, mitochondrial factors, inflammasomes, ppars, metbolic pathways, sirts, dna damage and roles of nrf2 and nf-kb, and another magic mushroom, yun-zhi continuereading →
ANTI-INFLAMMATORY HERBAL LIPOSOMAL PROPARATIONS … Vince, thank you for taking the time to explain your process and motivations in producing 4 Herb Synergy Gold. Your reasoning is correct, as it is difficult for even those of us with a background in the sciences to follow the great complexity of the processes that you explore in your blog.AMPK AND LONGEVITY
AMPK acts as an energy sensor of the cell and works as a key regulator of mitochondrial biogenesis. AMPK activity has been shown to decrease with age, which may contribute to decreased mitochondrial biogenesis and function with aging. The 2008 publication Mitochondrial biogenesis and healthy aging identifies yet-another theory of aging: that PGC-1-ALPHA AND EXERCISE PGC-1-alpha is a gene co-activator, necessary to turn on the PPARG gene and essential in the metabolic process. PGC-1-alpha (Peroxisome proliferator-activated receptor gamma coactivator 1-alpha) “is a protein that in humans is encoded by the PPARGC1A gene. The protein encoded by this gene is a transcriptional coactivator that regulatesthe
AGING, CELL AND TISSUE REPAIR, RENEWAL AND … By Vince Giuliano INTRODUCTION Many of us who have studied aging have long believed that, sooner or later we would discover keys to a long and healthy life via biological repair, renewal and regenerative processes. Based on what we have Continue reading → AGING, HEALTH AND DISEASE This blog entry looks at at aging, health and disease from the viewpoint of DNA methylation, that is, lifelong changes in methylation status of selected genes. This is a highly useful viewpoint because it: is a good predictor of all-cause mortality. According to this viewpoint, genomic methylation: INFLAMMATION PART 6: THE SCIENCE BEHIND THE 4 HERB … Ancient plant wisdom meets nanotechnology By Vince Giuliano May 28, 2019 This blog entry is concerned with a new dietary supplement that my colleagues I have sourced, called 4 Herb Synergy. It is concerned with the scientific considerations we have Continue reading → TRANSPOSABLE DNA ELEMENTS Transposable DNA elements – Part 1: basics and importance. Posted on 12. November 2015 by Vince Giuliano. This is the first blog entry in a three-part series concerned with transposable DNA entries (TEs). It focuses on basics of what TEs are, why they are important for us who are concerned with health and aging, and briefly outlines what TELOMERASE UPDATE –ARGUMENTS FOR AND AGAINST USING By Vince Giuliano In past blog entries and in my treatise I have explained how I was an early adapter at taking telomerase extenders like astrogaloside4 and cycloastragenol, and why, later as a result of following much research, I stopped Continue reading → SALAMANDERS AND HUMAN LIMB REGENERATION This recent citation outlines the general process. “When a salamander loses an appendage, such as a limb, a remarkable series of events unfolds: a clump of cells forms at the site of the injury, and this deceptively simple structure, known as a blastema, regenerates the missing body parts. Skin, muscle, bone, blood vessels and neuronsall
AGINGSCIENCES™
this gallery contains 5 photos.. review of scientific aspects related to neuroinflammation: reactive oxygen species, mitochondrial factors, inflammasomes, ppars, metbolic pathways, sirts, dna damage and roles of nrf2 and nf-kb, and another magic mushroom, yun-zhi continuereading →
THE REPUTATION OF AGING IN ANCIENT AND CURRENT MYTHOLOGY Why the pursuit of anti-aging science? I take a short break from science in this blog entry and look at myths about aging and how aging is viewed in popular folklore – ancient and current. These myths are important because aging science exists in our more-general culture and efforts to suggest an impending possibility for life-extension are often met with misplaced negative reactions.AMPK AND LONGEVITY
The AMPK signaling pathway is one that is increasingly being viewed as playing a central role in metabolism and growth(ref). And that pathway appears to have a lot to do with longevity. In fact, it is possible that some degree Continue reading → PART 2 OF INTERVENTIONS THAT REDUCE ALL CAUSE MORTALITY by James P Watson and Vince Giuliano. There is a community of self-experimenters who are taking the drug Metformin, not because they are diabetic or prediabetic, the FDA-approved reasons for prescribing the drug, but rather because they believe it probably has an impact in promoting general health and retarding aging().In fact, it is probably the pharmaceutical most used for this purpose. AGING, HEALTH AND DISEASE VINCE GIULIANO, AUTHOR AT AGINGSCIENCES™ About Vince Giuliano Being a follower, connoisseur, and interpreter of longevity research is my latest career, since 2007. I believe I am unique among the researchers and writers in the aging sciences community in one critical respect.AGINGSCIENCES™
this gallery contains 5 photos.. review of scientific aspects related to neuroinflammation: reactive oxygen species, mitochondrial factors, inflammasomes, ppars, metbolic pathways, sirts, dna damage and roles of nrf2 and nf-kb, and another magic mushroom, yun-zhi continuereading →
THE REPUTATION OF AGING IN ANCIENT AND CURRENT MYTHOLOGY Why the pursuit of anti-aging science? I take a short break from science in this blog entry and look at myths about aging and how aging is viewed in popular folklore – ancient and current. These myths are important because aging science exists in our more-general culture and efforts to suggest an impending possibility for life-extension are often met with misplaced negative reactions.AMPK AND LONGEVITY
The AMPK signaling pathway is one that is increasingly being viewed as playing a central role in metabolism and growth(ref). And that pathway appears to have a lot to do with longevity. In fact, it is possible that some degree Continue reading → PART 2 OF INTERVENTIONS THAT REDUCE ALL CAUSE MORTALITY by James P Watson and Vince Giuliano. There is a community of self-experimenters who are taking the drug Metformin, not because they are diabetic or prediabetic, the FDA-approved reasons for prescribing the drug, but rather because they believe it probably has an impact in promoting general health and retarding aging().In fact, it is probably the pharmaceutical most used for this purpose. AGING, HEALTH AND DISEASE VINCE GIULIANO, AUTHOR AT AGINGSCIENCES™ About Vince Giuliano Being a follower, connoisseur, and interpreter of longevity research is my latest career, since 2007. I believe I am unique among the researchers and writers in the aging sciences community in one critical respect.AGINGSCIENCES™
This gallery contains 4 photos.. I expand on the hypothesized scientific basis for YOUNGING1.0, which is the reversal of global H3K27 histone methylation via JMJD2/JMJD3.AGINGSCIENCES™
this gallery contains 5 photos.. review of scientific aspects related to neuroinflammation: reactive oxygen species, mitochondrial factors, inflammasomes, ppars, metbolic pathways, sirts, dna damage and roles of nrf2 and nf-kb, and another magic mushroom, yun-zhi continuereading →
AMPK AND LONGEVITY
The AMPK signaling pathway is one that is increasingly being viewed as playing a central role in metabolism and growth(ref). And that pathway appears to have a lot to do with longevity. In fact, it is possible that some degree Continue reading → AGING, CELL AND TISSUE REPAIR, RENEWAL AND … By Vince Giuliano INTRODUCTION Many of us who have studied aging have long believed that, sooner or later we would discover keys to a long and healthy life via biological repair, renewal and regenerative processes. Based on what we have Continue reading → TRANSPOSABLE DNA ELEMENTS By Vince Giuliano, inspired by interaction by James P. Watson This is the first blog entry in a three-part series concerned with transposable DNA entries (TEs). It focuses on basics of what TEs are, why they are important for us Continue reading →LONGEVITY VIEWS,
By Vince Giuliano I am writing this at a time when like tens of millions throughout the world I am shuttered at home as protection against the COVID-19 pandemic. On November 17, 2019, I turned 90. Because of my age Continue reading → NEUROGENESIS, CURCUMIN AND LONGEVITY I have discussed both neurogenesis and curcumin in my treatise and in numerous blog entries but have never examined their relationship. This blog entry is about the actions of curcumin in promoting neurogenesis in the hippocampus and highly-likely mental-health implications of taking curcumin supplements. Finally, I touch on something else that is new – on how curcumin might JAMES WATSON, AUTHOR AT AGINGSCIENCES™ About James Watson I am a physician with a keen interest in the molecular biology of aging. I have specific interests in the theories of antagonistic pleiotropy and hormesis as frameworks to understand cellular senescence and mechanisms for coping with cellular stress. MY THOUGHTS ON HOW TO LIVE MY LONGEST HEALTHY LIFE Stan Goldfarb Introduction by Vince Giuliano Stan Goldfarb is a friend and a colleague who often contributes to online longevity discussions, particularly ones concerned with dietary supplements. Although not a scientist he has strong and sometimes unique views on what Continuereading →
THE ALPHA AND BETA OF GSK-3S The Molecules that Play Dr. Jeckel and Mr. Hyde in Aging, Alzheimer’s Disease, and Type II Diabetes By James P Watson, with summary and contributions from Vince Giuliano Introduction – GSK-3s – The “Dr. Jeckel and Mr. Hyde” Molecules Have Continue reading→
AGINGSCIENCES™
This gallery contains 4 photos.. I expand on the hypothesized scientific basis for YOUNGING1.0, which is the reversal of global H3K27 histone methylation via JMJD2/JMJD3. YGD YOUNGING1.0 PART 4: UNDERLYING MECHANISMS OF … About Vince Giuliano Being a follower, connoisseur, and interpreter of longevity research is my latest career, since 2007. I believe I am unique among the researchers and writers in the aging sciences community in one critical respect. ANTI-INFLAMMATORY HERBAL LIPOSOMAL PROPARATIONS … By Vince Giuliano Frequent Frequent readers of this blog know that I have invented a dietary supplement for the control of chronic inflammation, an important hallmark of aging disabilities. The purpose of this blog entry is Continue reading → YGC MORE ON YOUNGING1.0 By Vince Giuliano. Methuselah –Methuselah lived 969 years according to Genesis 5:27, the oldest person who ever lived. Image source I believe the previous blog entry YGB YOUNGING1.0 – THE EMERGING AGING REVERSAL STRATEGY may well turn out to be the most important one published in this blog so far. In that blog entry, Steve Buss and I described some key elements of a strategy for age VINCE GIULIANO, AUTHOR AT AGINGSCIENCES™ January 2021 by Vince Giuliano. This gallery contains 4 photos . I expand on the hypothesized scientific basis for YOUNGING1.0, which is the reversal of global H3K27 histone methylation via JMJD2/JMJD3. I go deeper into the biology and processes of histone methylation – andrelate these to
YGB YOUNGING1.0
By Vince Giuliano and Steve Buss (A general introduction to this first substantive Blog Post in a new YOUNGING Series is provided in the post Introduction to the YOUNGING Series – Emerging Aging Reversal Strategies and Treatments).. The key elements of a strategy for age reversal are emerging in the recent literature –we call itYOUNGING1.0.
PQQ – ACTIVATOR OF PGC-1ALPHA, SIRT3 AND MITOCHONDRIAL By Vince Giuliano Minor update July 12, 2013. Pyrroloquinoline quinone (PQQ), a redox cofactor available as a dietary supplement, appears to have at least three central biological effects with powerful downstream health and longevity consequences: it stimulates the generation of PGC1-alpha, results in expression of SIRT3, and induces mitochondrial biogenesis.AGINGSCIENCES™
This gallery contains 4 photos.. I expand on the hypothesized scientific basis for YOUNGING1.0, which is the reversal of global H3K27 histone methylation via JMJD2/JMJD3. YGD YOUNGING1.0 PART 4: UNDERLYING MECHANISMS OF … About Vince Giuliano Being a follower, connoisseur, and interpreter of longevity research is my latest career, since 2007. I believe I am unique among the researchers and writers in the aging sciences community in one critical respect. ANTI-INFLAMMATORY HERBAL LIPOSOMAL PROPARATIONS … By Vince Giuliano Frequent Frequent readers of this blog know that I have invented a dietary supplement for the control of chronic inflammation, an important hallmark of aging disabilities. The purpose of this blog entry is Continue reading → YGC MORE ON YOUNGING1.0 By Vince Giuliano. Methuselah –Methuselah lived 969 years according to Genesis 5:27, the oldest person who ever lived. Image source I believe the previous blog entry YGB YOUNGING1.0 – THE EMERGING AGING REVERSAL STRATEGY may well turn out to be the most important one published in this blog so far. In that blog entry, Steve Buss and I described some key elements of a strategy for age VINCE GIULIANO, AUTHOR AT AGINGSCIENCES™ January 2021 by Vince Giuliano. This gallery contains 4 photos . I expand on the hypothesized scientific basis for YOUNGING1.0, which is the reversal of global H3K27 histone methylation via JMJD2/JMJD3. I go deeper into the biology and processes of histone methylation – andrelate these to
YGB YOUNGING1.0
By Vince Giuliano and Steve Buss (A general introduction to this first substantive Blog Post in a new YOUNGING Series is provided in the post Introduction to the YOUNGING Series – Emerging Aging Reversal Strategies and Treatments).. The key elements of a strategy for age reversal are emerging in the recent literature –we call itYOUNGING1.0.
PQQ – ACTIVATOR OF PGC-1ALPHA, SIRT3 AND MITOCHONDRIAL By Vince Giuliano Minor update July 12, 2013. Pyrroloquinoline quinone (PQQ), a redox cofactor available as a dietary supplement, appears to have at least three central biological effects with powerful downstream health and longevity consequences: it stimulates the generation of PGC1-alpha, results in expression of SIRT3, and induces mitochondrial biogenesis. AGING, HEALTH AND DISEASE THE REPUTATION OF AGING IN ANCIENT AND CURRENT MYTHOLOGY The reputation of aging in our culture is generally not a good one. Facts about aging are often misperceived. Aging is usually ignored, viewed in a context of resignation, or felt to be irrelevant until it is imminent. Diseases and accidents are seen to be the main causes of death even though those diseases and accidents are ones of old age. NIACIN OR NIACINAMIDE SUPPLEMENTATION €“ GOOD OR BAD IDEA Niacin also assists in antioxidant and detoxification functions, and the production of sex and adrenal hormones. Vitamin B3 (niacin, niacinamide, nicotinic acid) lowers cholesterol by preventing its buildup in the liver and arteries. Niacin moves fat from tissues for fat metabolism, burning itAGINGSCIENCES™
This gallery contains 4 photos.. I expand on the hypothesized scientific basis for YOUNGING1.0, which is the reversal of global H3K27 histone methylation via JMJD2/JMJD3. MY THOUGHTS ON HOW TO LIVE MY LONGEST HEALTHY LIFE Stan Goldfarb Introduction by Vince Giuliano Stan Goldfarb is a friend and a colleague who often contributes to online longevity discussions, particularly ones concerned with dietary supplements. Although not a scientist he has strong and sometimes unique views on what Continuereading →
AGING, HEALTH AND DISEASE This blog entry looks at at aging, health and disease from the viewpoint of DNA methylation, that is, lifelong changes in methylation status of selected genes. This is a highly useful viewpoint because it: is a good predictor of all-cause mortality. According to this viewpoint, genomic methylation: JAMES WATSON, AUTHOR AT AGINGSCIENCES™ Inflammation Part 2: The Tale of Three Stress Sensors and their Interactions: 1)Inflammation, 2)Genomic Instability (p53), and 3)Oxidative stress (Nrf2) Posted on 5. November 2016 by James Watson. By James Watson, with contributions and editing by Vince Giuliano We promised a major series of blog entries related to inflammation backin May 2016.
AGING, CELL AND TISSUE REPAIR, RENEWAL AND … By Vince Giuliano INTRODUCTION Many of us who have studied aging have long believed that, sooner or later we would discover keys to a long and healthy life via biological repair, renewal and regenerative processes. Based on what we have Continue reading → THE MAKING OF A DIETARY SUPPLEMENT By Vince Giuliano June 3 2019. This blog entry tells the stories of how our new dietary supplement 4 Herb Synergy came into being. As such, this blog entry tells two short histories: a universal history over more than a billion years, and a highly personal history duringmy adult lifetime.
TELOMERASE UPDATE –ARGUMENTS FOR AND AGAINST USING By Vince Giuliano In past blog entries and in my treatise I have explained how I was an early adapter at taking telomerase extenders like astrogaloside4 and cycloastragenol, and why, later as a result of following much research, I stopped Continue reading → NEUROGENESIS, CURCUMIN AND LONGEVITY Neurogenesis takes place throughout the life of a mammal in two major brain structures: the dentate gyrus of the hippocampus and the subventricular zone of the forebrain. In these regions neural progenitor cells continuously divide and give birth to new neurons and glial cells. In the mammalian brain neural progenitor cells aremultipotent.
THE CURIOUS CASE OF L-CARNOSINE Carnosine is an efficient chelating agents for copper and other transition metals, and Carnosine appears to protect neurons from zinc- and copper-mediated neurotoxicity. Carnosine appears to expand the resistance of rats to various induced stresses. It can be used in the treatment o severe gingivostomatitis. TREHALOSE – A NATURAL SUGAR THAT COULD POSSIBLY BE By Vince Giuliano and James P Watson. Trehalose is a natural disaccharide sugar contained in mushrooms and many other organisms. It has remarkable health-producing and life-extending properties that work in mice and lower organisms. That is why we choose toAGINGSCIENCES™
This gallery contains 4 photos.. I expand on the hypothesized scientific basis for YOUNGING1.0, which is the reversal of global H3K27 histone methylation via JMJD2/JMJD3.AGINGSCIENCES™
this gallery contains 5 photos.. review of scientific aspects related to neuroinflammation: reactive oxygen species, mitochondrial factors, inflammasomes, ppars, metbolic pathways, sirts, dna damage and roles of nrf2 and nf-kb, and another magic mushroom, yun-zhi continuereading →
VINCE GIULIANO, AUTHOR AT AGINGSCIENCES™ January 2021 by Vince Giuliano. This gallery contains 4 photos . I expand on the hypothesized scientific basis for YOUNGING1.0, which is the reversal of global H3K27 histone methylation via JMJD2/JMJD3. I go deeper into the biology and processes of histone methylation – andrelate these to
YGB YOUNGING1.0
By Vince Giuliano and Steve Buss (A general introduction to this first substantive Blog Post in a new YOUNGING Series is provided in the post Introduction to the YOUNGING Series – Emerging Aging Reversal Strategies and Treatments).. The key elements of a strategy for age reversal are emerging in the recent literature –we call itYOUNGING1.0.
AGING, HEALTH AND DISEASE GLUCOSAMINE FOR LONGEVITY Glucosamine is one of the most popular dietary supplements, used by millions who hope that it will lessen the ravages of osteoarthritis, arthritis, loss of cartilage and associated pain and discomfort. This natural shellfish-derived substance has been known since 1876 and its biological impacts were reported as far back as in 1919 ( ref ). PART 2 OF INTERVENTIONS THAT REDUCE ALL CAUSE MORTALITY by James P Watson and Vince Giuliano. There is a community of self-experimenters who are taking the drug Metformin, not because they are diabetic or prediabetic, the FDA-approved reasons for prescribing the drug, but rather because they believe it probably has an impact in promoting general health and retarding aging().In fact, it is probably the pharmaceutical most used for this purpose. TRANSPOSABLE DNA ELEMENTS Transposable DNA elements – Part 1: basics and importance. Posted on 12. November 2015 by Vince Giuliano. This is the first blog entry in a three-part series concerned with transposable DNA entries (TEs). It focuses on basics of what TEs are, why they are important for us who are concerned with health and aging, and briefly outlines what THE REPUTATION OF AGING IN ANCIENT AND CURRENT MYTHOLOGY The reputation of aging in our culture is generally not a good one. Facts about aging are often misperceived. Aging is usually ignored, viewed in a context of resignation, or felt to be irrelevant until it is imminent. Diseases and accidents are seen to be the main causes of death even though those diseases and accidents are ones of old age. PQQ – ACTIVATOR OF PGC-1ALPHA, SIRT3 AND MITOCHONDRIAL By Vince Giuliano Minor update July 12, 2013. Pyrroloquinoline quinone (PQQ), a redox cofactor available as a dietary supplement, appears to have at least three central biological effects with powerful downstream health and longevity consequences: it stimulates the generation of PGC1-alpha, results in expression of SIRT3, and induces mitochondrial biogenesis.AGINGSCIENCES™
This gallery contains 4 photos.. I expand on the hypothesized scientific basis for YOUNGING1.0, which is the reversal of global H3K27 histone methylation via JMJD2/JMJD3.AGINGSCIENCES™
this gallery contains 5 photos.. review of scientific aspects related to neuroinflammation: reactive oxygen species, mitochondrial factors, inflammasomes, ppars, metbolic pathways, sirts, dna damage and roles of nrf2 and nf-kb, and another magic mushroom, yun-zhi continuereading →
VINCE GIULIANO, AUTHOR AT AGINGSCIENCES™ January 2021 by Vince Giuliano. This gallery contains 4 photos . I expand on the hypothesized scientific basis for YOUNGING1.0, which is the reversal of global H3K27 histone methylation via JMJD2/JMJD3. I go deeper into the biology and processes of histone methylation – andrelate these to
YGB YOUNGING1.0
By Vince Giuliano and Steve Buss (A general introduction to this first substantive Blog Post in a new YOUNGING Series is provided in the post Introduction to the YOUNGING Series – Emerging Aging Reversal Strategies and Treatments).. The key elements of a strategy for age reversal are emerging in the recent literature –we call itYOUNGING1.0.
AGING, HEALTH AND DISEASE GLUCOSAMINE FOR LONGEVITY Glucosamine is one of the most popular dietary supplements, used by millions who hope that it will lessen the ravages of osteoarthritis, arthritis, loss of cartilage and associated pain and discomfort. This natural shellfish-derived substance has been known since 1876 and its biological impacts were reported as far back as in 1919 ( ref ). PART 2 OF INTERVENTIONS THAT REDUCE ALL CAUSE MORTALITY by James P Watson and Vince Giuliano. There is a community of self-experimenters who are taking the drug Metformin, not because they are diabetic or prediabetic, the FDA-approved reasons for prescribing the drug, but rather because they believe it probably has an impact in promoting general health and retarding aging().In fact, it is probably the pharmaceutical most used for this purpose. TRANSPOSABLE DNA ELEMENTS Transposable DNA elements – Part 1: basics and importance. Posted on 12. November 2015 by Vince Giuliano. This is the first blog entry in a three-part series concerned with transposable DNA entries (TEs). It focuses on basics of what TEs are, why they are important for us who are concerned with health and aging, and briefly outlines what THE REPUTATION OF AGING IN ANCIENT AND CURRENT MYTHOLOGY The reputation of aging in our culture is generally not a good one. Facts about aging are often misperceived. Aging is usually ignored, viewed in a context of resignation, or felt to be irrelevant until it is imminent. Diseases and accidents are seen to be the main causes of death even though those diseases and accidents are ones of old age. PQQ – ACTIVATOR OF PGC-1ALPHA, SIRT3 AND MITOCHONDRIAL By Vince Giuliano Minor update July 12, 2013. Pyrroloquinoline quinone (PQQ), a redox cofactor available as a dietary supplement, appears to have at least three central biological effects with powerful downstream health and longevity consequences: it stimulates the generation of PGC1-alpha, results in expression of SIRT3, and induces mitochondrial biogenesis.AGINGSCIENCES™
This gallery contains 4 photos.. I expand on the hypothesized scientific basis for YOUNGING1.0, which is the reversal of global H3K27 histone methylation via JMJD2/JMJD3.AGINGSCIENCES™
this gallery contains 5 photos.. review of scientific aspects related to neuroinflammation: reactive oxygen species, mitochondrial factors, inflammasomes, ppars, metbolic pathways, sirts, dna damage and roles of nrf2 and nf-kb, and another magic mushroom, yun-zhi continuereading →
LONGEVITY VIEWS,
A traditional anti-malarial and anti-arthritic drug now subject to much political controversy because the President is advocating its widespread use to treat COVID-19, but prominent physicians say its use for this purpose is unwarranted until its efficacy GLUCOSAMINE FOR LONGEVITY Glucosamine is one of the most popular dietary supplements, used by millions who hope that it will lessen the ravages of osteoarthritis, arthritis, loss of cartilage and associated pain and discomfort. This natural shellfish-derived substance has been known since 1876 and its biological impacts were reported as far back as in 1919 ( ref ). AGING, CELL AND TISSUE REPAIR, RENEWAL AND … By Vince Giuliano INTRODUCTION Many of us who have studied aging have long believed that, sooner or later we would discover keys to a long and healthy life via biological repair, renewal and regenerative processes. Based on what we have Continue reading → THE MAKING OF A DIETARY SUPPLEMENT By Vince Giuliano June 3 2019. This blog entry tells the stories of how our new dietary supplement 4 Herb Synergy came into being. As such, this blog entry tells two short histories: a universal history over more than a billion years, and a highly personal history duringmy adult lifetime.
AMPK AND LONGEVITY
AMPK acts as an energy sensor of the cell and works as a key regulator of mitochondrial biogenesis. AMPK activity has been shown to decrease with age, which may contribute to decreased mitochondrial biogenesis and function with aging. The 2008 publication Mitochondrial biogenesis and healthy aging identifies yet-another theory of aging: that PQQ – ACTIVATOR OF PGC-1ALPHA, SIRT3 AND MITOCHONDRIAL By Vince Giuliano Minor update July 12, 2013. Pyrroloquinoline quinone (PQQ), a redox cofactor available as a dietary supplement, appears to have at least three central biological effects with powerful downstream health and longevity consequences: it stimulates the generation of PGC1-alpha, results in expression of SIRT3, and induces mitochondrial biogenesis. UPDATE ON LONGEVITY INTERVENTIONS Supplement with Quercetin and Fisetin to support body removal of senescent cells. Supplement with Acetyl-l-Carnosine, Acetyl-l-Carnitine, Alpha-Lipoic Acid, and melatonin for impact on mitochondria among other reasons. Manage stress, Use of stresses as hormetic interventions – heat shock and cold shock. THE CURIOUS CASE OF L-CARNOSINE Carnosine is an efficient chelating agents for copper and other transition metals, and Carnosine appears to protect neurons from zinc- and copper-mediated neurotoxicity. Carnosine appears to expand the resistance of rats to various induced stresses. It can be used in the treatment o severe gingivostomatitis.AGINGSCIENCES™
This gallery contains 4 photos.. I expand on the hypothesized scientific basis for YOUNGING1.0, which is the reversal of global H3K27 histone methylation via JMJD2/JMJD3.AGINGSCIENCES™
this gallery contains 5 photos.. review of scientific aspects related to neuroinflammation: reactive oxygen species, mitochondrial factors, inflammasomes, ppars, metbolic pathways, sirts, dna damage and roles of nrf2 and nf-kb, and another magic mushroom, yun-zhi continuereading →
VINCE GIULIANO, AUTHOR AT AGINGSCIENCES™ January 2021 by Vince Giuliano. This gallery contains 4 photos . I expand on the hypothesized scientific basis for YOUNGING1.0, which is the reversal of global H3K27 histone methylation via JMJD2/JMJD3. I go deeper into the biology and processes of histone methylation – andrelate these to
YGB YOUNGING1.0
By Vince Giuliano and Steve Buss (A general introduction to this first substantive Blog Post in a new YOUNGING Series is provided in the post Introduction to the YOUNGING Series – Emerging Aging Reversal Strategies and Treatments).. The key elements of a strategy for age reversal are emerging in the recent literature –we call itYOUNGING1.0.
AGING, HEALTH AND DISEASE GLUCOSAMINE FOR LONGEVITY Glucosamine is one of the most popular dietary supplements, used by millions who hope that it will lessen the ravages of osteoarthritis, arthritis, loss of cartilage and associated pain and discomfort. This natural shellfish-derived substance has been known since 1876 and its biological impacts were reported as far back as in 1919 ( ref ). PART 2 OF INTERVENTIONS THAT REDUCE ALL CAUSE MORTALITY by James P Watson and Vince Giuliano. There is a community of self-experimenters who are taking the drug Metformin, not because they are diabetic or prediabetic, the FDA-approved reasons for prescribing the drug, but rather because they believe it probably has an impact in promoting general health and retarding aging().In fact, it is probably the pharmaceutical most used for this purpose. TRANSPOSABLE DNA ELEMENTS Transposable DNA elements – Part 1: basics and importance. Posted on 12. November 2015 by Vince Giuliano. This is the first blog entry in a three-part series concerned with transposable DNA entries (TEs). It focuses on basics of what TEs are, why they are important for us who are concerned with health and aging, and briefly outlines whatAGINGSCIENCES™
This gallery contains 4 photos.. I expand on the hypothesized scientific basis for YOUNGING1.0, which is the reversal of global H3K27 histone methylation via JMJD2/JMJD3.AGINGSCIENCES™
this gallery contains 5 photos.. review of scientific aspects related to neuroinflammation: reactive oxygen species, mitochondrial factors, inflammasomes, ppars, metbolic pathways, sirts, dna damage and roles of nrf2 and nf-kb, and another magic mushroom, yun-zhi continuereading →
VINCE GIULIANO, AUTHOR AT AGINGSCIENCES™ January 2021 by Vince Giuliano. This gallery contains 4 photos . I expand on the hypothesized scientific basis for YOUNGING1.0, which is the reversal of global H3K27 histone methylation via JMJD2/JMJD3. I go deeper into the biology and processes of histone methylation – andrelate these to
YGB YOUNGING1.0
By Vince Giuliano and Steve Buss (A general introduction to this first substantive Blog Post in a new YOUNGING Series is provided in the post Introduction to the YOUNGING Series – Emerging Aging Reversal Strategies and Treatments).. The key elements of a strategy for age reversal are emerging in the recent literature –we call itYOUNGING1.0.
AGING, HEALTH AND DISEASE GLUCOSAMINE FOR LONGEVITY Glucosamine is one of the most popular dietary supplements, used by millions who hope that it will lessen the ravages of osteoarthritis, arthritis, loss of cartilage and associated pain and discomfort. This natural shellfish-derived substance has been known since 1876 and its biological impacts were reported as far back as in 1919 ( ref ). PART 2 OF INTERVENTIONS THAT REDUCE ALL CAUSE MORTALITY by James P Watson and Vince Giuliano. There is a community of self-experimenters who are taking the drug Metformin, not because they are diabetic or prediabetic, the FDA-approved reasons for prescribing the drug, but rather because they believe it probably has an impact in promoting general health and retarding aging().In fact, it is probably the pharmaceutical most used for this purpose. TRANSPOSABLE DNA ELEMENTS Transposable DNA elements – Part 1: basics and importance. Posted on 12. November 2015 by Vince Giuliano. This is the first blog entry in a three-part series concerned with transposable DNA entries (TEs). It focuses on basics of what TEs are, why they are important for us who are concerned with health and aging, and briefly outlines what THE REPUTATION OF AGING IN ANCIENT AND CURRENT MYTHOLOGY The reputation of aging in our culture is generally not a good one. Facts about aging are often misperceived. Aging is usually ignored, viewed in a context of resignation, or felt to be irrelevant until it is imminent. Diseases and accidents are seen to be the main causes of death even though those diseases and accidents are ones of old age. PQQ – ACTIVATOR OF PGC-1ALPHA, SIRT3 AND MITOCHONDRIAL By Vince Giuliano Minor update July 12, 2013. Pyrroloquinoline quinone (PQQ), a redox cofactor available as a dietary supplement, appears to have at least three central biological effects with powerful downstream health and longevity consequences: it stimulates the generation of PGC1-alpha, results in expression of SIRT3, and induces mitochondrial biogenesis.AGINGSCIENCES™
This gallery contains 4 photos.. I expand on the hypothesized scientific basis for YOUNGING1.0, which is the reversal of global H3K27 histone methylation via JMJD2/JMJD3.AGINGSCIENCES™
this gallery contains 5 photos.. review of scientific aspects related to neuroinflammation: reactive oxygen species, mitochondrial factors, inflammasomes, ppars, metbolic pathways, sirts, dna damage and roles of nrf2 and nf-kb, and another magic mushroom, yun-zhi continuereading →
LONGEVITY VIEWS,
A traditional anti-malarial and anti-arthritic drug now subject to much political controversy because the President is advocating its widespread use to treat COVID-19, but prominent physicians say its use for this purpose is unwarranted until its efficacy GLUCOSAMINE FOR LONGEVITY Glucosamine is one of the most popular dietary supplements, used by millions who hope that it will lessen the ravages of osteoarthritis, arthritis, loss of cartilage and associated pain and discomfort. This natural shellfish-derived substance has been known since 1876 and its biological impacts were reported as far back as in 1919 ( ref ). AGING, CELL AND TISSUE REPAIR, RENEWAL AND … By Vince Giuliano INTRODUCTION Many of us who have studied aging have long believed that, sooner or later we would discover keys to a long and healthy life via biological repair, renewal and regenerative processes. Based on what we have Continue reading → THE MAKING OF A DIETARY SUPPLEMENT By Vince Giuliano June 3 2019. This blog entry tells the stories of how our new dietary supplement 4 Herb Synergy came into being. As such, this blog entry tells two short histories: a universal history over more than a billion years, and a highly personal history duringmy adult lifetime.
AMPK AND LONGEVITY
AMPK acts as an energy sensor of the cell and works as a key regulator of mitochondrial biogenesis. AMPK activity has been shown to decrease with age, which may contribute to decreased mitochondrial biogenesis and function with aging. The 2008 publication Mitochondrial biogenesis and healthy aging identifies yet-another theory of aging: that PQQ – ACTIVATOR OF PGC-1ALPHA, SIRT3 AND MITOCHONDRIAL By Vince Giuliano Minor update July 12, 2013. Pyrroloquinoline quinone (PQQ), a redox cofactor available as a dietary supplement, appears to have at least three central biological effects with powerful downstream health and longevity consequences: it stimulates the generation of PGC1-alpha, results in expression of SIRT3, and induces mitochondrial biogenesis. UPDATE ON LONGEVITY INTERVENTIONS Supplement with Quercetin and Fisetin to support body removal of senescent cells. Supplement with Acetyl-l-Carnosine, Acetyl-l-Carnitine, Alpha-Lipoic Acid, and melatonin for impact on mitochondria among other reasons. Manage stress, Use of stresses as hormetic interventions – heat shock and cold shock. THE CURIOUS CASE OF L-CARNOSINE Carnosine is an efficient chelating agents for copper and other transition metals, and Carnosine appears to protect neurons from zinc- and copper-mediated neurotoxicity. Carnosine appears to expand the resistance of rats to various induced stresses. It can be used in the treatment o severe gingivostomatitis.AGINGSCIENCES™
this gallery contains 5 photos.. review of scientific aspects related to neuroinflammation: reactive oxygen species, mitochondrial factors, inflammasomes, ppars, metbolic pathways, sirts, dna damage and roles of nrf2 and nf-kb, and another magic mushroom, yun-zhi continuereading →
VINCE GIULIANO, AUTHOR AT AGINGSCIENCES™ January 2021 by Vince Giuliano. This gallery contains 4 photos . I expand on the hypothesized scientific basis for YOUNGING1.0, which is the reversal of global H3K27 histone methylation via JMJD2/JMJD3. I go deeper into the biology and processes of histone methylation – andrelate these to
GLUCOSAMINE FOR LONGEVITY Glucosamine is one of the most popular dietary supplements, used by millions who hope that it will lessen the ravages of osteoarthritis, arthritis, loss of cartilage and associated pain and discomfort. This natural shellfish-derived substance has been known since 1876 and its biological impacts were reported as far back as in 1919 ( ref ). JAMES WATSON, AUTHOR AT AGINGSCIENCES™ Inflammation Part 2: The Tale of Three Stress Sensors and their Interactions: 1)Inflammation, 2)Genomic Instability (p53), and 3)Oxidative stress (Nrf2) Posted on 5. November 2016 by James Watson. By James Watson, with contributions and editing by Vince Giuliano We promised a major series of blog entries related to inflammation backin May 2016.
AGING, HEALTH AND DISEASE THE REPUTATION OF AGING IN ANCIENT AND CURRENT MYTHOLOGY The reputation of aging in our culture is generally not a good one. Facts about aging are often misperceived. Aging is usually ignored, viewed in a context of resignation, or felt to be irrelevant until it is imminent. Diseases and accidents are seen to be the main causes of death even though those diseases and accidents are ones of old age. TRANSPOSABLE DNA ELEMENTS Transposable DNA elements – Part 1: basics and importance. Posted on 12. November 2015 by Vince Giuliano. This is the first blog entry in a three-part series concerned with transposable DNA entries (TEs). It focuses on basics of what TEs are, why they are important for us who are concerned with health and aging, and briefly outlines what PART 2 OF INTERVENTIONS THAT REDUCE ALL CAUSE MORTALITY by James P Watson and Vince Giuliano. There is a community of self-experimenters who are taking the drug Metformin, not because they are diabetic or prediabetic, the FDA-approved reasons for prescribing the drug, but rather because they believe it probably has an impact in promoting general health and retarding aging().In fact, it is probably the pharmaceutical most used for this purpose. NIACIN OR NIACINAMIDE SUPPLEMENTATION €“ GOOD OR BAD IDEANIACIN VS NIACINAMIDE FOR SKINNIACINAMIDE OR NIACINNIACIN NIACINAMIDE DIFFERENCENIACIN NIACINAMIDE NICOTINAMIDENIACINAMIDE AND NIACIN DIFFERENCESNIACINAMIDE AND CHOLESTEROL Niacin also assists in antioxidant and detoxification functions, and the production of sex and adrenal hormones. Vitamin B3 (niacin, niacinamide, nicotinic acid) lowers cholesterol by preventing its buildup in the liver and arteries. Niacin moves fat from tissues for fat metabolism, burning itAGINGSCIENCES™
I expand on the hypothesized scientific basis for YOUNGING1.0, which is the reversal of global H3K27 histone methylation via JMJD2/JMJD3. I go deeper into the biology and processes of histone methylation - and relate these to longevity and YOUNGING01.AGINGSCIENCES™
this gallery contains 5 photos.. review of scientific aspects related to neuroinflammation: reactive oxygen species, mitochondrial factors, inflammasomes, ppars, metbolic pathways, sirts, dna damage and roles of nrf2 and nf-kb, and another magic mushroom, yun-zhi continuereading →
VINCE GIULIANO, AUTHOR AT AGINGSCIENCES™ January 2021 by Vince Giuliano. This gallery contains 4 photos . I expand on the hypothesized scientific basis for YOUNGING1.0, which is the reversal of global H3K27 histone methylation via JMJD2/JMJD3. I go deeper into the biology and processes of histone methylation – andrelate these to
GLUCOSAMINE FOR LONGEVITY Glucosamine is one of the most popular dietary supplements, used by millions who hope that it will lessen the ravages of osteoarthritis, arthritis, loss of cartilage and associated pain and discomfort. This natural shellfish-derived substance has been known since 1876 and its biological impacts were reported as far back as in 1919 ( ref ). JAMES WATSON, AUTHOR AT AGINGSCIENCES™ Inflammation Part 2: The Tale of Three Stress Sensors and their Interactions: 1)Inflammation, 2)Genomic Instability (p53), and 3)Oxidative stress (Nrf2) Posted on 5. November 2016 by James Watson. By James Watson, with contributions and editing by Vince Giuliano We promised a major series of blog entries related to inflammation backin May 2016.
AGING, HEALTH AND DISEASE THE REPUTATION OF AGING IN ANCIENT AND CURRENT MYTHOLOGY The reputation of aging in our culture is generally not a good one. Facts about aging are often misperceived. Aging is usually ignored, viewed in a context of resignation, or felt to be irrelevant until it is imminent. Diseases and accidents are seen to be the main causes of death even though those diseases and accidents are ones of old age. TRANSPOSABLE DNA ELEMENTS Transposable DNA elements – Part 1: basics and importance. Posted on 12. November 2015 by Vince Giuliano. This is the first blog entry in a three-part series concerned with transposable DNA entries (TEs). It focuses on basics of what TEs are, why they are important for us who are concerned with health and aging, and briefly outlines what PART 2 OF INTERVENTIONS THAT REDUCE ALL CAUSE MORTALITY by James P Watson and Vince Giuliano. There is a community of self-experimenters who are taking the drug Metformin, not because they are diabetic or prediabetic, the FDA-approved reasons for prescribing the drug, but rather because they believe it probably has an impact in promoting general health and retarding aging().In fact, it is probably the pharmaceutical most used for this purpose. NIACIN OR NIACINAMIDE SUPPLEMENTATION €“ GOOD OR BAD IDEANIACIN VS NIACINAMIDE FOR SKINNIACINAMIDE OR NIACINNIACIN NIACINAMIDE DIFFERENCENIACIN NIACINAMIDE NICOTINAMIDENIACINAMIDE AND NIACIN DIFFERENCESNIACINAMIDE AND CHOLESTEROL Niacin also assists in antioxidant and detoxification functions, and the production of sex and adrenal hormones. Vitamin B3 (niacin, niacinamide, nicotinic acid) lowers cholesterol by preventing its buildup in the liver and arteries. Niacin moves fat from tissues for fat metabolism, burning itAGINGSCIENCES™
I expand on the hypothesized scientific basis for YOUNGING1.0, which is the reversal of global H3K27 histone methylation via JMJD2/JMJD3. I go deeper into the biology and processes of histone methylation - and relate these to longevity and YOUNGING01.AGINGSCIENCES™
this gallery contains 5 photos.. review of scientific aspects related to neuroinflammation: reactive oxygen species, mitochondrial factors, inflammasomes, ppars, metbolic pathways, sirts, dna damage and roles of nrf2 and nf-kb, and another magic mushroom, yun-zhi continuereading →
YGB YOUNGING1.0
By Vince Giuliano and Steve Buss (A general introduction to this first substantive Blog Post in a new YOUNGING Series is provided in the post Introduction to the YOUNGING Series – Emerging Aging Reversal Strategies and Treatments).. The key elements of a strategy for age reversal are emerging in the recent literature –we call itYOUNGING1.0.
LONGEVITY VIEWS,
A traditional anti-malarial and anti-arthritic drug now subject to much political controversy because the President is advocating its widespread use to treat COVID-19, but prominent physicians say its use for this purpose is unwarranted until its efficacy YGC MORE ON YOUNGING1.0 By Vince Giuliano. Methuselah –Methuselah lived 969 years according to Genesis 5:27, the oldest person who ever lived. Image source I believe the previous blog entry YGB YOUNGING1.0 – THE EMERGING AGING REVERSAL STRATEGY may well turn out to be the most important one published in this blog so far. In that blog entry, Steve Buss and I described some key elements of a strategy for age GLUCOSAMINE FOR LONGEVITY Glucosamine is one of the most popular dietary supplements, used by millions who hope that it will lessen the ravages of osteoarthritis, arthritis, loss of cartilage and associated pain and discomfort. This natural shellfish-derived substance has been known since 1876 and its biological impacts were reported as far back as in 1919 ( ref ). WEEKLY POSTS ARCHIVES This week’s anti-aging news Jan 31, 2009. Posted on 31. January 2009 by Vince Giuliano. More research progress on telomerase Telomerase is the wonderful enzyme that offers the possibility of stopping and reversing the aging clock in cells. Astragaloside IV, one of the key firewall substances in the anti-aging regimen, is intended to activate MY THOUGHTS ON HOW TO LIVE MY LONGEST HEALTHY LIFE Stan Goldfarb Introduction by Vince Giuliano Stan Goldfarb is a friend and a colleague who often contributes to online longevity discussions, particularly ones concerned with dietary supplements. Although not a scientist he has strong and sometimes unique views on what Continuereading →
AGING, CELL AND TISSUE REPAIR, RENEWAL AND … By Vince Giuliano INTRODUCTION Many of us who have studied aging have long believed that, sooner or later we would discover keys to a long and healthy life via biological repair, renewal and regenerative processes. Based on what we have Continue reading → AGING, HEALTH AND DISEASE This blog entry looks at at aging, health and disease from the viewpoint of DNA methylation, that is, lifelong changes in methylation status of selected genes. This is a highly useful viewpoint because it: is a good predictor of all-cause mortality. According to this viewpoint, genomic methylation:AGINGSCIENCES™
I expand on the hypothesized scientific basis for YOUNGING1.0, which is the reversal of global H3K27 histone methylation via JMJD2/JMJD3. I go deeper into the biology and processes of histone methylation - and relate these to longevity and YOUNGING01. AGINGSCIENCES™ – ANTI-AGING FIREWALLS™ A weblog on the sciences and practices of living healthily very long – perhaps hundreds of years.Skip to content
* Home
* Alerts Signup
← Older posts
INFLAMMATION PART 7: NEUROHORMESIS, NEUROINFLAMMATORY DISEASES, AND THEIR TREATMENT BY MUSHROOM SUBSTANCES (SECTION 1) Posted on 9. October 2019by Vince Giuliano
_ This gallery contains 7 photos.
_
Can a mushroom play an important role in the health and anti-aging picture? Recent research says Yes, and this blog entry tells the story Current medical treatments for age-related neurological brain diseases like Alzheimer’s and Parkinson’s remain largely ineffective, despite … Continue reading →More Galleries |
Leave a comment
SELECTED NOTICES AND BOOK REVIEW Posted on 3. October 2019by Vince Giuliano
From time to time I will be listing a few notices that I think might be of particular interest to my readers, starting here. I also review a new book I think to be of special importance. 1. PHONE CALL-IN … Continue reading →More Galleries |
Leave a comment
FUNNY THINGS ARE HAPPENING TO ME ON THE WAY TO 100 Posted on 22. August 2019by Vince Giuliano
_ This gallery contains 5 photos.
_
This is a highly personal blog entry, generally light in its approach but containing some relevant scientific content. It raconteurs a variety of topics, and is intended to provide context and information about me for blog readers. It is especially … Continue reading →More Galleries |
2 Comments
THE MAKING OF A DIETARY SUPPLEMENT – THE LONG AND SHORT HISTORIES OFIT
Posted on 7. June 2019by Vince Giuliano
_ This gallery contains 33 photos.
_
By Vince Giuliano June 3 2019 This blog entry tells the stories of how our new dietary supplement 4 Herb Synergy came into being. As such, this blog entry tells two short histories: a universal history over more than … Continue reading →More Galleries |
7 Comments
INFLAMMATION PART 6: THE SCIENCE BEHIND THE 4 HERB SYNERGY DIETARYSUPPLEMENT
Posted on 7. June 2019by Vince Giuliano
_ This gallery contains 15 photos.
_
Ancient plant wisdom meets nanotechnology By VinceGiuliano
May
28, 2019 This blog entry is concerned with a new dietary supplement that my colleagues I have sourced, called 4 Herb Synergy. It is concerned with the scientific considerations we have … Continuereading →
More Galleries |
2 Comments
UPDATE ON LONGEVITY INTERVENTIONS – MAINLY PERSONAL Posted on 11. April 2019by Vince Giuliano
_ This gallery contains 11 photos.
_
“Start with the impossible. Proceed calmly towards the improbable. No worry, there are at least five exits.” —Father Daniel Berrigan By Vince Giuliano 4/11/19 This blog entry is about my ideas about my personal health and longevity. It is not … Continue reading →More Galleries |
4 Comments
AGING, CELL AND TISSUE REPAIR, RENEWAL AND REGENERATION, INFLAMMATIONAND THE SASP
Posted on 2. September 2018by Vince Giuliano
_ This gallery contains 6 photos.
_
By Vince Giuliano INTRODUCTION Many of us who have studied aging have long believed that, sooner or later we would discover keys to a long and healthy life via biological repair, renewal and regenerative processes. Based on what we have … Continue reading →More Galleries |
8 Comments
INFLAMMATION PART 5: INFLAMMASOMES – SCIENCE OF AND DISEASEIMPLICATIONS
Posted on 5. June 2018by Vince Giuliano
_ This gallery contains 10 photos.
_
By James P. Watson and Vince Giuliano Inflammasomes are multimeric self-assembling protein complexes within the cytosol of mammalian cells, pattern-recognizing components of the innate immune system. They can be thought of as finely tuned alarm, triggering and amplifying systems that … Continue reading →More Galleries |
1 Comment
2018 MEETING OF THE INTERNATIONAL DOSE-RESPONSE SOCIETY Posted on 11. April 2018by Vince Giuliano
By Vince Giuliano As in previous years, I am posting this note regarding the forthcoming 2018 annual meeting of the International Dose-response Society. It will be held as usual on the Campus of the University of Massachusetts in Amherst MA on April … Continuereading →
More Galleries |
1 Comment
THE DOUBLE GENE KNOCKOUT BEHIND OUR OBESITY EPIDEMIC Posted on 11. March 2018by James Watson
_ This gallery contains 7 photos.
_
By James P Watson with assistance and added commentary by Vince Giuliano This is a story of how we got here to our obesity and metabolic disease epidemic. Goes a bit back – around 30-40 million years – with another … Continue reading →More Galleries |
Leave a comment
← Older posts
*
SEARCH
Search for:
*
CALENDAR
October 2019
M
T
W
T
F
S
S
Aug
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
*
CATEGORIES
* Uncategorized
(512)
* Weekly Posts
(2)
*
RECENT POSTS
* Inflammation Part 7: Neurohormesis, neuroinflammatory diseases, and their treatment by mushroom substances (Section 1) * SELECTED NOTICES AND BOOK REVIEW * Funny Things Are Happening To Me On The Way To 100 * The making of a dietary supplement – the long and shorthistories of it
* INFLAMMATION PART 6: THE SCIENCE BEHIND THE 4 HERB SYNERGY DIETARYSUPPLEMENT
* UPDATE ON LONGEVITY INTERVENTIONS – MAINLY PERSONAL * AGING, CELL AND TISSUE REPAIR, RENEWAL AND REGENERATION, INFLAMMATION AND THE SASP * Inflammation Part 5: Inflammasomes – science of and diseaseimplications
* 2018 meeting of the International Dose-Response Society * THE DOUBLE GENE KNOCKOUT BEHIND OUR OBESITY EPIDEMIC*
ARCHIVES
* October 2019 (2)* August 2019 (1)
* June 2019 (2)
* April 2019 (1)
* September 2018 (1)* June 2018 (1)
* April 2018 (1)
* March 2018 (1)
* January 2018 (1) * September 2017 (1)* August 2017 (1)
* July 2017 (1)
* April 2017 (1)
* December 2016 (1) * November 2016 (1) * September 2016 (1)* June 2016 (1)
* May 2016 (2)
* March 2016 (1)
* February 2016 (1) * December 2015 (1) * November 2015 (2) * September 2015 (1)* July 2015 (1)
* May 2015 (2)
* April 2015 (1)
* February 2015 (2) * January 2015 (2) * December 2014 (1) * November 2014 (1) * October 2014 (1) * September 2014 (2)* August 2014 (1)
* July 2014 (3)
* June 2014 (3)
* May 2014 (2)
* April 2014 (2)
* March 2014 (4)
* February 2014 (3) * January 2014 (2) * December 2013 (2) * November 2013 (1) * October 2013 (3) * September 2013 (1)* August 2013 (2)
* July 2013 (2)
* June 2013 (1)
* May 2013 (3)
* April 2013 (3)
* March 2013 (3)
* January 2013 (2) * December 2012 (3) * November 2012 (2) * October 2012 (2) * September 2012 (2)* August 2012 (2)
* July 2012 (2)
* June 2012 (3)
* May 2012 (2)
* April 2012 (5)
* March 2012 (4)
* February 2012 (5) * January 2012 (5) * December 2011 (3) * November 2011 (4) * October 2011 (3) * September 2011 (4)* August 2011 (3)
* July 2011 (4)
* June 2011 (9)
* May 2011 (9)
* April 2011 (6)
* March 2011 (7)
* February 2011 (6) * January 2011 (7) * December 2010 (4) * November 2010 (9) * October 2010 (8) * September 2010 (7)* August 2010 (6)
* July 2010 (7)
* June 2010 (9)
* May 2010 (7)
* April 2010 (14)
* March 2010 (13)
* February 2010 (14) * January 2010 (15) * December 2009 (16) * November 2009 (14) * October 2009 (20)* September 2009
(16)
* August 2009 (19)* July 2009 (22)
* June 2009 (24)
* May 2009 (22)
* April 2009 (18)
* March 2009 (20)
* February 2009 (19) * January 2009 (6)*
META
* Register
* Log in
* Entries RSS
* Comments RSS
* WordPress.org
AGINGSCIENCES™ – Anti-Aging Firewalls™ Proudly powered by WordPress.ORIGINAL TEXT
Contribute a better translation -------------------------Details
Copyright © 2024 ArchiveBay.com. All rights reserved. Terms of Use | Privacy Policy | DMCA | 2021 | Feedback | Advertising | RSS 2.0