Are you over 18 and want to see adult content?
More Annotations
A complete backup of news.now.com/home/life/player?newsId=382262
Are you over 18 and want to see adult content?
A complete backup of soccer.sina.com.hk/news/1/20200227/11267296/
Are you over 18 and want to see adult content?
A complete backup of zonawrestling.net/risultati-wwe-super-showdown-2020/
Are you over 18 and want to see adult content?
A complete backup of www.ziare.com/nicusor-dan/candidat-primaria-bucuresti/orban-confirma-pnl-il-sprijina-pe-nicusor-dan-la-prim
Are you over 18 and want to see adult content?
Favourite Annotations
A complete backup of glazermuseum.org
Are you over 18 and want to see adult content?
A complete backup of ostermanconsult.com
Are you over 18 and want to see adult content?
A complete backup of mywyckedways.com
Are you over 18 and want to see adult content?
A complete backup of mustangdepot.com
Are you over 18 and want to see adult content?
A complete backup of scalable.capital
Are you over 18 and want to see adult content?
Text
BIOANALYSIS
Bioanalysis welcomes unsolicited article proposals. Email us today to discuss the suitability of your research and our options for authors, including our Accelerated Publication and Open Access services. Visit Bioanalysis Zone our online community. Supplement: The Bioanalysis Glossary. View the Decennial Index of the WRIB White Papers. TUMOR CELL INVASION INTO MATRIGEL: OPTIMIZED PROTOCOL FOR An optimized method for RNA extraction from highly invasive glioma cells embedded into Matrigel was achieved by using TRIzol, used for matrix dissociation, cell lysis and RNA separation, in combination with a specific commercial kit used to perform the DNAse treatment and optimal RNA purification on column. A STRATEGIC APPROACH TO NONCLINICAL IMMUNOGENICITY Review of the current recommendations. Guidance for nonclinical immunogenicity assessments is sparse. However, the key points from published literature and guidelines are summarized in Table 1.Initial requirements for assays used for the detection of host antibodies against biotechnology products were published to provide harmonized scientific recommendations for assays used in RATIONAL APPLICATION OF DRUG PROMISCUITY IN MEDICINAL Rational application of drug promiscuity in medicinal chemistry. ‘Drug promiscuity’ refers to a drug that can act on multiple molecular targets, exhibiting similar or different pharmacological effects. Drugs may interact with unwanted targets, leading to off-target effects (one of the main reasons for side effects). Thus,intervention to
CRISPR-CAS13A-BASED DIAGNOSTIC METHOD FOR CHLAMYDIA Aim: Development of a routine screening technique for Chlamydia trachomatis infection. The proposed approach involves the CRISPR RNA (crRNA). In the presence of the target sequence, the RNase activity of the Cas13a protein is activated, and it cleaves RNA fluorescent probe so that fluorescence will be emitted. THE NEW FACE OF ELECTROPHORESIS: MODERNIZATION OF A Automated Analysis of Protein Purity. One of the most appropriate applications of automated protein electrophoresis is to accelerate process development by monitoring column fractions during chromatographic purification ().This can apply to checking the purity of a monoclonal antibody in an industrial quality control setting or following the purification of an engineered polyhistidinetagged INTELLECTUAL PROPERTY AND ITS ROLE IN THE PHARMACEUTICAL Intellectual property & its role in the pharmaceutical industry | Editorial future science group www.future-science.com 1549 companies tend to obtain patent protection in DRUG DELIVERY TO THE LUNGS: CHALLENGES AND OPPORTUNITIES 648 Ther. Deliv. (2017) 8(8) Review Newman mechanisms that are intended to keep inhaled m aterials out of the lungs, as well as removing or inactivating them once they have been deposited.Second,it is
EBF RECOMMENDATION FOR STABILITY TESTING OF ANTI-DRUG future science rou www.future-science.com 1411 EBF recommendation for stability testing of anti-drug antibodies White Paper on the methodological approaches (e.g., RECOMMENDATIONS FOR THE DEVELOPMENT AND VALIDATION OF 1620 Bioanalysis (2015) 7(13) White Paper Jani, Marsden, Mikulskis et al. minimum of 50% inhibition, to widely accepted and applied complex statistical methods using the variation of percent inhibitions from a therapeutic-naïve popu-BIOANALYSIS
Bioanalysis welcomes unsolicited article proposals. Email us today to discuss the suitability of your research and our options for authors, including our Accelerated Publication and Open Access services. Visit Bioanalysis Zone our online community. Supplement: The Bioanalysis Glossary. View the Decennial Index of the WRIB White Papers. TUMOR CELL INVASION INTO MATRIGEL: OPTIMIZED PROTOCOL FOR An optimized method for RNA extraction from highly invasive glioma cells embedded into Matrigel was achieved by using TRIzol, used for matrix dissociation, cell lysis and RNA separation, in combination with a specific commercial kit used to perform the DNAse treatment and optimal RNA purification on column. A STRATEGIC APPROACH TO NONCLINICAL IMMUNOGENICITY Review of the current recommendations. Guidance for nonclinical immunogenicity assessments is sparse. However, the key points from published literature and guidelines are summarized in Table 1.Initial requirements for assays used for the detection of host antibodies against biotechnology products were published to provide harmonized scientific recommendations for assays used in RATIONAL APPLICATION OF DRUG PROMISCUITY IN MEDICINAL Rational application of drug promiscuity in medicinal chemistry. ‘Drug promiscuity’ refers to a drug that can act on multiple molecular targets, exhibiting similar or different pharmacological effects. Drugs may interact with unwanted targets, leading to off-target effects (one of the main reasons for side effects). Thus,intervention to
CRISPR-CAS13A-BASED DIAGNOSTIC METHOD FOR CHLAMYDIA Aim: Development of a routine screening technique for Chlamydia trachomatis infection. The proposed approach involves the CRISPR RNA (crRNA). In the presence of the target sequence, the RNase activity of the Cas13a protein is activated, and it cleaves RNA fluorescent probe so that fluorescence will be emitted. THE NEW FACE OF ELECTROPHORESIS: MODERNIZATION OF A Automated Analysis of Protein Purity. One of the most appropriate applications of automated protein electrophoresis is to accelerate process development by monitoring column fractions during chromatographic purification ().This can apply to checking the purity of a monoclonal antibody in an industrial quality control setting or following the purification of an engineered polyhistidinetagged INTELLECTUAL PROPERTY AND ITS ROLE IN THE PHARMACEUTICAL Intellectual property & its role in the pharmaceutical industry | Editorial future science group www.future-science.com 1549 companies tend to obtain patent protection in DRUG DELIVERY TO THE LUNGS: CHALLENGES AND OPPORTUNITIES 648 Ther. Deliv. (2017) 8(8) Review Newman mechanisms that are intended to keep inhaled m aterials out of the lungs, as well as removing or inactivating them once they have been deposited.Second,it is
RECOMMENDATIONS FOR THE DEVELOPMENT AND VALIDATION OF 1620 Bioanalysis (2015) 7(13) White Paper Jani, Marsden, Mikulskis et al. minimum of 50% inhibition, to widely accepted and applied complex statistical methods using the variation of percent inhibitions from a therapeutic-naïve popu- EBF RECOMMENDATION FOR STABILITY TESTING OF ANTI-DRUG future science rou www.future-science.com 1411 EBF recommendation for stability testing of anti-drug antibodies White Paper on the methodological approaches (e.g.,BIOANALYSIS
Bioanalysis welcomes unsolicited article proposals. Email us today to discuss the suitability of your research and our options for authors, including our Accelerated Publication and Open Access services. Visit Bioanalysis Zone our online community. Supplement: The Bioanalysis Glossary. View the Decennial Index of the WRIB White Papers.FUTURE SCIENCE OA
Future Science OA welcomes unsolicited article proposals. Email us today to discuss the suitability of your research and our options for authors, including our Accelerated Publication service, ensuring rapid publication of your article subject to acceptance. Not sure why you should publish open access? A STRATEGIC APPROACH TO NONCLINICAL IMMUNOGENICITY Review of the current recommendations. Guidance for nonclinical immunogenicity assessments is sparse. However, the key points from published literature and guidelines are summarized in Table 1.Initial requirements for assays used for the detection of host antibodies against biotechnology products were published to provide harmonized scientific recommendations for assays used in 2020WHITEPAPERONRECENTISSUESIN BIOANALYSIS WhitePaper For reprint orders, please contact: reprints@future-science.com 2020WhitePaperonRecentIssuesin Bioanalysis:VaccineAssayValidation,qPCR A NOVEL METHOD FOR REMOVING POLYETHYLENEIMINE FROM Detecting and quantifying residual host cell DNA is an essential impurity test for all biopharmaceutical products; levels of residual DNA must be closely monitored and controlled throughout the production and release of the drug substance. qPCR is a widely accepted approach for the quantification of residual DNA in recombinant therapeutic proteins and the TaqMan qPCR ASSAYS AND TECHNOLOGIES FOR DEVELOPING PROTEOLYSIS Review Liu,Zhang,Lv,Yuan,Zheng&Zhou Degradation pathway Ub Ub Ub Ub Ub Ub E2 E2 E3 Ub E2 E3 E3 Binary target engagement Ub Ub Ub Ub Ub Ub Ub Ub Recycle Proteasome PROTACs Penetration Ternary complex formation ANALYSIS AND QUANTIFICATION OF IN VITRO MYOBLAST FUSION Adult skeletal muscle tissue contains a population of precursor cells, known as satellite cells, that are responsible for skeletal muscle repair (1–3).Activated satellite cells (myoblasts) migrate to the site of muscle trauma, where they proliferate, differentiate, and fuse into multinucleated myotubes (3–5).The ultimate success of this process is measured by the degree to which resident DRUG DELIVERY TO THE LUNGS: CHALLENGES AND OPPORTUNITIES 648 Ther. Deliv. (2017) 8(8) Review Newman mechanisms that are intended to keep inhaled m aterials out of the lungs, as well as removing or inactivating them once they have been deposited.Second,it is
BIOANALYSIS AUTHOR GUIDELINES Bioanalysis author guidelines Future perspective - The author is challenged to include speculative viewpoint on how the field will have evolved 5–10 years from the point at which the article was written. Executive summary - A series of bulleted statements representing key conclusions, unresolved issues and points for emphasis of work in future, under the main headings of BIOANALYSIS FOR PLASMA PROTEIN BINDING STUDIES IN DRUG Drug molecules in animals and humans are either bound to proteins and lipids or are freely available. This article focuses on analysis ofprotein bind-
BIOANALYSIS
Bioanalysis welcomes unsolicited article proposals. Email us today to discuss the suitability of your research and our options for authors, including our Accelerated Publication and Open Access services. Visit Bioanalysis Zone our online community. Supplement: The Bioanalysis Glossary. View the Decennial Index of the WRIB White Papers. TUMOR CELL INVASION INTO MATRIGEL: OPTIMIZED PROTOCOL FOR An optimized method for RNA extraction from highly invasive glioma cells embedded into Matrigel was achieved by using TRIzol, used for matrix dissociation, cell lysis and RNA separation, in combination with a specific commercial kit used to perform the DNAse treatment and optimal RNA purification on column. A STRATEGIC APPROACH TO NONCLINICAL IMMUNOGENICITY Review of the current recommendations. Guidance for nonclinical immunogenicity assessments is sparse. However, the key points from published literature and guidelines are summarized in Table 1.Initial requirements for assays used for the detection of host antibodies against biotechnology products were published to provide harmonized scientific recommendations for assays used in RATIONAL APPLICATION OF DRUG PROMISCUITY IN MEDICINAL Rational application of drug promiscuity in medicinal chemistry. ‘Drug promiscuity’ refers to a drug that can act on multiple molecular targets, exhibiting similar or different pharmacological effects. Drugs may interact with unwanted targets, leading to off-target effects (one of the main reasons for side effects). Thus,intervention to
CRISPR-CAS13A-BASED DIAGNOSTIC METHOD FOR CHLAMYDIA Aim: Development of a routine screening technique for Chlamydia trachomatis infection. The proposed approach involves the CRISPR RNA (crRNA). In the presence of the target sequence, the RNase activity of the Cas13a protein is activated, and it cleaves RNA fluorescent probe so that fluorescence will be emitted. THE NEW FACE OF ELECTROPHORESIS: MODERNIZATION OF A Automated Analysis of Protein Purity. One of the most appropriate applications of automated protein electrophoresis is to accelerate process development by monitoring column fractions during chromatographic purification ().This can apply to checking the purity of a monoclonal antibody in an industrial quality control setting or following the purification of an engineered polyhistidinetagged INTELLECTUAL PROPERTY AND ITS ROLE IN THE PHARMACEUTICAL Intellectual property & its role in the pharmaceutical industry | Editorial future science group www.future-science.com 1549 companies tend to obtain patent protection in DRUG DELIVERY TO THE LUNGS: CHALLENGES AND OPPORTUNITIES 648 Ther. Deliv. (2017) 8(8) Review Newman mechanisms that are intended to keep inhaled m aterials out of the lungs, as well as removing or inactivating them once they have been deposited.Second,it is
EBF RECOMMENDATION FOR STABILITY TESTING OF ANTI-DRUG future science rou www.future-science.com 1411 EBF recommendation for stability testing of anti-drug antibodies White Paper on the methodological approaches (e.g., RECOMMENDATIONS FOR THE DEVELOPMENT AND VALIDATION OF 1620 Bioanalysis (2015) 7(13) White Paper Jani, Marsden, Mikulskis et al. minimum of 50% inhibition, to widely accepted and applied complex statistical methods using the variation of percent inhibitions from a therapeutic-naïve popu-BIOANALYSIS
Bioanalysis welcomes unsolicited article proposals. Email us today to discuss the suitability of your research and our options for authors, including our Accelerated Publication and Open Access services. Visit Bioanalysis Zone our online community. Supplement: The Bioanalysis Glossary. View the Decennial Index of the WRIB White Papers. TUMOR CELL INVASION INTO MATRIGEL: OPTIMIZED PROTOCOL FOR An optimized method for RNA extraction from highly invasive glioma cells embedded into Matrigel was achieved by using TRIzol, used for matrix dissociation, cell lysis and RNA separation, in combination with a specific commercial kit used to perform the DNAse treatment and optimal RNA purification on column. A STRATEGIC APPROACH TO NONCLINICAL IMMUNOGENICITY Review of the current recommendations. Guidance for nonclinical immunogenicity assessments is sparse. However, the key points from published literature and guidelines are summarized in Table 1.Initial requirements for assays used for the detection of host antibodies against biotechnology products were published to provide harmonized scientific recommendations for assays used in RATIONAL APPLICATION OF DRUG PROMISCUITY IN MEDICINAL Rational application of drug promiscuity in medicinal chemistry. ‘Drug promiscuity’ refers to a drug that can act on multiple molecular targets, exhibiting similar or different pharmacological effects. Drugs may interact with unwanted targets, leading to off-target effects (one of the main reasons for side effects). Thus,intervention to
CRISPR-CAS13A-BASED DIAGNOSTIC METHOD FOR CHLAMYDIA Aim: Development of a routine screening technique for Chlamydia trachomatis infection. The proposed approach involves the CRISPR RNA (crRNA). In the presence of the target sequence, the RNase activity of the Cas13a protein is activated, and it cleaves RNA fluorescent probe so that fluorescence will be emitted. THE NEW FACE OF ELECTROPHORESIS: MODERNIZATION OF A Automated Analysis of Protein Purity. One of the most appropriate applications of automated protein electrophoresis is to accelerate process development by monitoring column fractions during chromatographic purification ().This can apply to checking the purity of a monoclonal antibody in an industrial quality control setting or following the purification of an engineered polyhistidinetagged INTELLECTUAL PROPERTY AND ITS ROLE IN THE PHARMACEUTICAL Intellectual property & its role in the pharmaceutical industry | Editorial future science group www.future-science.com 1549 companies tend to obtain patent protection in DRUG DELIVERY TO THE LUNGS: CHALLENGES AND OPPORTUNITIES 648 Ther. Deliv. (2017) 8(8) Review Newman mechanisms that are intended to keep inhaled m aterials out of the lungs, as well as removing or inactivating them once they have been deposited.Second,it is
EBF RECOMMENDATION FOR STABILITY TESTING OF ANTI-DRUG future science rou www.future-science.com 1411 EBF recommendation for stability testing of anti-drug antibodies White Paper on the methodological approaches (e.g., RECOMMENDATIONS FOR THE DEVELOPMENT AND VALIDATION OF 1620 Bioanalysis (2015) 7(13) White Paper Jani, Marsden, Mikulskis et al. minimum of 50% inhibition, to widely accepted and applied complex statistical methods using the variation of percent inhibitions from a therapeutic-naïve popu-BIOANALYSIS
Bioanalysis welcomes unsolicited article proposals. Email us today to discuss the suitability of your research and our options for authors, including our Accelerated Publication and Open Access services. Visit Bioanalysis Zone our online community. Supplement: The Bioanalysis Glossary. View the Decennial Index of the WRIB White Papers.FUTURE SCIENCE OA
Future Science OA welcomes unsolicited article proposals. Email us today to discuss the suitability of your research and our options for authors, including our Accelerated Publication service, ensuring rapid publication of your article subject to acceptance. Not sure why you should publish open access? A STRATEGIC APPROACH TO NONCLINICAL IMMUNOGENICITY Review of the current recommendations. Guidance for nonclinical immunogenicity assessments is sparse. However, the key points from published literature and guidelines are summarized in Table 1.Initial requirements for assays used for the detection of host antibodies against biotechnology products were published to provide harmonized scientific recommendations for assays used in 2020WHITEPAPERONRECENTISSUESIN BIOANALYSIS WhitePaper For reprint orders, please contact: reprints@future-science.com 2020WhitePaperonRecentIssuesin Bioanalysis:VaccineAssayValidation,qPCR A NOVEL METHOD FOR REMOVING POLYETHYLENEIMINE FROM Detecting and quantifying residual host cell DNA is an essential impurity test for all biopharmaceutical products; levels of residual DNA must be closely monitored and controlled throughout the production and release of the drug substance. qPCR is a widely accepted approach for the quantification of residual DNA in recombinant therapeutic proteins and the TaqMan qPCR ASSAYS AND TECHNOLOGIES FOR DEVELOPING PROTEOLYSIS Review Liu,Zhang,Lv,Yuan,Zheng&Zhou Degradation pathway Ub Ub Ub Ub Ub Ub E2 E2 E3 Ub E2 E3 E3 Binary target engagement Ub Ub Ub Ub Ub Ub Ub Ub Recycle Proteasome PROTACs Penetration Ternary complex formation ANALYSIS AND QUANTIFICATION OF IN VITRO MYOBLAST FUSION Adult skeletal muscle tissue contains a population of precursor cells, known as satellite cells, that are responsible for skeletal muscle repair (1–3).Activated satellite cells (myoblasts) migrate to the site of muscle trauma, where they proliferate, differentiate, and fuse into multinucleated myotubes (3–5).The ultimate success of this process is measured by the degree to which resident DRUG DELIVERY TO THE LUNGS: CHALLENGES AND OPPORTUNITIES 648 Ther. Deliv. (2017) 8(8) Review Newman mechanisms that are intended to keep inhaled m aterials out of the lungs, as well as removing or inactivating them once they have been deposited.Second,it is
BIOANALYSIS AUTHOR GUIDELINES Bioanalysis author guidelines Future perspective - The author is challenged to include speculative viewpoint on how the field will have evolved 5–10 years from the point at which the article was written. Executive summary - A series of bulleted statements representing key conclusions, unresolved issues and points for emphasis of work in future, under the main headings of BIOANALYSIS FOR PLASMA PROTEIN BINDING STUDIES IN DRUG Drug molecules in animals and humans are either bound to proteins and lipids or are freely available. This article focuses on analysis ofprotein bind-
BIOANALYSIS
Bioanalysis welcomes unsolicited article proposals. Email us today to discuss the suitability of your research and our options for authors, including our Accelerated Publication and Open Access services. Visit Bioanalysis Zone our online community. Supplement: The Bioanalysis Glossary. View the Decennial Index of the WRIB White Papers. TUMOR CELL INVASION INTO MATRIGEL: OPTIMIZED PROTOCOL FOR An optimized method for RNA extraction from highly invasive glioma cells embedded into Matrigel was achieved by using TRIzol, used for matrix dissociation, cell lysis and RNA separation, in combination with a specific commercial kit used to perform the DNAse treatment and optimal RNA purification on column. A STRATEGIC APPROACH TO NONCLINICAL IMMUNOGENICITY Review of the current recommendations. Guidance for nonclinical immunogenicity assessments is sparse. However, the key points from published literature and guidelines are summarized in Table 1.Initial requirements for assays used for the detection of host antibodies against biotechnology products were published to provide harmonized scientific recommendations for assays used in RATIONAL APPLICATION OF DRUG PROMISCUITY IN MEDICINAL Rational application of drug promiscuity in medicinal chemistry. ‘Drug promiscuity’ refers to a drug that can act on multiple molecular targets, exhibiting similar or different pharmacological effects. Drugs may interact with unwanted targets, leading to off-target effects (one of the main reasons for side effects). Thus,intervention to
CRISPR-CAS13A-BASED DIAGNOSTIC METHOD FOR CHLAMYDIA Aim: Development of a routine screening technique for Chlamydia trachomatis infection. The proposed approach involves the CRISPR RNA (crRNA). In the presence of the target sequence, the RNase activity of the Cas13a protein is activated, and it cleaves RNA fluorescent probe so that fluorescence will be emitted. THE NEW FACE OF ELECTROPHORESIS: MODERNIZATION OF A Automated Analysis of Protein Purity. One of the most appropriate applications of automated protein electrophoresis is to accelerate process development by monitoring column fractions during chromatographic purification ().This can apply to checking the purity of a monoclonal antibody in an industrial quality control setting or following the purification of an engineered polyhistidinetagged INTELLECTUAL PROPERTY AND ITS ROLE IN THE PHARMACEUTICAL Intellectual property & its role in the pharmaceutical industry | Editorial future science group www.future-science.com 1549 companies tend to obtain patent protection in DRUG DELIVERY TO THE LUNGS: CHALLENGES AND OPPORTUNITIES 648 Ther. Deliv. (2017) 8(8) Review Newman mechanisms that are intended to keep inhaled m aterials out of the lungs, as well as removing or inactivating them once they have been deposited.Second,it is
EBF RECOMMENDATION FOR STABILITY TESTING OF ANTI-DRUG future science rou www.future-science.com 1411 EBF recommendation for stability testing of anti-drug antibodies White Paper on the methodological approaches (e.g., RECOMMENDATIONS FOR THE DEVELOPMENT AND VALIDATION OF 1620 Bioanalysis (2015) 7(13) White Paper Jani, Marsden, Mikulskis et al. minimum of 50% inhibition, to widely accepted and applied complex statistical methods using the variation of percent inhibitions from a therapeutic-naïve popu-BIOANALYSIS
Bioanalysis welcomes unsolicited article proposals. Email us today to discuss the suitability of your research and our options for authors, including our Accelerated Publication and Open Access services. Visit Bioanalysis Zone our online community. Supplement: The Bioanalysis Glossary. View the Decennial Index of the WRIB White Papers. TUMOR CELL INVASION INTO MATRIGEL: OPTIMIZED PROTOCOL FOR An optimized method for RNA extraction from highly invasive glioma cells embedded into Matrigel was achieved by using TRIzol, used for matrix dissociation, cell lysis and RNA separation, in combination with a specific commercial kit used to perform the DNAse treatment and optimal RNA purification on column. A STRATEGIC APPROACH TO NONCLINICAL IMMUNOGENICITY Review of the current recommendations. Guidance for nonclinical immunogenicity assessments is sparse. However, the key points from published literature and guidelines are summarized in Table 1.Initial requirements for assays used for the detection of host antibodies against biotechnology products were published to provide harmonized scientific recommendations for assays used in RATIONAL APPLICATION OF DRUG PROMISCUITY IN MEDICINAL Rational application of drug promiscuity in medicinal chemistry. ‘Drug promiscuity’ refers to a drug that can act on multiple molecular targets, exhibiting similar or different pharmacological effects. Drugs may interact with unwanted targets, leading to off-target effects (one of the main reasons for side effects). Thus,intervention to
CRISPR-CAS13A-BASED DIAGNOSTIC METHOD FOR CHLAMYDIA Aim: Development of a routine screening technique for Chlamydia trachomatis infection. The proposed approach involves the CRISPR RNA (crRNA). In the presence of the target sequence, the RNase activity of the Cas13a protein is activated, and it cleaves RNA fluorescent probe so that fluorescence will be emitted. THE NEW FACE OF ELECTROPHORESIS: MODERNIZATION OF A Automated Analysis of Protein Purity. One of the most appropriate applications of automated protein electrophoresis is to accelerate process development by monitoring column fractions during chromatographic purification ().This can apply to checking the purity of a monoclonal antibody in an industrial quality control setting or following the purification of an engineered polyhistidinetagged INTELLECTUAL PROPERTY AND ITS ROLE IN THE PHARMACEUTICAL Intellectual property & its role in the pharmaceutical industry | Editorial future science group www.future-science.com 1549 companies tend to obtain patent protection in DRUG DELIVERY TO THE LUNGS: CHALLENGES AND OPPORTUNITIES 648 Ther. Deliv. (2017) 8(8) Review Newman mechanisms that are intended to keep inhaled m aterials out of the lungs, as well as removing or inactivating them once they have been deposited.Second,it is
EBF RECOMMENDATION FOR STABILITY TESTING OF ANTI-DRUG future science rou www.future-science.com 1411 EBF recommendation for stability testing of anti-drug antibodies White Paper on the methodological approaches (e.g., RECOMMENDATIONS FOR THE DEVELOPMENT AND VALIDATION OF 1620 Bioanalysis (2015) 7(13) White Paper Jani, Marsden, Mikulskis et al. minimum of 50% inhibition, to widely accepted and applied complex statistical methods using the variation of percent inhibitions from a therapeutic-naïve popu-BIOANALYSIS
Bioanalysis welcomes unsolicited article proposals. Email us today to discuss the suitability of your research and our options for authors, including our Accelerated Publication and Open Access services. Visit Bioanalysis Zone our online community. Supplement: The Bioanalysis Glossary. View the Decennial Index of the WRIB White Papers.FUTURE SCIENCE OA
Future Science OA welcomes unsolicited article proposals. Email us today to discuss the suitability of your research and our options for authors, including our Accelerated Publication service, ensuring rapid publication of your article subject to acceptance. Not sure why you should publish open access? A STRATEGIC APPROACH TO NONCLINICAL IMMUNOGENICITY Review of the current recommendations. Guidance for nonclinical immunogenicity assessments is sparse. However, the key points from published literature and guidelines are summarized in Table 1.Initial requirements for assays used for the detection of host antibodies against biotechnology products were published to provide harmonized scientific recommendations for assays used in 2020WHITEPAPERONRECENTISSUESIN BIOANALYSIS WhitePaper For reprint orders, please contact: reprints@future-science.com 2020WhitePaperonRecentIssuesin Bioanalysis:VaccineAssayValidation,qPCR A NOVEL METHOD FOR REMOVING POLYETHYLENEIMINE FROM Detecting and quantifying residual host cell DNA is an essential impurity test for all biopharmaceutical products; levels of residual DNA must be closely monitored and controlled throughout the production and release of the drug substance. qPCR is a widely accepted approach for the quantification of residual DNA in recombinant therapeutic proteins and the TaqMan qPCR ASSAYS AND TECHNOLOGIES FOR DEVELOPING PROTEOLYSIS Review Liu,Zhang,Lv,Yuan,Zheng&Zhou Degradation pathway Ub Ub Ub Ub Ub Ub E2 E2 E3 Ub E2 E3 E3 Binary target engagement Ub Ub Ub Ub Ub Ub Ub Ub Recycle Proteasome PROTACs Penetration Ternary complex formation ANALYSIS AND QUANTIFICATION OF IN VITRO MYOBLAST FUSION Adult skeletal muscle tissue contains a population of precursor cells, known as satellite cells, that are responsible for skeletal muscle repair (1–3).Activated satellite cells (myoblasts) migrate to the site of muscle trauma, where they proliferate, differentiate, and fuse into multinucleated myotubes (3–5).The ultimate success of this process is measured by the degree to which resident DRUG DELIVERY TO THE LUNGS: CHALLENGES AND OPPORTUNITIES 648 Ther. Deliv. (2017) 8(8) Review Newman mechanisms that are intended to keep inhaled m aterials out of the lungs, as well as removing or inactivating them once they have been deposited.Second,it is
BIOANALYSIS AUTHOR GUIDELINES Bioanalysis author guidelines Future perspective - The author is challenged to include speculative viewpoint on how the field will have evolved 5–10 years from the point at which the article was written. Executive summary - A series of bulleted statements representing key conclusions, unresolved issues and points for emphasis of work in future, under the main headings of BIOANALYSIS FOR PLASMA PROTEIN BINDING STUDIES IN DRUG Drug molecules in animals and humans are either bound to proteins and lipids or are freely available. This article focuses on analysis ofprotein bind-
BIOANALYSIS
Bioanalysis welcomes unsolicited article proposals. Email us today to discuss the suitability of your research and our options for authors, including our Accelerated Publication and Open Access services. Visit Bioanalysis Zone our online community. Supplement: The Bioanalysis Glossary. View the Decennial Index of the WRIB White Papers. TUMOR CELL INVASION INTO MATRIGEL: OPTIMIZED PROTOCOL FOR An optimized method for RNA extraction from highly invasive glioma cells embedded into Matrigel was achieved by using TRIzol, used for matrix dissociation, cell lysis and RNA separation, in combination with a specific commercial kit used to perform the DNAse treatment and optimal RNA purification on column. A STRATEGIC APPROACH TO NONCLINICAL IMMUNOGENICITY Review of the current recommendations. Guidance for nonclinical immunogenicity assessments is sparse. However, the key points from published literature and guidelines are summarized in Table 1.Initial requirements for assays used for the detection of host antibodies against biotechnology products were published to provide harmonized scientific recommendations for assays used in RATIONAL APPLICATION OF DRUG PROMISCUITY IN MEDICINAL Rational application of drug promiscuity in medicinal chemistry. ‘Drug promiscuity’ refers to a drug that can act on multiple molecular targets, exhibiting similar or different pharmacological effects. Drugs may interact with unwanted targets, leading to off-target effects (one of the main reasons for side effects). Thus,intervention to
CRISPR-CAS13A-BASED DIAGNOSTIC METHOD FOR CHLAMYDIA Aim: Development of a routine screening technique for Chlamydia trachomatis infection. The proposed approach involves the CRISPR RNA (crRNA). In the presence of the target sequence, the RNase activity of the Cas13a protein is activated, and it cleaves RNA fluorescent probe so that fluorescence will be emitted. THE NEW FACE OF ELECTROPHORESIS: MODERNIZATION OF A Automated Analysis of Protein Purity. One of the most appropriate applications of automated protein electrophoresis is to accelerate process development by monitoring column fractions during chromatographic purification ().This can apply to checking the purity of a monoclonal antibody in an industrial quality control setting or following the purification of an engineered polyhistidinetagged INTELLECTUAL PROPERTY AND ITS ROLE IN THE PHARMACEUTICAL Intellectual property & its role in the pharmaceutical industry | Editorial future science group www.future-science.com 1549 companies tend to obtain patent protection in DRUG DELIVERY TO THE LUNGS: CHALLENGES AND OPPORTUNITIES 648 Ther. Deliv. (2017) 8(8) Review Newman mechanisms that are intended to keep inhaled m aterials out of the lungs, as well as removing or inactivating them once they have been deposited.Second,it is
EBF RECOMMENDATION FOR STABILITY TESTING OF ANTI-DRUG future science rou www.future-science.com 1411 EBF recommendation for stability testing of anti-drug antibodies White Paper on the methodological approaches (e.g., RECOMMENDATIONS FOR THE DEVELOPMENT AND VALIDATION OF 1620 Bioanalysis (2015) 7(13) White Paper Jani, Marsden, Mikulskis et al. minimum of 50% inhibition, to widely accepted and applied complex statistical methods using the variation of percent inhibitions from a therapeutic-naïve popu-BIOANALYSIS
Bioanalysis welcomes unsolicited article proposals. Email us today to discuss the suitability of your research and our options for authors, including our Accelerated Publication and Open Access services. Visit Bioanalysis Zone our online community. Supplement: The Bioanalysis Glossary. View the Decennial Index of the WRIB White Papers. TUMOR CELL INVASION INTO MATRIGEL: OPTIMIZED PROTOCOL FOR An optimized method for RNA extraction from highly invasive glioma cells embedded into Matrigel was achieved by using TRIzol, used for matrix dissociation, cell lysis and RNA separation, in combination with a specific commercial kit used to perform the DNAse treatment and optimal RNA purification on column. A STRATEGIC APPROACH TO NONCLINICAL IMMUNOGENICITY Review of the current recommendations. Guidance for nonclinical immunogenicity assessments is sparse. However, the key points from published literature and guidelines are summarized in Table 1.Initial requirements for assays used for the detection of host antibodies against biotechnology products were published to provide harmonized scientific recommendations for assays used in RATIONAL APPLICATION OF DRUG PROMISCUITY IN MEDICINAL Rational application of drug promiscuity in medicinal chemistry. ‘Drug promiscuity’ refers to a drug that can act on multiple molecular targets, exhibiting similar or different pharmacological effects. Drugs may interact with unwanted targets, leading to off-target effects (one of the main reasons for side effects). Thus,intervention to
CRISPR-CAS13A-BASED DIAGNOSTIC METHOD FOR CHLAMYDIA Aim: Development of a routine screening technique for Chlamydia trachomatis infection. The proposed approach involves the CRISPR RNA (crRNA). In the presence of the target sequence, the RNase activity of the Cas13a protein is activated, and it cleaves RNA fluorescent probe so that fluorescence will be emitted. THE NEW FACE OF ELECTROPHORESIS: MODERNIZATION OF A Automated Analysis of Protein Purity. One of the most appropriate applications of automated protein electrophoresis is to accelerate process development by monitoring column fractions during chromatographic purification ().This can apply to checking the purity of a monoclonal antibody in an industrial quality control setting or following the purification of an engineered polyhistidinetagged INTELLECTUAL PROPERTY AND ITS ROLE IN THE PHARMACEUTICAL Intellectual property & its role in the pharmaceutical industry | Editorial future science group www.future-science.com 1549 companies tend to obtain patent protection in DRUG DELIVERY TO THE LUNGS: CHALLENGES AND OPPORTUNITIES 648 Ther. Deliv. (2017) 8(8) Review Newman mechanisms that are intended to keep inhaled m aterials out of the lungs, as well as removing or inactivating them once they have been deposited.Second,it is
EBF RECOMMENDATION FOR STABILITY TESTING OF ANTI-DRUG future science rou www.future-science.com 1411 EBF recommendation for stability testing of anti-drug antibodies White Paper on the methodological approaches (e.g., RECOMMENDATIONS FOR THE DEVELOPMENT AND VALIDATION OF 1620 Bioanalysis (2015) 7(13) White Paper Jani, Marsden, Mikulskis et al. minimum of 50% inhibition, to widely accepted and applied complex statistical methods using the variation of percent inhibitions from a therapeutic-naïve popu-BIOANALYSIS
Bioanalysis welcomes unsolicited article proposals. Email us today to discuss the suitability of your research and our options for authors, including our Accelerated Publication and Open Access services. Visit Bioanalysis Zone our online community. Supplement: The Bioanalysis Glossary. View the Decennial Index of the WRIB White Papers.FUTURE SCIENCE OA
Future Science OA welcomes unsolicited article proposals. Email us today to discuss the suitability of your research and our options for authors, including our Accelerated Publication service, ensuring rapid publication of your article subject to acceptance. Not sure why you should publish open access? A STRATEGIC APPROACH TO NONCLINICAL IMMUNOGENICITY Review of the current recommendations. Guidance for nonclinical immunogenicity assessments is sparse. However, the key points from published literature and guidelines are summarized in Table 1.Initial requirements for assays used for the detection of host antibodies against biotechnology products were published to provide harmonized scientific recommendations for assays used in 2020WHITEPAPERONRECENTISSUESIN BIOANALYSIS WhitePaper For reprint orders, please contact: reprints@future-science.com 2020WhitePaperonRecentIssuesin Bioanalysis:VaccineAssayValidation,qPCR A NOVEL METHOD FOR REMOVING POLYETHYLENEIMINE FROM Detecting and quantifying residual host cell DNA is an essential impurity test for all biopharmaceutical products; levels of residual DNA must be closely monitored and controlled throughout the production and release of the drug substance. qPCR is a widely accepted approach for the quantification of residual DNA in recombinant therapeutic proteins and the TaqMan qPCR ASSAYS AND TECHNOLOGIES FOR DEVELOPING PROTEOLYSIS Review Liu,Zhang,Lv,Yuan,Zheng&Zhou Degradation pathway Ub Ub Ub Ub Ub Ub E2 E2 E3 Ub E2 E3 E3 Binary target engagement Ub Ub Ub Ub Ub Ub Ub Ub Recycle Proteasome PROTACs Penetration Ternary complex formation ANALYSIS AND QUANTIFICATION OF IN VITRO MYOBLAST FUSION Adult skeletal muscle tissue contains a population of precursor cells, known as satellite cells, that are responsible for skeletal muscle repair (1–3).Activated satellite cells (myoblasts) migrate to the site of muscle trauma, where they proliferate, differentiate, and fuse into multinucleated myotubes (3–5).The ultimate success of this process is measured by the degree to which resident DRUG DELIVERY TO THE LUNGS: CHALLENGES AND OPPORTUNITIES 648 Ther. Deliv. (2017) 8(8) Review Newman mechanisms that are intended to keep inhaled m aterials out of the lungs, as well as removing or inactivating them once they have been deposited.Second,it is
BIOANALYSIS AUTHOR GUIDELINES Bioanalysis author guidelines Future perspective - The author is challenged to include speculative viewpoint on how the field will have evolved 5–10 years from the point at which the article was written. Executive summary - A series of bulleted statements representing key conclusions, unresolved issues and points for emphasis of work in future, under the main headings of BIOANALYSIS FOR PLASMA PROTEIN BINDING STUDIES IN DRUG Drug molecules in animals and humans are either bound to proteins and lipids or are freely available. This article focuses on analysis ofprotein bind-
We use cookies to improve your experience. By continuing to browse this site, you accept our cookie policy .×__
LOGIN TO YOUR ACCOUNTEmail:
Password
Forgot password?
Keep me logged in
New User
Institutional Login
__
CHANGE PASSWORD
Old Password
New Password
PASSWORD CHANGED SUCCESSFULLY Your password has been changed__
CREATE A NEW ACCOUNTReturning user
Can't sign in? Forgot your password? Enter your email address below and we will send you the resetinstructions
Email:
Cancel
If the address matches an existing account you will receive an email with instructions to reset your passwordClose
__
REQUEST USERNAME
Can't sign in? Forgot your username? Enter your email address below and we will send you your usernameEmail:
Close
If the address matches an existing account you will receive an email with instructions to retrieve your username* __Search
Anywhere__
* Anywhere
* Quick Search anywhere Enter words / phrases / DOI / ISBN / keywords / authors /etcSearchSearch
Advanced Search
*
0 My Cart
*
Sign in
Skip main navigation____Home
* Journals
* Books
* About Us
* Contact Us
* For Authors
* For Reviewers
* For Librarians
* For Advertisers
* Publishing Solutions* News
* Help
* Catalogue
* Submit an Article
* Reprints and Permissions* Pay Your Invoice
Skip slideshow
prev__next__
LATEST ARTICLES
*
EFFECT OF PINEAPPLE JUICE ON THE PHARMACOKINETICS OF CELECOXIB AND MONTELUKAST IN HUMANS* Sally A Helmy
, * Heba M El-Bedaiwy & * Soha M El-Masry 8 Jun 2020 Therapeutic Delivery*
TARGET SEQUENCE HETEROGENEITY CAUSES THE ‘HOOK EFFECT’ IN FLUORESCENT DYE-BASED QUANTITATIVE PCR* Kristina Warton
, * Yue Xu
& * Caroline Elizabeth Ford 5 Jun 2020 BioTechniques*
INTRODUCING AUTOMATION TO A REGULATED LABORATORY – AN EXPERIENCEREPORT
* Michael Gröschl
5 Jun 2020 Bioanalysis*
BIOANALYSIS: WAITING FOR NAPOLEON?* Anthony B Jones
5 Jun 2020 Bioanalysis*
DETECTION AND DIFFERENTIATION OF BACTERIA BY ELECTRICAL BIOIMPEDANCESPECTROSCOPY
* Rima Gnaim
, * Alexander Golberg , * Julia Sheviryov, * Boris Rubinsky
& * César A González 3 Jun 2020 BioTechniques*
AUTOFLUORESCENCE-BASED ANALYSES OF INTRANUCLEAR INCLUSIONS OF FRAGILE X-ASSOCIATED TREMOR/ATAXIA SYNDROME* Lisa Ma
& * Paul J Hagerman 3 Jun 2020 BioTechniques SUPPORT AND RESOURCESFOR AUTHORS
FOR REVIEWERS
FOR LIBRARIANS
PUBLISHING SOLUTIONSMOST READ ARTICLES
*
REAL-TIME PCR FOR MRNA QUANTITATION* Marisa L. Wong
& * Juan F. Medrano 30 May 2018 BioTechniques*
THE DECENNIAL INDEX OF THE WHITE PAPERS IN BIOANALYSIS: _‘A DECADE OF RECOMMENDATIONS (2007–2016)’_* Wei Garofolo
& * Natasha Savoie
3 Nov 2017 Bioanalysis*
GENETICALLY MODIFIED HUMANS: THE X-MEN OF SCIENTIFIC RESEARCH* Jenny Straiton
24 May 2019 BioTechniques*
A SINGLE PROTOCOL FOR EXTRACTION OF GDNA FROM BACTERIA AND YEAST * Laurie Vingataramin& * Eric H. Frost
3 Apr 2018 BioTechniques*
LOOKING BEYOND THE WRIB DECENNIAL INDEX OF THE WHITE PAPERS IN_BIOANALYSIS_
* Wei Garofolo
& * Natasha Savoie
4 Apr 2019 Bioanalysis*
CHELEX 100 AS A MEDIUM FOR SIMPLE EXTRACTION OF DNA FOR PCR-BASED TYPING FROM FORENSIC MATERIAL* P. Sean Walsh
, * David A. Metzger & * Russell Higuchi 3 Apr 2018 BioTechniques* Contact Us
* About
* Newsletter
* __
* __
* __
* __
Future Science Ltd, Unitec House, 2 Albert Place, London, N3 1QB, UK+44 (0)20 8371 6090
INFORMATION
* For Authors
* For Reviewers
* For Librarians
* For Advertisers
* Publishing SolutionsHELP & ABOUT US
* News
* Help
* About Us
* Contact Us
LINKS & RESOURCES
* Catalogue
* Submit an Article
* Reprints and Permissions* Pay Your Invoice
* Terms and conditions* Privacy policy
* Accessibility
2020 Future Science Group Close crossmark popupDetails
Copyright © 2024 ArchiveBay.com. All rights reserved. Terms of Use | Privacy Policy | DMCA | 2021 | Feedback | Advertising | RSS 2.0