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GRAND CHALLENGES
Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems. GLOBAL GRAND CHALLENGESABOUTPARTNERSHIPSCHALLENGESAWARDED GRANTSGRANTOPPORTUNITIESNEWS
Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems CHALLENGES | GLOBAL GRAND CHALLENGES Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems. Each initiative is an experiment in the use of challenges to focus innovation on making an impact. Individual challenges address some ofINFLUENZA VACCINE
FARMING DIGITAL TECHNOLOGIES Note: Please see the request for proposals document with additional background as a PDF file on the right. Summary Smart Farming Innovations for Small-Scale Producers Request for Proposals (RFP) seeks Smart Farming solutions that leverage digital technology innovations that have the potential to drive positive impact for smallscale producer (SSP) entrepreneurs delivered through bundledfarmer
DATA SYSTEMS
In Partnership with Liquidnet for Good Background: In the fall of 2012, IBM reported that 90% of the world’s data was created in the previous two years. We are now able to decode the human genome in just under one week, where it took 10 years to do so originally. We are awash in data and computing power, and while most industries are racing to take advantage of this resource and BLOOD SEPARATOR DEVICE Blood Separator Device. David Anderson of the Macfarlane Burnet Institute for Medical Research in Australia will develop a low-cost, simple to use, sample collection device to improve sample quality and ensure accurate and timely diagnosis in remote, low-resource areas. Obtaining high quality serum samples needed for diagnosing a varietyof
DEVELOPMENT OF A NOVEL ORGAN-ON-CHIP OF THE ENDOMETRIUM Kevin Osteen of Vanderbilt University Medical Center in the U.S. is developing a three-dimensional cell model that mimics the lining of the human uterus (endometrium), including different cell types and a vascular system, that can be used for affordable medium-to-high-throughput compound screening to discover new contraceptives with minimal adverse side effects. INTRACELLULAR SURVIVAL OF S. TYPHI IN ENVIRONMENTAL Dilip Abraham of Christian Medical College in India will analyze water samples from peri-urban and rural areas in India to study whether and how the typhoid fever-causing bacterium S. Typhi survives by living inside the common amoebae, Acanthamoeba. Acanthamoeba spp. are known to internalize S. Typhi, and may provide an intracellular environmental niche and extend survival of the bacteria. LOW-COST REAL-TIME SENSOR NETWORK FOR LARGE-AREA PEST AND Low-Cost Real-Time Sensor Network for Large-Area Pest and Disease Surveillance of Crop Plants. Hanseup Kim of the University of Utah in the U.S. will develop small, ultra-low power, chemical sensors that can be distributed around farms to help detect crop diseases in low-resource settings. Plants under attack from pests and diseasesrelease low
GRAND CHALLENGES
Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems. GLOBAL GRAND CHALLENGESABOUTPARTNERSHIPSCHALLENGESAWARDED GRANTSGRANTOPPORTUNITIESNEWS
Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems CHALLENGES | GLOBAL GRAND CHALLENGES Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems. Each initiative is an experiment in the use of challenges to focus innovation on making an impact. Individual challenges address some ofINFLUENZA VACCINE
FARMING DIGITAL TECHNOLOGIES Note: Please see the request for proposals document with additional background as a PDF file on the right. Summary Smart Farming Innovations for Small-Scale Producers Request for Proposals (RFP) seeks Smart Farming solutions that leverage digital technology innovations that have the potential to drive positive impact for smallscale producer (SSP) entrepreneurs delivered through bundledfarmer
DATA SYSTEMS
In Partnership with Liquidnet for Good Background: In the fall of 2012, IBM reported that 90% of the world’s data was created in the previous two years. We are now able to decode the human genome in just under one week, where it took 10 years to do so originally. We are awash in data and computing power, and while most industries are racing to take advantage of this resource and BLOOD SEPARATOR DEVICE Blood Separator Device. David Anderson of the Macfarlane Burnet Institute for Medical Research in Australia will develop a low-cost, simple to use, sample collection device to improve sample quality and ensure accurate and timely diagnosis in remote, low-resource areas. Obtaining high quality serum samples needed for diagnosing a varietyof
DEVELOPMENT OF A NOVEL ORGAN-ON-CHIP OF THE ENDOMETRIUM Kevin Osteen of Vanderbilt University Medical Center in the U.S. is developing a three-dimensional cell model that mimics the lining of the human uterus (endometrium), including different cell types and a vascular system, that can be used for affordable medium-to-high-throughput compound screening to discover new contraceptives with minimal adverse side effects. INTRACELLULAR SURVIVAL OF S. TYPHI IN ENVIRONMENTAL Dilip Abraham of Christian Medical College in India will analyze water samples from peri-urban and rural areas in India to study whether and how the typhoid fever-causing bacterium S. Typhi survives by living inside the common amoebae, Acanthamoeba. Acanthamoeba spp. are known to internalize S. Typhi, and may provide an intracellular environmental niche and extend survival of the bacteria. LOW-COST REAL-TIME SENSOR NETWORK FOR LARGE-AREA PEST AND Low-Cost Real-Time Sensor Network for Large-Area Pest and Disease Surveillance of Crop Plants. Hanseup Kim of the University of Utah in the U.S. will develop small, ultra-low power, chemical sensors that can be distributed around farms to help detect crop diseases in low-resource settings. Plants under attack from pests and diseasesrelease low
ABOUT GRAND CHALLENGES INITIATIVES Launched in 2011 by the U.S. Agency for International Development (USAID) and partners, Grand Challenges for Development seeks to create and support sustainable solutions for a variety of development challenges. The first challenge to be addressed – Saving Lives at Birth – is a partnership between USAID, the Norwegian Agency for Development Cooperation (Norad), the Bill & Melinda Gates GLOBAL GRAND CHALLENGES Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problemsGRANT OPPORTUNITIES
The Grand Challenges family of initiatives fosters innovation to solve key health and development problems. See below for Grand Challenges grant opportunities with the Bill & Melinda Gates Foundation as sole or contributing funder. GLOBAL HEALTH INTERVENTIONS The Bill & Melinda Gates Foundation is launching a new Grand Challenge: New Interventions for Global Health. This challenge focuses on innovative concepts for vaccines, therapeutics, and diagnostics with the potential to be translated into safe, effective, affordable, and widely utilized interventions to protect against the acquisition, progression, or transmission of infectious diseases, or SANITATION TECHNOLOGIES What is the Challenge? 2.1 billion of the world’s urban population use non-piped (non-sewered) sanitation technologies such as latrines, cesspools, septic tanks, or aqua privies to capture and contain their excreta (fecal matter and urine). These types of sanitation “solutions” tend to be unsustainable and are often detrimental topublic health.
BEHAVIOR CHANGE
Background: Convincing people to take simple steps for their own health should be easy. But encouraging healthy behaviors is not straightforward. Living a healthy, productive life requires individuals, families, and communities to embrace behaviors, products and services that promote well-being. Despite increasing recognition of behavioral effects on health, and increasing availability of CONTRACEPTIVE DISCOVERY The Opportunity Family planning is one of the most cost-effective ways to reduce maternal, infant and child mortality and contributes to the empowerment of women and families and the expansion of opportunities for economic development. In recent decades, there have been tremendous improvements in the reproductive health of women and men in the developing world. DRUG RESISTANCE BURDEN Appropriate antibiotic use has the power to save lives in the most vulnerable communities, and antimicrobial resistance (AMR) impacts multiple global health priority areas: HIV/AIDS, tuberculosis, maternal and neonatal health, pneumonia, and enteric and diarrheal diseases. It is critical to better understand the prevalence of AMR and its impact on mortality in developing countries so that NANOEMULSIONS AS ADJUVANTS FOR NASAL-SPRAY VACCINES Nanoemulsions as Adjuvants for Nasal-Spray Vaccines. Vaccines that can be delivered without needles have the potential to be simpler to administer and less prone to spreading infection. Dr. Baker's team is developing a new way of preparing vaccines so that they can be given as nasal drops. These nanoemulsion-based vaccines use non-toxic lipid BLOOD SEPARATOR DEVICE David Anderson of the Macfarlane Burnet Institute for Medical Research in Australia will develop a low-cost, simple to use, sample collection device to improve sample quality and ensure accurate and timely diagnosis in remote, low-resource areas. Obtaining high quality serum samples needed for diagnosing a variety of diseases is challenging in these regions due to the lack ofGRAND CHALLENGES
Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems. GLOBAL GRAND CHALLENGESABOUTPARTNERSHIPSCHALLENGESAWARDED GRANTSGRANTOPPORTUNITIESNEWS
Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems CHALLENGES | GLOBAL GRAND CHALLENGES Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems. Each initiative is an experiment in the use of challenges to focus innovation on making an impact. Individual challenges address some ofINFLUENZA VACCINE
FARMING DIGITAL TECHNOLOGIES Note: Please see the request for proposals document with additional background as a PDF file on the right. Summary Smart Farming Innovations for Small-Scale Producers Request for Proposals (RFP) seeks Smart Farming solutions that leverage digital technology innovations that have the potential to drive positive impact for smallscale producer (SSP) entrepreneurs delivered through bundledfarmer
DATA SYSTEMS
In Partnership with Liquidnet for Good Background: In the fall of 2012, IBM reported that 90% of the world’s data was created in the previous two years. We are now able to decode the human genome in just under one week, where it took 10 years to do so originally. We are awash in data and computing power, and while most industries are racing to take advantage of this resource and BLOOD SEPARATOR DEVICE Blood Separator Device. David Anderson of the Macfarlane Burnet Institute for Medical Research in Australia will develop a low-cost, simple to use, sample collection device to improve sample quality and ensure accurate and timely diagnosis in remote, low-resource areas. Obtaining high quality serum samples needed for diagnosing a varietyof
DEVELOPMENT OF A NOVEL ORGAN-ON-CHIP OF THE ENDOMETRIUM Kevin Osteen of Vanderbilt University Medical Center in the U.S. is developing a three-dimensional cell model that mimics the lining of the human uterus (endometrium), including different cell types and a vascular system, that can be used for affordable medium-to-high-throughput compound screening to discover new contraceptives with minimal adverse side effects. INTRACELLULAR SURVIVAL OF S. TYPHI IN ENVIRONMENTAL Dilip Abraham of Christian Medical College in India will analyze water samples from peri-urban and rural areas in India to study whether and how the typhoid fever-causing bacterium S. Typhi survives by living inside the common amoebae, Acanthamoeba. Acanthamoeba spp. are known to internalize S. Typhi, and may provide an intracellular environmental niche and extend survival of the bacteria. LOW-COST REAL-TIME SENSOR NETWORK FOR LARGE-AREA PEST AND Low-Cost Real-Time Sensor Network for Large-Area Pest and Disease Surveillance of Crop Plants. Hanseup Kim of the University of Utah in the U.S. will develop small, ultra-low power, chemical sensors that can be distributed around farms to help detect crop diseases in low-resource settings. Plants under attack from pests and diseasesrelease low
GRAND CHALLENGES
Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems. GLOBAL GRAND CHALLENGESABOUTPARTNERSHIPSCHALLENGESAWARDED GRANTSGRANTOPPORTUNITIESNEWS
Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems CHALLENGES | GLOBAL GRAND CHALLENGES Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems. Each initiative is an experiment in the use of challenges to focus innovation on making an impact. Individual challenges address some ofINFLUENZA VACCINE
FARMING DIGITAL TECHNOLOGIES Note: Please see the request for proposals document with additional background as a PDF file on the right. Summary Smart Farming Innovations for Small-Scale Producers Request for Proposals (RFP) seeks Smart Farming solutions that leverage digital technology innovations that have the potential to drive positive impact for smallscale producer (SSP) entrepreneurs delivered through bundledfarmer
DATA SYSTEMS
In Partnership with Liquidnet for Good Background: In the fall of 2012, IBM reported that 90% of the world’s data was created in the previous two years. We are now able to decode the human genome in just under one week, where it took 10 years to do so originally. We are awash in data and computing power, and while most industries are racing to take advantage of this resource and BLOOD SEPARATOR DEVICE Blood Separator Device. David Anderson of the Macfarlane Burnet Institute for Medical Research in Australia will develop a low-cost, simple to use, sample collection device to improve sample quality and ensure accurate and timely diagnosis in remote, low-resource areas. Obtaining high quality serum samples needed for diagnosing a varietyof
DEVELOPMENT OF A NOVEL ORGAN-ON-CHIP OF THE ENDOMETRIUM Kevin Osteen of Vanderbilt University Medical Center in the U.S. is developing a three-dimensional cell model that mimics the lining of the human uterus (endometrium), including different cell types and a vascular system, that can be used for affordable medium-to-high-throughput compound screening to discover new contraceptives with minimal adverse side effects. INTRACELLULAR SURVIVAL OF S. TYPHI IN ENVIRONMENTAL Dilip Abraham of Christian Medical College in India will analyze water samples from peri-urban and rural areas in India to study whether and how the typhoid fever-causing bacterium S. Typhi survives by living inside the common amoebae, Acanthamoeba. Acanthamoeba spp. are known to internalize S. Typhi, and may provide an intracellular environmental niche and extend survival of the bacteria. LOW-COST REAL-TIME SENSOR NETWORK FOR LARGE-AREA PEST AND Low-Cost Real-Time Sensor Network for Large-Area Pest and Disease Surveillance of Crop Plants. Hanseup Kim of the University of Utah in the U.S. will develop small, ultra-low power, chemical sensors that can be distributed around farms to help detect crop diseases in low-resource settings. Plants under attack from pests and diseasesrelease low
ABOUT GRAND CHALLENGES INITIATIVES Launched in 2011 by the U.S. Agency for International Development (USAID) and partners, Grand Challenges for Development seeks to create and support sustainable solutions for a variety of development challenges. The first challenge to be addressed – Saving Lives at Birth – is a partnership between USAID, the Norwegian Agency for Development Cooperation (Norad), the Bill & Melinda Gates GLOBAL GRAND CHALLENGES Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problemsGRANT OPPORTUNITIES
The Grand Challenges family of initiatives fosters innovation to solve key health and development problems. See below for Grand Challenges grant opportunities with the Bill & Melinda Gates Foundation as sole or contributing funder. GLOBAL HEALTH INTERVENTIONS The Bill & Melinda Gates Foundation is launching a new Grand Challenge: New Interventions for Global Health. This challenge focuses on innovative concepts for vaccines, therapeutics, and diagnostics with the potential to be translated into safe, effective, affordable, and widely utilized interventions to protect against the acquisition, progression, or transmission of infectious diseases, or SANITATION TECHNOLOGIES What is the Challenge? 2.1 billion of the world’s urban population use non-piped (non-sewered) sanitation technologies such as latrines, cesspools, septic tanks, or aqua privies to capture and contain their excreta (fecal matter and urine). These types of sanitation “solutions” tend to be unsustainable and are often detrimental topublic health.
BEHAVIOR CHANGE
Background: Convincing people to take simple steps for their own health should be easy. But encouraging healthy behaviors is not straightforward. Living a healthy, productive life requires individuals, families, and communities to embrace behaviors, products and services that promote well-being. Despite increasing recognition of behavioral effects on health, and increasing availability of CONTRACEPTIVE DISCOVERY The Opportunity Family planning is one of the most cost-effective ways to reduce maternal, infant and child mortality and contributes to the empowerment of women and families and the expansion of opportunities for economic development. In recent decades, there have been tremendous improvements in the reproductive health of women and men in the developing world. DRUG RESISTANCE BURDEN Appropriate antibiotic use has the power to save lives in the most vulnerable communities, and antimicrobial resistance (AMR) impacts multiple global health priority areas: HIV/AIDS, tuberculosis, maternal and neonatal health, pneumonia, and enteric and diarrheal diseases. It is critical to better understand the prevalence of AMR and its impact on mortality in developing countries so that NANOEMULSIONS AS ADJUVANTS FOR NASAL-SPRAY VACCINES Nanoemulsions as Adjuvants for Nasal-Spray Vaccines. Vaccines that can be delivered without needles have the potential to be simpler to administer and less prone to spreading infection. Dr. Baker's team is developing a new way of preparing vaccines so that they can be given as nasal drops. These nanoemulsion-based vaccines use non-toxic lipid BLOOD SEPARATOR DEVICE David Anderson of the Macfarlane Burnet Institute for Medical Research in Australia will develop a low-cost, simple to use, sample collection device to improve sample quality and ensure accurate and timely diagnosis in remote, low-resource areas. Obtaining high quality serum samples needed for diagnosing a variety of diseases is challenging in these regions due to the lack ofGRAND CHALLENGES
Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems. GLOBAL GRAND CHALLENGESABOUTPARTNERSHIPSCHALLENGESAWARDED GRANTSGRANTOPPORTUNITIESNEWS
Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems CHALLENGES | GLOBAL GRAND CHALLENGES Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems. Each initiative is an experiment in the use of challenges to focus innovation on making an impact. Individual challenges address some ofGRANT OPPORTUNITIES
The Grand Challenges family of initiatives fosters innovation to solve key health and development problems. See below for Grand Challenges grant opportunities with the Bill & Melinda Gates Foundation as sole or contributing funder.INFLUENZA VACCINE
FARMING DIGITAL TECHNOLOGIES Note: Please see the request for proposals document with additional background as a PDF file on the right. Summary Smart Farming Innovations for Small-Scale Producers Request for Proposals (RFP) seeks Smart Farming solutions that leverage digital technology innovations that have the potential to drive positive impact for smallscale producer (SSP) entrepreneurs delivered through bundledfarmer
DATA SYSTEMS
In Partnership with Liquidnet for Good Background: In the fall of 2012, IBM reported that 90% of the world’s data was created in the previous two years. We are now able to decode the human genome in just under one week, where it took 10 years to do so originally. We are awash in data and computing power, and while most industries are racing to take advantage of this resource and INTRACELLULAR SURVIVAL OF S. TYPHI IN ENVIRONMENTAL Dilip Abraham of Christian Medical College in India will analyze water samples from peri-urban and rural areas in India to study whether and how the typhoid fever-causing bacterium S. Typhi survives by living inside the common amoebae, Acanthamoeba. Acanthamoeba spp. are known to internalize S. Typhi, and may provide an intracellular environmental niche and extend survival of the bacteria. BLOOD SEPARATOR DEVICE Blood Separator Device. David Anderson of the Macfarlane Burnet Institute for Medical Research in Australia will develop a low-cost, simple to use, sample collection device to improve sample quality and ensure accurate and timely diagnosis in remote, low-resource areas. Obtaining high quality serum samples needed for diagnosing a varietyof
DEVELOPMENT OF A NOVEL ORGAN-ON-CHIP OF THE ENDOMETRIUM Kevin Osteen of Vanderbilt University Medical Center in the U.S. is developing a three-dimensional cell model that mimics the lining of the human uterus (endometrium), including different cell types and a vascular system, that can be used for affordable medium-to-high-throughput compound screening to discover new contraceptives with minimal adverse side effects.GRAND CHALLENGES
Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems. GLOBAL GRAND CHALLENGESABOUTPARTNERSHIPSCHALLENGESAWARDED GRANTSGRANTOPPORTUNITIESNEWS
Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems CHALLENGES | GLOBAL GRAND CHALLENGES Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems. Each initiative is an experiment in the use of challenges to focus innovation on making an impact. Individual challenges address some ofGRANT OPPORTUNITIES
The Grand Challenges family of initiatives fosters innovation to solve key health and development problems. See below for Grand Challenges grant opportunities with the Bill & Melinda Gates Foundation as sole or contributing funder.INFLUENZA VACCINE
FARMING DIGITAL TECHNOLOGIES Note: Please see the request for proposals document with additional background as a PDF file on the right. Summary Smart Farming Innovations for Small-Scale Producers Request for Proposals (RFP) seeks Smart Farming solutions that leverage digital technology innovations that have the potential to drive positive impact for smallscale producer (SSP) entrepreneurs delivered through bundledfarmer
DATA SYSTEMS
In Partnership with Liquidnet for Good Background: In the fall of 2012, IBM reported that 90% of the world’s data was created in the previous two years. We are now able to decode the human genome in just under one week, where it took 10 years to do so originally. We are awash in data and computing power, and while most industries are racing to take advantage of this resource and INTRACELLULAR SURVIVAL OF S. TYPHI IN ENVIRONMENTAL Dilip Abraham of Christian Medical College in India will analyze water samples from peri-urban and rural areas in India to study whether and how the typhoid fever-causing bacterium S. Typhi survives by living inside the common amoebae, Acanthamoeba. Acanthamoeba spp. are known to internalize S. Typhi, and may provide an intracellular environmental niche and extend survival of the bacteria. BLOOD SEPARATOR DEVICE Blood Separator Device. David Anderson of the Macfarlane Burnet Institute for Medical Research in Australia will develop a low-cost, simple to use, sample collection device to improve sample quality and ensure accurate and timely diagnosis in remote, low-resource areas. Obtaining high quality serum samples needed for diagnosing a varietyof
DEVELOPMENT OF A NOVEL ORGAN-ON-CHIP OF THE ENDOMETRIUM Kevin Osteen of Vanderbilt University Medical Center in the U.S. is developing a three-dimensional cell model that mimics the lining of the human uterus (endometrium), including different cell types and a vascular system, that can be used for affordable medium-to-high-throughput compound screening to discover new contraceptives with minimal adverse side effects. ABOUT GRAND CHALLENGES INITIATIVES Launched in 2003 by the Bill & Melinda Gates Foundation as Grand Challenges in Global Health, this initiative initially focused on 14 major scientific challenges that, if solved, could lead to key advances in preventing, treating, and curing the diseases and health conditions contributing most to global health inequity. It was relaunched in 2014 as Grand Challenges, its new name reflecting its GLOBAL GRAND CHALLENGES Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problemsINFLUENZA VACCINE
The Grand Challenge (Facilitating innovation requires understanding) how do we create ecosystems that promote creativitythat promote innovation of benefit to the world and to humanity. Eliane Ubalijoro, McGill University, GCE Grantee The net effect of Grand Challenges will be a massive return – these investments, really, will be traceable to saving millions of lives.FERMENTED FOODS
THE OPPORTUNITY Embracing the tradition of microbial fermentation to transform locally available foods into naturally vitamin-fortified, toxin-free, flavorful, and shelf-stable products could empower local communities to mitigate the impact of COVID-19 on supply chain/food security and improve the health and nutrition of mothers and children in the most vulnerable settings. GLOBAL HEALTH INTERVENTIONS The Bill & Melinda Gates Foundation is launching a new Grand Challenge: New Interventions for Global Health. This challenge focuses on innovative concepts for vaccines, therapeutics, and diagnostics with the potential to be translated into safe, effective, affordable, and widely utilized interventions to protect against the acquisition, progression, or transmission of infectious diseases, orBEHAVIOR CHANGE
Background: Convincing people to take simple steps for their own health should be easy. But encouraging healthy behaviors is not straightforward. Living a healthy, productive life requires individuals, families, and communities to embrace behaviors, products and services that promote well-being. Despite increasing recognition of behavioral effects on health, and increasing availability of BALANCE THE EQUATION RULES AND GUIDELINES 1 . Balance the Equation Rules and Guidelines . A Grand Challenge for Algebra 1. Applications due no later than . Friday, November 06, 2020, at. Noon U.S. Pacific Time DRUG RESISTANCE BURDEN Appropriate antibiotic use has the power to save lives in the most vulnerable communities, and antimicrobial resistance (AMR) impacts multiple global health priority areas: HIV/AIDS, tuberculosis, maternal and neonatal health, pneumonia, and enteric and diarrheal diseases. It is critical to better understand the prevalence of AMR and its impact on mortality in developing countries so that BLOOD SEPARATOR DEVICE Blood Separator Device. David Anderson of the Macfarlane Burnet Institute for Medical Research in Australia will develop a low-cost, simple to use, sample collection device to improve sample quality and ensure accurate and timely diagnosis in remote, low-resource areas. Obtaining high quality serum samples needed for diagnosing a varietyof
GRAND CHALLENGES BUDGET TEMPLATE AND NARRATIVE Grand Challenges Budget Template and Narrative : Smart Farming Innovations for Small-Scale Producers. Budget Template . Please complete a high-level budget with the below categories.GRAND CHALLENGES
Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems. GLOBAL GRAND CHALLENGESABOUTPARTNERSHIPSCHALLENGESAWARDED GRANTSGRANTOPPORTUNITIESNEWS
Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problemsGRANT OPPORTUNITIES
Description. Grand Challenges Canada’s Stars in Global Health program is seeking bold ideas that will improve the sexual and reproductive health and rights of women, adolescents, children and LGBTQI+ people in Sub-Saharan Africa. The bold ideas are expected to improve the access, use and quality of comprehensive sexual andreproductive health
GRANT OPPORTUNITIES
The Grand Challenges family of initiatives fosters innovation to solve key health and development problems. See below for Grand Challenges grant opportunities with the Bill & Melinda Gates Foundation as sole or contributing funder. CHALLENGES | GLOBAL GRAND CHALLENGES Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems. Each initiative is an experiment in the use of challenges to focus innovation on making an impact. Individual challenges address some ofINFLUENZA VACCINE
HEALTH CAMPAIGNS
Campaign-based delivery of health interventions is typically time-limited, intermittent, and implemented at-scale. All countries utilize health campaigns in some capacity - such as for outbreak response - and campaigns have been shown to be an effective way of driving health impact. For example, Vitamin A supplementation isestimated to reduce
CONTRACEPTIVE DISCOVERY The Opportunity Family planning is one of the most cost-effective ways to reduce maternal, infant and child mortality and contributes to the empowerment of women and families and the expansion of opportunities for economic development. In recent decades, there have been tremendous improvements in the reproductive health of women and men in the developing world. FARMING DIGITAL TECHNOLOGIES Note: Please see the request for proposals document with additional background as a PDF file on the right. Summary Smart Farming Innovations for Small-Scale Producers Request for Proposals (RFP) seeks Smart Farming solutions that leverage digital technology innovations that have the potential to drive positive impact for smallscale producer (SSP) entrepreneurs delivered through bundledfarmer
SALMONELLA TYPHI
THE OPPORTUNITY Salmonella enterica ssp. enterica serovar Typhi (S. Typhi) caused an estimated 10 million typhoid cases and 117,000 deaths in 2017 (Global Burden of Disease 2017). S. Typhi strains that are resistant to multiple antibiotics have emerged (Klemm et al. 2018) and are stretching health systems in multiple low- and middle-income settings (Andrews et al. 2018).GRAND CHALLENGES
Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems. GLOBAL GRAND CHALLENGESABOUTPARTNERSHIPSCHALLENGESAWARDED GRANTSGRANTOPPORTUNITIESNEWS
Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problemsGRANT OPPORTUNITIES
Description. Grand Challenges Canada’s Stars in Global Health program is seeking bold ideas that will improve the sexual and reproductive health and rights of women, adolescents, children and LGBTQI+ people in Sub-Saharan Africa. The bold ideas are expected to improve the access, use and quality of comprehensive sexual andreproductive health
GRANT OPPORTUNITIES
The Grand Challenges family of initiatives fosters innovation to solve key health and development problems. See below for Grand Challenges grant opportunities with the Bill & Melinda Gates Foundation as sole or contributing funder. CHALLENGES | GLOBAL GRAND CHALLENGES Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems. Each initiative is an experiment in the use of challenges to focus innovation on making an impact. Individual challenges address some ofINFLUENZA VACCINE
HEALTH CAMPAIGNS
Campaign-based delivery of health interventions is typically time-limited, intermittent, and implemented at-scale. All countries utilize health campaigns in some capacity - such as for outbreak response - and campaigns have been shown to be an effective way of driving health impact. For example, Vitamin A supplementation isestimated to reduce
CONTRACEPTIVE DISCOVERY The Opportunity Family planning is one of the most cost-effective ways to reduce maternal, infant and child mortality and contributes to the empowerment of women and families and the expansion of opportunities for economic development. In recent decades, there have been tremendous improvements in the reproductive health of women and men in the developing world. FARMING DIGITAL TECHNOLOGIES Note: Please see the request for proposals document with additional background as a PDF file on the right. Summary Smart Farming Innovations for Small-Scale Producers Request for Proposals (RFP) seeks Smart Farming solutions that leverage digital technology innovations that have the potential to drive positive impact for smallscale producer (SSP) entrepreneurs delivered through bundledfarmer
SALMONELLA TYPHI
THE OPPORTUNITY Salmonella enterica ssp. enterica serovar Typhi (S. Typhi) caused an estimated 10 million typhoid cases and 117,000 deaths in 2017 (Global Burden of Disease 2017). S. Typhi strains that are resistant to multiple antibiotics have emerged (Klemm et al. 2018) and are stretching health systems in multiple low- and middle-income settings (Andrews et al. 2018). ABOUT GRAND CHALLENGES INITIATIVES Launched in 2003 by the Bill & Melinda Gates Foundation as Grand Challenges in Global Health, this initiative initially focused on 14 major scientific challenges that, if solved, could lead to key advances in preventing, treating, and curing the diseases and health conditions contributing most to global health inequity. It was relaunched in 2014 as Grand Challenges, its new name reflecting its ABOUT GRAND CHALLENGES Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems. A Family of Initiatives with One Purpose Grand Challenges initiatives use challenges to focus attention and effort on specific problems, and they can be traced back to the mathematician David Hilbert, who over a century ago defined a set of unsolved problems to spark CHALLENGES | GLOBAL GRAND CHALLENGES Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems. Each initiative is an experiment in the use of challenges to focus innovation on making an impact. Individual challenges address some of NEWS | GLOBAL GRAND CHALLENGES Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems ECONOMIC OPPORTUNITY June 10, 2020 Update: We are proud to announce 28 grants of $100,000 each in the Voices for Economic Opportunity Grand Challenge, to a wide array of organizations that will work to correct mistaken assumptions and improve understanding of the barriers to economic mobility through the stories of those who experience poverty. Read the press releaseand blog post.
AWARDED GRANTS
Awarded Grants. Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems. Each initiative is an experiment in the use of challenges to focus innovation on making an impact. Individual challenges address some ofHEALTH CAMPAIGNS
Campaign-based delivery of health interventions is typically time-limited, intermittent, and implemented at-scale. All countries utilize health campaigns in some capacity - such as for outbreak response - and campaigns have been shown to be an effective way of driving health impact. For example, Vitamin A supplementation isestimated to reduce
CONTRACEPTIVE DISCOVERY "That's the idea behind Grand Challenges - to focus bright scientists on the problems of the poorest, take some risks, and deliver results." Bill Gates "Family planning and access to contraception - including information, supplies, and services - is an issue that I am passionate about, and it has become one of my personal priorities at thefoundation.
NANOEMULSIONS AS ADJUVANTS FOR NASAL-SPRAY VACCINES Vaccines that can be delivered without needles have the potential to be simpler to administer and less prone to spreading infection. Dr. Baker's team is developing a new way of preparing vaccines so that they can be given as nasal drops. These nanoemulsion-based vaccines use non-toxic lipid droplets less than 200 nanometers in diameter that are absorbed through the mucosal surfaces DEVELOPMENT OF A NOVEL ORGAN-ON-CHIP OF THE ENDOMETRIUM Kevin Osteen of Vanderbilt University Medical Center in the U.S. is developing a three-dimensional cell model that mimics the lining of the human uterus (endometrium), including different cell types and a vascular system, that can be used for affordable medium-to-high-throughput compound screening to discover new contraceptives with minimal adverse side effects.GRAND CHALLENGES
Solving global health and development problems for those most in needGrant Opportunities
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2019
TOWARD A PERMANENT INFLUENZA VACCINE: DESIGN OF HEMAGGLUTININ ANTIGEN ANALOGS AND VACCINATION PROTOCOLS BY STRUCTURAL MODELING, ATOM-BASED SIMULATIONS, MACHINE LEARNING, AND EXPERIMENTS Martin Karplus, Harvard University (Cambridge, Massachusetts, UnitedStates)
Grand Challenges > Ending the Pandemic Threat: A Grand Challenge for Universal Influenza VaccineDevelopment
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2019
TURNING INFLUENZA INTO MEASLES VIA MOSAIC NATURAL SELECTIVE TARGETING OF IMMUNE RESPONSES (MONSTIR) Patrick Wilson, University of Chicago (Chicago, Illinois, UnitedStates)
Grand Challenges > Ending the Pandemic Threat: A Grand Challenge for Universal Influenza VaccineDevelopment
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2019
COMBINING EPITOPE-BASED VACCINE DESIGN WITH INFORMATICS-BASED EVALUATION TO OBTAIN A UNIVERSAL INFLUENZA VACCINE Rebeca Salmeron, Foundation for the National Institutes of Health Inc (North Bethesda, Maryland, United States) Grand Challenges > Ending the Pandemic Threat: A Grand Challenge for Universal Influenza VaccineDevelopment
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2019
AN UNCONVENTIONALLY MHC-RESTRICTED T CELL VACCINE FOR INFLUENZA Jonah Sacha, Oregon Health and Science University (Portland, Oregon,United States)
Grand Challenges > Ending the Pandemic Threat: A Grand Challenge for Universal Influenza VaccineDevelopment
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2019
A NEW STRATEGY TO ELICIT BROADLY PROTECTIVE ANTIBODIES TO INFLUENZAVIRUSES
Yoshihiro Kawaoka, The University of Tokyo (Tokyo, Japan) Grand Challenges > Ending the Pandemic Threat: A Grand Challenge for Universal Influenza VaccineDevelopment
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2019
NEW SAFER CONTRACEPTIVES THAT BLOCK OVULATION Darryl Russell, University of Adelaide (Adelaide, South Australia,Australia)
Grand Challenges Explorations > Develop Novel Platforms to Accelerate Contraceptive Drug Discovery (Round 18)*
2019
DIGITAL IMMUNE OPTIMIZED AND SELECTED UNIVERSAL INFLUENZA VACCINE ANTIGENS (DIOS-UIVA) Jonathan Heeney, University of Cambridge (Cambridge, United Kingdom) Grand Challenges > Ending the Pandemic Threat: A Grand Challenge for Universal Influenza VaccineDevelopment
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2019
PREDICTIVE SUPPLY CHAIN FOR VACCINES Benjamin Fels, Macro-Eyes, Inc. (Fall City, Washington, United States) Grand Challenges Explorations> Health Systems
Strengthening: Ensuring Effective Health Supply Chains (Round 19)*
2019
RATIONAL DESIGN OF A UNIVERSAL FLU VACCINE USING RECOMBINANTNEURAMINIDASE
Alice McHardy, The Helmholtz Centre for Infection Research (Braunschweig, Germany) Grand Challenges > Ending the Pandemic Threat: A Grand Challenge for Universal Influenza VaccineDevelopment
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2019
DETECTION TECHNOLOGY FOR EVALUATING CROP THREATS (DETECT) Peter Wagstaff, Self Help Africa (Dublin, Ireland) Grand Challenges Explorations > Tools and Technologies for Broad-Scale Pest and Disease Surveillance of Crop Plants in Low-Income Countries (Round 22) pagination.perPage">* <<
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GRAND CHALLENGES is a family of initiatives fostering innovation to solve key global health and development problems. Next phase of Grand Challenges launched,
October 2014
View the Grand Challenges Meeting Videos , October 2018Grant Opportunities
New grant opportunities posted , September 18,2019
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