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CANCER CELL MODELS
We are confident that HAP1 and Cancer-related Ready-to-go cell lines are the ideal product to further your research. However, if you are not totally satisfied with the performance of any of our HAP1 and Cancer-related Ready-to-go cell lines, for any reason, we will gladlyrefund your
SIDESIGN CENTER
siDESIGN Center. The siDESIGN Center is an advanced, user-friendly siRNA design tool, which significantly improves the likelihood of identifying functional siRNA. One-of-a-kind options are available to enhance target specificity and adapt siRNA designs for more sophisticated experimental design. View the online User Guide for helpusing
HAP1 PARENTAL CELL LINES HAP1 is a human near-haploid cell line derived from the male chronic myelogenous leukemia (CML) cell line KBM-7. For more details on how the HAP1 cell line was created, please see the references tab. HAP1 cell line properties include: Sustained growth at single celldilutions. Ease of
STRUCTURAL MULTIPLEX REFERENCE STANDARD (GDNA) The Structural Multiplex Reference Standard covers a wide range of mutations in defined genomic context. This standard is designed to challenge your molecular and bioinformatic work flow by providing validated copy number variants/amplifications, translocations, and large insertions/deletions. Additionally, you may examine the genomiccontext
STRUCTURAL MULTIPLEX CFDNA REFERENCE STANDARD The Structural Multiplex cfDNA Reference Standard covers a wide range of mutations in a defined genomic context. This standard consists of DNA derived from human cell lines that is fragmented to an average size of 160 bp to closely resemble cfDNA extracted from human plasma. This product is designed to challenge your molecular and bioinformatic QUANTITATIVE MULTIPLEX REFERENCE STANDARD (FFPE)SEE MORE ON HORIZONDISCOVERY.COM CHALICE BIOINFORMATICS SOFTWARE Chalice Bioinformatics Software. Developed to provide collaborators the same proven analysis tools employed by Horizon’s combination screening scientists, The Chalice software is a proprietary data analysis platform for characterizing single agent and multi-target screening results. The tool allows researchers to quantitativelyassess the
ALK RET ROS RNA FUSION The ALK-RET-ROS1 targeted FFPE RNA Fusion Reference Standards are a highly-characterized, biologically-relevant quality control material used to assess the performance of NGS, RT-PCR and RT-qPCR assays aimed at detecting gene fusions. Each section contains formalin-fixed, paraffin-embedded (FFPE) cell line multiplex verified to contain EML4-ALK, CCDC6-RET and SLC34A2-ROS1 fusions. BRCA SOMATIC MULTIPLEX I (GDNA) BRCA Somatic Multiplex I (gDNA) Afghanistan Aland Islands Albania Algeria American Samoa Andorra Angola Anguilla Antarctica Antigua And Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia, Plurinational State Of Bonaire, Saint Eustatius AndSaba
SIGLO CONTROLS
Fluorescent controls are useful for visual indication of delivery, and when combined with functional knockdown assessment, provide a useful tool for optimization. siGLO Positive controls will effectively silence the indicated gene, and result in punctate cytoplasmicfluorescence.
CANCER CELL MODELS
We are confident that HAP1 and Cancer-related Ready-to-go cell lines are the ideal product to further your research. However, if you are not totally satisfied with the performance of any of our HAP1 and Cancer-related Ready-to-go cell lines, for any reason, we will gladlyrefund your
SIDESIGN CENTER
siDESIGN Center. The siDESIGN Center is an advanced, user-friendly siRNA design tool, which significantly improves the likelihood of identifying functional siRNA. One-of-a-kind options are available to enhance target specificity and adapt siRNA designs for more sophisticated experimental design. View the online User Guide for helpusing
HAP1 PARENTAL CELL LINES HAP1 is a human near-haploid cell line derived from the male chronic myelogenous leukemia (CML) cell line KBM-7. For more details on how the HAP1 cell line was created, please see the references tab. HAP1 cell line properties include: Sustained growth at single celldilutions. Ease of
STRUCTURAL MULTIPLEX REFERENCE STANDARD (GDNA) The Structural Multiplex Reference Standard covers a wide range of mutations in defined genomic context. This standard is designed to challenge your molecular and bioinformatic work flow by providing validated copy number variants/amplifications, translocations, and large insertions/deletions. Additionally, you may examine the genomiccontext
STRUCTURAL MULTIPLEX CFDNA REFERENCE STANDARD The Structural Multiplex cfDNA Reference Standard covers a wide range of mutations in a defined genomic context. This standard consists of DNA derived from human cell lines that is fragmented to an average size of 160 bp to closely resemble cfDNA extracted from human plasma. This product is designed to challenge your molecular and bioinformatic QUANTITATIVE MULTIPLEX REFERENCE STANDARD (FFPE)SEE MORE ON HORIZONDISCOVERY.COM CHALICE BIOINFORMATICS SOFTWARE Chalice Bioinformatics Software. Developed to provide collaborators the same proven analysis tools employed by Horizon’s combination screening scientists, The Chalice software is a proprietary data analysis platform for characterizing single agent and multi-target screening results. The tool allows researchers to quantitativelyassess the
ALK RET ROS RNA FUSION The ALK-RET-ROS1 targeted FFPE RNA Fusion Reference Standards are a highly-characterized, biologically-relevant quality control material used to assess the performance of NGS, RT-PCR and RT-qPCR assays aimed at detecting gene fusions. Each section contains formalin-fixed, paraffin-embedded (FFPE) cell line multiplex verified to contain EML4-ALK, CCDC6-RET and SLC34A2-ROS1 fusions. BRCA SOMATIC MULTIPLEX I (GDNA) BRCA Somatic Multiplex I (gDNA) Afghanistan Aland Islands Albania Algeria American Samoa Andorra Angola Anguilla Antarctica Antigua And Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia, Plurinational State Of Bonaire, Saint Eustatius AndSaba
SIGLO CONTROLS
Fluorescent controls are useful for visual indication of delivery, and when combined with functional knockdown assessment, provide a useful tool for optimization. siGLO Positive controls will effectively silence the indicated gene, and result in punctate cytoplasmicfluorescence.
CUSTOM RNA SYNTHESIS Custom RNA synthesis by Dharmacon. Create and order RNA molecules with a wide variety of chemical modifications or learn about our capabilities for long RNA oligos, dye labeling and custom amidites. These tools are for ordering RNA and RNA-DNA chimeras only. Ordercustom DNA
QUANTITATIVE MULTIPLEX REFERENCE STANDARD (GDNA) The Quantitative Multiplex DNA Reference Standard is a highly-characterized, biologically-relevant quality control material used to assess the performance of NGS assays that detect somaticmutations.
HAP1 KNOCKOUT CELL LINES HAP1 knockout cell lines. The single largest bank of isogenic cell lines with over 7,500 cell lines to choose from and trusted by academia, biotech, and pharma research labs. Cell models to suit any application, from TIDVAL to antibody validation, delivered in ALK RET ROS RNA FUSION The ALK-RET-ROS1 targeted FFPE RNA Fusion Reference Standards are a highly-characterized, biologically-relevant quality control material used to assess the performance of NGS, RT-PCR and RT-qPCR assays aimed at detecting gene fusions. Each section contains formalin-fixed, paraffin-embedded (FFPE) cell line multiplex verified to contain EML4-ALK, CCDC6-RET and SLC34A2-ROS1 fusions. MULTIPLEX I CFDNA REFERENCE STANDARD SET The Multiplex I cfDNA Reference Standards are highly-characterized, biologically-relevant reference materials used to assess the performance of cfDNA assays that detect somatic mutations, including quantitative PCR, next-generation sequencing, and other novel assays DHARMAFECT 1 TRANSFECTION REAGENT DharmaFECT 1 is our most all-purpose transfection reagent formulation; demonstrating efficient, low-toxicity delivery to over 35 cell types. DharmaFECT 1 achieves effective transfection of siRNA and microRNA reagents at low concentrations and with low cytotoxicity, especially when compared to transfection reagents designed for use with plasmidDNA.
TRU-Q 7 (1.3% TIER) REFERENCE STANDARD Tru-Q 7 (1.3% Tier) Reference Standard. The Tru-Q DNA Reference Standards are a highly-characterized, biologically-relevant quality control material used to assess the performance of NGS assays that detect somatic mutations. The specifications of some variants within the Tru-Q product line have been changed for batches manufacturedafter the
GIPZ LENTIVIRAL SHRNA GIPZ Lentiviral shRNA. microRNA-adapted shRNA based on miR-30 for specific gene silencing with minimal cytotoxicity. Perform specific and efficient, transient or long-term RNAi with GIPZ Lentiviral shRNA. GIPZ Lentiviral shRNA targets human and mouse genes using multiple shRNA constructs that have been cloned into the pGIPZ lentiviralvector.
PRECISION LENTIORF COLLECTION Precision LentiORF collection. Precision LentiORFs are human cDNA open reading frames (ORFs) cloned into a lentiviral expression vector, used for overexpressing human genes and proteins in mammalian cells. Ideal for use in primary or difficult to transfect cells, Precision LentiORFs can be used to create stably expressing cell lines ON-TARGETPLUS NON-TARGETING CONTROL POOL ON-TARGETplus Non-targeting Control Pool is the ideal negative control for RNAi experiments in human, mouse, and rat cells. The four component ON-TARGETplus Non-targeting siRNAs were designed to leverage seed-region optimization and patented ON-TARGETplus modification patterns to have fewer off-targets than traditionally designed negative control siRNAs, and screened by genomewide microarray GENE EDITING AND GENE MODULATION FOR LIFE SCIENCESCHOSOURCEGENE EDITINGTOOLSSCREENINGBASE EDITINGTRANSFECTION REAGENTS & BUFFERS Horizon Discovery drives the application of gene editing and gene modulation to enable world-leading academic institutes, pharmaceutical and biotechnology companies, as well as clinical diagnostic laboratories, to identify the genetic drivers behind human disease, develop and validate diagnostic workflows, and deliver new therapies for precision medicine.CANCER CELL MODELS
We are confident that HAP1 and Cancer-related Ready-to-go cell lines are the ideal product to further your research. However, if you are not totally satisfied with the performance of any of our HAP1 and Cancer-related Ready-to-go cell lines, for any reason, we will gladlyrefund your
HAP1 PARENTAL CELL LINES HAP1 is a human near-haploid cell line derived from the male chronic myelogenous leukemia (CML) cell line KBM-7. For more details on how the HAP1 cell line was created, please see the references tab. HAP1 cell line properties include: Sustained growth at single celldilutions. Ease of
CUSTOM RNA SYNTHESIS Custom RNA synthesis by Dharmacon. Create and order RNA molecules with a wide variety of chemical modifications or learn about our capabilities for long RNA oligos, dye labeling and custom amidites. These tools are for ordering RNA and RNA-DNA chimeras only. Ordercustom DNA
SIDESIGN CENTER
siDESIGN Center. The siDESIGN Center is an advanced, user-friendly siRNA design tool, which significantly improves the likelihood of identifying functional siRNA. One-of-a-kind options are available to enhance target specificity and adapt siRNA designs for more sophisticated experimental design. View the online User Guide for helpusing
DHARMAFECT 1 TRANSFECTION REAGENT DharmaFECT 1 is our most all-purpose transfection reagent formulation; demonstrating efficient, low-toxicity delivery to over 35 cell types. DharmaFECT 1 achieves effective transfection of siRNA and microRNA reagents at low concentrations and with low cytotoxicity, especially when compared to transfection reagents designed for use with plasmidDNA.
QUANTITATIVE MULTIPLEX REFERENCE STANDARD (FFPE)SEE MORE ON HORIZONDISCOVERY.COM DHARMAFECT TRANSFECTION REAGENTS DharmaFECT Transfection Reagents. Afghanistan Aland Islands Albania Algeria American Samoa Andorra Angola Anguilla Antarctica Antigua And Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia, Plurinational State Of Bonaire, Saint Eustatius AndSaba
STRUCTURAL MULTIPLEX CFDNA REFERENCE STANDARD The Structural Multiplex cfDNA Reference Standard covers a wide range of mutations in a defined genomic context. This standard consists of DNA derived from human cell lines that is fragmented to an average size of 160 bp to closely resemble cfDNA extracted from human plasma. This product is designed to challenge your molecular and bioinformatic BRCA SOMATIC MULTIPLEX I (GDNA) BRCA Somatic Multiplex I (gDNA) Afghanistan Aland Islands Albania Algeria American Samoa Andorra Angola Anguilla Antarctica Antigua And Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia, Plurinational State Of Bonaire, Saint Eustatius AndSaba
GENE EDITING AND GENE MODULATION FOR LIFE SCIENCESCHOSOURCEGENE EDITINGTOOLSSCREENINGBASE EDITINGTRANSFECTION REAGENTS & BUFFERS Horizon Discovery drives the application of gene editing and gene modulation to enable world-leading academic institutes, pharmaceutical and biotechnology companies, as well as clinical diagnostic laboratories, to identify the genetic drivers behind human disease, develop and validate diagnostic workflows, and deliver new therapies for precision medicine.CANCER CELL MODELS
We are confident that HAP1 and Cancer-related Ready-to-go cell lines are the ideal product to further your research. However, if you are not totally satisfied with the performance of any of our HAP1 and Cancer-related Ready-to-go cell lines, for any reason, we will gladlyrefund your
HAP1 PARENTAL CELL LINES HAP1 is a human near-haploid cell line derived from the male chronic myelogenous leukemia (CML) cell line KBM-7. For more details on how the HAP1 cell line was created, please see the references tab. HAP1 cell line properties include: Sustained growth at single celldilutions. Ease of
CUSTOM RNA SYNTHESIS Custom RNA synthesis by Dharmacon. Create and order RNA molecules with a wide variety of chemical modifications or learn about our capabilities for long RNA oligos, dye labeling and custom amidites. These tools are for ordering RNA and RNA-DNA chimeras only. Ordercustom DNA
SIDESIGN CENTER
siDESIGN Center. The siDESIGN Center is an advanced, user-friendly siRNA design tool, which significantly improves the likelihood of identifying functional siRNA. One-of-a-kind options are available to enhance target specificity and adapt siRNA designs for more sophisticated experimental design. View the online User Guide for helpusing
DHARMAFECT 1 TRANSFECTION REAGENT DharmaFECT 1 is our most all-purpose transfection reagent formulation; demonstrating efficient, low-toxicity delivery to over 35 cell types. DharmaFECT 1 achieves effective transfection of siRNA and microRNA reagents at low concentrations and with low cytotoxicity, especially when compared to transfection reagents designed for use with plasmidDNA.
QUANTITATIVE MULTIPLEX REFERENCE STANDARD (FFPE)SEE MORE ON HORIZONDISCOVERY.COM DHARMAFECT TRANSFECTION REAGENTS DharmaFECT Transfection Reagents. Afghanistan Aland Islands Albania Algeria American Samoa Andorra Angola Anguilla Antarctica Antigua And Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia, Plurinational State Of Bonaire, Saint Eustatius AndSaba
STRUCTURAL MULTIPLEX CFDNA REFERENCE STANDARD The Structural Multiplex cfDNA Reference Standard covers a wide range of mutations in a defined genomic context. This standard consists of DNA derived from human cell lines that is fragmented to an average size of 160 bp to closely resemble cfDNA extracted from human plasma. This product is designed to challenge your molecular and bioinformatic BRCA SOMATIC MULTIPLEX I (GDNA) BRCA Somatic Multiplex I (gDNA) Afghanistan Aland Islands Albania Algeria American Samoa Andorra Angola Anguilla Antarctica Antigua And Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia, Plurinational State Of Bonaire, Saint Eustatius AndSaba
CUSTOM RNA SYNTHESIS Custom RNA synthesis by Dharmacon. Create and order RNA molecules with a wide variety of chemical modifications or learn about our capabilities for long RNA oligos, dye labeling and custom amidites. These tools are for ordering RNA and RNA-DNA chimeras only. Ordercustom DNA
SIDESIGN CENTER
siDESIGN Center. The siDESIGN Center is an advanced, user-friendly siRNA design tool, which significantly improves the likelihood of identifying functional siRNA. One-of-a-kind options are available to enhance target specificity and adapt siRNA designs for more sophisticated experimental design. View the online User Guide for helpusing
STRUCTURAL MULTIPLEX REFERENCE STANDARD (GDNA) The Structural Multiplex Reference Standard covers a wide range of mutations in defined genomic context. This standard is designed to challenge your molecular and bioinformatic work flow by providing validated copy number variants/amplifications, translocations, and large insertions/deletions. Additionally, you may examine the genomiccontext
ON TARGETPLUS SIRNA
ON-TARGETplus Control siRNAs and pools are produced with the patented ON-TARGETplus modification pattern for optimal specificity. They are recommended as controls for any siRNA experiment due to their minimized off-target effects. Select a species-specific positive control to silence an expressed housekeeping gene in your experimentalcell type.
MULTIPLEX I CFDNA REFERENCE STANDARD SET The Multiplex I cfDNA Reference Standards are highly-characterized, biologically-relevant reference materials used to assess the performance of cfDNA assays that detect somatic mutations, including quantitative PCR, next-generation sequencing, and other novel assays GIPZ LENTIVIRAL SHRNA GIPZ Lentiviral shRNA. microRNA-adapted shRNA based on miR-30 for specific gene silencing with minimal cytotoxicity. Perform specific and efficient, transient or long-term RNAi with GIPZ Lentiviral shRNA. GIPZ Lentiviral shRNA targets human and mouse genes using multiple shRNA constructs that have been cloned into the pGIPZ lentiviralvector.
PRECISION LENTIORF COLLECTION Precision LentiORF collection. Precision LentiORFs are human cDNA open reading frames (ORFs) cloned into a lentiviral expression vector, used for overexpressing human genes and proteins in mammalian cells. Ideal for use in primary or difficult to transfect cells, Precision LentiORFs can be used to create stably expressing cell linesSYNTHETIC LETHALITY
Synthetic lethality. Redundancy is an inherent property of biological networks, and enables living systems to survive in response to genetic and environmental perturbations. Synthetic lethality occurs when the simultaneous disruption of two non-essential genes prohibits growth or results in death; this occurs even though the loss of either gene DHARMACON EDIT-R CRISPR-CAS9 GENE ENGINEERING SYSTEM The Edit-R CRISPR-Cas9 system includes the three critical components required for gene editing in mammalian cells, based on the natural S. pyogenes system: a plasmid expressing a mammalian codon-optimized gene sequence encoding Cas9 nuclease. a 74-nucleotide tracrRNA. a custom crRNA designed to the target site of interest. ON-TARGETPLUS NON-TARGETING CONTROL POOL ON-TARGETplus Non-targeting Control Pool is the ideal negative control for RNAi experiments in human, mouse, and rat cells. The four component ON-TARGETplus Non-targeting siRNAs were designed to leverage seed-region optimization and patented ON-TARGETplus modification patterns to have fewer off-targets than traditionally designed negative control siRNAs, and screened by genomewide microarray GENE EDITING AND GENE MODULATION FOR LIFE SCIENCESCHOSOURCEGENE EDITINGTOOLSSCREENINGBASE EDITINGTRANSFECTION REAGENTS & BUFFERS Horizon Discovery drives the application of gene editing and gene modulation to enable world-leading academic institutes, pharmaceutical and biotechnology companies, as well as clinical diagnostic laboratories, to identify the genetic drivers behind human disease, develop and validate diagnostic workflows, and deliver new therapies for precision medicine.CANCER CELL MODELS
We are confident that HAP1 and Cancer-related Ready-to-go cell lines are the ideal product to further your research. However, if you are not totally satisfied with the performance of any of our HAP1 and Cancer-related Ready-to-go cell lines, for any reason, we will gladlyrefund your
HAP1 PARENTAL CELL LINES HAP1 is a human near-haploid cell line derived from the male chronic myelogenous leukemia (CML) cell line KBM-7. For more details on how the HAP1 cell line was created, please see the references tab. HAP1 cell line properties include: Sustained growth at single celldilutions. Ease of
QUANTITATIVE MULTIPLEX REFERENCE STANDARD (GDNA) The Quantitative Multiplex DNA Reference Standard is a highly-characterized, biologically-relevant quality control material used to assess the performance of NGS assays that detect somaticmutations.
SIDESIGN CENTER
siDESIGN Center. The siDESIGN Center is an advanced, user-friendly siRNA design tool, which significantly improves the likelihood of identifying functional siRNA. One-of-a-kind options are available to enhance target specificity and adapt siRNA designs for more sophisticated experimental design. View the online User Guide for helpusing
SIRNA SOLUTIONS BY DHARMACON™ siRNA solutions by Dharmacon™. Reliably silence gene function in any cell type. RNA interference via synthetic small interfering RNA (siRNA) is the preferred choice for fast but reliable loss-of-function studies. Broadly useful across many applications and in any cell line, siRNA offers a straightforward and widely cited technique for STRUCTURAL MULTIPLEX CFDNA REFERENCE STANDARD The Structural Multiplex cfDNA Reference Standard covers a wide range of mutations in a defined genomic context. This standard consists of DNA derived from human cell lines that is fragmented to an average size of 160 bp to closely resemble cfDNA extracted from human plasma. This product is designed to challenge your molecular and bioinformatic BRCA SOMATIC MULTIPLEX I (GDNA) BRCA Somatic Multiplex I (gDNA) Afghanistan Aland Islands Albania Algeria American Samoa Andorra Angola Anguilla Antarctica Antigua And Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia, Plurinational State Of Bonaire, Saint Eustatius AndSaba
DHARMAFECT TRANSFECTION REAGENTS DharmaFECT Transfection Reagents. Afghanistan Aland Islands Albania Algeria American Samoa Andorra Angola Anguilla Antarctica Antigua And Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia, Plurinational State Of Bonaire, Saint Eustatius AndSaba
DHARMAFECT 1 TRANSFECTION REAGENT DharmaFECT 1 is our most all-purpose transfection reagent formulation; demonstrating efficient, low-toxicity delivery to over 35 cell types. DharmaFECT 1 achieves effective transfection of siRNA and microRNA reagents at low concentrations and with low cytotoxicity, especially when compared to transfection reagents designed for use with plasmidDNA.
GENE EDITING AND GENE MODULATION FOR LIFE SCIENCESCHOSOURCEGENE EDITINGTOOLSSCREENINGBASE EDITINGTRANSFECTION REAGENTS & BUFFERS Horizon Discovery drives the application of gene editing and gene modulation to enable world-leading academic institutes, pharmaceutical and biotechnology companies, as well as clinical diagnostic laboratories, to identify the genetic drivers behind human disease, develop and validate diagnostic workflows, and deliver new therapies for precision medicine.CANCER CELL MODELS
We are confident that HAP1 and Cancer-related Ready-to-go cell lines are the ideal product to further your research. However, if you are not totally satisfied with the performance of any of our HAP1 and Cancer-related Ready-to-go cell lines, for any reason, we will gladlyrefund your
HAP1 PARENTAL CELL LINES HAP1 is a human near-haploid cell line derived from the male chronic myelogenous leukemia (CML) cell line KBM-7. For more details on how the HAP1 cell line was created, please see the references tab. HAP1 cell line properties include: Sustained growth at single celldilutions. Ease of
QUANTITATIVE MULTIPLEX REFERENCE STANDARD (GDNA) The Quantitative Multiplex DNA Reference Standard is a highly-characterized, biologically-relevant quality control material used to assess the performance of NGS assays that detect somaticmutations.
SIDESIGN CENTER
siDESIGN Center. The siDESIGN Center is an advanced, user-friendly siRNA design tool, which significantly improves the likelihood of identifying functional siRNA. One-of-a-kind options are available to enhance target specificity and adapt siRNA designs for more sophisticated experimental design. View the online User Guide for helpusing
SIRNA SOLUTIONS BY DHARMACON™ siRNA solutions by Dharmacon™. Reliably silence gene function in any cell type. RNA interference via synthetic small interfering RNA (siRNA) is the preferred choice for fast but reliable loss-of-function studies. Broadly useful across many applications and in any cell line, siRNA offers a straightforward and widely cited technique for STRUCTURAL MULTIPLEX CFDNA REFERENCE STANDARD The Structural Multiplex cfDNA Reference Standard covers a wide range of mutations in a defined genomic context. This standard consists of DNA derived from human cell lines that is fragmented to an average size of 160 bp to closely resemble cfDNA extracted from human plasma. This product is designed to challenge your molecular and bioinformatic BRCA SOMATIC MULTIPLEX I (GDNA) BRCA Somatic Multiplex I (gDNA) Afghanistan Aland Islands Albania Algeria American Samoa Andorra Angola Anguilla Antarctica Antigua And Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia, Plurinational State Of Bonaire, Saint Eustatius AndSaba
DHARMAFECT TRANSFECTION REAGENTS DharmaFECT Transfection Reagents. Afghanistan Aland Islands Albania Algeria American Samoa Andorra Angola Anguilla Antarctica Antigua And Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia, Plurinational State Of Bonaire, Saint Eustatius AndSaba
DHARMAFECT 1 TRANSFECTION REAGENT DharmaFECT 1 is our most all-purpose transfection reagent formulation; demonstrating efficient, low-toxicity delivery to over 35 cell types. DharmaFECT 1 achieves effective transfection of siRNA and microRNA reagents at low concentrations and with low cytotoxicity, especially when compared to transfection reagents designed for use with plasmidDNA.
SIDESIGN CENTER
siDESIGN Center. The siDESIGN Center is an advanced, user-friendly siRNA design tool, which significantly improves the likelihood of identifying functional siRNA. One-of-a-kind options are available to enhance target specificity and adapt siRNA designs for more sophisticated experimental design. View the online User Guide for helpusing
CUSTOM RNA SYNTHESIS Custom RNA synthesis by Dharmacon. Create and order RNA molecules with a wide variety of chemical modifications or learn about our capabilities for long RNA oligos, dye labeling and custom amidites. These tools are for ordering RNA and RNA-DNA chimeras only. Ordercustom DNA
STRUCTURAL MULTIPLEX REFERENCE STANDARD (GDNA) The Structural Multiplex Reference Standard covers a wide range of mutations in defined genomic context. This standard is designed to challenge your molecular and bioinformatic work flow by providing validated copy number variants/amplifications, translocations, and large insertions/deletions. Additionally, you may examine the genomiccontext
ON TARGETPLUS SIRNA
ON-TARGETplus Control siRNAs and pools are produced with the patented ON-TARGETplus modification pattern for optimal specificity. They are recommended as controls for any siRNA experiment due to their minimized off-target effects. Select a species-specific positive control to silence an expressed housekeeping gene in your experimentalcell type.
GIPZ LENTIVIRAL SHRNA GIPZ Lentiviral shRNA. microRNA-adapted shRNA based on miR-30 for specific gene silencing with minimal cytotoxicity. Perform specific and efficient, transient or long-term RNAi with GIPZ Lentiviral shRNA. GIPZ Lentiviral shRNA targets human and mouse genes using multiple shRNA constructs that have been cloned into the pGIPZ lentiviralvector.
STRUCTURAL MULTIPLEX REFERENCE STANDARD (FFPE) The Structural Multiplex Reference Standard covers a wide range of mutations in defined genomic context. This standard is designed to challenge your molecular and bioinformatics workflow by providing validated copy number variants/ amplifications, translocations and large insertions/deletions.SYNTHETIC LETHALITY
Synthetic lethality. Redundancy is an inherent property of biological networks, and enables living systems to survive in response to genetic and environmental perturbations. Synthetic lethality occurs when the simultaneous disruption of two non-essential genes prohibits growth or results in death; this occurs even though the loss of either geneYEAST KNOCKOUT
A wealth of information - including genetic and physical maps along with DNA sequence information - is available from the Saccharomyces Genome Database (SGD) at Stanford University.. Note. We provide certain clone resources developed by leading academic laboratories. DHARMACON EDIT-R CRISPR-CAS9 GENE ENGINEERING SYSTEM The Edit-R CRISPR-Cas9 system includes the three critical components required for gene editing in mammalian cells, based on the natural S. pyogenes system: a plasmid expressing a mammalian codon-optimized gene sequence encoding Cas9 nuclease. a 74-nucleotide tracrRNA. a custom crRNA designed to the target site of interest. ON-TARGETPLUS NON-TARGETING CONTROL POOL ON-TARGETplus Non-targeting Control Pool is the ideal negative control for RNAi experiments in human, mouse, and rat cells. The four component ON-TARGETplus Non-targeting siRNAs were designed to leverage seed-region optimization and patented ON-TARGETplus modification patterns to have fewer off-targets than traditionally designed negative control siRNAs, and screened by genomewide microarray GENE EDITING AND GENE MODULATION FOR LIFE SCIENCESCHOSOURCEGENE EDITINGTOOLSSCREENINGBASE EDITINGTRANSFECTION REAGENTS & BUFFERS Horizon Discovery drives the application of gene editing and gene modulation to enable world-leading academic institutes, pharmaceutical and biotechnology companies, as well as clinical diagnostic laboratories, to identify the genetic drivers behind human disease, develop and validate diagnostic workflows, and deliver new therapies for precision medicine.SIDESIGN CENTER
The siDESIGN Center is an advanced, user-friendly siRNA design tool, which significantly improves the likelihood of identifying functional siRNA. One-of-a-kind options are available to enhance target specificity and adapt siRNA designs for more sophisticated experimental design.CANCER CELL MODELS
We are confident that HAP1 and Cancer-related Ready-to-go cell lines are the ideal product to further your research. However, if you are not totally satisfied with the performance of any of our HAP1 and Cancer-related Ready-to-go cell lines, for any reason, we will gladlyrefund your
EDIT-R CRISPR-CAS9 GENE KNOCKOUT CRISPRA AND HDR PRODUCTSDHARMACON EDIT RR CODE EDITORR ONLINE EDITOR Optimized tools for high-confidence genome engineering. The Dharmacon Edit-R CRISPR-Cas9 platform provides guaranteed, predesigned, ready-to-use guide RNAs to enable rapid and highly functional gene editing experiments.. Higher assurance of functional knockout or transcriptional activation from predesigned genomewide guide RNAs HAP1 KNOCKOUT CELL LINES CHALICE BIOINFORMATICS SOFTWARE Chalice Bioinformatics Software. Developed to provide collaborators the same proven analysis tools employed by Horizon’s combination screening scientists, The Chalice software is a proprietary data analysis platform for characterizing single agent and multi-target screening results. The tool allows researchers to quantitativelyassess the
ON TARGETPLUS SIRNA
ON TARGETplus siRNA. Guaranteed gene knockdown with up to 90% fewer off-target effects. Start your gene search. siRNA designed and modified for greater specificity. ON-TARGET plus siRNA reagents reduce off-targets utilizing a patented dual-strand modification, while still providing guaranteed gene silencing of human, mouse and rat genetargets.
SIGLO CONTROLS
Fluorescent controls are useful for visual indication of delivery, and when combined with functional knockdown assessment, provide a useful tool for optimization. siGLO Positive controls will effectively silence the indicated gene, and result in punctate cytoplasmicfluorescence.
MULTIPLEX GDNA REFERENCE STANDARD Certificate of Analysis Horizon Discovery 8100 CambridgeResearch Park, Waterbeach, Cambridge, CB25 9TL, United Kingdom www.horizondiscovery.com/ DHARMAFECT™ TRANSFECTION REAGENTS—SIRNA TRANSFECTION PROTOCOLDHARMACON SIRNA TRANSFECTION PROTOCOLAAV SIRNA KNOCKDOWN PROTOCOLDHARMACON SIRNA PROTOCOLDHARMACON SIRNA PROTOCOLSIRNA PROTOCOL INVITROGENSIRNA SYNTHESIS PROTOCOL PROTOCOL The following is a general protocol for use of DharmaFECT™ transfection reagents to deliver siRNA into cultured mammalian cells.The examples
GENE EDITING AND GENE MODULATION FOR LIFE SCIENCESCHOSOURCEGENE EDITINGTOOLSSCREENINGBASE EDITINGTRANSFECTION REAGENTS & BUFFERS Horizon Discovery drives the application of gene editing and gene modulation to enable world-leading academic institutes, pharmaceutical and biotechnology companies, as well as clinical diagnostic laboratories, to identify the genetic drivers behind human disease, develop and validate diagnostic workflows, and deliver new therapies for precision medicine.SIDESIGN CENTER
The siDESIGN Center is an advanced, user-friendly siRNA design tool, which significantly improves the likelihood of identifying functional siRNA. One-of-a-kind options are available to enhance target specificity and adapt siRNA designs for more sophisticated experimental design.CANCER CELL MODELS
We are confident that HAP1 and Cancer-related Ready-to-go cell lines are the ideal product to further your research. However, if you are not totally satisfied with the performance of any of our HAP1 and Cancer-related Ready-to-go cell lines, for any reason, we will gladlyrefund your
EDIT-R CRISPR-CAS9 GENE KNOCKOUT CRISPRA AND HDR PRODUCTSDHARMACON EDIT RR CODE EDITORR ONLINE EDITOR Optimized tools for high-confidence genome engineering. The Dharmacon Edit-R CRISPR-Cas9 platform provides guaranteed, predesigned, ready-to-use guide RNAs to enable rapid and highly functional gene editing experiments.. Higher assurance of functional knockout or transcriptional activation from predesigned genomewide guide RNAs HAP1 KNOCKOUT CELL LINES CHALICE BIOINFORMATICS SOFTWARE Chalice Bioinformatics Software. Developed to provide collaborators the same proven analysis tools employed by Horizon’s combination screening scientists, The Chalice software is a proprietary data analysis platform for characterizing single agent and multi-target screening results. The tool allows researchers to quantitativelyassess the
ON TARGETPLUS SIRNA
ON TARGETplus siRNA. Guaranteed gene knockdown with up to 90% fewer off-target effects. Start your gene search. siRNA designed and modified for greater specificity. ON-TARGET plus siRNA reagents reduce off-targets utilizing a patented dual-strand modification, while still providing guaranteed gene silencing of human, mouse and rat genetargets.
SIGLO CONTROLS
Fluorescent controls are useful for visual indication of delivery, and when combined with functional knockdown assessment, provide a useful tool for optimization. siGLO Positive controls will effectively silence the indicated gene, and result in punctate cytoplasmicfluorescence.
MULTIPLEX GDNA REFERENCE STANDARD Certificate of Analysis Horizon Discovery 8100 CambridgeResearch Park, Waterbeach, Cambridge, CB25 9TL, United Kingdom www.horizondiscovery.com/ DHARMAFECT™ TRANSFECTION REAGENTS—SIRNA TRANSFECTION PROTOCOLDHARMACON SIRNA TRANSFECTION PROTOCOLAAV SIRNA KNOCKDOWN PROTOCOLDHARMACON SIRNA PROTOCOLDHARMACON SIRNA PROTOCOLSIRNA PROTOCOL INVITROGENSIRNA SYNTHESIS PROTOCOL PROTOCOL The following is a general protocol for use of DharmaFECT™ transfection reagents to deliver siRNA into cultured mammalian cells.The examples
HAP1 KNOCKOUT CELL LINES HAP1 knockout cell lines. The single largest bank of isogenic cell lines with over 7,500 cell lines to choose from and trusted by academia, biotech, and pharma research labs. Cell models to suit any application, from TIDVAL to antibody validation, delivered in CUSTOM RNA SYNTHESIS Incorporating molecular probes at any RNA site. Incorporation of molecular probes at defined sites within synthetic RNA was accomplished using the 2’-ACE®-5’-Silyl RNA synthesis platform in combination with the Levulinyl protecting group. This process results in excellent yields of modified full length RNA and superiorqualities.
HAP1 PARENTAL CELL LINES HAP1 is a human near-haploid cell line derived from the male chronic myelogenous leukemia (CML) cell line KBM-7. For more details on how the HAP1 cell line was created, please see the references tab. HAP1 cell line properties include: Sustained growth at single celldilutions. Ease of
ON-TARGETPLUS SIRNA REAGENTS Human, mouse, rat. D-001810-10. Order quantity guidelines. ON-TARGETplus reagents are routinely used at 5 to 25 nM concentration. The calculations below, based on 25 nM, are for estimation purposes only and assume no loss from pipetting. Approximate # reactions (wells) at 25nM siRNA concentration. nmol. ONCOSIGNATURE™ CELL PANEL SCREENING SERVICE 3:36. Our 2D OncoSignature ™ Service includes: Screen across a diverse, clinically relevant 300 cell line panel or a more focused, tissue-specific panel such as lung, lymphoma, head & neck, or breast. Access to a library of over 350 standard of care compounds. Cell lines grown in vendor-recommended media. 10 point, 3-fold dilution forsingle
QUANTITATIVE MULTIPLEX REFERENCE STANDARD (FFPE) The Quantitative Multiplex FFPE Reference Standard is a highly-characterized, biologically-relevant quality control material used to assess the performance of NGS assays that detect somaticmutations.
TRU-Q 7 (1.3% TIER) REFERENCE STANDARD Tru-Q 7 (1.3% Tier) Reference Standard. The Tru-Q DNA Reference Standards are a highly-characterized, biologically-relevant quality control material used to assess the performance of NGS assays that detect somatic mutations. The specifications of some variants within the Tru-Q product line have been changed for batches manufacturedafter the
QUANTITATIVE MULTIPLEX REFERENCE STANDARD FCDNA (SEVERE) The Quantitative Multiplex Formalin Compromised DNA Reference Standards (Mild, Moderate and Severe) provide biologically-relevant quality control material which can be used to assess the performanceof NGS assays.
STRUCTURAL MULTIPLEX CFDNA REFERENCE STANDARD The Structural Multiplex cfDNA Reference Standard covers a wide range of mutations in a defined genomic context. This standard consists of DNA derived from human cell lines that is fragmented to an average size of 160 bp to closely resemble cfDNA extracted from human plasma. This product is designed to challenge your molecular and bioinformatic ON-TARGETPLUS NON-TARGETING CONTROL POOL ON-TARGETplus Non-targeting Control Pool is the ideal negative control for RNAi experiments in human, mouse, and rat cells. The four component ON-TARGETplus Non-targeting siRNAs were designed to leverage seed-region optimization and patented ON-TARGETplus modification patterns to have fewer off-targets than traditionally designed negative control siRNAs, and screened by genomewide microarray GENE EDITING AND GENE MODULATION FOR LIFE SCIENCESCHOSOURCEGENE EDITINGTOOLSSCREENINGBASE EDITINGTRANSFECTION REAGENTS & BUFFERS Horizon Discovery drives the application of gene editing and gene modulation to enable world-leading academic institutes, pharmaceutical and biotechnology companies, as well as clinical diagnostic laboratories, to identify the genetic drivers behind human disease, develop and validate diagnostic workflows, and deliver new therapies for precision medicine.SIDESIGN CENTER
The siDESIGN Center is an advanced, user-friendly siRNA design tool, which significantly improves the likelihood of identifying functional siRNA. One-of-a-kind options are available to enhance target specificity and adapt siRNA designs for more sophisticated experimental design.CANCER CELL MODELS
We are confident that HAP1 and Cancer-related Ready-to-go cell lines are the ideal product to further your research. However, if you are not totally satisfied with the performance of any of our HAP1 and Cancer-related Ready-to-go cell lines, for any reason, we will gladlyrefund your
EDIT-R CRISPR-CAS9 GENE KNOCKOUT CRISPRA AND HDR PRODUCTSDHARMACON EDIT RR CODE EDITORR ONLINE EDITOR Optimized tools for high-confidence genome engineering. The Dharmacon Edit-R CRISPR-Cas9 platform provides guaranteed, predesigned, ready-to-use guide RNAs to enable rapid and highly functional gene editing experiments.. Higher assurance of functional knockout or transcriptional activation from predesigned genomewide guide RNAs HAP1 KNOCKOUT CELL LINES CHALICE BIOINFORMATICS SOFTWARE Chalice Bioinformatics Software. Developed to provide collaborators the same proven analysis tools employed by Horizon’s combination screening scientists, The Chalice software is a proprietary data analysis platform for characterizing single agent and multi-target screening results. The tool allows researchers to quantitativelyassess the
ON TARGETPLUS SIRNA
ON TARGETplus siRNA. Guaranteed gene knockdown with up to 90% fewer off-target effects. Start your gene search. siRNA designed and modified for greater specificity. ON-TARGET plus siRNA reagents reduce off-targets utilizing a patented dual-strand modification, while still providing guaranteed gene silencing of human, mouse and rat genetargets.
SIGLO CONTROLS
Fluorescent controls are useful for visual indication of delivery, and when combined with functional knockdown assessment, provide a useful tool for optimization. siGLO Positive controls will effectively silence the indicated gene, and result in punctate cytoplasmicfluorescence.
MULTIPLEX GDNA REFERENCE STANDARD Certificate of Analysis Horizon Discovery 8100 CambridgeResearch Park, Waterbeach, Cambridge, CB25 9TL, United Kingdom www.horizondiscovery.com/ DHARMAFECT™ TRANSFECTION REAGENTS—SIRNA TRANSFECTION PROTOCOLDHARMACON SIRNA TRANSFECTION PROTOCOLAAV SIRNA KNOCKDOWN PROTOCOLDHARMACON SIRNA PROTOCOLDHARMACON SIRNA PROTOCOLSIRNA PROTOCOL INVITROGENSIRNA SYNTHESIS PROTOCOL PROTOCOL The following is a general protocol for use of DharmaFECT™ transfection reagents to deliver siRNA into cultured mammalian cells.The examples
GENE EDITING AND GENE MODULATION FOR LIFE SCIENCESCHOSOURCEGENE EDITINGTOOLSSCREENINGBASE EDITINGTRANSFECTION REAGENTS & BUFFERS Horizon Discovery drives the application of gene editing and gene modulation to enable world-leading academic institutes, pharmaceutical and biotechnology companies, as well as clinical diagnostic laboratories, to identify the genetic drivers behind human disease, develop and validate diagnostic workflows, and deliver new therapies for precision medicine.SIDESIGN CENTER
The siDESIGN Center is an advanced, user-friendly siRNA design tool, which significantly improves the likelihood of identifying functional siRNA. One-of-a-kind options are available to enhance target specificity and adapt siRNA designs for more sophisticated experimental design.CANCER CELL MODELS
We are confident that HAP1 and Cancer-related Ready-to-go cell lines are the ideal product to further your research. However, if you are not totally satisfied with the performance of any of our HAP1 and Cancer-related Ready-to-go cell lines, for any reason, we will gladlyrefund your
EDIT-R CRISPR-CAS9 GENE KNOCKOUT CRISPRA AND HDR PRODUCTSDHARMACON EDIT RR CODE EDITORR ONLINE EDITOR Optimized tools for high-confidence genome engineering. The Dharmacon Edit-R CRISPR-Cas9 platform provides guaranteed, predesigned, ready-to-use guide RNAs to enable rapid and highly functional gene editing experiments.. Higher assurance of functional knockout or transcriptional activation from predesigned genomewide guide RNAs HAP1 KNOCKOUT CELL LINES CHALICE BIOINFORMATICS SOFTWARE Chalice Bioinformatics Software. Developed to provide collaborators the same proven analysis tools employed by Horizon’s combination screening scientists, The Chalice software is a proprietary data analysis platform for characterizing single agent and multi-target screening results. The tool allows researchers to quantitativelyassess the
ON TARGETPLUS SIRNA
ON TARGETplus siRNA. Guaranteed gene knockdown with up to 90% fewer off-target effects. Start your gene search. siRNA designed and modified for greater specificity. ON-TARGET plus siRNA reagents reduce off-targets utilizing a patented dual-strand modification, while still providing guaranteed gene silencing of human, mouse and rat genetargets.
SIGLO CONTROLS
Fluorescent controls are useful for visual indication of delivery, and when combined with functional knockdown assessment, provide a useful tool for optimization. siGLO Positive controls will effectively silence the indicated gene, and result in punctate cytoplasmicfluorescence.
MULTIPLEX GDNA REFERENCE STANDARD Certificate of Analysis Horizon Discovery 8100 CambridgeResearch Park, Waterbeach, Cambridge, CB25 9TL, United Kingdom www.horizondiscovery.com/ DHARMAFECT™ TRANSFECTION REAGENTS—SIRNA TRANSFECTION PROTOCOLDHARMACON SIRNA TRANSFECTION PROTOCOLAAV SIRNA KNOCKDOWN PROTOCOLDHARMACON SIRNA PROTOCOLDHARMACON SIRNA PROTOCOLSIRNA PROTOCOL INVITROGENSIRNA SYNTHESIS PROTOCOL PROTOCOL The following is a general protocol for use of DharmaFECT™ transfection reagents to deliver siRNA into cultured mammalian cells.The examples
HAP1 KNOCKOUT CELL LINES HAP1 knockout cell lines. The single largest bank of isogenic cell lines with over 7,500 cell lines to choose from and trusted by academia, biotech, and pharma research labs. Cell models to suit any application, from TIDVAL to antibody validation, delivered in CUSTOM RNA SYNTHESIS Incorporating molecular probes at any RNA site. Incorporation of molecular probes at defined sites within synthetic RNA was accomplished using the 2’-ACE®-5’-Silyl RNA synthesis platform in combination with the Levulinyl protecting group. This process results in excellent yields of modified full length RNA and superiorqualities.
HAP1 PARENTAL CELL LINES HAP1 is a human near-haploid cell line derived from the male chronic myelogenous leukemia (CML) cell line KBM-7. For more details on how the HAP1 cell line was created, please see the references tab. HAP1 cell line properties include: Sustained growth at single celldilutions. Ease of
ON-TARGETPLUS SIRNA REAGENTS Human, mouse, rat. D-001810-10. Order quantity guidelines. ON-TARGETplus reagents are routinely used at 5 to 25 nM concentration. The calculations below, based on 25 nM, are for estimation purposes only and assume no loss from pipetting. Approximate # reactions (wells) at 25nM siRNA concentration. nmol. ONCOSIGNATURE™ CELL PANEL SCREENING SERVICE 3:36. Our 2D OncoSignature ™ Service includes: Screen across a diverse, clinically relevant 300 cell line panel or a more focused, tissue-specific panel such as lung, lymphoma, head & neck, or breast. Access to a library of over 350 standard of care compounds. Cell lines grown in vendor-recommended media. 10 point, 3-fold dilution forsingle
QUANTITATIVE MULTIPLEX REFERENCE STANDARD (FFPE) The Quantitative Multiplex FFPE Reference Standard is a highly-characterized, biologically-relevant quality control material used to assess the performance of NGS assays that detect somaticmutations.
TRU-Q 7 (1.3% TIER) REFERENCE STANDARD Tru-Q 7 (1.3% Tier) Reference Standard. The Tru-Q DNA Reference Standards are a highly-characterized, biologically-relevant quality control material used to assess the performance of NGS assays that detect somatic mutations. The specifications of some variants within the Tru-Q product line have been changed for batches manufacturedafter the
QUANTITATIVE MULTIPLEX REFERENCE STANDARD FCDNA (SEVERE) The Quantitative Multiplex Formalin Compromised DNA Reference Standards (Mild, Moderate and Severe) provide biologically-relevant quality control material which can be used to assess the performanceof NGS assays.
STRUCTURAL MULTIPLEX CFDNA REFERENCE STANDARD The Structural Multiplex cfDNA Reference Standard covers a wide range of mutations in a defined genomic context. This standard consists of DNA derived from human cell lines that is fragmented to an average size of 160 bp to closely resemble cfDNA extracted from human plasma. This product is designed to challenge your molecular and bioinformatic ON-TARGETPLUS NON-TARGETING CONTROL POOL ON-TARGETplus Non-targeting Control Pool is the ideal negative control for RNAi experiments in human, mouse, and rat cells. The four component ON-TARGETplus Non-targeting siRNAs were designed to leverage seed-region optimization and patented ON-TARGETplus modification patterns to have fewer off-targets than traditionally designed negative control siRNAs, and screened by genomewide microarray GENE EDITING AND GENE MODULATION FOR LIFE SCIENCESCHOSOURCEGENE EDITINGTOOLSSCREENINGBASE EDITINGTRANSFECTION REAGENTS & BUFFERS Horizon Discovery drives the application of gene editing and gene modulation to enable world-leading academic institutes, pharmaceutical and biotechnology companies, as well as clinical diagnostic laboratories, to identify the genetic drivers behind human disease, develop and validate diagnostic workflows, and deliver new therapies for precision medicine.SIDESIGN CENTER
The siDESIGN Center is an advanced, user-friendly siRNA design tool, which significantly improves the likelihood of identifying functional siRNA. One-of-a-kind options are available to enhance target specificity and adapt siRNA designs for more sophisticated experimental design.CANCER CELL MODELS
We are confident that HAP1 and Cancer-related Ready-to-go cell lines are the ideal product to further your research. However, if you are not totally satisfied with the performance of any of our HAP1 and Cancer-related Ready-to-go cell lines, for any reason, we will gladlyrefund your
EDIT-R CRISPR-CAS9 GENE KNOCKOUT CRISPRA AND HDR PRODUCTSDHARMACON EDIT RR CODE EDITORR ONLINE EDITOR Optimized tools for high-confidence genome engineering. The Dharmacon Edit-R CRISPR-Cas9 platform provides guaranteed, predesigned, ready-to-use guide RNAs to enable rapid and highly functional gene editing experiments.. Higher assurance of functional knockout or transcriptional activation from predesigned genomewide guide RNAs HAP1 KNOCKOUT CELL LINES CHALICE BIOINFORMATICS SOFTWARE Chalice Bioinformatics Software. Developed to provide collaborators the same proven analysis tools employed by Horizon’s combination screening scientists, The Chalice software is a proprietary data analysis platform for characterizing single agent and multi-target screening results. The tool allows researchers to quantitativelyassess the
ON TARGETPLUS SIRNA
ON TARGETplus siRNA. Guaranteed gene knockdown with up to 90% fewer off-target effects. Start your gene search. siRNA designed and modified for greater specificity. ON-TARGET plus siRNA reagents reduce off-targets utilizing a patented dual-strand modification, while still providing guaranteed gene silencing of human, mouse and rat genetargets.
SIGLO CONTROLS
Fluorescent controls are useful for visual indication of delivery, and when combined with functional knockdown assessment, provide a useful tool for optimization. siGLO Positive controls will effectively silence the indicated gene, and result in punctate cytoplasmicfluorescence.
MULTIPLEX GDNA REFERENCE STANDARD Certificate of Analysis Horizon Discovery 8100 CambridgeResearch Park, Waterbeach, Cambridge, CB25 9TL, United Kingdom www.horizondiscovery.com/ DHARMAFECT™ TRANSFECTION REAGENTS—SIRNA TRANSFECTION PROTOCOLDHARMACON SIRNA TRANSFECTION PROTOCOLAAV SIRNA KNOCKDOWN PROTOCOLDHARMACON SIRNA PROTOCOLDHARMACON SIRNA PROTOCOLSIRNA PROTOCOL INVITROGENSIRNA SYNTHESIS PROTOCOL PROTOCOL The following is a general protocol for use of DharmaFECT™ transfection reagents to deliver siRNA into cultured mammalian cells.The examples
GENE EDITING AND GENE MODULATION FOR LIFE SCIENCESCHOSOURCEGENE EDITINGTOOLSSCREENINGBASE EDITINGTRANSFECTION REAGENTS & BUFFERS Horizon Discovery drives the application of gene editing and gene modulation to enable world-leading academic institutes, pharmaceutical and biotechnology companies, as well as clinical diagnostic laboratories, to identify the genetic drivers behind human disease, develop and validate diagnostic workflows, and deliver new therapies for precision medicine.SIDESIGN CENTER
The siDESIGN Center is an advanced, user-friendly siRNA design tool, which significantly improves the likelihood of identifying functional siRNA. One-of-a-kind options are available to enhance target specificity and adapt siRNA designs for more sophisticated experimental design.CANCER CELL MODELS
We are confident that HAP1 and Cancer-related Ready-to-go cell lines are the ideal product to further your research. However, if you are not totally satisfied with the performance of any of our HAP1 and Cancer-related Ready-to-go cell lines, for any reason, we will gladlyrefund your
EDIT-R CRISPR-CAS9 GENE KNOCKOUT CRISPRA AND HDR PRODUCTSDHARMACON EDIT RR CODE EDITORR ONLINE EDITOR Optimized tools for high-confidence genome engineering. The Dharmacon Edit-R CRISPR-Cas9 platform provides guaranteed, predesigned, ready-to-use guide RNAs to enable rapid and highly functional gene editing experiments.. Higher assurance of functional knockout or transcriptional activation from predesigned genomewide guide RNAs HAP1 KNOCKOUT CELL LINES CHALICE BIOINFORMATICS SOFTWARE Chalice Bioinformatics Software. Developed to provide collaborators the same proven analysis tools employed by Horizon’s combination screening scientists, The Chalice software is a proprietary data analysis platform for characterizing single agent and multi-target screening results. The tool allows researchers to quantitativelyassess the
ON TARGETPLUS SIRNA
ON TARGETplus siRNA. Guaranteed gene knockdown with up to 90% fewer off-target effects. Start your gene search. siRNA designed and modified for greater specificity. ON-TARGET plus siRNA reagents reduce off-targets utilizing a patented dual-strand modification, while still providing guaranteed gene silencing of human, mouse and rat genetargets.
SIGLO CONTROLS
Fluorescent controls are useful for visual indication of delivery, and when combined with functional knockdown assessment, provide a useful tool for optimization. siGLO Positive controls will effectively silence the indicated gene, and result in punctate cytoplasmicfluorescence.
MULTIPLEX GDNA REFERENCE STANDARD Certificate of Analysis Horizon Discovery 8100 CambridgeResearch Park, Waterbeach, Cambridge, CB25 9TL, United Kingdom www.horizondiscovery.com/ DHARMAFECT™ TRANSFECTION REAGENTS—SIRNA TRANSFECTION PROTOCOLDHARMACON SIRNA TRANSFECTION PROTOCOLAAV SIRNA KNOCKDOWN PROTOCOLDHARMACON SIRNA PROTOCOLDHARMACON SIRNA PROTOCOLSIRNA PROTOCOL INVITROGENSIRNA SYNTHESIS PROTOCOL PROTOCOL The following is a general protocol for use of DharmaFECT™ transfection reagents to deliver siRNA into cultured mammalian cells.The examples
HAP1 KNOCKOUT CELL LINES HAP1 knockout cell lines. The single largest bank of isogenic cell lines with over 7,500 cell lines to choose from and trusted by academia, biotech, and pharma research labs. Cell models to suit any application, from TIDVAL to antibody validation, delivered in CUSTOM RNA SYNTHESIS Incorporating molecular probes at any RNA site. Incorporation of molecular probes at defined sites within synthetic RNA was accomplished using the 2’-ACE®-5’-Silyl RNA synthesis platform in combination with the Levulinyl protecting group. This process results in excellent yields of modified full length RNA and superiorqualities.
HAP1 PARENTAL CELL LINES HAP1 is a human near-haploid cell line derived from the male chronic myelogenous leukemia (CML) cell line KBM-7. For more details on how the HAP1 cell line was created, please see the references tab. HAP1 cell line properties include: Sustained growth at single celldilutions. Ease of
ON-TARGETPLUS SIRNA REAGENTS Human, mouse, rat. D-001810-10. Order quantity guidelines. ON-TARGETplus reagents are routinely used at 5 to 25 nM concentration. The calculations below, based on 25 nM, are for estimation purposes only and assume no loss from pipetting. Approximate # reactions (wells) at 25nM siRNA concentration. nmol. ONCOSIGNATURE™ CELL PANEL SCREENING SERVICE 3:36. Our 2D OncoSignature ™ Service includes: Screen across a diverse, clinically relevant 300 cell line panel or a more focused, tissue-specific panel such as lung, lymphoma, head & neck, or breast. Access to a library of over 350 standard of care compounds. Cell lines grown in vendor-recommended media. 10 point, 3-fold dilution forsingle
QUANTITATIVE MULTIPLEX REFERENCE STANDARD (FFPE) The Quantitative Multiplex FFPE Reference Standard is a highly-characterized, biologically-relevant quality control material used to assess the performance of NGS assays that detect somaticmutations.
TRU-Q 7 (1.3% TIER) REFERENCE STANDARD Tru-Q 7 (1.3% Tier) Reference Standard. The Tru-Q DNA Reference Standards are a highly-characterized, biologically-relevant quality control material used to assess the performance of NGS assays that detect somatic mutations. The specifications of some variants within the Tru-Q product line have been changed for batches manufacturedafter the
QUANTITATIVE MULTIPLEX REFERENCE STANDARD FCDNA (SEVERE) The Quantitative Multiplex Formalin Compromised DNA Reference Standards (Mild, Moderate and Severe) provide biologically-relevant quality control material which can be used to assess the performanceof NGS assays.
STRUCTURAL MULTIPLEX CFDNA REFERENCE STANDARD The Structural Multiplex cfDNA Reference Standard covers a wide range of mutations in a defined genomic context. This standard consists of DNA derived from human cell lines that is fragmented to an average size of 160 bp to closely resemble cfDNA extracted from human plasma. This product is designed to challenge your molecular and bioinformatic ON-TARGETPLUS NON-TARGETING CONTROL POOL ON-TARGETplus Non-targeting Control Pool is the ideal negative control for RNAi experiments in human, mouse, and rat cells. The four component ON-TARGETplus Non-targeting siRNAs were designed to leverage seed-region optimization and patented ON-TARGETplus modification patterns to have fewer off-targets than traditionally designed negative control siRNAs, and screened by genomewide microarray Cookies on HorizonWe use cookies to ensure we give you the best experience on our website. We use cookies to help remember your log-in details and optimise the site functionality for your use. To learn about how Horizon uses cookies, please see our Cookie Policy×
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