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2 MINUTE MEDICINE
2 Minute Medicine® is an award winning, physician-run, expert medical media company originally founded out of Harvard Medical School and the Massachusetts Institute of Technology. RANDOMIZED TRIAL OF PLANT-DERIVED VACCINE FOR COVID-19 1. A plant-derived, virus-like particle displays the SARS-CoV-2 spike glycoprotein and appears to be a promising candidate for a vaccine. 2. Adverse outcomes were mild-to-moderate, transient, and dependent on adjuvant. Evidence Rating Level: 1 (Excellent) Study Rundown: Available vaccines for COVID-19 are proving to be effective and safe. However, the demand for vaccines across 2 MINUTE MEDICINE REWIND MAY 31, 2021 A population-based analysis of the impact of the COVID-19 pandemic on common abdominal and gynecological emergency department visits 1. Emergency department visits for common medical emergencies dropped at the start of the COVID-19 pandemic, but with no changes in complication or mortality rates from these emergencies. Evidence Rating Level: 2 (Good) Due to the IMPLANTABLE LOOP RECORDER ASSOCIATED WITH INCREASED 1. In patients with recent ischemic stroke and no diagnosed atrial fibrillation (AF), there were increased AF diagnoses in those who received an implantable loop recorder compared with those who received an external loop recorder within 12 months of the intervention. Evidence Rating Level: 1 (Excellent) Study Rundown: Atrial fibrillation (AF) is one of the ELECTRONIC VAPOR PRODUCT USE IN ADOLESCENTS ASSOCIATED 1. In a cross-sectional study of U.S. high school students, those who used electronic vapor products were more likely than non-users to have engaged in sexual risk behaviors. 2. Findings were similar amongst those who used electronic vapor products occasionally, frequently, and daily. Evidence Rating Level: 2 (Good) Study Rundown: Although previous research has identified SURVIVORS OF INTENSIVE CARE UNIT ADMISSIONS MAY HAVE 1. Patients with prior episodes of critical illness requiring ICU admission were found to have an elevated risk of suicide and self-harm. 2. Suicide and self-harm were further correlated to the prevalence pre-existing psychiatric conditions as well as the receipt of life support. Evidence Rating Level: 2 (Good) Study Rundown: Due to advances in critical FORTIFICATION OF BREAST MILK WITH PRETERM FORMULA POWDER 1. Fortification of expressed breast milk with preterm formula was found to be non-inferior to human milk fortifier with regards to short-term weight gain among preterm neonates. Evidence Level Rating: 1 (Excellent) Because expressed breast milk (EBM) is not sufficient to meet the high nutrient requirements of preterm neonates, many countries, especially low- and low-middle ANTIRETROVIRAL THERAPY DEFERRAL ASSOCIATED WITH INCREASED 1. Deferral of antiretroviral therapy was associated with a small increase risk in acquired immunodeficiency syndrome (AIDS)-defining cancers at 10-year follow-up in young, human immunodeficiency virus (HIV)-positive patients. 2. The study was inconclusive on the long-term risk association of early antiretroviral therapy initiation and non-AIDS-defining cancers in the patient PRETERM FORMULA POWDER IS NOT INFERIOR TO HUMAN MILK 1. When used to fortify human breast milk for preterm neonates, no significant weight gain differences were seen from using either Preterm Formula Powder or Breast Milk Fortifier. 2. A higher prevalence of feed intolerance was reported when breast milk was fortified with human milk fortifier compared to preterm formula powder. Evidence Rating Level: 1 TIRBANIBULIN OINTMENT POTENTIALLY EFFECTIVE FOR ACTINIC 1. In these two identical, randomized, placebo-controlled clinical trials, tirbanibulin ointment was more effective than placebo in reducing the actinic keratosis. 2. Nearly half of the patients who had complete resolution of the lesion had a recurrence at one-year. Evidence Rating Level: 1 (Excellent) Study Rundown: Actinic keratosis is a common pre-malignant lesion of the2 MINUTE MEDICINE
2 Minute Medicine® is an award winning, physician-run, expert medical media company originally founded out of Harvard Medical School and the Massachusetts Institute of Technology. RANDOMIZED TRIAL OF PLANT-DERIVED VACCINE FOR COVID-19 1. A plant-derived, virus-like particle displays the SARS-CoV-2 spike glycoprotein and appears to be a promising candidate for a vaccine. 2. Adverse outcomes were mild-to-moderate, transient, and dependent on adjuvant. Evidence Rating Level: 1 (Excellent) Study Rundown: Available vaccines for COVID-19 are proving to be effective and safe. However, the demand for vaccines across 2 MINUTE MEDICINE REWIND MAY 31, 2021 A population-based analysis of the impact of the COVID-19 pandemic on common abdominal and gynecological emergency department visits 1. Emergency department visits for common medical emergencies dropped at the start of the COVID-19 pandemic, but with no changes in complication or mortality rates from these emergencies. Evidence Rating Level: 2 (Good) Due to the IMPLANTABLE LOOP RECORDER ASSOCIATED WITH INCREASED 1. In patients with recent ischemic stroke and no diagnosed atrial fibrillation (AF), there were increased AF diagnoses in those who received an implantable loop recorder compared with those who received an external loop recorder within 12 months of the intervention. Evidence Rating Level: 1 (Excellent) Study Rundown: Atrial fibrillation (AF) is one of the ELECTRONIC VAPOR PRODUCT USE IN ADOLESCENTS ASSOCIATED 1. In a cross-sectional study of U.S. high school students, those who used electronic vapor products were more likely than non-users to have engaged in sexual risk behaviors. 2. Findings were similar amongst those who used electronic vapor products occasionally, frequently, and daily. Evidence Rating Level: 2 (Good) Study Rundown: Although previous research has identified SURVIVORS OF INTENSIVE CARE UNIT ADMISSIONS MAY HAVE 1. Patients with prior episodes of critical illness requiring ICU admission were found to have an elevated risk of suicide and self-harm. 2. Suicide and self-harm were further correlated to the prevalence pre-existing psychiatric conditions as well as the receipt of life support. Evidence Rating Level: 2 (Good) Study Rundown: Due to advances in critical FORTIFICATION OF BREAST MILK WITH PRETERM FORMULA POWDER 1. Fortification of expressed breast milk with preterm formula was found to be non-inferior to human milk fortifier with regards to short-term weight gain among preterm neonates. Evidence Level Rating: 1 (Excellent) Because expressed breast milk (EBM) is not sufficient to meet the high nutrient requirements of preterm neonates, many countries, especially low- and low-middle ANTIRETROVIRAL THERAPY DEFERRAL ASSOCIATED WITH INCREASED 1. Deferral of antiretroviral therapy was associated with a small increase risk in acquired immunodeficiency syndrome (AIDS)-defining cancers at 10-year follow-up in young, human immunodeficiency virus (HIV)-positive patients. 2. The study was inconclusive on the long-term risk association of early antiretroviral therapy initiation and non-AIDS-defining cancers in the patient PRETERM FORMULA POWDER IS NOT INFERIOR TO HUMAN MILK 1. When used to fortify human breast milk for preterm neonates, no significant weight gain differences were seen from using either Preterm Formula Powder or Breast Milk Fortifier. 2. A higher prevalence of feed intolerance was reported when breast milk was fortified with human milk fortifier compared to preterm formula powder. Evidence Rating Level: 1 TIRBANIBULIN OINTMENT POTENTIALLY EFFECTIVE FOR ACTINIC 1. In these two identical, randomized, placebo-controlled clinical trials, tirbanibulin ointment was more effective than placebo in reducing the actinic keratosis. 2. Nearly half of the patients who had complete resolution of the lesion had a recurrence at one-year. Evidence Rating Level: 1 (Excellent) Study Rundown: Actinic keratosis is a common pre-malignant lesion of the WELLNESS CHECK: MENTAL HEALTH 9 hours ago · 2 Minute Medicine is pleased to announce that we are launching Wellness Check, a new series dedicated to exploring new research evidence focused on wellness. Each week, we will report on articles examining different aspects of wellness, including (but not limited to) nutrition, sleep, reproductive health, substance use and mental health. This week, we explore REPORTS OF MYOCARDITIS IN HEALTHY ADOLESCENTS AFTER PFIZER 1 day ago · 1. In a case series, 7 healthy male adolescents aged 14-19 developed acute myocarditis or myopericarditis within 4 days of receiving the second dose of the Pfizer-BioNTech COVID-19 vaccine. 2. All patients recovered rapidly after treatment with non-steroidal anti-inflammatory (NSAID) medications, intravenous immune globulin, and/or corticosteroids. REINFECTION RATES AMONG PATIENTS PREVIOUSLY TESTING 1. Among a large U.S. cohort, previous infection with SARS-CoV-2 appears to confer high levels of immunity against reinfection for at least 8 months. Evidence Level Rating: 2 (Good) As of early March 2021, SARS-CoV-2 has infected nearly 120 million individuals worldwide. The subsequent duration of immunity to reinfection is unknown; infection with common seasonal FACTORS ASSOCIATED WITH FUNCTIONAL IMPAIRMENT AFTER 23 hours ago · 1. Most injured children and adolescents return to baseline functional status by discharge. 2. Pediatric populations with extremity injuries or severe head injuries were at greatest risk of functional impairment at discharge. Evidence Rating Level: 2 (Good) Pediatric injuries often result in short- and long-term functional impairments, negatively impacting quality of life to a degree ZILTIVEKIMAB ANTAGONISM OF IL-6 REDUCES INFLAMMATION AND 12 hours ago · 1. Ziltivekimab lowered high-sensitivity CRP levels, a predictor of vascular events, compared to placebo in a dose-dependent manner. 2. Thrombotic biomarkers including fibrinogen, serum amyloid A, haptoglobin, secretory phospholipase A2, and lipoprotein were lower in treatment groups compared to placebo. Evidence Rating Level: 1 (Excellent) Study Rundown: Prior studies,including the
IMPLANTABLE LOOP RECORDER ASSOCIATED WITH INCREASED 1. In patients with recent ischemic stroke and no diagnosed atrial fibrillation (AF), there were increased AF diagnoses in those who received an implantable loop recorder compared with those who received an external loop recorder within 12 months of the intervention. Evidence Rating Level: 1 (Excellent) Study Rundown: Atrial fibrillation (AF) is one of the TYMPANOSTOMY TUBES NOT SUPERIOR TO MEDICAL MANAGEMENT FOR 1. Tympanostomy tubes were not shown to be superior to medical management for recurrent acute otitis media. 2. There was no substantial difference for elevated antimicrobial resistance in medical management compared to tympanostomy tube treatment. Evidence Rating Level: 1 (Excellent) Study Rundown: Acute otitis media is the second most commonly diagnosed childhood illness in EARLY INITIATION OF RHYTHM-CONTROL FOR ATRIAL FIBRILLATION 1. Compared to patients only receiving rate-control treatment, those who received rhythm-control treatment within one year of diagnosis of atrial fibrillation had a lower risk of adverse cardiovascular outcomes. 2. This association was not seen if the treatment was initiated over one year after the diagnosis of atrial fibrillation. Evidence Rating Level: 2 (Good) Study NET FLUID BALANCE NOT ASSOCIATED WITH HOSPITAL READMISSION 1. There was no association found between positive fluid balance at the time of discharge and readmission at 30 days post-discharge in non-critically ill patients hospitalized for sepsis. Evidence Rating Level: 2 (Good) Study Rundown: Evidence suggests that the administration of intravenous fluids in patients hospitalized for sepsis is associated with lower mortality. CARRIERS OF GENETIC VARIANTS OF INHERITED CARDIOMYOPATHIES 1. In this study of White and African American adults who had unexplained sudden cardiac death, nearly 20% of individuals had pathogenic or likely pathogenic variants consistent with inherited cardiomyopathies or arrhythmia syndromes, despite having normal cardiac findings. 2. These findings suggest that genetic testing could play a greater role in the prevention of unexplained2 MINUTE MEDICINE
2 Minute Medicine® is an award winning, physician-run, expert medical media company originally founded out of Harvard Medical School and the Massachusetts Institute of Technology. 2 MINUTE MEDICINE REWIND MAY 31, 2021 A population-based analysis of the impact of the COVID-19 pandemic on common abdominal and gynecological emergency department visits 1. Emergency department visits for common medical emergencies dropped at the start of the COVID-19 pandemic, but with no changes in complication or mortality rates from these emergencies. Evidence Rating Level: 2 (Good) Due to the ELECTRONIC VAPOR PRODUCT USE IN ADOLESCENTS ASSOCIATED 1. In a cross-sectional study of U.S. high school students, those who used electronic vapor products were more likely than non-users to have engaged in sexual risk behaviors. 2. Findings were similar amongst those who used electronic vapor products occasionally, frequently, and daily. Evidence Rating Level: 2 (Good) Study Rundown: Although previous research has identified SURVIVORS OF INTENSIVE CARE UNIT ADMISSIONS MAY HAVE 1. Patients with prior episodes of critical illness requiring ICU admission were found to have an elevated risk of suicide and self-harm. 2. Suicide and self-harm were further correlated to the prevalence pre-existing psychiatric conditions as well as the receipt of life support. Evidence Rating Level: 2 (Good) Study Rundown: Due to advances in critical COMBINED CAGRILINTIDE AND SEMAGLUTIDE FOR WEIGHT 1. Semaglutide 2.4 mg combined with once weekly cagrilintide therapy was not associated with increase in adverse events compared to semaglutide alone. 2. Compared to control, combined cagrilintide and semaglutide improved glycemic parameters and mean body weight reduction at 20 weeks. Evidence Rating Level: 1 (Excellent) Study Rundown: Semaglutide is a glucagon-like peptide-1 FORTIFICATION OF BREAST MILK WITH PRETERM FORMULA POWDER 1. Fortification of expressed breast milk with preterm formula was found to be non-inferior to human milk fortifier with regards to short-term weight gain among preterm neonates. Evidence Level Rating: 1 (Excellent) Because expressed breast milk (EBM) is not sufficient to meet the high nutrient requirements of preterm neonates, many countries, especially low- and low-middle ANTIRETROVIRAL THERAPY DEFERRAL ASSOCIATED WITH INCREASED 1. Deferral of antiretroviral therapy was associated with a small increase risk in acquired immunodeficiency syndrome (AIDS)-defining cancers at 10-year follow-up in young, human immunodeficiency virus (HIV)-positive patients. 2. The study was inconclusive on the long-term risk association of early antiretroviral therapy initiation and non-AIDS-defining cancers in the patient PRETERM FORMULA POWDER IS NOT INFERIOR TO HUMAN MILK 1. When used to fortify human breast milk for preterm neonates, no significant weight gain differences were seen from using either Preterm Formula Powder or Breast Milk Fortifier. 2. A higher prevalence of feed intolerance was reported when breast milk was fortified with human milk fortifier compared to preterm formula powder. Evidence Rating Level: 1 SEPSIS PERFORMANCE MEASURE IMPLEMENTATION NOT ASSOCIATED 1. Adoption of the Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) program resulted in greater adherence to individual process measures such as lactate measurement, early antibiotics, and fluid therapy. 2. These increases were variable in magnitude and did not associate with meaningful changes in sepsis outcomes. Evidence Rating Level: 2 (Good) Study Rundown: #VISUALABSTRACT: POSITIVE ANTI-SPIKE OR ANTI-NUCLEOCAPSIDAUTHOR:CONSTANCE WU
1. Health care workers with anti-spike antibodies revealed no symptomatic infections during the follow-up period for at least six months. 2. Participants with anti-nucleocapsid IgG antibodies also displayed a lower risk of reinfection of COVID-19 disease during the follow-up period. Evidence Rating Level: 2 (Good) Study Rundown: Vaccines have been great with combating the flu every year.2 MINUTE MEDICINE
2 Minute Medicine® is an award winning, physician-run, expert medical media company originally founded out of Harvard Medical School and the Massachusetts Institute of Technology. 2 MINUTE MEDICINE REWIND MAY 31, 2021 A population-based analysis of the impact of the COVID-19 pandemic on common abdominal and gynecological emergency department visits 1. Emergency department visits for common medical emergencies dropped at the start of the COVID-19 pandemic, but with no changes in complication or mortality rates from these emergencies. Evidence Rating Level: 2 (Good) Due to the ELECTRONIC VAPOR PRODUCT USE IN ADOLESCENTS ASSOCIATED 1. In a cross-sectional study of U.S. high school students, those who used electronic vapor products were more likely than non-users to have engaged in sexual risk behaviors. 2. Findings were similar amongst those who used electronic vapor products occasionally, frequently, and daily. Evidence Rating Level: 2 (Good) Study Rundown: Although previous research has identified SURVIVORS OF INTENSIVE CARE UNIT ADMISSIONS MAY HAVE 1. Patients with prior episodes of critical illness requiring ICU admission were found to have an elevated risk of suicide and self-harm. 2. Suicide and self-harm were further correlated to the prevalence pre-existing psychiatric conditions as well as the receipt of life support. Evidence Rating Level: 2 (Good) Study Rundown: Due to advances in critical COMBINED CAGRILINTIDE AND SEMAGLUTIDE FOR WEIGHT 1. Semaglutide 2.4 mg combined with once weekly cagrilintide therapy was not associated with increase in adverse events compared to semaglutide alone. 2. Compared to control, combined cagrilintide and semaglutide improved glycemic parameters and mean body weight reduction at 20 weeks. Evidence Rating Level: 1 (Excellent) Study Rundown: Semaglutide is a glucagon-like peptide-1 FORTIFICATION OF BREAST MILK WITH PRETERM FORMULA POWDER 1. Fortification of expressed breast milk with preterm formula was found to be non-inferior to human milk fortifier with regards to short-term weight gain among preterm neonates. Evidence Level Rating: 1 (Excellent) Because expressed breast milk (EBM) is not sufficient to meet the high nutrient requirements of preterm neonates, many countries, especially low- and low-middle ANTIRETROVIRAL THERAPY DEFERRAL ASSOCIATED WITH INCREASED 1. Deferral of antiretroviral therapy was associated with a small increase risk in acquired immunodeficiency syndrome (AIDS)-defining cancers at 10-year follow-up in young, human immunodeficiency virus (HIV)-positive patients. 2. The study was inconclusive on the long-term risk association of early antiretroviral therapy initiation and non-AIDS-defining cancers in the patient PRETERM FORMULA POWDER IS NOT INFERIOR TO HUMAN MILK 1. When used to fortify human breast milk for preterm neonates, no significant weight gain differences were seen from using either Preterm Formula Powder or Breast Milk Fortifier. 2. A higher prevalence of feed intolerance was reported when breast milk was fortified with human milk fortifier compared to preterm formula powder. Evidence Rating Level: 1 SEPSIS PERFORMANCE MEASURE IMPLEMENTATION NOT ASSOCIATED 1. Adoption of the Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) program resulted in greater adherence to individual process measures such as lactate measurement, early antibiotics, and fluid therapy. 2. These increases were variable in magnitude and did not associate with meaningful changes in sepsis outcomes. Evidence Rating Level: 2 (Good) Study Rundown: #VISUALABSTRACT: POSITIVE ANTI-SPIKE OR ANTI-NUCLEOCAPSIDAUTHOR:CONSTANCE WU
1. Health care workers with anti-spike antibodies revealed no symptomatic infections during the follow-up period for at least six months. 2. Participants with anti-nucleocapsid IgG antibodies also displayed a lower risk of reinfection of COVID-19 disease during the follow-up period. Evidence Rating Level: 2 (Good) Study Rundown: Vaccines have been great with combating the flu every year. RANDOMIZED TRIAL OF PLANT-DERIVED VACCINE FOR COVID-19 1. A plant-derived, virus-like particle displays the SARS-CoV-2 spike glycoprotein and appears to be a promising candidate for a vaccine. 2. Adverse outcomes were mild-to-moderate, transient, and dependent on adjuvant. Evidence Rating Level: 1 (Excellent) Study Rundown: Available vaccines for COVID-19 are proving to be effective and safe. REPORTS OF MYOCARDITIS IN HEALTHY ADOLESCENTS AFTER PFIZER 20 hours ago · 1. In a case series, 7 healthy male adolescents aged 14-19 developed acute myocarditis or myopericarditis within 4 days of receiving the second dose of the Pfizer-BioNTech COVID-19 vaccine. 2. All patients recovered rapidly after treatment with non-steroidal anti-inflammatory (NSAID) medications, intravenous immune globulin, and/or corticosteroids. VOCLOSPORIN SHOWS CLINICAL PROMISE FOR TREATMENT OF ACTIVE 20 hours ago · 1. A significantly greater proportion of patients in the voclosporin group achieved complete renal responses after 52 weeks compared to the placebo group. 2. The safety profile between the voclosporin group and placebo group were comparable with 21% of patients in both groups experiencing serious adverse events. Evidence Rating Level: 1 (Excellent) Study Rundown: Nearly RAPID RESPIRATORY PATHOGEN TESTING DOES NOT SIGNIFICANTLY 22 hours ago · 1. When treating children with an acute respiratory illness in the emergency department, no significant difference in antibiotic prescription rates was observed when clinicians knew rapid respiratory pathogen test results, compared to when clinicians did not. 2. Children with an acute respiratory illness whose clinician knew rapid respiratory pathogen test results had longer emergency REINFECTION RATES AMONG PATIENTS PREVIOUSLY TESTING Initial infection status was based on PCR testing performed prior to 30 August 2020. 150,325 patients had tests performed prior to this date, with 8,845 testing positive. After at least 90 days, 1,278 of these previously positive patients were retested, with 62 reviewed for reinfection. 31 of these reinfected patients were symptomatic, and 18 TYMPANOSTOMY TUBES NOT SUPERIOR TO MEDICAL MANAGEMENT FOR 1. Tympanostomy tubes were not shown to be superior to medical management for recurrent acute otitis media. 2. There was no substantial difference for elevated antimicrobial resistance in medical management compared to tympanostomy tube treatment. Evidence Rating Level: 1 (Excellent) Study Rundown: Acute otitis media is the second most commonly diagnosed childhood illness in BNT162B2 MRNA VACCINE SHOWS BENEFIT AGAINST SYMPTOMATIC 1. Vaccinated individuals reported fewer SARS-CoV-2 infections and a lesser proportion of cases were symptomatic compared to the unvaccinated cohort. 2. BNT162b2 mRNA vaccine showed an effectiveness of 70% 21 days after a single dose. Evidence Rating Level: 2 (Good) Study Rundown: The BNT162b2 mRNA (Pfizer-BioNTech) and ChAdOx1 nCoV-19 adenoviral (Oxford-AstraZeneca) COVID IMPLANTABLE LOOP RECORDER ASSOCIATED WITH INCREASED 1. In patients with recent ischemic stroke and no diagnosed atrial fibrillation (AF), there were increased AF diagnoses in those who received an implantable loop recorder compared with those who received an external loop recorder within 12 months of the intervention. Evidence Rating Level: 1 (Excellent) Study Rundown: Atrial fibrillation (AF) is one of the EFFECT OF COGNITIVE BEHAVIORAL THERAPY-BASED COUNSELING ON 1 day ago · 1. Cognitive behavioral therapy (CBT)-based counseling significantly improved perceived stress, anxiety, and quality of life among women with primary infertility. 2. Measures of depression suggested minimal effects of CBT-based counseling on these symptoms, based on this sample. Evidence Rating Level: 1 (Excellent) It is estimated that infertility impacts 11 to 51 million people worldwide. CHEMORADIOTHERAPY ASSOCIATED WITH EFFECTIVENESS COMPARABLE 1. Primary treatment with chemoradiotherapy when treating oropharyngeal squamous cell carcinoma had improved progression-free survival and distant metastasis-free survival compared to when treated with upfront surgery. 2. There was no significant difference in mortality during the study period in the upfront surgical treatment versus chemoradiotherapy groups.2 MINUTE MEDICINE
2 Minute Medicine® is an award winning, physician-run, expert medical media company originally founded out of Harvard Medical School and the Massachusetts Institute of Technology. REINFECTION RATES AMONG PATIENTS PREVIOUSLY TESTING Initial infection status was based on PCR testing performed prior to 30 August 2020. 150,325 patients had tests performed prior to this date, with 8,845 testing positive. After at least 90 days, 1,278 of these previously positive patients were retested, with 62 reviewed for reinfection. 31 of these reinfected patients were symptomatic, and 18 PATIENT BASICS: ENDOSCOPY 2 Minute Medicine® is an award winning, physician-run, expert medical media company originally founded out of Harvard Medical School and the Massachusetts Institute of Technology. PATIENT BASICS: CYSTS (OVERVIEW) FLUTICASONE-SALMETEROL COMBINATION THERAPY SAFE AND 1. For patients with moderate-to-severe asthma, fluticasone-salmeterol combination therapy was not associated with a higher risk of serious asthma-related events than fluticasone alone. 2. Fluticasone-salmeterol combination therapy, especially during adolescence, is associated with a significantly lower risk of severe asthma exacerbations. THE CLOT TRIAL: DALTEPARIN VERSUS WARFARIN [CLASSICS This study summary is an excerpt from the book 2 Minute Medicine’s The Classics in Medicine: Summaries of the Landmark Trials, 1e (The Classics Series). 1. Dalteparin, a low-molecular-weight heparin, is superior to warfarin in preventing recurrent venous thromboembolism in the setting of malignancy. 2. There is no significant difference in risk of major bleeding with RECURRENCE OF ENDOMETRIAL HYPERPLASIA FOLLOWING MEDICAL Recurrence of endometrial hyperplasia following medical therapy is common. 1. Many women developed recurrence, most within the first 6 months after cessation of therapy. 2. There were no differences in relapse rate between the 3 treatment arms. Study Rundown: Endometrial cancer is the most common gynecologic malignancy affecting women inthe U.S.
COGNITIVE DYSFUNCTION IS COMMON IN LACUNAR STROKE PATIENTS Image: CC/GGeek. Lacunar Infarct Key study points: Lacunar strokes are a common occurrence in patients with vascular risk factors and can lead to a wide range of cognitive and sensorimotor sequelae. Cognitive deficits following lacunar strokes may be more prevalent than sensorimotor symptoms, and are characterized by impaired verbal fluency, executive dysfunction, and RISKS OF LONG-TERM TYLENOL USE CORROBORATED IN META 1. This recent meta-analysis found a slightly increased cardiovascular, renal, and gastrointestinal adverse outcomes with prolonged, chronic acetaminophen (tylenol/paracematol) use. 2. While dose-response relationships were seemingly found in the included studies, dosage definitions varied, study populations were not generalizable, and prospective studies were limited. CARDIAC RISK FACTORS ASSOCIATED WITH NONCALCIFIED PLAQUE 1. In asymptomatic patients with low-to-moderate risk for coronary artery disease, computed tomography coronary angiography revealed increased total coronary plaque index in men than in women. 2. Total non-calcified, soft coronary plaque burden in asymptomatic patients was associated with risk factors for cardiovascular disease including low-density lipoprotein cholesterol levels,2 MINUTE MEDICINE
2 Minute Medicine® is an award winning, physician-run, expert medical media company originally founded out of Harvard Medical School and the Massachusetts Institute of Technology. REINFECTION RATES AMONG PATIENTS PREVIOUSLY TESTING Initial infection status was based on PCR testing performed prior to 30 August 2020. 150,325 patients had tests performed prior to this date, with 8,845 testing positive. After at least 90 days, 1,278 of these previously positive patients were retested, with 62 reviewed for reinfection. 31 of these reinfected patients were symptomatic, and 18 PATIENT BASICS: ENDOSCOPY 2 Minute Medicine® is an award winning, physician-run, expert medical media company originally founded out of Harvard Medical School and the Massachusetts Institute of Technology. PATIENT BASICS: CYSTS (OVERVIEW) FLUTICASONE-SALMETEROL COMBINATION THERAPY SAFE AND 1. For patients with moderate-to-severe asthma, fluticasone-salmeterol combination therapy was not associated with a higher risk of serious asthma-related events than fluticasone alone. 2. Fluticasone-salmeterol combination therapy, especially during adolescence, is associated with a significantly lower risk of severe asthma exacerbations. THE CLOT TRIAL: DALTEPARIN VERSUS WARFARIN [CLASSICS This study summary is an excerpt from the book 2 Minute Medicine’s The Classics in Medicine: Summaries of the Landmark Trials, 1e (The Classics Series). 1. Dalteparin, a low-molecular-weight heparin, is superior to warfarin in preventing recurrent venous thromboembolism in the setting of malignancy. 2. There is no significant difference in risk of major bleeding with RECURRENCE OF ENDOMETRIAL HYPERPLASIA FOLLOWING MEDICAL Recurrence of endometrial hyperplasia following medical therapy is common. 1. Many women developed recurrence, most within the first 6 months after cessation of therapy. 2. There were no differences in relapse rate between the 3 treatment arms. Study Rundown: Endometrial cancer is the most common gynecologic malignancy affecting women inthe U.S.
COGNITIVE DYSFUNCTION IS COMMON IN LACUNAR STROKE PATIENTS Image: CC/GGeek. Lacunar Infarct Key study points: Lacunar strokes are a common occurrence in patients with vascular risk factors and can lead to a wide range of cognitive and sensorimotor sequelae. Cognitive deficits following lacunar strokes may be more prevalent than sensorimotor symptoms, and are characterized by impaired verbal fluency, executive dysfunction, and RISKS OF LONG-TERM TYLENOL USE CORROBORATED IN META 1. This recent meta-analysis found a slightly increased cardiovascular, renal, and gastrointestinal adverse outcomes with prolonged, chronic acetaminophen (tylenol/paracematol) use. 2. While dose-response relationships were seemingly found in the included studies, dosage definitions varied, study populations were not generalizable, and prospective studies were limited. CARDIAC RISK FACTORS ASSOCIATED WITH NONCALCIFIED PLAQUE 1. In asymptomatic patients with low-to-moderate risk for coronary artery disease, computed tomography coronary angiography revealed increased total coronary plaque index in men than in women. 2. Total non-calcified, soft coronary plaque burden in asymptomatic patients was associated with risk factors for cardiovascular disease including low-density lipoprotein cholesterol levels, CONVALESCENT PLASMA DOES NOT IMPROVE SURVIVAL IN PATIENTS 3 hours ago · 1. A similar proportion of patients died within 28 days of randomization in both groups (high-titre convalescent plasma vs. usual care). 2. Allocation to convalescent plasma had no significant effect on the proportion of patients discharged from hospital within 28 days. Evidence Rating Level: 1 (Excellent) Study Rundown: Convalescent plasma is a form of passive TYMPANOSTOMY TUBES NOT SUPERIOR TO MEDICAL MANAGEMENT FOR 1 day ago · 1. Tympanostomy tubes were not shown to be superior to medical management for recurrent acute otitis media. 2. There was no substantial difference for elevated antimicrobial resistance in medical management compared to tympanostomy tube treatment. Evidence Rating Level: 1 (Excellent) Study Rundown: Acute otitis media is the second most commonly diagnosed childhood illness in MATERNAL INFLUENZA VACCINE DURING PREGNANCY NOT LINKED TO 4 hours ago · 1. Over a mean follow-up period of 3.6 years, no significant association was detected between maternal influenza vaccination during pregnancy and early childhood health outcomes including pediatric asthma, neoplasms and sensory impairment. Evidence Rating: 2 (Good) Study Rundown: Vaccine hesitancy, particularly during pregnancy and early childhood, is a key issue that presents GENETIC VARIANTS ASSOCIATED WITH UNEXPLAINED SUDDEN 14 hours ago · 1. Nearly 20% of participants with unexplained sudden cardiac death carried pathogenic or likely pathogenic variants of cardiomyopathies and arrhythmia syndromes. Evidence Rating Level: 2 (Good) Genetic testing allows for diagnosing inheritable cardiac diseases in unexplained sudden cardiac death (SCD). However, it is currently unknown the degree to which pathogenic or likely pathogenic EARLY INITIATION OF RHYTHM-CONTROL FOR ATRIAL FIBRILLATION 1. Compared to patients only receiving rate-control treatment, those who received rhythm-control treatment within one year of diagnosis of atrial fibrillation had a lower risk of adverse cardiovascular outcomes. 2. This association was not seen if the treatment was initiated over one year after the diagnosis of atrial fibrillation. Evidence Rating Level: 2 (Good) Study PEMBROLIZUMAB PLUS CONCURRENT CHEMORADIATION THERAPY 3 hours ago · 1. Concomitant pembrolizumab plus chemoradiation therapy was associated with improved antitumor activity and safety profile in patients with previously untreated, locally advanced, stage III non-small cell lung cancer. 2. This treatment regimen represents a promising therapy in patients with previously untreated, locally advanced, stage III non-small cell lung cancer, regardless of tumorREBECCA SELIGA
1 day ago · 2 Minute Medicine® is an award winning, physician-run, expert medical media company originally founded out of Harvard Medical School and the Massachusetts Institute of Technology. Our content is curated, written and edited by practicing health professionals who have clinical and scientific PATIENT BASICS: CYSTS (OVERVIEW) Originally published by Harvard Health. What Is It? Cysts are sacs or capsules that form in the skin or inside the body. They may contain fluid or semisolid material. Although cysts can appear anywhere in the body, most frequently they live in the skin, ovaries, breasts or kidneys. Most cysts are not cancerous. Common locations of PROSTHETIC JOINT INFECTION 1. A six-week antibiotic therapy was not shown to be non-inferior to a 12-week antibiotic therapy for patients with confirmed prosthetic joint infections. 2.The six-week therapy resulted in more unfavorable outcomes for patients compared to the 12-week therapy. Evidence RatingLevel: 1
IMAGE-GUIDED SALVAGE RADIOTHERAPY IMPROVES OUTCOMES IN 1. 3-year event-free survival rates were significantly greater in the 18F-fluciclovine-PET group compared to conventional imaging. 2. Adverse reactions and toxicity levels were similar between the two groups. Evidence Rating Level: 1 (Excellent) Study Rundown: In patients with prostate cancer, prostatectomies are often followed with adjuvant or salvage radiotherapy.__
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EARLY INITIATION OF RHYTHM-CONTROL FOR ATRIAL FIBRILLATION ASSOCIATEDWITH LOWER RISK…
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LONG‐TERM CARDIOVASCULAR OUTCOMES AFTER PREGNANCY IN WOMEN WITHHEART DISEASE
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