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UTILITY OF PERIOPERATIVE WARMING FOR THE PREVENTION OF INTRODUCTION. In modern surgical procedures, a consistent risk is the development of surgical site infection (SSI) postoperatively, projected to be affecting approximately 1–3% of all American and European patients 1 and associated with $4.25 billion in preventable costs. 2 SSI are defined by the World Health Organization (WHO) and U.S. Centers for Disease Control and Prevention (CDC) as ONCOGENIC DRIVERS IN ADVANCED NSCLC: NAVIGATING AN Mutations in EGFR are present in approximately 15–30% of patients with NSCLC, 2,4 and classical activating mutations, such as EGFR exon 19 deletions and point mutations in exon 21 (L858R), are associated with responsiveness to targeted tyrosine kinase inhibitor (TKI) treatment. 5 In addition, many of the less commonly observed alterations, such as EGFR exon 19 insertions and point ACUTE KIDNEY INJURY: RISK FACTORS AND MANAGEMENT Acute kidney injury (AKI) is a major global health problem, occurring in >13 million people and responsible for >2.3 million deaths every year, 85% of which are in developing countries. CLINICAL CASES IN DERMATOLOGY: MODERN MANAGEMENT OF ACNE Treatment. Acnatac® cream (clindamycin 1%/tretinoin 0.025%) was prescribed as a once-daily application at bedtime per 90 days. Acnatac is indicated for the topical treatment of acne vulgaris when comedones, papules, and pustules are present in patients aged ≥12years. 5
LIVER DISORDERS IN INFLAMMATORY BOWEL DISEASE Autoimmune Hepatitis. Autoimmune hepatitis (AIH) is a chronic liver disease characterised by alteration of transaminases, hypergammaglobulinaemia, and periportal hepatitis in liver biopsy. The prevalence in patients with IBD is low. It has been reported mainly in PERNICIOUS ANAEMIA: MECHANISMS, DIAGNOSIS, AND MANAGEMENTSEE MORE ONEMJREVIEWS.COM
EMJ - INTEGRAL, IMPARTIAL, INDEPENDENTTHERAPEUTIC AREAABOUT USCONTRIBUTORSEUROPEAN MEDICAL JOURNALINTERVENTIONAL CARDIOLOGY The EMJ is an open-access, peer-reviewed medical journal. Founded in 2012 as an imprint of Gorely New Media, the EMJ provides reviews, symposiums and developments from Europe's medical congresses. Each journal is published six weeks after its relevant congress. LONG-TERM EFFICACY AND SAFETY OF TILDRAKIZUMAB: 5-YEAR Overview. While psoriasis is a systemic inflammatory disease, it predominantly manifests in the skin as thick, scaly, erythematous plaques. 1 Both patient and physician surveys alike reveal that, over the long term, factors deemed important when considering a psoriasis therapy include the appearance and amount of clear skin, overall symptom relief, maintenance of response over time, and safety REIMAGINING TREATMENT OF HR+, HER2- EARLY BREAST CANCER This satellite symposium took place during the virtual 17 th St Gallen International Breast Cancer Conference 2021. The objectives of the satellite symposium were to gain an understanding of key concepts within hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) early breast cancer (EBC) that impact treatment selection, such as risk of recurrence and how INFORMATION AND COMMUNICATION TECHNOLOGY IN THE FIGHT A new coronavirus infection named coronavirus disease (COVID-19) was discovered in Wuhan, China at the end of 2019, and has rapidlyprogressed
UTILITY OF PERIOPERATIVE WARMING FOR THE PREVENTION OF INTRODUCTION. In modern surgical procedures, a consistent risk is the development of surgical site infection (SSI) postoperatively, projected to be affecting approximately 1–3% of all American and European patients 1 and associated with $4.25 billion in preventable costs. 2 SSI are defined by the World Health Organization (WHO) and U.S. Centers for Disease Control and Prevention (CDC) as ONCOGENIC DRIVERS IN ADVANCED NSCLC: NAVIGATING AN Mutations in EGFR are present in approximately 15–30% of patients with NSCLC, 2,4 and classical activating mutations, such as EGFR exon 19 deletions and point mutations in exon 21 (L858R), are associated with responsiveness to targeted tyrosine kinase inhibitor (TKI) treatment. 5 In addition, many of the less commonly observed alterations, such as EGFR exon 19 insertions and point ACUTE KIDNEY INJURY: RISK FACTORS AND MANAGEMENT Acute kidney injury (AKI) is a major global health problem, occurring in >13 million people and responsible for >2.3 million deaths every year, 85% of which are in developing countries. CLINICAL CASES IN DERMATOLOGY: MODERN MANAGEMENT OF ACNE Treatment. Acnatac® cream (clindamycin 1%/tretinoin 0.025%) was prescribed as a once-daily application at bedtime per 90 days. Acnatac is indicated for the topical treatment of acne vulgaris when comedones, papules, and pustules are present in patients aged ≥12years. 5
LIVER DISORDERS IN INFLAMMATORY BOWEL DISEASE Autoimmune Hepatitis. Autoimmune hepatitis (AIH) is a chronic liver disease characterised by alteration of transaminases, hypergammaglobulinaemia, and periportal hepatitis in liver biopsy. The prevalence in patients with IBD is low. It has been reported mainly in PERNICIOUS ANAEMIA: MECHANISMS, DIAGNOSIS, AND MANAGEMENTSEE MORE ONEMJREVIEWS.COM
UTILITY OF PERIOPERATIVE WARMING FOR THE PREVENTION OF INTRODUCTION. In modern surgical procedures, a consistent risk is the development of surgical site infection (SSI) postoperatively, projected to be affecting approximately 1–3% of all American and European patients 1 and associated with $4.25 billion in preventable costs. 2 SSI are defined by the World Health Organization (WHO) and U.S. Centers for Disease Control and Prevention (CDC) as ‘DRY’ PERICARDITIS WITH RAPID PROGRESSION TO TAMPONADE AS Pericardial inflammation is a recognised feature of coronavirus disease (COVID-19). The authors herein present the case of a female with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection who developed a large and life-threatening pericardial effusion over a few days following the onset of pericarditis, despite prompt commencement of treatment. ADVERSE SKIN REACTIONS TO METFORMIN: A CASE REPORT AND INTRODUCTION. Metformin, a widely used antidiabetic and antiobesity drug, exerts multiple effects on the skin, and could potentially induce a variety of dermatoses. 1 Among others, the most commonly described drug-induced skin reactions include rash, urticaria, and lichenoid eruption. 2,3. LIVER DISORDERS IN INFLAMMATORY BOWEL DISEASE Autoimmune Hepatitis. Autoimmune hepatitis (AIH) is a chronic liver disease characterised by alteration of transaminases, hypergammaglobulinaemia, and periportal hepatitis in liver biopsy. The prevalence in patients with IBD is low. It has been reported mainly in MULTIDISCIPLINARY APPROACH TO MANAGEMENT AND CARE OF INTRODUCTION. Diabetes is a global epidemic affecting an estimated 425 million adults aged 20–79 years. In 2017, there were 58 million individuals in Europe with diabetes and this figure is set to rise to 67 million by 2045. 1 Adults with Type 2 diabetes mellitus (T2DM) make up 90% of all patients with diabetes. 2,3 T2DM prevalence is increasing due to population ageing, changes in dietary PRELIMINARY SAFETY, EFFICACY, AND PHARMACOKINETIC AND Preliminary Safety, Efficacy, and Pharmacokinetic and Pharmacodynamic Characterisation from GARNET, a Phase I Clinical Trial of the Anti-PD-1 Monoclonal Antibody TSR-042 in Patients with Recurrent or Advanced Microsatellite Instability-High Endometrial Cancer IS CD37-TARGETED THERAPY A VIABLE ALTERNATIVE IN THE UNMET NEED IN DIFFUSE LARGE B-CELL LYMPHOMA Professor Grzegorz S. Nowakowski. DLBCL is the most common type of NHL. The prevalence of DLBCL in NHL cases ranges from 30% to 58% in Europe, and 25% to 35% in the USA. 8 The disease is aggressive and patients typically present with rapidly enlarging lymphadenopathy, extranodal involvement, and constitutional symptoms, OSTEOARTHRITIS AND AGEING Osteoarthritis (OA) is the most common global chronic joint disease. The disease may affect single or multiple joints and even be generalised. OA is a chronic arthropathy affecting the entire joint, involving the cartilage, joint lining, ligaments, and underlying bone. In OA, cartilage loss, osteophyte formation (bone spurs), andsubchondral
CLIMATE CHANGE: WHAT CAN DOCTORS DO? Abstract. Global warming remains one of the largest global threats to our health. The size of the challenge is immense but political interventions have so far failed to create the drastic changes that are needed to avert this crisis. Concerned by the health risks of climate change, new health groups are emerging to champion this cause,raising
PRACTICAL MANAGEMENT OF ANAEMIA AFTER A GASTROINTESTINAL Prof Gralnek presented a clinical case on the management of gastrointestinal bleeding (GIB) as a result of Helicobacter pylori infection, and the role of intravenous (IV) ferric carboxymaltose (FCM) as a treatment option for iron deficiency anaemia (IDA) was discussed. IV iron is suitable for patients who have intolerance or limited or no response to oral iron, haemoglobin (Hb) 13 million people and responsible for >2.3 million deaths every year, 85% of which are in developing countries. PATHOGENESIS, DIAGNOSTICS, AND TREATMENT OF HEREDITARY NORMAL METABOLISM OF IRON AND HEREDITARY HAEMOCHROMATOSIS. Iron is an essential micronutrient that exists in different ionic states. This ability makes it a critical component of oxygen transport proteins, numerous metabolic enzymes, and reaction centres of a AN OVERVIEW OF ATOPIC DERMATITIS WITH A FOCUS ON NANO INTRODUCTION. Atopic dermatitis (AD), a multifaceted, chronic relapsing inflammatory skin disease, is commonly associated with other atopic manifestations, such as food allergy, allergic rhinitis, and asthma, and affects both children and adults with prevalence rates varying from 15–30%. 1 The phrase AD is a portmanteau of atopy, or atopic syndrome, and dermatitis. PRELIMINARY SAFETY, EFFICACY, AND PHARMACOKINETIC AND Preliminary Safety, Efficacy, and Pharmacokinetic and Pharmacodynamic Characterisation from GARNET, a Phase I Clinical Trial of the Anti-PD-1 Monoclonal Antibody TSR-042 in Patients with Recurrent or Advanced Microsatellite Instability-High Endometrial Cancer EAACI INTERVIEW: PROF DR. HAB. IOANA AGACHE The EAACI Guidelines on the use of biologicals in severe asthma follow the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) approach in formulating recommendations for each product and each outcome. In addition, a management algorithm for the use of biologicals in the clinic is proposed, together with future EXPECTATIONS AND EXPERIENCE: OPTIMISING EFFICACY AND First-Line Treatment of Follicular Lymphoma: Understanding the Key Learnings from the Latest Clinical Data Professor Gilles Salles. Over a decade ago, studies demonstrated that adding R (the first monoclonal antibody targeting CD20 approved for cancer therapy) to different chemotherapy regimens in FL increased survival compared tochemotherapy alone.
FROM EVOLUTION TO REVOLUTION: IL-23 IN THE TREATMENT OF This symposium, which took place during the 2018 meeting of the European Academy of Dermatology and Venereology (EADV) in Paris, France, provided an overview of the IL-23 revolution in psoriasis, with a specific focus on psoriasis pathogenesis and its relation to potential treatment targets and the development of novel targetedimmune therapies.
CHALLENGES OF INHALER USE IN THE TREATMENT OF ASTHMA AND The mainstay of the pharmacological management of asthma and chronic obstructive pulmonary disease (COPD) is the use of inhaled drugs. This route enables drugs to be delivered to the site of their action, minimising the risk of adverse effects caused by systemic absorption. ADVERSE SKIN REACTIONS TO METFORMIN: A CASE REPORT ANDSEE MORE ONEMJREVIEWS.COM
ACUTE KIDNEY INJURY: RISK FACTORS AND MANAGEMENT Acute kidney injury (AKI) is a major global health problem, occurring in >13 million people and responsible for >2.3 million deaths every year, 85% of which are in developing countries. LESSONS LEARNED FROM A GLOBAL HISTORY OF PANDEMICS A pinpoint in the history of pandemics is the first recorded outbreak of the plague, the plague of Justinian (541–542 AD, with recurrences until 750 AD), which was carried over the Mediterranean Sea from Egypt to Constantinople. Fleas carrying the bacteria Yersinia pestis infected rats, and these plague-infected rodents travelled aboardgrain
PATHOGENESIS, DIAGNOSTICS, AND TREATMENT OF HEREDITARY NORMAL METABOLISM OF IRON AND HEREDITARY HAEMOCHROMATOSIS. Iron is an essential micronutrient that exists in different ionic states. This ability makes it a critical component of oxygen transport proteins, numerous metabolic enzymes, and reaction centres of a PRELIMINARY SAFETY, EFFICACY, AND PHARMACOKINETIC AND Preliminary Safety, Efficacy, and Pharmacokinetic and Pharmacodynamic Characterisation from GARNET, a Phase I Clinical Trial of the Anti-PD-1 Monoclonal Antibody TSR-042 in Patients with Recurrent or Advanced Microsatellite Instability-High Endometrial Cancer AN OVERVIEW OF ATOPIC DERMATITIS WITH A FOCUS ON NANO INTRODUCTION. Atopic dermatitis (AD), a multifaceted, chronic relapsing inflammatory skin disease, is commonly associated with other atopic manifestations, such as food allergy, allergic rhinitis, and asthma, and affects both children and adults with prevalence rates varying from 15–30%. 1 The phrase AD is a portmanteau of atopy, or atopic syndrome, and dermatitis. EAACI INTERVIEW: PROF DR. HAB. IOANA AGACHE The EAACI Guidelines on the use of biologicals in severe asthma follow the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) approach in formulating recommendations for each product and each outcome. In addition, a management algorithm for the use of biologicals in the clinic is proposed, together with future A SYSTEMATIC REVIEW OF SCROTAL SQUAMOUS CELL CARCINOMA Abstract. The epidemiology of scrotal cancer has changed over time away from occupational exposure to soot. The current incidence of scrotal malignancy is approximately 1 per 1 million males per year. This review summarises the current literature on the management of scrotal squamous cell carcinoma (SCC), including pathogenesis,available
EXPECTATIONS AND EXPERIENCE: OPTIMISING EFFICACY AND First-Line Treatment of Follicular Lymphoma: Understanding the Key Learnings from the Latest Clinical Data Professor Gilles Salles. Over a decade ago, studies demonstrated that adding R (the first monoclonal antibody targeting CD20 approved for cancer therapy) to different chemotherapy regimens in FL increased survival compared tochemotherapy alone.
CHALLENGES OF INHALER USE IN THE TREATMENT OF ASTHMA AND The mainstay of the pharmacological management of asthma and chronic obstructive pulmonary disease (COPD) is the use of inhaled drugs. This route enables drugs to be delivered to the site of their action, minimising the risk of adverse effects caused by systemic absorption. RELATING VENTILATORY SUPPORT AND DRUG TREATMENT STRATEGIES INTRODUCTION. Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); 1 as of September 2020, there were >33 million cases and almost 1 million deaths worldwide. 2 An unknown number of people are asymptomatic carriers of SARS-CoV-2 but symptoms in the early phase of viral replication include fatigue, anosmia, fever, sore throat, and INFORMATION AND COMMUNICATION TECHNOLOGY IN THE FIGHT A new coronavirus infection named coronavirus disease (COVID-19) was discovered in Wuhan, China at the end of 2019, and has rapidlyprogressed
ARTIFICIAL INTELLIGENCE IN RADIOLOGY: AN EXCITING FUTURE 1. Mercy University Hospital, Cork, Ireland 2. University College Cork, Ireland 3. Second Vice President, European Society of Radiology (ESR), Vienna, Austria *Correspondence to EMJ RHEUMATOLOGY 8 2021 INFO. This review provides a summary of presentations from the virtual American College of Rheumatology (ACR) Convergence 2020 meeting and collectively describes psoriasis, psoriatic arthritis (PsA), and spondyloarthritis (SpA), with a focus on the role of immune function to aid clinicians to better diagnose and treat these inflammatoryconditions.
COVID-19: IS IT TIME TO REVISIT THE RESEARCH ON CALCIUM Zheng YY et al. COVID-19 and the cardiovascular system. Nat Rev Cardiol. 2020;17:259-60. . Zhou F et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. PATHOGENESIS, DIAGNOSTICS, AND TREATMENT OF HEREDITARY NORMAL METABOLISM OF IRON AND HEREDITARY HAEMOCHROMATOSIS. Iron is an essential micronutrient that exists in different ionic states. This ability makes it a critical component of oxygen transport proteins, numerous metabolic enzymes, and reaction centres of a EUROPEAN SOCIETY OF CARDIOLOGY CHRONIC CORONARY SYNDROMES New guidelines for the diagnosis and management of chronic coronary syndromes (CCS) 1 were released during the 2019 European Society of Cardiology (ESC) Congress. The new guidelines were discussed in multiple sessions with different formats across the congress; this review summarises some of the discussion among experts at the congress around what the new guidelines mean for the way LIVER DISORDERS IN INFLAMMATORY BOWEL DISEASE Autoimmune Hepatitis. Autoimmune hepatitis (AIH) is a chronic liver disease characterised by alteration of transaminases, hypergammaglobulinaemia, and periportal hepatitis in liver biopsy. The prevalence in patients with IBD is low. It has been reported mainly in A SYSTEMATIC REVIEW OF SCROTAL SQUAMOUS CELL CARCINOMA Abstract. The epidemiology of scrotal cancer has changed over time away from occupational exposure to soot. The current incidence of scrotal malignancy is approximately 1 per 1 million males per year. This review summarises the current literature on the management of scrotal squamous cell carcinoma (SCC), including pathogenesis,available
CHALLENGES OF INHALER USE IN THE TREATMENT OF ASTHMA AND The mainstay of the pharmacological management of asthma and chronic obstructive pulmonary disease (COPD) is the use of inhaled drugs. This route enables drugs to be delivered to the site of their action, minimising the risk of adverse effects caused by systemic absorption.×
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