Are you over 18 and want to see adult content?
More Annotations
A complete backup of https://vivalavita.gr
Are you over 18 and want to see adult content?
A complete backup of https://newsfood.com
Are you over 18 and want to see adult content?
A complete backup of https://brillen-sehhilfen.de
Are you over 18 and want to see adult content?
A complete backup of https://whitelodging.com
Are you over 18 and want to see adult content?
A complete backup of https://topformtemplates.com
Are you over 18 and want to see adult content?
A complete backup of https://light.gg
Are you over 18 and want to see adult content?
A complete backup of https://jemako-shop.com
Are you over 18 and want to see adult content?
A complete backup of https://henri-charpentier.com
Are you over 18 and want to see adult content?
A complete backup of https://jospongroup.com
Are you over 18 and want to see adult content?
A complete backup of https://eminism.org
Are you over 18 and want to see adult content?
A complete backup of https://graysonramsfootball.com
Are you over 18 and want to see adult content?
A complete backup of https://onumismata.com
Are you over 18 and want to see adult content?
Favourite Annotations
A complete backup of https://performancetrends.com
Are you over 18 and want to see adult content?
A complete backup of https://stylesbeautytips.com
Are you over 18 and want to see adult content?
A complete backup of https://culligan.com.tw
Are you over 18 and want to see adult content?
A complete backup of https://dw-formmailer.de
Are you over 18 and want to see adult content?
A complete backup of https://sharkstewards.org
Are you over 18 and want to see adult content?
A complete backup of https://oldcolonyymca.org
Are you over 18 and want to see adult content?
A complete backup of https://abfaisfahan.com
Are you over 18 and want to see adult content?
A complete backup of https://aytosanlorenzo.es
Are you over 18 and want to see adult content?
A complete backup of https://kdsm17.com
Are you over 18 and want to see adult content?
A complete backup of https://silverdaggers.net
Are you over 18 and want to see adult content?
Text
IIVSABOUT
Leader in In Vitro Toxicology Field, Rigorous Scientific & Compliance Programs, Promotes Use & Regulatory Acceptance of Alternative TestingMethods Worldwide,
ABOUT THE INSTITUTE FOR IN VITRO SCIENCES About. The Institute for In Vitro Sciences, Inc. is a non-profit research and testing laboratory dedicated to the advancement of in vitro (non-animal) methods worldwide. Founded in 1997, the Institute is unique in its position as a high quality testing laboratory while also offering technical and educational resources to advance thefield.
TOXICOLOGY TESTING, ACUTE TOXICITY, SYSTEMIC TOXICITY A leader in in vitro test methods, IIVS brings extensive expertise and knowledge in in vitro assay validation as well as extensive experience in serving the testing needs of diverse industrial clients. Our familiarity with an array of different assay systems and product lines gives us the knowledge and expertise to work with our clients to determine the optimum assay for specific testSENSITIZATION
The DPRA is an in chemico assay that models the first key event in the skin sensitization Adverse Outcome Pathway (AOP) – skin, protein reactivity. Compounds implicated in causing Allergic Contact Dermatitis (ACD) are generally electrophilic in nature. This assay identifies dermal sensitizers based on their reactivity with synthetic peptides containing the nucleophilic amino acid residues NOCIOCULAR EYE STING TRPV1 Channel Mechanism. The NociOcular Assay predicts the eye stinging potential of materials, such as cosmetics, sunscreens, surfactants, and ophthalmic products. The assay relies on the expression of functional ion channels (TRPV1) in a clone of the human cell line. The TRPV1 channel is a well characterized pain receptorthat is present in
SENS-IS® - IIVS
SENS-IS®. As a next-generation assay, SENS-IS employs a Reconstructed human Epidermal (RhE) model and examines changes in the gene expression of 65 markers associated with epidermal response to pure compounds and formulations. The RhE model provides several features not represented in monolayer-based assays, including the barrierproperties of
SKIN IRRITATION TEST (SIT, OECD 439) Skin Irritation in the regulatory hazard classification and labeling context is defined as the production of reversible damage to skin following a defined chemical exposure. The Skin Irritation Test (SIT) is an in vitro, non-animal test designed to identify those chemicals and mixtures capable of inducing moderate skin irritation (UN GHS CORROSITEX (OECD 435) Corrositex (OECD 435) The Corrositex® assay is a standardized and quantitative in vitro test developed as a replacement for the dermal corrosivity rabbit test. The Corrositex kit, manufactured by In Vitro International (IVI), uses a proprietary biobarrier membrane to model the skin for evaluating the potential dermal corrosivity of a testEPI-MODEL 24
Shipping Study to Evaluate the Performance of the LabCyte EPI-MODEL 24 Tissues for Use in the Skin Irritation Test (OECD TG 439) After Long-Haul Airfreight. March 18, 2019. It is recommended that an evaluation of the impact of shipping of Reconstructed human Epidermis (RhE) tissues be conducted especially after long-haul airfreightshipments.
EVALUATION OF TRPV1 ACTIVITY TO ASSESS THE EYE STINGING Evaluation of TRPV1 Activity to Assess the Eye Stinging Potential of Cosmetic Formulations Arvind Gill1, Wei Chen1, Kimberly Norman2, Lindsay Krawiec2, Dang Alphonsus1 and Cristi Gomez1 1 Department of Product Safety, Mary Kay Inc., Dallas, TX, USA 2 Institute for In Vitro Sciences, Inc., Gaithersburg, MD, USA BACKGROUND The Transient Receptor Potential Vanilloid type 1 (TRPV1) receptor is one NON ANIMAL TESTING, IN VITRO TOXICOLOGY, ALTERNATIVE TESTINGTESTING SERVICESINDUSTRIES WE SERVEEDUCATION & OUTREACHNEWS & RESOURCESWHYIIVSABOUT
Leader in In Vitro Toxicology Field, Rigorous Scientific & Compliance Programs, Promotes Use & Regulatory Acceptance of Alternative TestingMethods Worldwide,
ABOUT THE INSTITUTE FOR IN VITRO SCIENCES About. The Institute for In Vitro Sciences, Inc. is a non-profit research and testing laboratory dedicated to the advancement of in vitro (non-animal) methods worldwide. Founded in 1997, the Institute is unique in its position as a high quality testing laboratory while also offering technical and educational resources to advance thefield.
TOXICOLOGY TESTING, ACUTE TOXICITY, SYSTEMIC TOXICITY A leader in in vitro test methods, IIVS brings extensive expertise and knowledge in in vitro assay validation as well as extensive experience in serving the testing needs of diverse industrial clients. Our familiarity with an array of different assay systems and product lines gives us the knowledge and expertise to work with our clients to determine the optimum assay for specific testSENSITIZATION
The DPRA is an in chemico assay that models the first key event in the skin sensitization Adverse Outcome Pathway (AOP) – skin, protein reactivity. Compounds implicated in causing Allergic Contact Dermatitis (ACD) are generally electrophilic in nature. This assay identifies dermal sensitizers based on their reactivity with synthetic peptides containing the nucleophilic amino acid residues NOCIOCULAR EYE STING TRPV1 Channel Mechanism. The NociOcular Assay predicts the eye stinging potential of materials, such as cosmetics, sunscreens, surfactants, and ophthalmic products. The assay relies on the expression of functional ion channels (TRPV1) in a clone of the human cell line. The TRPV1 channel is a well characterized pain receptorthat is present in
SENS-IS® - IIVS
SENS-IS®. As a next-generation assay, SENS-IS employs a Reconstructed human Epidermal (RhE) model and examines changes in the gene expression of 65 markers associated with epidermal response to pure compounds and formulations. The RhE model provides several features not represented in monolayer-based assays, including the barrierproperties of
SKIN IRRITATION TEST (SIT, OECD 439) Skin Irritation in the regulatory hazard classification and labeling context is defined as the production of reversible damage to skin following a defined chemical exposure. The Skin Irritation Test (SIT) is an in vitro, non-animal test designed to identify those chemicals and mixtures capable of inducing moderate skin irritation (UN GHS CORROSITEX (OECD 435) Corrositex (OECD 435) The Corrositex® assay is a standardized and quantitative in vitro test developed as a replacement for the dermal corrosivity rabbit test. The Corrositex kit, manufactured by In Vitro International (IVI), uses a proprietary biobarrier membrane to model the skin for evaluating the potential dermal corrosivity of a testEPI-MODEL 24
Shipping Study to Evaluate the Performance of the LabCyte EPI-MODEL 24 Tissues for Use in the Skin Irritation Test (OECD TG 439) After Long-Haul Airfreight. March 18, 2019. It is recommended that an evaluation of the impact of shipping of Reconstructed human Epidermis (RhE) tissues be conducted especially after long-haul airfreightshipments.
EVALUATION OF TRPV1 ACTIVITY TO ASSESS THE EYE STINGING Evaluation of TRPV1 Activity to Assess the Eye Stinging Potential of Cosmetic Formulations Arvind Gill1, Wei Chen1, Kimberly Norman2, Lindsay Krawiec2, Dang Alphonsus1 and Cristi Gomez1 1 Department of Product Safety, Mary Kay Inc., Dallas, TX, USA 2 Institute for In Vitro Sciences, Inc., Gaithersburg, MD, USA BACKGROUND The Transient Receptor Potential Vanilloid type 1 (TRPV1) receptor is oneSENSITIZATION
The DPRA is an in chemico assay that models the first key event in the skin sensitization Adverse Outcome Pathway (AOP) – skin, protein reactivity. Compounds implicated in causing Allergic Contact Dermatitis (ACD) are generally electrophilic in nature. This assay identifies dermal sensitizers based on their reactivity with synthetic peptides containing the nucleophilic amino acid residues SKIN IRRITATION TEST (SIT, OECD 439) Skin Irritation in the regulatory hazard classification and labeling context is defined as the production of reversible damage to skin following a defined chemical exposure. The Skin Irritation Test (SIT) is an in vitro, non-animal test designed to identify those chemicals and mixtures capable of inducing moderate skin irritation (UN GHS TIERED TESTING APPROACHES Tiered Testing Approaches. In spite of intensive effort over the last twenty years, only a few in vitro assays for acute endpoints are internationally accepted as validated. However, many industrial organizations use multiple in vitro assays on a daily basis to make safety and efficacy decisions. Industry has confidence in thisapproach because
EYE IRRITATION TEST (EIT, OECD 492) Eye Irritation Test using Reconstructed Human Corneal Epithelium (RhCE) Models (EIT, OECD 492) The Eye Irritation Test (EIT) is an OECD-approved in vitro non-animal test method for identifying chemicals and mixtures that may be irritating to the corneal epithelium. The test method utilizes an in vitro reconstructed humancorneal epithelium
CORROSITEX (OECD 435) Corrositex (OECD 435) The Corrositex® assay is a standardized and quantitative in vitro test developed as a replacement for the dermal corrosivity rabbit test. The Corrositex kit, manufactured by In Vitro International (IVI), uses a proprietary biobarrier membrane to model the skin for evaluating the potential dermal corrosivity of a test SKIN IRRITATION TEST Skin Irritation Test (SIT) in a Reconstructed Human Epidermis (RhE) Model Skin Irritation in the regulatory hazard classification and labeling context is defined as the production of reversible damage to skin following a defined chemical exposure. The Skin Irritation Test (SIT) is an in vitro, non-animal test designed to identify thoseAGAR OVERLAY
AGAR Overlay August 22, 2016 The agar overlay assay or agar diffusion test is an in vitro cytotoxicity assay designed to show the presence of toxic material eluted from a test sample as it affects L929 cells cultured in the presence of the test article. RECONSTRUCTED HUMAN EPIDERMIS (RHE) MODELS The 3-D Phototoxicity assay uses reconstructed human epidermal (RhE) tissue constructs to evaluate the dermal phototoxicity potential of a test material. Toxicity is determined by measuring cytotoxicity in cultures treated with the test material in the presence and absence ofEPI-MODEL 24
Shipping Study to Evaluate the Performance of the LabCyte EPI-MODEL 24 Tissues for Use in the Skin Irritation Test (OECD TG 439) After Long-Haul Airfreight. March 18, 2019. It is recommended that an evaluation of the impact of shipping of Reconstructed human Epidermis (RhE) tissues be conducted especially after long-haul airfreightshipments.
CURRENT STATUS OF AVAILABLE IN VITRO TESTS FOR VAGINAL Whole animal test systems In vitro alternative models Rabbit Slug (Arion lusitanicus) Cell culture systems Reconstructed tissues Explantsel • Preclinical safety testing of microbicides • Testing of vaginal tolerance to spermicidal preparations NON ANIMAL TESTING, IN VITRO TOXICOLOGY, ALTERNATIVE TESTINGTESTING SERVICESINDUSTRIES WE SERVEEDUCATION & OUTREACHNEWS & RESOURCESWHYIIVSABOUT
Leader in In Vitro Toxicology Field, Rigorous Scientific & Compliance Programs, Promotes Use & Regulatory Acceptance of Alternative TestingMethods Worldwide,
ABOUT THE INSTITUTE FOR IN VITRO SCIENCES About. The Institute for In Vitro Sciences, Inc. is a non-profit research and testing laboratory dedicated to the advancement of in vitro (non-animal) methods worldwide. Founded in 1997, the Institute is unique in its position as a high quality testing laboratory while also offering technical and educational resources to advance thefield.
SENSITIZATION
The DPRA is an in chemico assay that models the first key event in the skin sensitization Adverse Outcome Pathway (AOP) – skin, protein reactivity. Compounds implicated in causing Allergic Contact Dermatitis (ACD) are generally electrophilic in nature. This assay identifies dermal sensitizers based on their reactivity with synthetic peptides containing the nucleophilic amino acid residues TOXICOLOGY TESTING, ACUTE TOXICITY, SYSTEMIC TOXICITY A leader in in vitro test methods, IIVS brings extensive expertise and knowledge in in vitro assay validation as well as extensive experience in serving the testing needs of diverse industrial clients. Our familiarity with an array of different assay systems and product lines gives us the knowledge and expertise to work with our clients to determine the optimum assay for specific test EYE IRRITATION TEST (EIT, OECD 492) Eye Irritation Test using Reconstructed Human Corneal Epithelium (RhCE) Models (EIT, OECD 492) The Eye Irritation Test (EIT) is an OECD-approved in vitro non-animal test method for identifying chemicals and mixtures that may be irritating to the corneal epithelium. The test method utilizes an in vitro reconstructed humancorneal epithelium
MEM ELUTION
The MEM elution assay or elution test is an in vitro cytotoxicity assay designed to show the presence of toxic material eluted from a test sample as it affects L929 cells cultured in the presence of the extract.. Extracts of test articles are applied to L929 cells. After treatment, the cells are exposed to neutral red dye to differentiate between the viable and stressed or lysed cells. SKIN IRRITATION TEST (SIT, OECD 439) Skin Irritation in the regulatory hazard classification and labeling context is defined as the production of reversible damage to skin following a defined chemical exposure. The Skin Irritation Test (SIT) is an in vitro, non-animal test designed to identify those chemicals and mixtures capable of inducing moderate skin irritation (UN GHS NOCIOCULAR EYE STING TRPV1 Channel Mechanism. The NociOcular Assay predicts the eye stinging potential of materials, such as cosmetics, sunscreens, surfactants, and ophthalmic products. The assay relies on the expression of functional ion channels (TRPV1) in a clone of the human cell line. The TRPV1 channel is a well characterized pain receptorthat is present in
SENS-IS® - IIVS
SENS-IS®. As a next-generation assay, SENS-IS employs a Reconstructed human Epidermal (RhE) model and examines changes in the gene expression of 65 markers associated with epidermal response to pure compounds and formulations. The RhE model provides several features not represented in monolayer-based assays, including the barrierproperties of
RECONSTRUCTED HUMAN EPIDERMIS (RHE) MODELS The 3-D Phototoxicity assay uses reconstructed human epidermal (RhE) tissue constructs to evaluate the dermal phototoxicity potential of a test material. Toxicity is determined by measuring cytotoxicity in cultures treated with the test material in the presence and absence of NON ANIMAL TESTING, IN VITRO TOXICOLOGY, ALTERNATIVE TESTINGTESTING SERVICESINDUSTRIES WE SERVEEDUCATION & OUTREACHNEWS & RESOURCESWHYIIVSABOUT
Leader in In Vitro Toxicology Field, Rigorous Scientific & Compliance Programs, Promotes Use & Regulatory Acceptance of Alternative TestingMethods Worldwide,
ABOUT THE INSTITUTE FOR IN VITRO SCIENCES About. The Institute for In Vitro Sciences, Inc. is a non-profit research and testing laboratory dedicated to the advancement of in vitro (non-animal) methods worldwide. Founded in 1997, the Institute is unique in its position as a high quality testing laboratory while also offering technical and educational resources to advance thefield.
SENSITIZATION
The DPRA is an in chemico assay that models the first key event in the skin sensitization Adverse Outcome Pathway (AOP) – skin, protein reactivity. Compounds implicated in causing Allergic Contact Dermatitis (ACD) are generally electrophilic in nature. This assay identifies dermal sensitizers based on their reactivity with synthetic peptides containing the nucleophilic amino acid residues TOXICOLOGY TESTING, ACUTE TOXICITY, SYSTEMIC TOXICITY A leader in in vitro test methods, IIVS brings extensive expertise and knowledge in in vitro assay validation as well as extensive experience in serving the testing needs of diverse industrial clients. Our familiarity with an array of different assay systems and product lines gives us the knowledge and expertise to work with our clients to determine the optimum assay for specific test EYE IRRITATION TEST (EIT, OECD 492) Eye Irritation Test using Reconstructed Human Corneal Epithelium (RhCE) Models (EIT, OECD 492) The Eye Irritation Test (EIT) is an OECD-approved in vitro non-animal test method for identifying chemicals and mixtures that may be irritating to the corneal epithelium. The test method utilizes an in vitro reconstructed humancorneal epithelium
MEM ELUTION
The MEM elution assay or elution test is an in vitro cytotoxicity assay designed to show the presence of toxic material eluted from a test sample as it affects L929 cells cultured in the presence of the extract.. Extracts of test articles are applied to L929 cells. After treatment, the cells are exposed to neutral red dye to differentiate between the viable and stressed or lysed cells. SKIN IRRITATION TEST (SIT, OECD 439) Skin Irritation in the regulatory hazard classification and labeling context is defined as the production of reversible damage to skin following a defined chemical exposure. The Skin Irritation Test (SIT) is an in vitro, non-animal test designed to identify those chemicals and mixtures capable of inducing moderate skin irritation (UN GHS NOCIOCULAR EYE STING TRPV1 Channel Mechanism. The NociOcular Assay predicts the eye stinging potential of materials, such as cosmetics, sunscreens, surfactants, and ophthalmic products. The assay relies on the expression of functional ion channels (TRPV1) in a clone of the human cell line. The TRPV1 channel is a well characterized pain receptorthat is present in
SENS-IS® - IIVS
SENS-IS®. As a next-generation assay, SENS-IS employs a Reconstructed human Epidermal (RhE) model and examines changes in the gene expression of 65 markers associated with epidermal response to pure compounds and formulations. The RhE model provides several features not represented in monolayer-based assays, including the barrierproperties of
RECONSTRUCTED HUMAN EPIDERMIS (RHE) MODELS The 3-D Phototoxicity assay uses reconstructed human epidermal (RhE) tissue constructs to evaluate the dermal phototoxicity potential of a test material. Toxicity is determined by measuring cytotoxicity in cultures treated with the test material in the presence and absence of TOXICOLOGY TESTING, ACUTE TOXICITY, SYSTEMIC TOXICITY A leader in in vitro test methods, IIVS brings extensive expertise and knowledge in in vitro assay validation as well as extensive experience in serving the testing needs of diverse industrial clients. Our familiarity with an array of different assay systems and product lines gives us the knowledge and expertise to work with our clients to determine the optimum assay for specific testMEM ELUTION
The MEM elution assay or elution test is an in vitro cytotoxicity assay designed to show the presence of toxic material eluted from a test sample as it affects L929 cells cultured in the presence of the extract.. Extracts of test articles are applied to L929 cells. After treatment, the cells are exposed to neutral red dye to differentiate between the viable and stressed or lysed cells. EXPERTS IN VITRO TOXICOLOGY, MANAGEMENT TEAM AT IIVS President. Ms. Hill co-founded IIVS in 1997 with Dr. Rodger Curren where she is currently President and a member of the Board of Directors. As President, Ms. Hill is responsible for planning, directing and coordinating activities to achieve IIVS’ mission of increasing the use and acceptance of in vitro methods. She also interacts with other groups, both domestic and international, who are EYE IRRITATION TEST (EIT, OECD 492) The Eye Irritation Test (EIT) is an OECD-approved in vitro non-animal test method for identifying chemicals and mixtures that may be irritating to the corneal epithelium. The test method utilizes an in vitro reconstructed human corneal epithelium (RhCE) model (EpiOcular™, MatTek Corp. or HCE, SkinEthic™), in an acute exposure assay to support international regulatory labelingrequirements
TIERED TESTING APPROACHES Tiered Testing Approaches. In spite of intensive effort over the last twenty years, only a few in vitro assays for acute endpoints are internationally accepted as validated. However, many industrial organizations use multiple in vitro assays on a daily basis to make safety and efficacy decisions. Industry has confidence in thisapproach because
CORROSITEX (OECD 435) Corrositex (OECD 435) The Corrositex® assay is a standardized and quantitative in vitro test developed as a replacement for the dermal corrosivity rabbit test. The Corrositex kit, manufactured by In Vitro International (IVI), uses a proprietary biobarrier membrane to model the skin for evaluating the potential dermal corrosivity of a test SKIN CORROSION TEST (OECD 431) Skin Corrosion Test (OECD 431) Skin Corrosion in the regulatory hazard classification and labeling context is defined as the production of irreversible damage to skin, generally evident as necrosis through the epidermis and into the dermis, following a defined chemical exposure. The In Vitro Skin Corrosion Test is an in vitro, non-animal test SKIN IRRITATION TEST Skin Irritation Test (SIT) in a Reconstructed Human Epidermis (RhE) Model Skin Irritation in the regulatory hazard classification and labeling context is defined as the production of reversible damage to skin following a defined chemical exposure. The Skin Irritation Test (SIT) is an in vitro, non-animal test designed to identify those ADDRESSING THE ASSIGNMENT OF US EPA HAZARD CATEGORIES FOR Addressing the Assignment of US EPA Hazard Categories for Dermal Safety by a Revised Prediction Model of the Validated In Vitro Skin Irritation Test (OECD TG 439) D. Sheehan, V. Diersen, R. Pham, A. Pidathala, M. Lamm, H. Raabe, R. Curren, and G.-E. Costin. EVALUATION OF TRPV1 ACTIVITY TO ASSESS THE EYE STINGING Evaluation of TRPV1 Activity to Assess the Eye Stinging Potential of Cosmetic Formulations Arvind Gill1, Wei Chen1, Kimberly Norman2, Lindsay Krawiec2, Dang Alphonsus1 and Cristi Gomez1 1 Department of Product Safety, Mary Kay Inc., Dallas, TX, USA 2 Institute for In Vitro Sciences, Inc., Gaithersburg, MD, USA BACKGROUND The Transient Receptor Potential Vanilloid type 1 (TRPV1) receptor is one NON ANIMAL TESTING, IN VITRO TOXICOLOGY, ALTERNATIVE TESTINGTESTING SERVICESINDUSTRIES WE SERVEEDUCATION & OUTREACHNEWS & RESOURCESWHYIIVSABOUT
Leader in In Vitro Toxicology Field, Rigorous Scientific & Compliance Programs, Promotes Use & Regulatory Acceptance of Alternative TestingMethods Worldwide,
ABOUT THE INSTITUTE FOR IN VITRO SCIENCES About. The Institute for In Vitro Sciences, Inc. is a non-profit research and testing laboratory dedicated to the advancement of in vitro (non-animal) methods worldwide. Founded in 1997, the Institute is unique in its position as a high quality testing laboratory while also offering technical and educational resources to advance thefield.
SENSITIZATION
The DPRA is an in chemico assay that models the first key event in the skin sensitization Adverse Outcome Pathway (AOP) – skin, protein reactivity. Compounds implicated in causing Allergic Contact Dermatitis (ACD) are generally electrophilic in nature. This assay identifies dermal sensitizers based on their reactivity with synthetic peptides containing the nucleophilic amino acid residues TOXICOLOGY TESTING, ACUTE TOXICITY, SYSTEMIC TOXICITY A leader in in vitro test methods, IIVS brings extensive expertise and knowledge in in vitro assay validation as well as extensive experience in serving the testing needs of diverse industrial clients. Our familiarity with an array of different assay systems and product lines gives us the knowledge and expertise to work with our clients to determine the optimum assay for specific test NOCIOCULAR EYE STING TRPV1 Channel Mechanism. The NociOcular Assay predicts the eye stinging potential of materials, such as cosmetics, sunscreens, surfactants, and ophthalmic products. The assay relies on the expression of functional ion channels (TRPV1) in a clone of the human cell line. The TRPV1 channel is a well characterized pain receptorthat is present in
SENS-IS® - IIVS
SENS-IS®. As a next-generation assay, SENS-IS employs a Reconstructed human Epidermal (RhE) model and examines changes in the gene expression of 65 markers associated with epidermal response to pure compounds and formulations. The RhE model provides several features not represented in monolayer-based assays, including the barrierproperties of
SKIN IRRITATION TEST (SIT, OECD 439) Skin Irritation in the regulatory hazard classification and labeling context is defined as the production of reversible damage to skin following a defined chemical exposure. The Skin Irritation Test (SIT) is an in vitro, non-animal test designed to identify those chemicals and mixtures capable of inducing moderate skin irritation (UN GHS 3T3 NEUTRAL RED UPTAKE (OECD 432) 3T3 Phototoxicity (OECD 432) The 3T3 Neutral Red Uptake (NRU) Phototoxicity assay is a 96-well cytotoxicity-based assay that utilizes BALB/c 3T3 mouse fibroblasts to measure the concentration-dependent reduction in neutral red uptake by the cells after exposure to a test material in the presence and absence of UVAlight.
RECONSTRUCTED HUMAN EPIDERMIS (RHE) MODELS The 3-D Phototoxicity assay uses reconstructed human epidermal (RhE) tissue constructs to evaluate the dermal phototoxicity potential of a test material. Toxicity is determined by measuring cytotoxicity in cultures treated with the test material in the presence and absence of APPLYING GOOD LABORATORY PRACTICES (GLPS) TO IN VITRO 0 50 100 150 200 7-J u l-0 4 2 1-J u l-0 4 4-A u g-0 4 1 8-A u g-0 4 1-S e p-0 4 1 5-S e p 0 4 2 9-S e p-0 4 1 3-O c t-0 4 2 7-O c t-0 4 1 0-N o v-0 4 2 4-N o v-0 4 8 NON ANIMAL TESTING, IN VITRO TOXICOLOGY, ALTERNATIVE TESTINGTESTING SERVICESINDUSTRIES WE SERVEEDUCATION & OUTREACHNEWS & RESOURCESWHYIIVSABOUT
Leader in In Vitro Toxicology Field, Rigorous Scientific & Compliance Programs, Promotes Use & Regulatory Acceptance of Alternative TestingMethods Worldwide,
ABOUT THE INSTITUTE FOR IN VITRO SCIENCES About. The Institute for In Vitro Sciences, Inc. is a non-profit research and testing laboratory dedicated to the advancement of in vitro (non-animal) methods worldwide. Founded in 1997, the Institute is unique in its position as a high quality testing laboratory while also offering technical and educational resources to advance thefield.
SENSITIZATION
The DPRA is an in chemico assay that models the first key event in the skin sensitization Adverse Outcome Pathway (AOP) – skin, protein reactivity. Compounds implicated in causing Allergic Contact Dermatitis (ACD) are generally electrophilic in nature. This assay identifies dermal sensitizers based on their reactivity with synthetic peptides containing the nucleophilic amino acid residues TOXICOLOGY TESTING, ACUTE TOXICITY, SYSTEMIC TOXICITY A leader in in vitro test methods, IIVS brings extensive expertise and knowledge in in vitro assay validation as well as extensive experience in serving the testing needs of diverse industrial clients. Our familiarity with an array of different assay systems and product lines gives us the knowledge and expertise to work with our clients to determine the optimum assay for specific test NOCIOCULAR EYE STING TRPV1 Channel Mechanism. The NociOcular Assay predicts the eye stinging potential of materials, such as cosmetics, sunscreens, surfactants, and ophthalmic products. The assay relies on the expression of functional ion channels (TRPV1) in a clone of the human cell line. The TRPV1 channel is a well characterized pain receptorthat is present in
SENS-IS® - IIVS
SENS-IS®. As a next-generation assay, SENS-IS employs a Reconstructed human Epidermal (RhE) model and examines changes in the gene expression of 65 markers associated with epidermal response to pure compounds and formulations. The RhE model provides several features not represented in monolayer-based assays, including the barrierproperties of
SKIN IRRITATION TEST (SIT, OECD 439) Skin Irritation in the regulatory hazard classification and labeling context is defined as the production of reversible damage to skin following a defined chemical exposure. The Skin Irritation Test (SIT) is an in vitro, non-animal test designed to identify those chemicals and mixtures capable of inducing moderate skin irritation (UN GHS 3T3 NEUTRAL RED UPTAKE (OECD 432) 3T3 Phototoxicity (OECD 432) The 3T3 Neutral Red Uptake (NRU) Phototoxicity assay is a 96-well cytotoxicity-based assay that utilizes BALB/c 3T3 mouse fibroblasts to measure the concentration-dependent reduction in neutral red uptake by the cells after exposure to a test material in the presence and absence of UVAlight.
RECONSTRUCTED HUMAN EPIDERMIS (RHE) MODELS The 3-D Phototoxicity assay uses reconstructed human epidermal (RhE) tissue constructs to evaluate the dermal phototoxicity potential of a test material. Toxicity is determined by measuring cytotoxicity in cultures treated with the test material in the presence and absence of APPLYING GOOD LABORATORY PRACTICES (GLPS) TO IN VITRO 0 50 100 150 200 7-J u l-0 4 2 1-J u l-0 4 4-A u g-0 4 1 8-A u g-0 4 1-S e p-0 4 1 5-S e p 0 4 2 9-S e p-0 4 1 3-O c t-0 4 2 7-O c t-0 4 1 0-N o v-0 4 2 4-N o v-0 4 8 EXPERTS IN VITRO TOXICOLOGY, MANAGEMENT TEAM AT IIVS President. Ms. Hill co-founded IIVS in 1997 with Dr. Rodger Curren where she is currently President and a member of the Board of Directors. As President, Ms. Hill is responsible for planning, directing and coordinating activities to achieve IIVS’ mission of increasing the use and acceptance of in vitro methods. She also interacts with other groups, both domestic and international, who are EYE IRRITATION TEST (EIT, OECD 492) Eye Irritation Test using Reconstructed Human Corneal Epithelium (RhCE) Models (EIT, OECD 492) The Eye Irritation Test (EIT) is an OECD-approved in vitro non-animal test method for identifying chemicals and mixtures that may be irritating to the corneal epithelium. The test method utilizes an in vitro reconstructed humancorneal epithelium
TIERED TESTING APPROACHES Tiered Testing Approaches. In spite of intensive effort over the last twenty years, only a few in vitro assays for acute endpoints are internationally accepted as validated. However, many industrial organizations use multiple in vitro assays on a daily basis to make safety and efficacy decisions. Industry has confidence in thisapproach because
CORROSITEX (OECD 435) Corrositex (OECD 435) The Corrositex® assay is a standardized and quantitative in vitro test developed as a replacement for the dermal corrosivity rabbit test. The Corrositex kit, manufactured by In Vitro International (IVI), uses a proprietary biobarrier membrane to model the skin for evaluating the potential dermal corrosivity of a test RECONSTRUCTED HUMAN EPIDERMIS (RHE) MODELS The 3-D Phototoxicity assay uses reconstructed human epidermal (RhE) tissue constructs to evaluate the dermal phototoxicity potential of a test material. Toxicity is determined by measuring cytotoxicity in cultures treated with the test material in the presence and absence of SKIN CORROSION TEST (OECD 431) Skin Corrosion Test (OECD 431) Skin Corrosion in the regulatory hazard classification and labeling context is defined as the production of irreversible damage to skin, generally evident as necrosis through the epidermis and into the dermis, following a defined chemical exposure. The In Vitro Skin Corrosion Test is an in vitro, non-animal testAGAR OVERLAY
AGAR Overlay. The agar overlay assay or agar diffusion test is an in vitro cytotoxicity assay designed to show the presence of toxic material eluted from a test sample as it affects L929 cells cultured in the presence of the test article. Test articles are placed onto the agar surface overlaid onto a L929 cell monolayer preventing directdamage
EPI-MODEL 24
Shipping Study to Evaluate the Performance of the LabCyte EPI-MODEL 24 Tissues for Use in the Skin Irritation Test (OECD TG 439) After Long-Haul Airfreight. March 18, 2019. It is recommended that an evaluation of the impact of shipping of Reconstructed human Epidermis (RhE) tissues be conducted especially after long-haul airfreightshipments.
ADDRESSING THE ASSIGNMENT OF US EPA HAZARD CATEGORIES FOR Addressing the Assignment of US EPA Hazard Categories for Dermal Safety by a Revised Prediction Model of the Validated In Vitro Skin Irritation Test (OECD TG 439) D. Sheehan, V. Diersen, R. Pham, A. Pidathala, M. Lamm, H. Raabe, R. Curren, and G.-E. Costin. EVALUATION OF TRPV1 ACTIVITY TO ASSESS THE EYE STINGING Evaluation of TRPV1 Activity to Assess the Eye Stinging Potential of Cosmetic Formulations Arvind Gill1, Wei Chen1, Kimberly Norman2, Lindsay Krawiec2, Dang Alphonsus1 and Cristi Gomez1 1 Department of Product Safety, Mary Kay Inc., Dallas, TX, USA 2 Institute for In Vitro Sciences, Inc., Gaithersburg, MD, USA BACKGROUND The Transient Receptor Potential Vanilloid type 1 (TRPV1) receptor is one__
__
Search __ __
__
* Careers
* Sign Up for Our Newsletter* Submit a Sample
__
* __ Testing Services* __Assays__
* __Eye Irritation
* __Skin Irritation, Corrosion, Pigmentation * __Skin Sensitization * __Phototoxicity & Photoallergy * __Mucosal Irritation * __Respiratory Toxicology * __Systemic Toxicity Screening * __Genetic Toxicology*
* __Custom Services__ * __Precision Cut Lung Slice Purchase Inquiry * __Efficacy Testing Services * __Industries We Serve * __Cosmetics & Personal Care * __Specialty Chemical * __Household & Cleaning Products * __Agro/Petrochemical* __Pharmaceutical
* __Fragrance & Flavors * __Next Generation Tobacco Products* __Medical Devices
* __Occupational Safety & Industrial Hygiene * __News & Resources * __Education & Outreach__ * __Practical Methods for In Vitro Toxicology Workshop * __Working With Regulators * __International Outreach Program * __Documents & Resources__* __Publications
* __Posters & Presentations * __Webinars & Videos * __News & IIVS Activities__* __Press Room
* __Newsletters
* __About IIVS
* __Contact Us
* __Contributors
* __IIVS Team
* __ Why IIVS? * Testing Services____
* Assays ____
* Eye Irritation
____
* Skin Irritation, Corrosion, Pigmentation____
* Skin Sensitization____
* Phototoxicity & Photoallergy____
* Mucosal Irritation____
* Respiratory Toxicology____
* Systemic Toxicity Screening____
* Genetic Toxicology____
*
* Custom Services
____
* Precision Cut Lung Slice Purchase Inquiry____ * Efficacy Testing Services____
* Industries We Serve ____ * Cosmetics & Personal Care____
* Specialty Chemical____
* Household & Cleaning Products____
* Agro/Petrochemical____
* Pharmaceutical
____
* Fragrance & Flavors____
* Next Generation Tobacco Products____
* Medical Devices
____
* Occupational Safety & Industrial Hygiene____
* News & Resources ____ * Education & Outreach ____ * Practical Methods for In Vitro Toxicology Workshop____
* Working With Regulators____
* International Outreach Program____
* Documents & Resources____
* Publications ____
* Posters & Presentations____
* Webinars & Videos ____ * News & IIVS Activities____
* Press Room ____
* Newsletters ____
* About IIVS ____
* Contact Us ____
* Contributors ____
* IIVS Team ____
* Why IIVS? ____* Careers ____
* Sign Up for Our Newsletter____
* Submit a Sample ______
YOUR TRUSTED PARTNER FOR IN VITRO TOXICOLOGY As a premier in vitro laboratory, IIVS couples rigorous scientific and compliance programs with education and outreach initiatives to promote the use and acceptance of these methods worldwide.WHY WORK WITH IIVS
WHAT WE DO
__
TESTING SERVICES
IIVS operates a GLP compliant facility with extensive technical capabilities. We perform standard testing services as well as optimize and validate new alternative assays. LEARN ABOUT OUR SERVICES__
INDUSTRIES WE SERVE
We offer in vitro testing services to a variety of industries, including cosmetics/personal care, household products, specialty chemicals, consumer products and pharmaceuticals. READ ABOUT OUR INDUSTRY WORK__
EDUCATION & OUTREACH Our Education and Outreach program is designed to increase the regulatory acceptance of alternative methods through science-based advocacy, rigorous validation and targeted educational programs. GET INVOLVED IN OUR PROGRAMS LATEST NEWS & RESOURCES*
News
IIVS e-News – May 2021 IIVS and the Research Institute for Fragrance Materials (RIFM) have initiated a collaboration to develop tests designed to assess potential respiratory allergens. Developing...May 06, 2021
*
Publication
How a GIVIMP Certification Program Can Increase Confidence in InVitro Methods
Regulatory bodies, validation authorities, method developers, and industry toxicologists realize the need to increase confidence in the scientific validity of novel in vitro...April 20, 2021
*
News
IIVS Co-Publishes Article on Ocular Animal Model Alternatives The human eye may be exposed to chemicals through various situations, such as accidental splashing or exposure to chemical particles, vapours or gases. Workers and consumers...April 20, 2021
* About
* Contribute
* Contact Us
* Sign Up for Our Newsletter* Sitemap
Notifications
Details
Copyright © 2024 ArchiveBay.com. All rights reserved. Terms of Use | Privacy Policy | DMCA | 2021 | Feedback | Advertising | RSS 2.0