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MELATONIN RESEARCH
Melatonin Research is the specific journal which covers any aspect of melatonin and its related research areas. These areas include the bio- physiological functions of melatonin in bacteria, archaea, fungi, plants and animals. The clinical applications of melatonin in humam diseases are especially welcome. VOL 4 NO 1 (2021): MELATONIN RESEARCH Vol 4 No 1 (2021): Melatonin Research. Although effective vaccines for SARS-CoV-2 are available in developed counties, the majority of the population in the developing world will have to wait months or even a year or more to acceess these treatments. During this relatively long period, other therapeutic methods, including melatonin, should beABOUT THE JOURNAL
Home / About the Journal Aims and Scope. Melatonin Research is a blind peer review acadamic journal which provides a platform for all researchers who can freely exchange their ideas, research experience and study results in melatonin and/or its related research fields. MELATONIN: A POTENTIAL THERAPEUTIC AGENT AGAINST COVID-19 Coronaviruses (CoVs) are RNA viruses that cause infections of the respiratory, gastrointestinal, and central nervous systems, among others. The pathological symptoms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) include excessive inflammation, elevated oxidative stress, and an exaggerated immune response, ultimately leading to a cytokine storm and ESTIMATED DOSES OF MELATONIN FOR TREATING DEADLY VIRUS Increased evidence implies that melatonin may be a promising molecule for combating COVID-19 due to its potent antioxidative, anti-inflammatory and immunoregulatory capacities. A frequently asked question concerns the suitable dosage of melatonin for deadly virus infections including COVID-19 patients. The golden standards for a suitable dosage of medicine are safety and effectiveness. POTENTIAL UTILITY OF MELATONIN IN DEADLY INFECTIOUS The high mortality of deadly virus infectious diseases including SARS, MERS, COVID-19, and avian flu is often caused by the uncontrolled innate immune response and destructive inflammation. The majority of viral diseases are self-limiting under the help of the activated adaptive immune system. This activity is cell proliferation dependent and thus, it requires several weeks to develop. A COMPUTER-ASSISTED SYSTEMATIC SEARCH FOR MELATONIN Melatonin Research (Melatonin Res.) http://www.melatonin-research.net Melatonin Res. 2018, Vol 1 (1) 27-58; doi: 10.32794/mr11250003 a A COMPUTER-ASSISTED SYSTEMATIC SEARCH FOR MELATONIN A systematic rational search for newly designed melatonin derivatives, was performed using a computer-assisted protocol. A total of 116 derivatives were generated by adding functional groups (i.e., -OH, -NH2, -SH and -COOH) to the melatonin structure. A selection score (SS) was built to sample the search space, simultaneously considering ADME (absorption, distribution, metabolism, VIEW OF MELATONIN-INDEX AS A BIOMARKER FOR PREDICTING THE Return to Article Details Melatonin-Index as a biomarker for predicting the distribution of presymptomatic and asymptomatic SARS-CoV-2 carriers Download Download PDF Melatonin-Index as a biomarker for predicting the distribution of presymptomatic and asymptomatic SARS-CoV-2 INJECTABLE MELATONIN: AN ANTI-CANCER AND ANTI-VIRAL Intravenous infusion of high doses of melatonin would represent the most eligible route to treat conveniently patients hospitalized in critical care units or with undergoing oncologic therapies, wherein adequate, accurate and constant dosages and high levels of melatonin would be required. After several attempts, a stable concentrate bulk solution of 10% melatonin (Survivis®) has beenMELATONIN RESEARCH
Melatonin Research is the specific journal which covers any aspect of melatonin and its related research areas. These areas include the bio- physiological functions of melatonin in bacteria, archaea, fungi, plants and animals. The clinical applications of melatonin in humam diseases are especially welcome. VOL 4 NO 1 (2021): MELATONIN RESEARCH Vol 4 No 1 (2021): Melatonin Research. Although effective vaccines for SARS-CoV-2 are available in developed counties, the majority of the population in the developing world will have to wait months or even a year or more to acceess these treatments. During this relatively long period, other therapeutic methods, including melatonin, should beABOUT THE JOURNAL
Home / About the Journal Aims and Scope. Melatonin Research is a blind peer review acadamic journal which provides a platform for all researchers who can freely exchange their ideas, research experience and study results in melatonin and/or its related research fields. MELATONIN: A POTENTIAL THERAPEUTIC AGENT AGAINST COVID-19 Coronaviruses (CoVs) are RNA viruses that cause infections of the respiratory, gastrointestinal, and central nervous systems, among others. The pathological symptoms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) include excessive inflammation, elevated oxidative stress, and an exaggerated immune response, ultimately leading to a cytokine storm and ESTIMATED DOSES OF MELATONIN FOR TREATING DEADLY VIRUS Increased evidence implies that melatonin may be a promising molecule for combating COVID-19 due to its potent antioxidative, anti-inflammatory and immunoregulatory capacities. A frequently asked question concerns the suitable dosage of melatonin for deadly virus infections including COVID-19 patients. The golden standards for a suitable dosage of medicine are safety and effectiveness. POTENTIAL UTILITY OF MELATONIN IN DEADLY INFECTIOUS The high mortality of deadly virus infectious diseases including SARS, MERS, COVID-19, and avian flu is often caused by the uncontrolled innate immune response and destructive inflammation. The majority of viral diseases are self-limiting under the help of the activated adaptive immune system. This activity is cell proliferation dependent and thus, it requires several weeks to develop. A COMPUTER-ASSISTED SYSTEMATIC SEARCH FOR MELATONIN Melatonin Research (Melatonin Res.) http://www.melatonin-research.net Melatonin Res. 2018, Vol 1 (1) 27-58; doi: 10.32794/mr11250003 a A COMPUTER-ASSISTED SYSTEMATIC SEARCH FOR MELATONIN A systematic rational search for newly designed melatonin derivatives, was performed using a computer-assisted protocol. A total of 116 derivatives were generated by adding functional groups (i.e., -OH, -NH2, -SH and -COOH) to the melatonin structure. A selection score (SS) was built to sample the search space, simultaneously considering ADME (absorption, distribution, metabolism, VIEW OF MELATONIN-INDEX AS A BIOMARKER FOR PREDICTING THE Return to Article Details Melatonin-Index as a biomarker for predicting the distribution of presymptomatic and asymptomatic SARS-CoV-2 carriers Download Download PDF Melatonin-Index as a biomarker for predicting the distribution of presymptomatic and asymptomatic SARS-CoV-2 INJECTABLE MELATONIN: AN ANTI-CANCER AND ANTI-VIRAL Intravenous infusion of high doses of melatonin would represent the most eligible route to treat conveniently patients hospitalized in critical care units or with undergoing oncologic therapies, wherein adequate, accurate and constant dosages and high levels of melatonin would be required. After several attempts, a stable concentrate bulk solution of 10% melatonin (Survivis®) has been MELATONIN: A POTENTIAL THERAPEUTIC AGENT AGAINST COVID-19 Coronaviruses (CoVs) are RNA viruses that cause infections of the respiratory, gastrointestinal, and central nervous systems, among others. The pathological symptoms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) include excessive inflammation, elevated oxidative stress, and an exaggerated immune response, ultimately leading to a cytokine storm and VOL 3 NO 3 (2020): MELATONIN AND COVID-19 SPECIAL ISSUE Vol 3 No 3 (2020): Melatonin and COVID-19 Special Issue. Since the outbreak of COVID-19 in December 2019, several hundred thousand of infected individuals have lost their life and the global economy has been negatively impacted. Scientists and physicians have spent multiple resources to develop effective vaccines in an attempt tofinally
DOES THE MELATONIN SUPPLEMENTATION DECREASE THE SEVERITY The Coronavirus Disease 2019 (COVID-19) is a global pandemic and there is no specific treatment for reducing the severity of this disease up to date. The majority of the treatments remain supportive and empirical. The aim of present study is to assess the relationship between melatonin supplementation and its effect on the severity of the outcomes in covid-19 patients. POTENTIAL UTILITY OF MELATONIN IN DEADLY INFECTIOUS The high mortality of deadly virus infectious diseases including SARS, MERS, COVID-19, and avian flu is often caused by the uncontrolled innate immune response and destructive inflammation. The majority of viral diseases are self-limiting under the help of the activated adaptive immune system. This activity is cell proliferation dependent and thus, it requires several weeks to develop. VOL 2 NO 2 (2019): MELATONIN RESEARCH Vol 2 No 2 (2019): Melatonin research. In this issue, Lee and Back publish an article (Lee, H.-J. and Back, K. 2019. 2-Hydroxymelatonin confers tolerance against combined cold and drought stress in tobacco, tomato, and cucumber as a potent anti-stress compound in the evolution of land plants. Melatonin Research. 2, 2, 36-47. MELATONIN ATTENUATES GROWTH FACTOR RECEPTOR SIGNALING Melatonin has recently been suggested as a non-specific agent to prevent early (asymptomatic or moderate) infections with SARS-CoV-2 virus, the agent responsible for COVID-19, from developing to severe conditions requiring hospitalization. This recommendation was based on the ability of melatonin to suppress excessive inflammatory reactions and to modulate the immune system by MELATONIN AND THE OPTICS OF THE HUMAN BODY Melatonin is fundamental to the lighting, display, and architectural industries as the primary biomarker used in circadian theory. Billions of dollars are being spent on research, product development, and marketing based on the impact of visible light on melatonin produced by the pineal gland. It has now been shown that the mitochondria produce melatonin in many cells in quantities which are MELATONIN AS AN ALTERNATIVE TO ANTI-FLU VACCINE IN 1. Donzelli A (2018) Influenza vaccinations for all pregnant women? better evidence is needed. Int. J. Environ. Res. Public Health. 15: 2034. doi: 10.3390/ijerph15092034. MELATONIN RECEPTOR-MEDIATED ATTENUATION OF EXCITOTOXIC Melatonin Research (Melatonin Res.) http://www.mealtonin-research.net Melatonin Res. 2021, Vol 4 (2) 336-347; doi: 10.32794/mr11250098 336Research Article
THE PHYTOMELATONIN RECEPTOR (PMRT1) ARABIDOPSIS CAND2 IS It was recently suggested that the protein Cand2 acts as a G protein–coupled receptor (GPCR) for melatonin in Arabidopsis by mediating stomatal closure via H2O2 production and Ca2+ influx. Here, we examined whether Cand2 is indeed a melatonin receptor. Contrary to previous reports, confocal microscopy analyses indicated that Cand2 protein is localized in the cytoplasm rather than the plasmaMELATONIN RESEARCH
Melatonin Research is the specific journal which covers any aspect of melatonin and its related research areas. These areas include the bio- physiological functions of melatonin in bacteria, archaea, fungi, plants and animals. The clinical applications of melatonin in humam diseases are especially welcome. VOL 4 NO 1 (2021): MELATONIN RESEARCH Vol 4 No 1 (2021): Melatonin Research. Although effective vaccines for SARS-CoV-2 are available in developed counties, the majority of the population in the developing world will have to wait months or even a year or more to acceess these treatments. During this relatively long period, other therapeutic methods, including melatonin, should beABOUT THE JOURNAL
Home / About the Journal Aims and Scope. Melatonin Research is a blind peer review acadamic journal which provides a platform for all researchers who can freely exchange their ideas, research experience and study results in melatonin and/or its related research fields. MELATONIN: A POTENTIAL THERAPEUTIC AGENT AGAINST COVID-191 Coronaviruses (CoVs) are RNA viruses that cause infections of the respiratory, gastrointestinal, and central nervous systems, among others. The pathological symptoms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) include excessive inflammation, elevated oxidative stress, and an exaggerated immune response, ultimately leading to a cytokine storm and DOES THE MELATONIN SUPPLEMENTATION DECREASE THE SEVERITY The Coronavirus Disease 2019 (COVID-19) is a global pandemic and there is no specific treatment for reducing the severity of this disease up to date. The majority of the treatments remain supportive and empirical. The aim of present study is to assess the relationship between melatonin supplementation and its effect on the severity of the outcomes in covid-19 patients. ESTIMATED DOSES OF MELATONIN FOR TREATING DEADLY VIRUS Increased evidence implies that melatonin may be a promising molecule for combating COVID-19 due to its potent antioxidative, anti-inflammatory and immunoregulatory capacities. A frequently asked question concerns the suitable dosage of melatonin for deadly virus infections including COVID-19 patients. The golden standards for a suitable dosage of medicine are safety and effectiveness. MELATONIN AND THE OPTICS OF THE HUMAN BODY Melatonin is fundamental to the lighting, display, and architectural industries as the primary biomarker used in circadian theory. Billions of dollars are being spent on research, product development, and marketing based on the impact of visible light on melatonin produced by the pineal gland. It has now been shown that the mitochondria produce melatonin in many cells in quantities which are POTENTIAL UTILITY OF MELATONIN IN DEADLY INFECTIOUS17 The high mortality of deadly virus infectious diseases including SARS, MERS, COVID-19, and avian flu is often caused by the uncontrolled innate immune response and destructive inflammation. The majority of viral diseases are self-limiting under the help of the activated adaptive immune system. This activity is cell proliferation dependent and thus, it requires several weeks to develop. A COMPUTER-ASSISTED SYSTEMATIC SEARCH FOR MELATONIN10 Melatonin Research (Melatonin Res.) http://www.melatonin-research.net Melatonin Res. 2018, Vol 1 (1) 27-58; doi: 10.32794/mr11250003 a INJECTABLE MELATONIN: AN ANTI-CANCER AND ANTI-VIRAL1 Intravenous infusion of high doses of melatonin would represent the most eligible route to treat conveniently patients hospitalized in critical care units or with undergoing oncologic therapies, wherein adequate, accurate and constant dosages and high levels of melatonin would be required. After several attempts, a stable concentrate bulk solution of 10% melatonin (Survivis®) has beenMELATONIN RESEARCH
Melatonin Research is the specific journal which covers any aspect of melatonin and its related research areas. These areas include the bio- physiological functions of melatonin in bacteria, archaea, fungi, plants and animals. The clinical applications of melatonin in humam diseases are especially welcome. VOL 4 NO 1 (2021): MELATONIN RESEARCH Vol 4 No 1 (2021): Melatonin Research. Although effective vaccines for SARS-CoV-2 are available in developed counties, the majority of the population in the developing world will have to wait months or even a year or more to acceess these treatments. During this relatively long period, other therapeutic methods, including melatonin, should beABOUT THE JOURNAL
Home / About the Journal Aims and Scope. Melatonin Research is a blind peer review acadamic journal which provides a platform for all researchers who can freely exchange their ideas, research experience and study results in melatonin and/or its related research fields. MELATONIN: A POTENTIAL THERAPEUTIC AGENT AGAINST COVID-191 Coronaviruses (CoVs) are RNA viruses that cause infections of the respiratory, gastrointestinal, and central nervous systems, among others. The pathological symptoms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) include excessive inflammation, elevated oxidative stress, and an exaggerated immune response, ultimately leading to a cytokine storm and DOES THE MELATONIN SUPPLEMENTATION DECREASE THE SEVERITY The Coronavirus Disease 2019 (COVID-19) is a global pandemic and there is no specific treatment for reducing the severity of this disease up to date. The majority of the treatments remain supportive and empirical. The aim of present study is to assess the relationship between melatonin supplementation and its effect on the severity of the outcomes in covid-19 patients. ESTIMATED DOSES OF MELATONIN FOR TREATING DEADLY VIRUS Increased evidence implies that melatonin may be a promising molecule for combating COVID-19 due to its potent antioxidative, anti-inflammatory and immunoregulatory capacities. A frequently asked question concerns the suitable dosage of melatonin for deadly virus infections including COVID-19 patients. The golden standards for a suitable dosage of medicine are safety and effectiveness. MELATONIN AND THE OPTICS OF THE HUMAN BODY Melatonin is fundamental to the lighting, display, and architectural industries as the primary biomarker used in circadian theory. Billions of dollars are being spent on research, product development, and marketing based on the impact of visible light on melatonin produced by the pineal gland. It has now been shown that the mitochondria produce melatonin in many cells in quantities which are POTENTIAL UTILITY OF MELATONIN IN DEADLY INFECTIOUS17 The high mortality of deadly virus infectious diseases including SARS, MERS, COVID-19, and avian flu is often caused by the uncontrolled innate immune response and destructive inflammation. The majority of viral diseases are self-limiting under the help of the activated adaptive immune system. This activity is cell proliferation dependent and thus, it requires several weeks to develop. A COMPUTER-ASSISTED SYSTEMATIC SEARCH FOR MELATONIN10 Melatonin Research (Melatonin Res.) http://www.melatonin-research.net Melatonin Res. 2018, Vol 1 (1) 27-58; doi: 10.32794/mr11250003 a INJECTABLE MELATONIN: AN ANTI-CANCER AND ANTI-VIRAL1 Intravenous infusion of high doses of melatonin would represent the most eligible route to treat conveniently patients hospitalized in critical care units or with undergoing oncologic therapies, wherein adequate, accurate and constant dosages and high levels of melatonin would be required. After several attempts, a stable concentrate bulk solution of 10% melatonin (Survivis®) has beenABOUT THE JOURNAL
Home / About the Journal Aims and Scope. Melatonin Research is a blind peer review acadamic journal which provides a platform for all researchers who can freely exchange their ideas, research experience and study results in melatonin and/or its related research fields. DOES THE MELATONIN SUPPLEMENTATION DECREASE THE SEVERITY The Coronavirus Disease 2019 (COVID-19) is a global pandemic and there is no specific treatment for reducing the severity of this disease up to date. The majority of the treatments remain supportive and empirical. The aim of present study is to assess the relationship between melatonin supplementation and its effect on the severity of the outcomes in covid-19 patients. VOL 3 NO 1 (2020): MELATONIN RESEARCH Vol 3 No 1 (2020): Melatonin Research. In this issue, the focus is on the potential utility of melatonin use for the unpredictable and rapidly-developing public health events such as in exposure to vesicant chemical warfare agents (Romero et al.), outbreak of Ebola infection (Reiter et al.) and the current COVID-19 pandemic (Tan &Hardeland).
MELATONIN ATTENUATES GROWTH FACTOR RECEPTOR SIGNALING Melatonin has recently been suggested as a non-specific agent to prevent early (asymptomatic or moderate) infections with SARS-CoV-2 virus, the agent responsible for COVID-19, from developing to severe conditions requiring hospitalization. This recommendation was based on the ability of melatonin to suppress excessive inflammatory reactions and to modulate the immune system by A POTENTIAL PROTECTION OF MELATONIN ON PATHOGENESIS OF Oral submucous fibrosisis (OSMF) is a clinical condition of the oral cavity which is caused predominantly by areca nut consumption. This fibrotic condition affects almost all parts of the oral cavity and can cause significant reduction in mouth opening, thereby, resulting in functional impairment. The other potential risk of OSMF is its malignant transformation into oral squamous cell A COMPUTER-ASSISTED SYSTEMATIC SEARCH FOR MELATONIN A systematic rational search for newly designed melatonin derivatives, was performed using a computer-assisted protocol. A total of 116 derivatives were generated by adding functional groups (i.e., -OH, -NH2, -SH and -COOH) to the melatonin structure. A selection score (SS) was built to sample the search space, simultaneously considering ADME (absorption, distribution, metabolism, MELATONIN AS AN ALTERNATIVE TO ANTI-FLU VACCINE IN 1. Donzelli A (2018) Influenza vaccinations for all pregnant women? better evidence is needed. Int. J. Environ. Res. Public Health. 15: 2034. doi: 10.3390/ijerph15092034. MELATONIN RECEPTOR-MEDIATED ATTENUATION OF EXCITOTOXIC Melatonin Research (Melatonin Res.) http://www.mealtonin-research.net Melatonin Res. 2021, Vol 4 (2) 336-347; doi: 10.32794/mr11250098 336Research Article
PLEIOTROPIC ROLES OF MELATONIN AGAINST OXIDATIVE STRESS The excessive production of free radicals and/or reactive oxygen species (ROS) in gastrointestinal (GI) tract leads to oxidative damages in GI tissues with development of varied pathological conditions and clinical symptoms. Many endogenous as well as exogenous factors are involved in such pathogenesis, herein, focus was given to the factors of metal toxicity, non-steroidal MITOCHONDRIA: THE BIRTH PLACE, BATTLE GROUND AND THE SITE It was a surprising discovery when mitochondria, as the power houses of cells, were also found to synthesize the potent mitochondrial targeted antioxidant, melatonin. The melatonin synthetic enzyme serotonin N-acetyltransferase (SNAT) was found in matrix and also in the intermembrane space of mitochondria. We hypothesize that the melatonin synthesis occurs in the matrix due to substrate (NMELATONIN RESEARCH
Melatonin Research is the specific journal which covers any aspect of melatonin and its related research areas. These areas include the bio- physiological functions of melatonin in bacteria, archaea, fungi, plants and animals. The clinical applications of melatonin in humam diseases are especially welcome. VOL 4 NO 1 (2021): MELATONIN RESEARCH Vol 4 No 1 (2021): Melatonin Research. Although effective vaccines for SARS-CoV-2 are available in developed counties, the majority of the population in the developing world will have to wait months or even a year or more to acceess these treatments. During this relatively long period, other therapeutic methods, including melatonin, should beABOUT THE JOURNAL
Home / About the Journal Aims and Scope. Melatonin Research is a blind peer review acadamic journal which provides a platform for all researchers who can freely exchange their ideas, research experience and study results in melatonin and/or its related research fields. MELATONIN-INDEX AS A BIOMARKER FOR PREDICTING THE The pandemic dissemination of the SARS-CoV-2 led, on the one hand, to a worldwide effort to develop mechanistic-based therapeutics and vaccines, and on the other hand, the searching for determining the spreaders and the mechanisms of transmission. Melatonin, a multitask molecule, orchestrates defense responses by allowing the proper mounting, duration, and magnitude of innate MELATONIN: A POTENTIAL THERAPEUTIC AGENT AGAINST COVID-19 Coronaviruses (CoVs) are RNA viruses that cause infections of the respiratory, gastrointestinal, and central nervous systems, among others. The pathological symptoms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) include excessive inflammation, elevated oxidative stress, and an exaggerated immune response, ultimately leading to a cytokine storm and HIGH DOSES OF MELATONIN AS A POTENTIAL THERAPEUTIC TOOL The therapeutic potential of melatonin as an agent to counteract the consequences of COVID-19 infections is due to its wide-ranging effects as a powerful antioxidant, anti-inflammatory, and immunostimulant, as well as to a possible antiviral action. In view of the recently reported evidence on the occurrence of neurological sequels in COVID-19-infected patients, another putative application of ESTIMATED DOSES OF MELATONIN FOR TREATING DEADLY VIRUS Increased evidence implies that melatonin may be a promising molecule for combating COVID-19 due to its potent antioxidative, anti-inflammatory and immunoregulatory capacities. A frequently asked question concerns the suitable dosage of melatonin for deadly virus infections including COVID-19 patients. The golden standards for a suitable dosage of medicine are safety and effectiveness. A COMPUTER-ASSISTED SYSTEMATIC SEARCH FOR MELATONIN Melatonin Research (Melatonin Res.) http://www.melatonin-research.net Melatonin Res. 2018, Vol 1 (1) 27-58; doi: 10.32794/mr11250003 a VIEW OF MELATONIN-INDEX AS A BIOMARKER FOR PREDICTING THE Return to Article Details Melatonin-Index as a biomarker for predicting the distribution of presymptomatic and asymptomatic SARS-CoV-2 carriers Download Download PDF Melatonin-Index as a biomarker for predicting the distribution of presymptomatic and asymptomatic SARS-CoV-2 A COMPUTER-ASSISTED SYSTEMATIC SEARCH FOR MELATONIN A systematic rational search for newly designed melatonin derivatives, was performed using a computer-assisted protocol. A total of 116 derivatives were generated by adding functional groups (i.e., -OH, -NH2, -SH and -COOH) to the melatonin structure. A selection score (SS) was built to sample the search space, simultaneously considering ADME (absorption, distribution, metabolism,MELATONIN RESEARCH
Melatonin Research is the specific journal which covers any aspect of melatonin and its related research areas. These areas include the bio- physiological functions of melatonin in bacteria, archaea, fungi, plants and animals. The clinical applications of melatonin in humam diseases are especially welcome. VOL 4 NO 1 (2021): MELATONIN RESEARCH Vol 4 No 1 (2021): Melatonin Research. Although effective vaccines for SARS-CoV-2 are available in developed counties, the majority of the population in the developing world will have to wait months or even a year or more to acceess these treatments. During this relatively long period, other therapeutic methods, including melatonin, should beABOUT THE JOURNAL
Home / About the Journal Aims and Scope. Melatonin Research is a blind peer review acadamic journal which provides a platform for all researchers who can freely exchange their ideas, research experience and study results in melatonin and/or its related research fields. MELATONIN-INDEX AS A BIOMARKER FOR PREDICTING THE The pandemic dissemination of the SARS-CoV-2 led, on the one hand, to a worldwide effort to develop mechanistic-based therapeutics and vaccines, and on the other hand, the searching for determining the spreaders and the mechanisms of transmission. Melatonin, a multitask molecule, orchestrates defense responses by allowing the proper mounting, duration, and magnitude of innate MELATONIN: A POTENTIAL THERAPEUTIC AGENT AGAINST COVID-19 Coronaviruses (CoVs) are RNA viruses that cause infections of the respiratory, gastrointestinal, and central nervous systems, among others. The pathological symptoms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) include excessive inflammation, elevated oxidative stress, and an exaggerated immune response, ultimately leading to a cytokine storm and HIGH DOSES OF MELATONIN AS A POTENTIAL THERAPEUTIC TOOL The therapeutic potential of melatonin as an agent to counteract the consequences of COVID-19 infections is due to its wide-ranging effects as a powerful antioxidant, anti-inflammatory, and immunostimulant, as well as to a possible antiviral action. In view of the recently reported evidence on the occurrence of neurological sequels in COVID-19-infected patients, another putative application of ESTIMATED DOSES OF MELATONIN FOR TREATING DEADLY VIRUS Increased evidence implies that melatonin may be a promising molecule for combating COVID-19 due to its potent antioxidative, anti-inflammatory and immunoregulatory capacities. A frequently asked question concerns the suitable dosage of melatonin for deadly virus infections including COVID-19 patients. The golden standards for a suitable dosage of medicine are safety and effectiveness. A COMPUTER-ASSISTED SYSTEMATIC SEARCH FOR MELATONIN Melatonin Research (Melatonin Res.) http://www.melatonin-research.net Melatonin Res. 2018, Vol 1 (1) 27-58; doi: 10.32794/mr11250003 a VIEW OF MELATONIN-INDEX AS A BIOMARKER FOR PREDICTING THE Return to Article Details Melatonin-Index as a biomarker for predicting the distribution of presymptomatic and asymptomatic SARS-CoV-2 carriers Download Download PDF Melatonin-Index as a biomarker for predicting the distribution of presymptomatic and asymptomatic SARS-CoV-2 A COMPUTER-ASSISTED SYSTEMATIC SEARCH FOR MELATONIN A systematic rational search for newly designed melatonin derivatives, was performed using a computer-assisted protocol. A total of 116 derivatives were generated by adding functional groups (i.e., -OH, -NH2, -SH and -COOH) to the melatonin structure. A selection score (SS) was built to sample the search space, simultaneously considering ADME (absorption, distribution, metabolism, HIGH DOSES OF MELATONIN AS A POTENTIAL THERAPEUTIC TOOL The therapeutic potential of melatonin as an agent to counteract the consequences of COVID-19 infections is due to its wide-ranging effects as a powerful antioxidant, anti-inflammatory, and immunostimulant, as well as to a possible antiviral action. In view of the recently reported evidence on the occurrence of neurological sequels in COVID-19-infected patients, another putative application of MELATONIN: A POTENTIAL THERAPEUTIC AGENT AGAINST COVID-19 Coronaviruses (CoVs) are RNA viruses that cause infections of the respiratory, gastrointestinal, and central nervous systems, among others. The pathological symptoms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) include excessive inflammation, elevated oxidative stress, and an exaggerated immune response, ultimately leading to a cytokine storm and POTENTIAL UTILITY OF MELATONIN IN DEADLY INFECTIOUS The high mortality of deadly virus infectious diseases including SARS, MERS, COVID-19, and avian flu is often caused by the uncontrolled innate immune response and destructive inflammation. The majority of viral diseases are self-limiting under the help of the activated adaptive immune system. This activity is cell proliferation dependent and thus, it requires several weeks to develop. MELATONIN-INDEX AS A BIOMARKER FOR PREDICTING THE Melatonin Research (Melatonin Res.) http://www.melatonin-research.net Melatonin Res. 2021, Vol 4 (1) 189 -205; doi: 10.32794/mr11250090 INJECTABLE MELATONIN: AN ANTI-CANCER AND ANTI-VIRAL Intravenous infusion of high doses of melatonin would represent the most eligible route to treat conveniently patients hospitalized in critical care units or with undergoing oncologic therapies, wherein adequate, accurate and constant dosages and high levels of melatonin would be required. After several attempts, a stable concentrate bulk solution of 10% melatonin (Survivis®) has been MELATONIN AND THE OPTICS OF THE HUMAN BODY Melatonin is fundamental to the lighting, display, and architectural industries as the primary biomarker used in circadian theory. Billions of dollars are being spent on research, product development, and marketing based on the impact of visible light on melatonin produced by the pineal gland. It has now been shown that the mitochondria produce melatonin in many cells in quantities which are MELATONIN ATTENUATES MICROGLIAL ACTIVATION AND IMPROVES Melatonin attenuates microglial activation and improves model MELATONIN RECEPTOR-MEDIATED ATTENUATION OF EXCITOTOXIC Melatonin Research (Melatonin Res.) http://www.mealtonin-research.net Melatonin Res. 2021, Vol 4 (2) 336-347; doi: 10.32794/mr11250098 337INTRODUCTION
MITOCHONDRIA AND THE GUT AS CRUCIAL HUBS FOR THE Two important hubs have emerged as cutting edge areas of research across a diverse array of medical conditions, the gut microbiome and mitochondria. This article highlights the role of melatonin in modulating changes in both the gut and mitochondria. The gut microbiome, especially via its production of the small chain fatty acid, butyate, can have a significant impact on immune THE PHYTOMELATONIN RECEPTOR (PMRT1) ARABIDOPSIS CAND2 IS It was recently suggested that the protein Cand2 acts as a G protein–coupled receptor (GPCR) for melatonin in Arabidopsis by mediating stomatal closure via H2O2 production and Ca2+ influx. Here, we examined whether Cand2 is indeed a melatonin receptor. Contrary to previous reports, confocal microscopy analyses indicated that Cand2 protein is localized in the cytoplasm rather than the plasma Skip to main content Skip to main navigation menu Skip to site footerMELATONIN RESEARCH
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Vol 4 No 2 (2021): Melatonin Research The neuroprotective effects of melatonin have been frequently studied in different pathological animal models. In some models, melatonin exhibits profound benificial effects, but in others, these actions are limited depending on the nature of the pathology and the species used. In the current issue, two reports have further investigated this issue from different perspectives. Haque _et al._ used cultured rat spinal cord slices and challenged them with L-glutamic acid to mimic spinal cord injury (SCI) related neuron loss. The authors observed that melatonin treatment significantly reduced cellular apoptosis and prevented penumbral neuron loss following SCI. This protective effect of melatonin was mediated by MT1/2 membrane receptors. In another study, Leung and Cheung directly injected type IV collagenase into the right striatum of rats to create intracerebral hemorrhage (ICH) pathology which is a severe form of stroke with a high mortality rate and also an important cause of permanent disability. Melatonin treatment at the dose of 50 mg/kg reduced the perihematomal microglial activation but had no effect on the size of hematoma. The microglial activation is a key factor in determing the prognosis of ICH. As a result of melatonin treatment, the neurological functions of the rats after ICH also were significantly improved. These two studies provide additional evidence that addresses the importance of melatonin in protecting against neurological pathology. We hope that these novel observations, along with those published earlier, will stimulate enthuasiam for investigations into the multipe benefits of melatonin in reducing neuropathologies including consideraton of human trials. Published: 2021-04-30REVIEWS
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Melatonin promotes gastric healing by modulating the components of matrix metalloproteinase signaling pathway: a novel scenario for gastric ulcer management Romit Majumder, Madhuri Datta, Aindrila Chattopadhyay, DebasishBandyopadhyay
213-231
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Melatonin and biological membrane bilayers: a never ending amity Adrita Banerjee, Aindrila Chattopadhyay, Debasish Bandyopadhyay232-252
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Melatonin as a prospective metabolic regulator in pathologically altered cardiac energy homeostasis Swaimanti Sarkar, Aindrila Chattopadhyay, Debasish Bandyopadhyay316-335
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Does the melatonin supplementation decrease the severity of the outcomes in COVID-19 patients? A mini review of observational data in the in vivo and in vitro studies Mohammad Gholizadeh, Faezeh Abaj, Hossein Hasani, Atieh Mirzababaei,Khadijeh Mirzaei
348-359
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RESEARCH ARTICLES
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Blood melatonin level can serve as a potential biomarker for prostate and hepatocellular carcinomas Lorenzo Silvestrin Sartorelli, Rubens José Bombardi Neto, Marina Gobbe Moscheta-Pinheiro, Tialfi Bergamin de Castro, Fabio Leite Couto Fernandes, Renato Silva, Adriana Alonso Novais, Luiz Gustavo de Almeida Chuffa, Russel J Reiter, Débora Aparecida Pires de CamposZuccari
253-269
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Study assessing the efficacy of herbal teas on bone health and quality of life in a population with osteopenia: rooibos actions on melatonin and tulsi actions on quality of life. Fahima Munmun, Alyssa Linden, Hunter Hanlon, Hannah Enderby, PaulaWitt-Enderby
270-298
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Melatonergic index as a prognostic biomarker of reproductive organ cancers: correlations with metabolic parameters as well as clock genesPER1 and TIMELESS
Luiz Gustavo de Almeida Chuffa, Robson F Carvalho, Fábio R Seiva, Debora Aparecida Pires de Campos Zuccari, Russel J Reiter299-315
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Melatonin receptor-mediated attenuation of excitotoxic cell death in cultured spinal cord slices Azizul Haque, Donald C Shields, Arabinda Das, Abhay Varma, Russel J Reiter, Narendra L Banik336-347
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Melatonin attenuates microglial activation and improves neurological functions in rat model of collagenase-induced intracerebral hemorrhage Joseph Wai-Hin Leung, Raymond Tak Fai Cheung360-376
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