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Whitney,
PEM AVOIDANCE TOOLKIT PEM Avoidance Toolkit: created by Jeff Hewitt, Sarah Hewitt, Dana Beltramo Hewitt, Dr. Bonilla, and Dr. Montoya and input from ME / CFS patients over the course of several patient workshops. PEM Avoidance Toolkit English PEM Avoidance Toolkit Deutsch MITOCHONDRIAL FUNCTION TEST Mitochondrial Function Test TECHNOLOGY VALUE Demonstrates a significant difference between ME / CFS patients and healthy controls. LEAD INVESTIGATORS Julie Wilhelmy Ronald W. Davis, PhD UPDATES AND POTENTIAL Coming soon TECHNOLOGY DESCRIPTION Developed by Julie Wilhelmy in collaboration with Ronald W. Davis, PhD, at Stanford University. The Seahorse instrument measures MESTINON CLINICAL TRIAL Open Medicine Foundation is delighted to announce its support of a clinical trial to test the exercise response to Mestinon in people with Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) with Preload Failure (Clinical Trials Number NCT03674541). This trial is being conducted at the Brigham & Women’s Hospital by Dr. David Systrom in association with the Harvard MELBOURNE ME/CFS COLLABORATION Established in 2020, the Melbourne ME/CFS Collaboration is directed by Christopher W. Armstrong, PhD. The Melbourne ME/CFS Collaboration seeks to characterize the unifying biological pathways of ME/CFS that relate to the shared disease experience between patients while also understanding each patients unique biology that create variation in disease experience and severity.NITROGEN HYPOTHESIS
Nitrogen Metabolism andTesting Nitrogen Hypothesis in ME/CFS Study AIM This project aims to test the nitrogen hypothesis, which is that damaging, nitrogen-containing by-products of energy metabolism accumulate more readily in the cells of ME/CFS patients. LEAD INVESTIGATORS Christopher Armstrong, PhD Ronald Davis, PhD Paul Gooley, PhD Neil McGregor, PhD Updates and Potential Of HEART PRELOAD FAILURE The PLF comes in 2 forms, a high flow and a low flow. The low flow form may be caused by a failure to reduce venous compliance with exercise or a pre-existing reduced overall blood volume. However, the latter is less likely because the PLF persists even when one liter of saline is given to increase the blood volume just prior to the iCPETstudy.
JONAS BERGQUIST, MD, PHD Dr. Bergquist is a Full Chair Professor in Analytical Chemistry and Neurochemistry in the Department of Chemistry at Uppsala University, Sweden, Adjunct Professor in Pathology at the University of Utah School of Medicine, and Distinguished Professor in Precision Medicine at Binzhou Medical University in Yantai, China. His group develops tools for screening and discovery of HOME | OPEN MEDICINE FOUNDATIONJOIN TEAM OMFCOVID-19 LATEST NEWSBOARD OF DIRECTORSWORLDWIDE TOURSTUART MURDOCHHISTORY OMF ACCELERATES RESEARCH ACROSS THE GLOBE Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) affects over 20 million people. Established in 2012, Open Medicine Foundation (OMF) leads the largest, concerted worldwide nonprofit effort to diagnose, treat, and prevent ME / CFS and related chronic, complex diseases such as Post Treatment Lyme Disease Syndrome (PTLDS), POST-COVID SYNDROME TO ME/CFS In 2020, OMF secured a $1 million grant to launch the first year of an international, multi-year study across the five OMF funded Collaborative Research Centers (CRC). The aim of this study is to examine Post-COVID Syndrome transitioning to ME/CFS. We are actively working to raise an additional $2 million for years two and three of the study. I am pleased to share with you an update on the EXCITING UPDATES FROM RONALD W. DAVIS, PH.D! From the Desk of Ronald W. Davis, Ph.D.,Chair of Open Medicine Foundation (OMF) Scientific Advisory Board I am honored to share that my research into Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) has been featured by People Magazine! This feature details my family’s personal struggle to find treatments or a cure for my sonWhitney,
PEM AVOIDANCE TOOLKIT PEM Avoidance Toolkit: created by Jeff Hewitt, Sarah Hewitt, Dana Beltramo Hewitt, Dr. Bonilla, and Dr. Montoya and input from ME / CFS patients over the course of several patient workshops. PEM Avoidance Toolkit English PEM Avoidance Toolkit Deutsch MITOCHONDRIAL FUNCTION TEST Mitochondrial Function Test TECHNOLOGY VALUE Demonstrates a significant difference between ME / CFS patients and healthy controls. LEAD INVESTIGATORS Julie Wilhelmy Ronald W. Davis, PhD UPDATES AND POTENTIAL Coming soon TECHNOLOGY DESCRIPTION Developed by Julie Wilhelmy in collaboration with Ronald W. Davis, PhD, at Stanford University. The Seahorse instrument measures MESTINON CLINICAL TRIAL Open Medicine Foundation is delighted to announce its support of a clinical trial to test the exercise response to Mestinon in people with Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) with Preload Failure (Clinical Trials Number NCT03674541). This trial is being conducted at the Brigham & Women’s Hospital by Dr. David Systrom in association with the Harvard MELBOURNE ME/CFS COLLABORATION Established in 2020, the Melbourne ME/CFS Collaboration is directed by Christopher W. Armstrong, PhD. The Melbourne ME/CFS Collaboration seeks to characterize the unifying biological pathways of ME/CFS that relate to the shared disease experience between patients while also understanding each patients unique biology that create variation in disease experience and severity.NITROGEN HYPOTHESIS
Nitrogen Metabolism andTesting Nitrogen Hypothesis in ME/CFS Study AIM This project aims to test the nitrogen hypothesis, which is that damaging, nitrogen-containing by-products of energy metabolism accumulate more readily in the cells of ME/CFS patients. LEAD INVESTIGATORS Christopher Armstrong, PhD Ronald Davis, PhD Paul Gooley, PhD Neil McGregor, PhD Updates and Potential Of HEART PRELOAD FAILURE The PLF comes in 2 forms, a high flow and a low flow. The low flow form may be caused by a failure to reduce venous compliance with exercise or a pre-existing reduced overall blood volume. However, the latter is less likely because the PLF persists even when one liter of saline is given to increase the blood volume just prior to the iCPETstudy.
JONAS BERGQUIST, MD, PHD Dr. Bergquist is a Full Chair Professor in Analytical Chemistry and Neurochemistry in the Department of Chemistry at Uppsala University, Sweden, Adjunct Professor in Pathology at the University of Utah School of Medicine, and Distinguished Professor in Precision Medicine at Binzhou Medical University in Yantai, China. His group develops tools for screening and discovery of POST-COVID SYNDROME TO ME/CFS In 2020, OMF secured a $1 million grant to launch the first year of an international, multi-year study across the five OMF funded Collaborative Research Centers (CRC). The aim of this study is to examine Post-COVID Syndrome transitioning to ME/CFS. We are actively working to raise an additional $2 million for years two and three of the study. I am pleased to share with you an update on the NEW GUIDELINES FOR DIAGNOSING AND TREATING ME / CFS A resource for clinicians and patients. The U.S. ME / CFS Clinician Coalition, a group of U.S. ME / CFS experts, has authored a handout on the basics of diagnosis and management of ME / CFS.. This handout is being made available on our website for the medical community to help them better understand how to recognize ME / CFS and how to appropriately care for patients. THE END ME / CFS PROJECT The End ME/CFS Project encompasses OMF funded and facilitated research conducted within five ME/CFS Collaborative Research Centers (CRCs).OMF’s guiding strategy focuses on open, collaborative research so that precise diagnostic tools and life-changing treatments can be available to people with related chronic complex diseases assoon as possible.
HISTORY OF ME / CFS
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex illness with a complex history. The best way to understand ME/CFS as we know it today is to understand the history of how it was first defined and how the diagnostic criteria has evolved over the past few decades. Summary of the 5 major diagnostic criteria from COLLABORATIVE RESEARCH CENTER STANFORD The ME/CFS Collaborative Research Center (previously known as the CFS Research Center) at Stanford University was established in 2014 and is part of the Stanford Genome Technology Center. Both centers are directed by Ronald W. Davis, PhD, Professor of Biochemistry and of Genetics at Stanford. COLLABORATIVE CENTER The ME/CFS Collaborationat Uppsala University State-of-the-art laboratory searching for biomarkers ofMyalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) in body and brain Core Aims What we hope to achieve Read more Philosophy Our fundamental philosophy Learn more Science Team List of scientific collaborators Click Here Research Current research projects More info About the research THE HARVARD ME / CFS COLLABORATION AT THE HARVARD The Research. Co-led by Ronald G. Tompkins, MD, ScD, and Wenzhong Xiao, PhD., this research collaboration seeks to conduct clinical and basic science studies to characterize the dynamic biological changes that occur during change in symptom expression of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) patients. THE IDO METABOLIC TRAP By Christopher Armstrong, PhD Dr. Robert Phair has recently published a paper detailing his “metabolic trap” hypothesis underlying ME / CFS, a theory that combines engineering and physiology put together by a man adept in both fields. Dr. Phair is co-founder and Chief Science Officer of Integrative Bioinformatics, Inc, a small company built around a unique softwareWENZHONG XIAO, PHD
As a world expert in computational genomics, Dr. Xiao develops bioinformatic and statistical tools for use in understanding human diseases, especially in studies of immuno-metabolic response. He focuses on integrative analysis and interpretation of multi-dimensional molecular, cellular, and clinical data of many types of patients, including those with ME / CFS. Dr. Xiao’s expertisewill be
RBC SHAPE, RBC DEFORMABILITY Many of you have been asking questions about our red blood cell research. For this #OMFScienceWednesday, we examine the difference between RBC shape and RBC deformability, and how they relate to blood flow. RBC shape You may have seen an image of a red blood cell (RBC) in the past: it is a small, pink DRIVING RESEARCH OF MYALGIC ENCEPHALOMYELITIS / CHRONIC FATIGUE SYNDROME (ME / CFS), POST TREATMENT LYME DISEASE SYNDROME (PTLDS), FIBROMYALGIA AND POSTCOVID .
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OMF FUNDED RESEARCH CENTERS THE END ME / CFS PROJECT* • Publications
COLLABORATIVE CENTER AT STANFORD * • Metabolic Trap * • Nanoneedle Technology COLLABORATIVE CENTER AT HARVARD * • Multi-omics Plasma Study * • PASS-Computerized Adaptive Testing COLLABORATIVE CENTER AT UPPSALA * • Kynurenine Trial * • Autoimmunity and Autoantibodies COLLABORATIVE CENTER AT MONTRÉAL * • Thrombospondin-1 study* • MicroRNAs
MELBOURNE ME/CFS COLLABORATION OMF FUNDED DATA CENTER For researchers only - login required*
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OMF ACCELERATES RESEARCH ACROSS THE GLOBE Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) affects over 20 million people. Established in 2012, Open Medicine Foundation (OMF) leads the largest, concerted worldwide nonprofit effort to diagnose, treat, and prevent ME / CFS and related chronic, complex diseases such as Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia and PostCOVID.
OMF adds urgency to the search for answers by driving transformational philanthropy and investments into global research. We have raised over $30 Million from private donors, and facilitated and funded the establishment of five prestigious ME / CFS Collaborative ResearchCenters.
__ Find Out More about ME / CFS Clinical Management Resources OMF FUNDED COLLABORATIVE RESEARCH CENTERS ME / CFS COLLABORATIVERESEARCH CENTER
AT STANFORD
Ronald W. Davis, PhDDirector
Innovative, collaborative, multi-disciplinary researchSee the research
THE HARVARD
ME / CFS COLLABORATION AT HARVARD AFFILIATED HOSPITALS Ronald G. Tompkins, MD, ScDWenzhong Xiao, PhD
Co-Directors
Clinical and scientific mechanistic studies towards discovering newtreatments
See the research
ME / CFS COLLABORATIVERESEARCH CENTER
AT UPPSALA, SWEDEN
Jonas Bergquist, MD, PhDDirector
Research for biomarkers in body and brainSee the research
ME / CFS COLLABORATIVE RESEARCH CENTER AT THE CHU SAINTE-JUSTINE/ UNIVERSITÉ DE MONTRÉALAlain Moreau, PhD
Director
Clinical and scientific intervention studiesSee the research
MELBOURNE ME / CFS COLLABORATION Chris Armstrong, PhDDirector
Precision personalized medicine research programSee the research
POST COVID-19 TO ME/CFS RESEARCH PLAN The current COVID-19 pandemic offers an unprecedented opportunity to understand how a viral infection may convert to ME/CFS in somepatients.
The five ME/CFS Collaborative Centers have begun a unique, extensive, in-depth longitudinal molecular study following COVID-19 patients. Their shared goal is to determine the pathways involved in maintaining long-term symptoms in some patients, possibly converting to ME/CFS. They seek to learn about these pathways so as to develop biomarkers, novel drug targets, new treatment, and preventionstrategies.
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OMF SCIENTIFIC ADVISORY BOARD AN ALLIANCE WITH BRILLIANT SCIENTIFIC MINDS 18 world-renowned scientists2 Nobel laureates
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VIEW OUR LATEST NEWS LAST CHANCE TO JOIN THE MOMENTUM: SUPPORT ME/CFS RESEARCH TODAY! Last chance to join the momentum: Support ME/CFS research today! This is the LAST chance for you to support Open Medicine Foundation’s #MayMomentum campaign! All proceeds help LAST DAY TO GIVE TO #MAYMOMENTUM! Last day to give to #MayMomentum! There’s still time to make an impact and accelerate research around the globe — donate to OMF’s May Momentum campaign ME/CFS RESEARCH DATA: THE HEART OF THE MATTER #MayMomentum research news! ME/CFS Research Data: the heart of the matter With your support, Open Medicine Foundation funds open, collaborative research so that, as soonPrevious Next »
JOIN OUR FIGHT TO IGNITE ME / CFS RESEARCHACROSS THE GLOBE!
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