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age in tissues
HUMAN AGEING GENOMIC RESOURCES Human Ageing Genomic Resources. The Human Ageing Genomic Resources (HAGR) is a collection of databases and tools designed to help researchers study the genetics of human ageing using modern approaches such as functional genomics, network analyses, systems biology and evolutionary analyses. GENAGE: THE AGEING GENE DATABASE Complementary to GenAge is a database of genes commonly altered during ageing, drawn from a microarray meta-analysis study, and the LongevityMap, a database of human genetic variants associated with longevity. You can view GenAge's statistics. Release notes for the current build are also available. Though deprecated, a list of genesthat may
SEARCH SIGNATURES OF CELLULAR SENESCENCE GenAge. A curated database of candidate human ageing-related genes and genes associated with longevity and/or ageing in model organisms. THE NUAK1 GENE AND ITS PUTATIVE ASSOCIATION WITH HUMAN AGEING Knockdown of the AMPK-related protein kinase 5 (NUAK1) resulted in an extension of cellular replicative lifespan in normal human diploid fibroblasts. In contrast, ectopic expression of NUAK1 triggered premature senescence. Humbert et al. (2010) "Regulation of ploidy and senescence by the AMPK-related kinase NUAK1." WHO'S WHO IN GERONTOLOGY: COMPANIES Gero. Gero is a data-driven longevity company focused on the development of new treatments to combat the aging process and extend healthy human lifespans, primarily around the topic of stability and stress resistance of gene regulatory networks. More Details ›. THE WRN GENE AND ITS PUTATIVE ASSOCIATION WITH HUMAN AGEING Human WRN-null mesenchymal stem cells show several features associated with accelerated aging . These include increased senescence associated markers, activation of the senescence-associated secretory phenotype and an increased DNA damage response. In addition, there is a global loss of H3K9me3 and accompanying changes in THE GLB1 GENE AND ITS PUTATIVE ASSOCIATION WITH HUMAN AGEING GLB1 Gene Information. This gene encodes a member of the glycosyl hydrolase 35 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature lysosomal enzyme. This enzyme catalyzes the hydrolysis of a terminalbeta-linked
ANNA'S HUMMINGBIRD (CALYPTE ANNA) LONGEVITY, AGEING, AND GenAge. A curated database of candidate human ageing-related genes and genes associated with longevity and/or ageing in model organisms. THE EEF1A1 GENE AND ITS PUTATIVE ASSOCIATION WITH HUMAN AGEING Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model. Description. EEF1A1 is involved in the binding of tRNA to ribosomes during protein synthesis. In fruit flies, overexpression of EEF1A1 increases longevity . Whether EEF1A1 has any role in mammalian ageing has not beendetermined.
CELLAGE: THE CELL SENESCENCE GENE DATABASE CellAge Database of Cell Senescence Genes. Cell senescence can be defined as the irreversible cessation of cell division of normally proliferating cells. Human cells become senescent from progressive shortening of telomeres as cells divide, stress or oncogenes. Primarily an anti-tumour mechanism, senescent cells accumulate withage in tissues
HUMAN AGEING GENOMIC RESOURCES Human Ageing Genomic Resources. The Human Ageing Genomic Resources (HAGR) is a collection of databases and tools designed to help researchers study the genetics of human ageing using modern approaches such as functional genomics, network analyses, systems biology and evolutionary analyses. GENAGE: THE AGEING GENE DATABASE Complementary to GenAge is a database of genes commonly altered during ageing, drawn from a microarray meta-analysis study, and the LongevityMap, a database of human genetic variants associated with longevity. You can view GenAge's statistics. Release notes for the current build are also available. Though deprecated, a list of genesthat may
SEARCH SIGNATURES OF CELLULAR SENESCENCE GenAge. A curated database of candidate human ageing-related genes and genes associated with longevity and/or ageing in model organisms. THE NUAK1 GENE AND ITS PUTATIVE ASSOCIATION WITH HUMAN AGEING Knockdown of the AMPK-related protein kinase 5 (NUAK1) resulted in an extension of cellular replicative lifespan in normal human diploid fibroblasts. In contrast, ectopic expression of NUAK1 triggered premature senescence. Humbert et al. (2010) "Regulation of ploidy and senescence by the AMPK-related kinase NUAK1." WHO'S WHO IN GERONTOLOGY: COMPANIES Gero. Gero is a data-driven longevity company focused on the development of new treatments to combat the aging process and extend healthy human lifespans, primarily around the topic of stability and stress resistance of gene regulatory networks. More Details ›. THE WRN GENE AND ITS PUTATIVE ASSOCIATION WITH HUMAN AGEING Human WRN-null mesenchymal stem cells show several features associated with accelerated aging . These include increased senescence associated markers, activation of the senescence-associated secretory phenotype and an increased DNA damage response. In addition, there is a global loss of H3K9me3 and accompanying changes in THE GLB1 GENE AND ITS PUTATIVE ASSOCIATION WITH HUMAN AGEING GLB1 Gene Information. This gene encodes a member of the glycosyl hydrolase 35 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature lysosomal enzyme. This enzyme catalyzes the hydrolysis of a terminalbeta-linked
ANNA'S HUMMINGBIRD (CALYPTE ANNA) LONGEVITY, AGEING, AND GenAge. A curated database of candidate human ageing-related genes and genes associated with longevity and/or ageing in model organisms. THE EEF1A1 GENE AND ITS PUTATIVE ASSOCIATION WITH HUMAN AGEING Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model. Description. EEF1A1 is involved in the binding of tRNA to ribosomes during protein synthesis. In fruit flies, overexpression of EEF1A1 increases longevity . Whether EEF1A1 has any role in mammalian ageing has not beendetermined.
GENAGE HUMAN GENES: LIST OF ENTRIES GenAge. A curated database of candidate human ageing-related genes and genes associated with longevity and/or ageing in model organisms. HUMAN AGEING-ASSOCIATED GENES GenAge Human Genes. This section of GenAge features genes possibly related to human ageing. Briefly, genes were selected for inclusion based on findings in model organisms put in context of human biology plus the few genes directly related to ageing in humans. As such, genes should be seen as candidate human ageing-associated genes. SEARCH THE ANAGE DATABASE GenAge. A curated database of candidate human ageing-related genes and genes associated with longevity and/or ageing in model organisms. THE GLB1 GENE AND ITS PUTATIVE ASSOCIATION WITH HUMAN AGEING GLB1 Gene Information. This gene encodes a member of the glycosyl hydrolase 35 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature lysosomal enzyme. This enzyme catalyzes the hydrolysis of a terminalbeta-linked
DRUGAGE: DATABASE OF AGEING-RELATED DRUGS DrugAge Database of Anti-Ageing Drugs. The DrugAge database contains an extensive compilation of drugs, compounds and supplements (including natural products and nutraceuticals) with anti-ageing properties that extend longevity in model organisms. Our focus is on drugs/compounds potentially impacting on ageing, and thereforedrugs/compounds
THE AGE-1 GENE AND ITS POSSIBLE RELATION TO AGEING IN Potential relevance to longevity and/or ageing. 65 % increase in mean lifespan and a 110 % increase in maximum lifespan at 25 degrees. age-1 mutant hermaphrodites show a 50% slower rate of mortality acceleration than wild-type. Maximum lifespan is 110% higher. Average lifespan is 65% higher. Mutants presented a double adult lifespan. THE WRN GENE AND ITS PUTATIVE ASSOCIATION WITH HUMAN AGEING Human WRN-null mesenchymal stem cells show several features associated with accelerated aging . These include increased senescence associated markers, activation of the senescence-associated secretory phenotype and an increased DNA damage response. In addition, there is a global loss of H3K9me3 and accompanying changes in THE BCL2 GENE AND ITS PUTATIVE ASSOCIATION WITH HUMAN AGEING Potential relevance to the human ageing process. BCL2 is an important suppressor of apoptosis and an oncogene. Apart from cancer, it may be involved in neurodegenerative disorders , and dendritic cell longevity in vivo has been reported to be controlled by BCL2 . BCL2 null mice die by six weeks of age with occurrence of grey hair THE CDKN2A GENE AND ITS PUTATIVE ASSOCIATION WITH HUMAN AGEING Description. The CDKN2A gene encodes different transcripts involved mostly in cell cycle regulation and cellular senescence, including the tumour suppressor proteins p16 and p19 . At least three alternatively spliced variants encoding distinct proteins have been reported. CDKN2A expression levels increase with age in rodents . THE EEF1A1 GENE AND ITS PUTATIVE ASSOCIATION WITH HUMAN AGEING Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model. Description. EEF1A1 is involved in the binding of tRNA to ribosomes during protein synthesis. In fruit flies, overexpression of EEF1A1 increases longevity . Whether EEF1A1 has any role in mammalian ageing has not beendetermined.
CELLAGE: THE CELL SENESCENCE GENE DATABASE CellAge Database of Cell Senescence Genes. Cell senescence can be defined as the irreversible cessation of cell division of normally proliferating cells. Human cells become senescent from progressive shortening of telomeres as cells divide, stress or oncogenes. Primarily an anti-tumour mechanism, senescent cells accumulate withage in tissues
HUMAN AGEING GENOMIC RESOURCES Human Ageing Genomic Resources. The Human Ageing Genomic Resources (HAGR) is a collection of databases and tools designed to help researchers study the genetics of human ageing using modern approaches such as functional genomics, network analyses, systems biology and evolutionary analyses. GENAGE: THE AGEING GENE DATABASE Complementary to GenAge is a database of genes commonly altered during ageing, drawn from a microarray meta-analysis study, and the LongevityMap, a database of human genetic variants associated with longevity. You can view GenAge's statistics. Release notes for the current build are also available. Though deprecated, a list of genesthat may
THE NUAK1 GENE AND ITS PUTATIVE ASSOCIATION WITH HUMAN AGEING Knockdown of the AMPK-related protein kinase 5 (NUAK1) resulted in an extension of cellular replicative lifespan in normal human diploid fibroblasts. In contrast, ectopic expression of NUAK1 triggered premature senescence. Humbert et al. (2010) "Regulation of ploidy and senescence by the AMPK-related kinase NUAK1." WHO'S WHO IN GERONTOLOGY: COMPANIES Gero. Gero is a data-driven longevity company focused on the development of new treatments to combat the aging process and extend healthy human lifespans, primarily around the topic of stability and stress resistance of gene regulatory networks. More Details ›. DRUGAGE: DATABASE OF AGEING-RELATED DRUGS DrugAge Database of Anti-Ageing Drugs. The DrugAge database contains an extensive compilation of drugs, compounds and supplements (including natural products and nutraceuticals) with anti-ageing properties that extend longevity in model organisms. Our focus is on drugs/compounds potentially impacting on ageing, and thereforedrugs/compounds
THE WRN GENE AND ITS PUTATIVE ASSOCIATION WITH HUMAN AGEING Human WRN-null mesenchymal stem cells show several features associated with accelerated aging . These include increased senescence associated markers, activation of the senescence-associated secretory phenotype and an increased DNA damage response. In addition, there is a global loss of H3K9me3 and accompanying changes in THE GLB1 GENE AND ITS PUTATIVE ASSOCIATION WITH HUMAN AGEING GLB1 Gene Information. This gene encodes a member of the glycosyl hydrolase 35 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature lysosomal enzyme. This enzyme catalyzes the hydrolysis of a terminalbeta-linked
ANNA'S HUMMINGBIRD (CALYPTE ANNA) LONGEVITY, AGEING, AND GenAge. A curated database of candidate human ageing-related genes and genes associated with longevity and/or ageing in model organisms. THE EEF1A1 GENE AND ITS PUTATIVE ASSOCIATION WITH HUMAN AGEING Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model. Description. EEF1A1 is involved in the binding of tRNA to ribosomes during protein synthesis. In fruit flies, overexpression of EEF1A1 increases longevity . Whether EEF1A1 has any role in mammalian ageing has not beendetermined.
CELLAGE: THE CELL SENESCENCE GENE DATABASE CellAge Database of Cell Senescence Genes. Cell senescence can be defined as the irreversible cessation of cell division of normally proliferating cells. Human cells become senescent from progressive shortening of telomeres as cells divide, stress or oncogenes. Primarily an anti-tumour mechanism, senescent cells accumulate withage in tissues
HUMAN AGEING GENOMIC RESOURCES Human Ageing Genomic Resources. The Human Ageing Genomic Resources (HAGR) is a collection of databases and tools designed to help researchers study the genetics of human ageing using modern approaches such as functional genomics, network analyses, systems biology and evolutionary analyses. GENAGE: THE AGEING GENE DATABASE Complementary to GenAge is a database of genes commonly altered during ageing, drawn from a microarray meta-analysis study, and the LongevityMap, a database of human genetic variants associated with longevity. You can view GenAge's statistics. Release notes for the current build are also available. Though deprecated, a list of genesthat may
THE NUAK1 GENE AND ITS PUTATIVE ASSOCIATION WITH HUMAN AGEING Knockdown of the AMPK-related protein kinase 5 (NUAK1) resulted in an extension of cellular replicative lifespan in normal human diploid fibroblasts. In contrast, ectopic expression of NUAK1 triggered premature senescence. Humbert et al. (2010) "Regulation of ploidy and senescence by the AMPK-related kinase NUAK1." WHO'S WHO IN GERONTOLOGY: COMPANIES Gero. Gero is a data-driven longevity company focused on the development of new treatments to combat the aging process and extend healthy human lifespans, primarily around the topic of stability and stress resistance of gene regulatory networks. More Details ›. DRUGAGE: DATABASE OF AGEING-RELATED DRUGS DrugAge Database of Anti-Ageing Drugs. The DrugAge database contains an extensive compilation of drugs, compounds and supplements (including natural products and nutraceuticals) with anti-ageing properties that extend longevity in model organisms. Our focus is on drugs/compounds potentially impacting on ageing, and thereforedrugs/compounds
THE WRN GENE AND ITS PUTATIVE ASSOCIATION WITH HUMAN AGEING Human WRN-null mesenchymal stem cells show several features associated with accelerated aging . These include increased senescence associated markers, activation of the senescence-associated secretory phenotype and an increased DNA damage response. In addition, there is a global loss of H3K9me3 and accompanying changes in THE GLB1 GENE AND ITS PUTATIVE ASSOCIATION WITH HUMAN AGEING GLB1 Gene Information. This gene encodes a member of the glycosyl hydrolase 35 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature lysosomal enzyme. This enzyme catalyzes the hydrolysis of a terminalbeta-linked
ANNA'S HUMMINGBIRD (CALYPTE ANNA) LONGEVITY, AGEING, AND GenAge. A curated database of candidate human ageing-related genes and genes associated with longevity and/or ageing in model organisms. THE EEF1A1 GENE AND ITS PUTATIVE ASSOCIATION WITH HUMAN AGEING Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model. Description. EEF1A1 is involved in the binding of tRNA to ribosomes during protein synthesis. In fruit flies, overexpression of EEF1A1 increases longevity . Whether EEF1A1 has any role in mammalian ageing has not beendetermined.
CELLAGE: THE CELL SENESCENCE GENE DATABASE CellAge Database of Cell Senescence Genes. Cell senescence can be defined as the irreversible cessation of cell division of normally proliferating cells. Human cells become senescent from progressive shortening of telomeres as cells divide, stress or oncogenes. Primarily an anti-tumour mechanism, senescent cells accumulate withage in tissues
SEARCH THE ANAGE DATABASE All HAGRID Species or taxon Common name Longevity Display entry; 03636: Poecilia reticulata: Guppy: 5: 03636: 04235: Arctica islandica: Ocean quahog clam: 507: 04235 SEARCH THE ANAGE DATABASE GenAge. A curated database of candidate human ageing-related genes and genes associated with longevity and/or ageing in model organisms. WHO'S WHO IN GERONTOLOGY: PEOPLE Botstein, David. David Botstein is a geneticist and the chief scientific officer of Calico, a company focused on understanding the biology that controls lifespan to develop interventions that enable people to lead longer and healthier lives. More Details ›. DRUGAGE: DATABASE OF AGEING-RELATED DRUGS DrugAge Database of Anti-Ageing Drugs. The DrugAge database contains an extensive compilation of drugs, compounds and supplements (including natural products and nutraceuticals) with anti-ageing properties that extend longevity in model organisms. Our focus is on drugs/compounds potentially impacting on ageing, and thereforedrugs/compounds
THE GLB1 GENE AND ITS PUTATIVE ASSOCIATION WITH HUMAN AGEING GLB1 Gene Information. This gene encodes a member of the glycosyl hydrolase 35 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature lysosomal enzyme. This enzyme catalyzes the hydrolysis of a terminalbeta-linked
THE EGR1 GENE AND ITS PUTATIVE ASSOCIATION WITH HUMAN AGEING An important regulator of the cell cycle, EGR1 has been suggested to act upstream of ageing-related genes such as TP53 . It also appears to be pro-apoptotic . EGR1's role in ageing is unknown, but it might be part of its signalling cascade. Further studies are necessary to establish whether EGR1 is a factor in human ageing. GENETIC VARIATION IN HLA-DRB1 AND HUMAN LONGEVITY 77 centenarians and 299 healthy controls were genotyped for HLA-DRB1 and 44 centenarians and 57 healthy controls for KIR receptors=HLA ligands. Conclusions. An HLA allele (DRB1*18) was associated with longevity. No significant association between successful aging and KIR gene content was observed in this Sicilian population. ALPHA-KETOGLUTARATE AND ITS POSSIBLE ANTI-AGEING PROPERTIES Chin, RM et al. (2014) The metabolite \u03b1-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature 510 (7505)397-401 PubMed. Edwards, C et al. (2015) Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans. BMC Genet. 16 ()8PubMed.
THE BCL2 GENE AND ITS PUTATIVE ASSOCIATION WITH HUMAN AGEING Potential relevance to the human ageing process. BCL2 is an important suppressor of apoptosis and an oncogene. Apart from cancer, it may be involved in neurodegenerative disorders , and dendritic cell longevity in vivo has been reported to be controlled by BCL2 . BCL2 null mice die by six weeks of age with occurrence of grey hair CELLAGE: THE CELL SENESCENCE GENE DATABASE CellAge Database of Cell Senescence Genes. Cell senescence can be defined as the irreversible cessation of cell division of normally proliferating cells. Human cells become senescent from progressive shortening of telomeres as cells divide, stress or oncogenes. Primarily an anti-tumour mechanism, senescent cells accumulate withage in tissues
HUMAN AGEING GENOMIC RESOURCES Human Ageing Genomic Resources. The Human Ageing Genomic Resources (HAGR) is a collection of databases and tools designed to help researchers study the genetics of human ageing using modern approaches such as functional genomics, network analyses, systems biology and evolutionary analyses. GENAGE: THE AGEING GENE DATABASE Complementary to GenAge is a database of genes commonly altered during ageing, drawn from a microarray meta-analysis study, and the LongevityMap, a database of human genetic variants associated with longevity. You can view GenAge's statistics. Release notes for the current build are also available. Though deprecated, a list of genesthat may
THE NUAK1 GENE AND ITS PUTATIVE ASSOCIATION WITH HUMAN AGEING Knockdown of the AMPK-related protein kinase 5 (NUAK1) resulted in an extension of cellular replicative lifespan in normal human diploid fibroblasts. In contrast, ectopic expression of NUAK1 triggered premature senescence. Humbert et al. (2010) "Regulation of ploidy and senescence by the AMPK-related kinase NUAK1." WHO'S WHO IN GERONTOLOGY: COMPANIES Gero. Gero is a data-driven longevity company focused on the development of new treatments to combat the aging process and extend healthy human lifespans, primarily around the topic of stability and stress resistance of gene regulatory networks. More Details ›. DRUGAGE: DATABASE OF AGEING-RELATED DRUGS DrugAge Database of Anti-Ageing Drugs. The DrugAge database contains an extensive compilation of drugs, compounds and supplements (including natural products and nutraceuticals) with anti-ageing properties that extend longevity in model organisms. Our focus is on drugs/compounds potentially impacting on ageing, and thereforedrugs/compounds
THE WRN GENE AND ITS PUTATIVE ASSOCIATION WITH HUMAN AGEING Human WRN-null mesenchymal stem cells show several features associated with accelerated aging . These include increased senescence associated markers, activation of the senescence-associated secretory phenotype and an increased DNA damage response. In addition, there is a global loss of H3K9me3 and accompanying changes in THE GLB1 GENE AND ITS PUTATIVE ASSOCIATION WITH HUMAN AGEING GLB1 Gene Information. This gene encodes a member of the glycosyl hydrolase 35 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature lysosomal enzyme. This enzyme catalyzes the hydrolysis of a terminalbeta-linked
ANNA'S HUMMINGBIRD (CALYPTE ANNA) LONGEVITY, AGEING, AND GenAge. A curated database of candidate human ageing-related genes and genes associated with longevity and/or ageing in model organisms. THE EEF1A1 GENE AND ITS PUTATIVE ASSOCIATION WITH HUMAN AGEING Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model. Description. EEF1A1 is involved in the binding of tRNA to ribosomes during protein synthesis. In fruit flies, overexpression of EEF1A1 increases longevity . Whether EEF1A1 has any role in mammalian ageing has not beendetermined.
CELLAGE: THE CELL SENESCENCE GENE DATABASE CellAge Database of Cell Senescence Genes. Cell senescence can be defined as the irreversible cessation of cell division of normally proliferating cells. Human cells become senescent from progressive shortening of telomeres as cells divide, stress or oncogenes. Primarily an anti-tumour mechanism, senescent cells accumulate withage in tissues
HUMAN AGEING GENOMIC RESOURCES Human Ageing Genomic Resources. The Human Ageing Genomic Resources (HAGR) is a collection of databases and tools designed to help researchers study the genetics of human ageing using modern approaches such as functional genomics, network analyses, systems biology and evolutionary analyses. GENAGE: THE AGEING GENE DATABASE Complementary to GenAge is a database of genes commonly altered during ageing, drawn from a microarray meta-analysis study, and the LongevityMap, a database of human genetic variants associated with longevity. You can view GenAge's statistics. Release notes for the current build are also available. Though deprecated, a list of genesthat may
THE NUAK1 GENE AND ITS PUTATIVE ASSOCIATION WITH HUMAN AGEING Knockdown of the AMPK-related protein kinase 5 (NUAK1) resulted in an extension of cellular replicative lifespan in normal human diploid fibroblasts. In contrast, ectopic expression of NUAK1 triggered premature senescence. Humbert et al. (2010) "Regulation of ploidy and senescence by the AMPK-related kinase NUAK1." WHO'S WHO IN GERONTOLOGY: COMPANIES Gero. Gero is a data-driven longevity company focused on the development of new treatments to combat the aging process and extend healthy human lifespans, primarily around the topic of stability and stress resistance of gene regulatory networks. More Details ›. DRUGAGE: DATABASE OF AGEING-RELATED DRUGS DrugAge Database of Anti-Ageing Drugs. The DrugAge database contains an extensive compilation of drugs, compounds and supplements (including natural products and nutraceuticals) with anti-ageing properties that extend longevity in model organisms. Our focus is on drugs/compounds potentially impacting on ageing, and thereforedrugs/compounds
THE WRN GENE AND ITS PUTATIVE ASSOCIATION WITH HUMAN AGEING Human WRN-null mesenchymal stem cells show several features associated with accelerated aging . These include increased senescence associated markers, activation of the senescence-associated secretory phenotype and an increased DNA damage response. In addition, there is a global loss of H3K9me3 and accompanying changes in THE GLB1 GENE AND ITS PUTATIVE ASSOCIATION WITH HUMAN AGEING GLB1 Gene Information. This gene encodes a member of the glycosyl hydrolase 35 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature lysosomal enzyme. This enzyme catalyzes the hydrolysis of a terminalbeta-linked
ANNA'S HUMMINGBIRD (CALYPTE ANNA) LONGEVITY, AGEING, AND GenAge. A curated database of candidate human ageing-related genes and genes associated with longevity and/or ageing in model organisms. THE EEF1A1 GENE AND ITS PUTATIVE ASSOCIATION WITH HUMAN AGEING Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model. Description. EEF1A1 is involved in the binding of tRNA to ribosomes during protein synthesis. In fruit flies, overexpression of EEF1A1 increases longevity . Whether EEF1A1 has any role in mammalian ageing has not beendetermined.
CELLAGE: THE CELL SENESCENCE GENE DATABASE CellAge Database of Cell Senescence Genes. Cell senescence can be defined as the irreversible cessation of cell division of normally proliferating cells. Human cells become senescent from progressive shortening of telomeres as cells divide, stress or oncogenes. Primarily an anti-tumour mechanism, senescent cells accumulate withage in tissues
SEARCH THE ANAGE DATABASE All HAGRID Species or taxon Common name Longevity Display entry; 03636: Poecilia reticulata: Guppy: 5: 03636: 04235: Arctica islandica: Ocean quahog clam: 507: 04235 SEARCH THE ANAGE DATABASE GenAge. A curated database of candidate human ageing-related genes and genes associated with longevity and/or ageing in model organisms. WHO'S WHO IN GERONTOLOGY: PEOPLE Botstein, David. David Botstein is a geneticist and the chief scientific officer of Calico, a company focused on understanding the biology that controls lifespan to develop interventions that enable people to lead longer and healthier lives. More Details ›. DRUGAGE: DATABASE OF AGEING-RELATED DRUGS DrugAge Database of Anti-Ageing Drugs. The DrugAge database contains an extensive compilation of drugs, compounds and supplements (including natural products and nutraceuticals) with anti-ageing properties that extend longevity in model organisms. Our focus is on drugs/compounds potentially impacting on ageing, and thereforedrugs/compounds
THE GLB1 GENE AND ITS PUTATIVE ASSOCIATION WITH HUMAN AGEING GLB1 Gene Information. This gene encodes a member of the glycosyl hydrolase 35 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature lysosomal enzyme. This enzyme catalyzes the hydrolysis of a terminalbeta-linked
THE EGR1 GENE AND ITS PUTATIVE ASSOCIATION WITH HUMAN AGEING An important regulator of the cell cycle, EGR1 has been suggested to act upstream of ageing-related genes such as TP53 . It also appears to be pro-apoptotic . EGR1's role in ageing is unknown, but it might be part of its signalling cascade. Further studies are necessary to establish whether EGR1 is a factor in human ageing. GENETIC VARIATION IN HLA-DRB1 AND HUMAN LONGEVITY 77 centenarians and 299 healthy controls were genotyped for HLA-DRB1 and 44 centenarians and 57 healthy controls for KIR receptors=HLA ligands. Conclusions. An HLA allele (DRB1*18) was associated with longevity. No significant association between successful aging and KIR gene content was observed in this Sicilian population. ALPHA-KETOGLUTARATE AND ITS POSSIBLE ANTI-AGEING PROPERTIES Chin, RM et al. (2014) The metabolite \u03b1-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature 510 (7505)397-401 PubMed. Edwards, C et al. (2015) Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans. BMC Genet. 16 ()8PubMed.
THE BCL2 GENE AND ITS PUTATIVE ASSOCIATION WITH HUMAN AGEING Potential relevance to the human ageing process. BCL2 is an important suppressor of apoptosis and an oncogene. Apart from cancer, it may be involved in neurodegenerative disorders , and dendritic cell longevity in vivo has been reported to be controlled by BCL2 . BCL2 null mice die by six weeks of age with occurrence of grey hairHome
About
A Vision for senescence.info Author Information Integrative Genomics of Ageing Group Disclaimer, Copyright and Citation Introduction The Grandparents of Tomorrow Here's to Wine, Chocolate and a Long Healthy LifeAnti-Aging Medicine
Caloric Restriction
Should We Cure Aging? How to Become a Biogerontologist Biology of Aging BooksBiology of Aging
What Is Aging? Some Animals Age, Others May Not Comparative Biology of Aging The Evolutionary Theory of Aging Human Aging Model Systems Cellular Senescence Telomeres and Telomerase Is Aging Genetic or Is It Wear and Tear? Why Do We Age? Damage-Based Theories of Aging Programmed Theories of Aging Curing Aging and the Science of Immortality Strategies for Engineered Negligible SenescenceGodseed Genomics
GenAge: The Ageing Gene Database CellAge: The Cell Senescence Gene Database DrugAge: Database of Ageing-Related DrugsGenDR: Caloric
Restriction-Associated Genes LongevityMap: Genetic Variants Associated with Human Longevity AnAge: The Animal Ageing and Longevity Database The Digital Ageing Atlas GlobalPerspective
How to Help Fight Aging Immortality andSociety Glossary
Bibliography Links on Aging Who's Who in Gerontology TwitterContact
WELCOME TO SENESCENCE.INFO! AN EDUCATIONAL AND INFORMATION RESOURCE ON THE SCIENCE OF AGING ------------------------- > "The knowledge that every ambition is doomed to frustration at the > hands of a skeleton have never prevented the majority of human > beings from behaving as though death were no more than an unfounded> rumor."
>
> _Aldous Huxley_
------------------------- Aging , or senescence, is the major cause of suffering, disease, and death in modern times. With the worldwide graying of the population, we are now aging for a longer period of time than ever before. Gerontology , and its sub-field biogerontology in particular, is the science that studies the aging process to prevent age-related disease and degeneration, preserve health, and prolong human life. SENESCENCE.INFO aims to highlight the importance of research on aging and give an overview of current knowledge on the biology and genetics of aging , including anti-aging therapies , models and theories of aging . The most ambitious, even if distant, goal of gerontological research is to make aging optional, to develop a cure for aging , and the social implications of a radical increase in human lifespan due to scientific breakthroughs are also discussed.
SENESCENCE.INFO is aimed at a vast audience and includes tutorials for the non-specialist. Though of course my personal points of view are more prevalent, I try to mention different perspectives, even if I do not agree with them. Although SENESCENCE.INFO is not peer-reviewed, it is used as a reference by scientists and students in the field and recognized as a major knowledge and information website on the aging process; as evidence of its academic standing, SENESCENCE.INFO has been highlighted in _Science_ (307:187), _Aging Cell_ (8:65) and _Nucleic Acids Research_(41:D1027).
_Keywords: Aging Biology, Aging Research, Geroscience, Longevity Science, Longevity Technology_ -------------------------> PROLOGUE
>
>> Why I study aging, what is on offer at SENESCENCE.INFO, my goals >> for this website, and how best to use its resources.>>
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>> A Vision for senescence.info is an >> introduction to the problematic of aging that explains why I >> decided to dedicate my life to the study of aging.>>
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>> Author Information ; for more about me.>>
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>>> Integrative Genomics of Ageing Group >>> ; describes our lab's work.>>
>> *
>> Disclaimer, Copyright and Citation ; it is >> boring but please read the legal stuff prior to accessing any>> information.
>
> VISITOR'S RESOURCES>
>> An introduction to work done in the biology of aging, its >> importance, potential implications and career advice.>>
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>> The Grandparents of Tomorrow is an >> introduction essay on aging and the ongoing efforts to cure aging, >> originally published in The Futurist>> .
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>> Here's to Wine, Chocolate and a Long Healthy Life >> is another introduction essay on >> aging and genetics, originally published in The Conversation>> .
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>> Anti-Aging Medicine presents and >> discusses the most popular life-extension and anti-aging>> treatments.
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>>> Caloric Restriction reviews and >>> discusses CR facts and products trying to mimic its effects.>>
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>> Should We Cure Aging? debates >> several myths about aging and whether we should aim to cure aging.>>
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>> How to Become a Biogerontologist >> offers career advice for students.>>
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>> Biology of Aging Books ; book suggestions and reviews >> for students and researchers.>
> GERONTOLOGY INFORMATION>
>> An overview of current research on the biology of human aging >> featuring key observations, concepts, and theories. Thanks to >> David Bahry, available is also a printer-friendly version >> (last updated in August>> 2013).
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>> What Is Aging? defines the basic concepts >> in the study of longevity and aging.>>
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>> Some Animals Age, Others May Not ; a look at >> the diverse lifespans and aging phenotypes found in nature.>>
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>>> Comparative Biology of Aging >>> presents trends found in comparative studies of aging.>>
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>> The Evolutionary Theory of Aging >> debates the models and hypotheses put forward to explain how aging>> evolved.
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>> Human Aging Model Systems introduces and >> discusses the different model organisms used to study human aging.>>
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>>> Cellular Senescence ; cellular models of aging >>> and the rationale behind them.>>>
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>>>> Telomeres and Telomerase presents >>>> the telomeres, their maintenance mechanisms, and their >>>> relation to human aging.>>
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>> Is Aging Genetic or Is It Wear and Tear? >> discusses the genetic basis of human aging.>>
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>> Why Do We Age? offers an overview of the >> predominant causal theories of aging.>>
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>>> Damage-Based Theories of Aging >>> introduces and discusses theories of aging based on damage >>> accumulation.>>>
>>> * >>> Programmed Theories of Aging introduces >>> and discusses theories of aging based on programmed events.>>
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>> Curing Aging and the Science of Immortality >> presents possible approaches to retard and reverse human aging.>>
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>>> Strategies for Engineered Negligible Senescence or >>> SENS is a proposal to cure aging which is appraised here.>>
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>> Godseed speculates how we will be able >> to change ourselves onto non-aging organisms.>
> GENOMICS OF AGING>
>> I am the principal investigator of the Integrative Genomics of >> Ageing Group at the University of >> Liverpool in the UK. Amongst other >> projects , we >> maintain the Human Ageing Genomic Resources >> , a series of tools and >> databases aimed at understanding the genetic basis of human aging.>>
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>> GenAge is a curated >> database of genes related to aging in humans and in model>> organisms.
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>> CellAge is a curated >> database of human genes associated with cellular senescence.>>
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>> DrugAge is a curated >> database of compounds that modulate longevity in model organisms.>>
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>> GenDR is the first >> database of dietary restriction-associated genes.>>
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>> LongevityMap is the >> first database of human genetic variants associated with>> longevity.
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>> AnAge is an >> aging-oriented animal database featuring over 4,000 species.>>
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>> The Digital Ageing Atlas is the >> first centralized collection of aging changes and pathologies.>
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> THE GLOBAL SPHERE>
>> Cooperation and networking are keys to success.>>
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>> How to Help Fight Aging offers ideas and >> suggestions on how to contribute to progress in gerontology.>>
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>> Immortality and Society paints a picture >> of a world without aging and debates the consequences of a future >> cure for aging.>>
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>> Glossary
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>> Bibliography ; all the roughly 1,000 >> references cited in SENESCENCE.INFO.>>
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>> Links on Aging>>
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>> Who's Who in Gerontology is a >> list of individuals and companies working on aging, longevity and >> related fields.>>
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>> For the latest news, findings and papers on the biology of aging:>>
>> Follow @AgingBiology ------------------------- Creation date: Circa 1997 Last modified: February 10, 2021 Thank you for visiting my website. Please feel free to contact me if you have any questions, ideas, comments or suggestions. Copyright © 1997 - 2014, 2018, 2021 by João Pedro de Magalhães . All rights reserved.Details
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