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View in Chinese. recommend vancomycin or daptomycin . Vancomycin is the agent for which there is the greatest cumulative clinical experience for the treatment of MRSA bacteremia. Due to risk of nephrotoxicity, vancomycin requires . ›. Vancomycin-resistant enterococci: Epidemiology, prevention, andUPTODATE
INTRODUCTION. Syphilis is an infection caused by the bacterium Treponema pallidum. During the initial phase of infection, the organism disseminates widely, setting the stage for subsequent manifestations. If untreated, syphilis can have a number of significant late adverse outcomes, including cardiovascular, gummatous, and neurologic complications. UPTODATESEARCH UPTODATEMY ACCOUNT LOGINRESET PASSWORD UpToDate offers a number of subscriptions and add-on products, allowing you to have the most up-to-date information and improvepatient care.
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{{configCtrl2.info.metaDescription}} transplant increases . As such, a decision regarding the best search plan must take into account the risk of relapse while performing a more extensive search.If the risk of relapse is high and the chance of findingUPTODATE
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View in Chinese. recommend vancomycin or daptomycin . Vancomycin is the agent for which there is the greatest cumulative clinical experience for the treatment of MRSA bacteremia. Due to risk of nephrotoxicity, vancomycin requires . ›. Vancomycin-resistant enterococci: Epidemiology, prevention, andUPTODATE
INTRODUCTION. Syphilis is an infection caused by the bacterium Treponema pallidum. During the initial phase of infection, the organism disseminates widely, setting the stage for subsequent manifestations. If untreated, syphilis can have a number of significant late adverse outcomes, including cardiovascular, gummatous, and neurologic complications.UPTODATE
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INTRODUCTION. Conjunctivitis is a common diagnosis in patients who complain of a red eye. It is usually a benign or self-limited condition, or one that is easily treated. Other causes of red eye are discussed elsewhere. (See "Overview of the red eye" .) This topic will review the clinical manifestations, diagnosis, and treatment ofconjunctivitis.
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Neurosyphilis can occur at any time after initial infection. Early in the course of syphilis, the most common forms of neurosyphilis involve the cerebrospinal fluid, meninges, and vasculature (asymptomatic meningitis, symptomatic meningitis, and meningovascular disease). Late in disease, the most common forms involve the brain and spinal cordUPTODATE
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{{configCtrl2.info.metaDescription}} INTRODUCTION. Medical therapy, cardiac resynchronization therapy, and implantable cardioverter-defibrillators have improved the survival of many with heart failure with reduced ejection fraction (HFrEF), but there remains a large group of patients who have advanced HF with poor prognosis despite optimal medical therapy.WWW.UPTODATE.COM
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Fenves AZ, Emmett M, White MG. Lithium intoxication associated with acute renal failure. South Med J 1984; 77:1472. Vodovar D, El Balkhi S, Curis E, et al. Lithium poisoning in the intensive care unit: predictive factors of severity and indications for extracorporeal toxin removal to improve outcome.HICCUPS - UPTODATE
A hiccup occurs due to an involuntary, intermittent, spasmodic contraction of the diaphragm and intercostal muscles. This causes sudden inspiration that ends with abrupt closure of the glottis, generating the “hic” sound. The left hemidiaphragm is involved in approximately 80 percent of cases . UPTODATESEARCH UPTODATEMY ACCOUNT LOGINRESET PASSWORD UpToDate offers a number of subscriptions and add-on products, allowing you to have the most up-to-date information and improvepatient care.
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MECHANISM OF ACTION. Acyclovir (9- guanine) is a nucleoside analog that selectively inhibits the replication of herpes simplex virus types 1 and 2 (HSV-1, HSV-2) and varicella-zoster virus (VZV). After intracellular uptake, it is converted to acyclovirmonophosphate by
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Paronychia is an inflammation involving the lateral and proximal nail folds. It may be acute (lasting for less than six weeks) or chronic (lasting for six weeks or longer) . Predisposing factors include overzealous manicuring, nail biting, picking at a hangnail, thumbsucking, ingrown nail, diabetes mellitus, and occupations inwhich the
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Onychomycosis, fungal infection of the nail, can cause disfigurement of the nail, pain, and may increase risk for soft tissue bacterial infection in immunocompromised patients. Dermatophytes, particularly Trichophyton rubrum, are the most common causes of onychomycosis.UPTODATE
View in Chinese. recommend vancomycin or daptomycin . Vancomycin is the agent for which there is the greatest cumulative clinical experience for the treatment of MRSA bacteremia. Due to risk of nephrotoxicity, vancomycin requires . ›. Vancomycin-resistant enterococci: Epidemiology, prevention, and UPTODATESEARCH UPTODATEMY ACCOUNT LOGINRESET PASSWORD UpToDate offers a number of subscriptions and add-on products, allowing you to have the most up-to-date information and improvepatient care.
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MECHANISM OF ACTION. Acyclovir (9- guanine) is a nucleoside analog that selectively inhibits the replication of herpes simplex virus types 1 and 2 (HSV-1, HSV-2) and varicella-zoster virus (VZV). After intracellular uptake, it is converted to acyclovirmonophosphate by
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Paronychia is an inflammation involving the lateral and proximal nail folds. It may be acute (lasting for less than six weeks) or chronic (lasting for six weeks or longer) . Predisposing factors include overzealous manicuring, nail biting, picking at a hangnail, thumbsucking, ingrown nail, diabetes mellitus, and occupations inwhich the
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Onychomycosis, fungal infection of the nail, can cause disfigurement of the nail, pain, and may increase risk for soft tissue bacterial infection in immunocompromised patients. Dermatophytes, particularly Trichophyton rubrum, are the most common causes of onychomycosis.UPTODATE
View in Chinese. recommend vancomycin or daptomycin . Vancomycin is the agent for which there is the greatest cumulative clinical experience for the treatment of MRSA bacteremia. Due to risk of nephrotoxicity, vancomycin requires . ›. Vancomycin-resistant enterococci: Epidemiology, prevention, andLOGIN - UPTODATE
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Symptoms associated with coronavirus disease 2019 (COVID-19) Quick reference for evaluation and management of COVID-19-associated hypercoagulability. Diagnostic tests for COVID-19 Laboratory features associated with severe COVID-19 Diagnostic criteria forKawasaki disease.
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INTRODUCTION. Syphilis is an infection caused by the bacterium Treponema pallidum. During the initial phase of infection, the organism disseminates widely, setting the stage for subsequent manifestations. If untreated, syphilis can have a number of significant late adverse outcomes, including cardiovascular, gummatous, and neurologic complications.UPTODATE
Acute urinary retention (AUR) is the inability to voluntarily pass urine. It is the most common urologic emergency . In men, AUR is most often secondary to benign prostatic hyperplasia (BPH); AUR is rare in women . This topic will review issues related to evaluation and management of AUR.UPTODATE
View in Chinese. recommend vancomycin or daptomycin . Vancomycin is the agent for which there is the greatest cumulative clinical experience for the treatment of MRSA bacteremia. Due to risk of nephrotoxicity, vancomycin requires . ›. Vancomycin-resistant enterococci: Epidemiology, prevention, andUPTODATE
INTRODUCTION. Conjunctivitis is a common diagnosis in patients who complain of a red eye. It is usually a benign or self-limited condition, or one that is easily treated. Other causes of red eye are discussed elsewhere. (See "Overview of the red eye" .) This topic will review the clinical manifestations, diagnosis, and treatment ofconjunctivitis.
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Management of actinomycosis often entails prolonged courses of antimicrobials. Surgical intervention may also be necessary in more complicated cases, such as infection in critical spaces (eg, epidural infections, brain abscesses), patients with massive hemoptysis, or when extensive abscesses and fistulous tracts are present. EXTERNAL OTITIS: TREATMENT The term "external otitis" (also known as otitis externa or swimmer's ear) refers to inflammation of the external auditory canal or auricle. This topic will focus on the treatment of external otitis. The clinical manifestations and diagnosis of external otitis are discussed elsewhere. (See "External otitis: Pathogenesis, clinical features, and We use cookies for various purposes including enabling website functionality and targeted marketing activities. For more information about cookies, please review our Privacy & Cookie Notice . You can manage your cookie settings by clicking 'Manage cookie settings and details'.Accept All Cookies
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Caring for patients with COVID-19? Find answers you can trust inUpToDate.
Browse our COVID-19 resources MORE THAN 100 STUDIES CONCUR: PATIENTS RECEIVE BETTER CARE WHEN CLINICIANS USE UPTODATE Healthcare professionals around the world turn to UpToDate as the one trusted reference for answers even when the evidence isn’t clear. When you face a challenging clinical question or need to confirm your approach, you can turn to UpToDate for trusted answers based on the latest evidence and best practice. For over 25 years, we’ve been relentless in our quest to bring you the latest medical evidence, best practices and the right technology so you get answers fast. We are committed to you, so you can focus on what matters most: providing the best care possible to your patients. With more than 25 medical specialties, UpToDate enables confidence and provides clarity in decision-making as you treat each patient—even when evidence isn’t clear.Watch Video
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Dr. John Clark
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Dr. Satoshi Hayano
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Dr. Shannon Heinrich …there are some cases I’ve never encountered before. In the case of HLH, UpToDate helped me learn enough about the condition in a matter of minutes, which had a potentially life-saving outcome for mypatient.
Dr. John Clark
Internist/Pulmonologist, Alaska Regional Hospital and Providence Alaska Medical CenterRead His Story
Read His Clinician Story In this era of information overload, high-quality information curated from the viewpoint of clinicians is really valuable. For me, UpToDate has been a reliable companion from my days in training as a medical student and a resident, to the present, where I am a specialist and ateaching doctor.
Dr. Satoshi Hayano
Pediatric Cardiologist and Chief Physician, Department of Pediatrics, Chutoen General Medical CenterRead His Story
Read His Clinician Story I have no doubt that my patient could have lost his leg, or died, had I not had access to UpToDate, which helped me identify him as a candidate for anti-venom. Dr. Shannon Heinrich Hospitalist, AlabamaRead More
Read Her Clinician Story The only evidence-based resource associated with improved outcomes More than 100 independent research studies show that using UpToDate improves patient outcomes and hospital performance, including less errors, shorter hospital stays, and more efficient resourceallocation.
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Driven by leading physicians and pharmacists At the heart of UpToDate is a global community of more than 7,300 authors, editors, and peer reviewers who are widely regarded as leaders in their field. They follow a rigorous editorial process and align with our Lexicomp® editors to provide holistic decisionsupport.
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Focused on value-generating technology Our dedicated engineering team continuously innovates to stay ahead of your evolving needs so that you benefit from value-generating technology and practice medicine with greater satisfaction. Also, our editorial team, all leaders in their fields, are continually developing content to address emerging topics to support complexclinical decisions.
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INNOVATION THAT MAKES AN IMPACT UpToDate is dedicated to meeting the rapidly evolving needs of healthcare providers. We are constantly innovating both our emerging medicine content and our leading-edge technology to help you improve care delivery and stay ahead of hard-to-predict health events. Find out about our latest innovations COVID-19 resources available to all Our commitment to you is to continue to respond quickly with the latest evidence-based COVID-19 information, including recent updates to support the successful deployment of the vaccines at scale. View our categorized collection of all UpToDate COVID-19 content including clinical topics, algorithms, patient education and society guideline links - available for free.View Our COVID-19 Resources Medical insurers, pharmacies, and life science businesses achieve their goals with UpToDate From reviewing medical issues and recommended treatments, to studying epidemiology and pursuing continuing medical education, discover why UpToDate is the only evidence-based clinical decision support you need to power your research, claims adjudication, formulary development, clinical trials, and more.Learn More Latest News and UpdatesView More
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Press Release
Health
June 02, 2021
Mongolia Ministry of Health boosts rural healthcare with UpToDatenational access
Thousands of rural doctors and healthcare professionals in the world’s most sparsely populated nation are now using the UpToDate app, often without a cellular signal, to quickly find answers to clinical questions across 25 clinical specialties.Learn More
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Article
Health
May 26, 2021
Cannabis and CBD: A Clinician’s Guide to Advising Patients Advising patients on cannabis use can be challenging for clinicians – while it’s legal or approved for medical use in many U.S. states, because it’s illegal at the federal level, there’s lack of clinical standards and knowledge about interactions.Learn More
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Article
Health
May 17, 2021
Equity equals quality: Improving diversity and inclusivity in clinicalcontent
Failing to account for the differences among patients, such as race, ethnicity, gender, sexual orientation, etc., can adversely affect diagnosis, treatment, and health outcomes.Learn More
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Press Release
Health
May 07, 2021
In India, Wolters Kluwer provides free access to UpToDate coronavirus resources & tools for front-line clinicians & medical researchers For clinicians on the front lines of the COVID-19 pandemic who are seeking the most current, evidence-based content, all coronavirus topics in Wolters Kluwer’s UpToDate are available for free.Learn More
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