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CLEVERS GROUP
Hans Clevers. Hans Clevers is group leader at the Hubrecht Institute for Developmental Biology and Stem Cell Research and at the Princess Máxima Center for Pediatric Oncology. He is also University Professor at the University Utrecht and Oncode Investigator.TANENBAUM GROUP
Marvin Tanenbaum is group leader at the Hubrecht Institute. His group studies the molecular mechanisms of gene expression control at the single cell level and aims to understand how control of gene expression affects important cellular decisions. The Tanenbaum group has developed several new techniques, including the SunTag fluorescence imaging KIND GROUP - HUBRECHT INSTITUTE Jop Kind is group leader at the Hubrecht Institute. His group is interested in elucidating the role of chromatin and nuclear architecture in gene-regulation and DNA-repair. The Kind group develops new techniques, such as the recently developed DamID and m6 ATracer techniques. These techniques enable them to study genome architecture and proteinDE LAAT GROUP
Wouter de Laat. Wouter de Laat is group leader at the Hubrecht Institute and professor of Biomedical Genomics at University Medical Center Utrecht. His research focuses on two main themes, with a strong emphasis on technology development.RABOUILLE GROUP
Catherine Rabouille. Catherine Rabouille is group leader at the Hubrecht Institute and Professor of Cell Biology at the University Medical Center Groningen, and is also affiliated with the University Medical Center Utrecht. After studying the early secretory pathway in Drosophila melanogaster, her group now focuses on how nutrient stress(serum
ZEB2 GENE IMPROVES HEALING AFTER HEART ATTACK IN MICE The gene ZEB2 improves healing after a heart attack in mice. Researchers in the group of Eva van Rooij have found that the gene ZEB2 promotes angiogenesis, the formation of blood vessels, in the heart after a heart attack. They discovered that in mice in which they provided ZEB2 through gene therapy, the hearts were better able topump blood
HUBRECHT INSTITUTEABOUT USRESEARCH GROUPSFACILITIESNEWSSOCIETYFRIENDS Computer simulations visualize in atomic detail how DNA opens while wrapped around proteins. Researchers from the Hubrecht Institute in Utrecht (The Netherlands) and the Max Planck Institute for Molecular Biomedicine in Münster (Germany) used computer simulations to reveal in atomic detail how a short piece of DNA opens while it is tightlyCLEVERS GROUP
Hans Clevers. Hans Clevers is group leader at the Hubrecht Institute for Developmental Biology and Stem Cell Research and at the Princess Máxima Center for Pediatric Oncology. He is also University Professor at the University Utrecht and Oncode Investigator.TANENBAUM GROUP
Marvin Tanenbaum is group leader at the Hubrecht Institute. His group studies the molecular mechanisms of gene expression control at the single cell level and aims to understand how control of gene expression affects important cellular decisions. The Tanenbaum group has developed several new techniques, including the SunTag fluorescence imaging KIND GROUP - HUBRECHT INSTITUTE Jop Kind is group leader at the Hubrecht Institute. His group is interested in elucidating the role of chromatin and nuclear architecture in gene-regulation and DNA-repair. The Kind group develops new techniques, such as the recently developed DamID and m6 ATracer techniques. These techniques enable them to study genome architecture and proteinDE LAAT GROUP
Wouter de Laat. Wouter de Laat is group leader at the Hubrecht Institute and professor of Biomedical Genomics at University Medical Center Utrecht. His research focuses on two main themes, with a strong emphasis on technology development.RABOUILLE GROUP
Catherine Rabouille. Catherine Rabouille is group leader at the Hubrecht Institute and Professor of Cell Biology at the University Medical Center Groningen, and is also affiliated with the University Medical Center Utrecht. After studying the early secretory pathway in Drosophila melanogaster, her group now focuses on how nutrient stress(serum
ZEB2 GENE IMPROVES HEALING AFTER HEART ATTACK IN MICE The gene ZEB2 improves healing after a heart attack in mice. Researchers in the group of Eva van Rooij have found that the gene ZEB2 promotes angiogenesis, the formation of blood vessels, in the heart after a heart attack. They discovered that in mice in which they provided ZEB2 through gene therapy, the hearts were better able topump blood
KING SPEAKS WITH HUBRECHT RESEARCHERS DURING WORK VISIT TO His Majesty the King paid a digital work visit to the Royal Netherlands Academy of Arts and Sciences (KNAW) on Thursday 3 June. The central topic of the visit was the impact of the corona crisis onscience.
COLLABORATIVE RESEARCH PROJECT RECEIVES FUNDING FROM ZONMW Researchers from the groups of Jeroen Bakkers (Hubrecht Institute), Folkert Asselbergs and Magdalena Harakalova (UMC Utrecht), and Frédéric Vaz (Amsterdam UMC) receive €936.000 from the ZonMw Open Competition for their CONTRACT project. They will study how mutations in the PLN gene affect the energy supply of the heart. The results will contribute to the development of new treatment MICROBES MEET ORGANOIDS What can we learn about the impact of the billions of microbes in our gut on health and disease by rebuilding these interactions in a dish? Researchers from the group of Hans Clevers address this question in a review on recent advances with modelling host-microbe interactions using organoids and organs-on-chips. Focusing on the various mechanisms by which microbes such as bacteria, NOVEL TECHNOLOGY FOR DETECTING CHROMOSOMAL REARRANGEMENTS Researchers from the group of Wouter de Laat, in collaboration with biotech company Cergentis and lymphoma experts of 5 Dutch hospitals, developed a novel technology for improved detection of clinically relevant chromosomal rearrangements in tumors. The method, FFPE-TLC technology, promises to improve diagnostics for lymphoma and may also be relevant for rearrangement detection in otherBARTSCHERER GROUP
Group leader Kerstin Bartscherer. Kerstin Bartscherer is a group leader at the Hubrecht Institute. Using both excellent invertebrate (planarian flatworms) and mammalian regenerators (African spiny mice) as experimental models, in combination with comparative approaches, the group aims to unveil the mechanisms that facilitate tissueregeneration.
KOPS GROUP - HUBRECHT INSTITUTE Geert Kops. Geert Kops is group leader at the Hubrecht Institute, professor of Molecular Tumor Cell Biology at the University Medical Center Utrecht and Scientific Director of Oncode Institute. His group is interested in the processes that ensure correct chromosome segregation during cell division.DE LAAT GROUP
Wouter de Laat. Wouter de Laat is group leader at the Hubrecht Institute and professor of Biomedical Genomics at University Medical Center Utrecht. His research focuses on two main themes, with a strong emphasis on technology development.MATTIROLI GROUP
Francesca Mattiroli. Francesca Mattiroli is a group leader at the Hubrecht Institute since January 2018. Her group investigates chromatin dynamics during DNA replication and repair. The Mattiroli group uses biochemical reconstitutions, structural approaches and cell biology to elucidate the biophysical and structural properties ofchromatin and
SIGNALING PROTEINS IN PACEMAKER CELLS REGULATE CARDIAC Signaling proteins in pacemaker cells regulate cardiac rhythm. A signaling process with which cells pass on signals during cardiac development, called Wnt/ß-catenin-signaling, influences the control of the autonomic nervous system on heart rate in zebrafish. That is the conclusion of Silja Burkhard, one of the Hubrecht researchers ofthe
THESIS DEFENSE ELSE DRIEHUIS: ORGANOIDS AS A TOOL FOR Else Driehuis from the Clevers group successfully defended her thesis “Organoids as a tool for fundamental and translational oncology research” on the 1 st of October. HUBRECHT INSTITUTEABOUT USRESEARCH GROUPSFACILITIESNEWSSOCIETYFRIENDS The institute encompasses 23 research groups that perform fundamental, multidisciplinary research on healthy and diseased cells, tissues andorganisms.
TANENBAUM GROUP
Marvin Tanenbaum is group leader at the Hubrecht Institute. His group studies the molecular mechanisms of gene expression control at the single cell level and aims to understand how control of gene expression affects important cellular decisions. The Tanenbaum group has developed several new techniques, including the SunTag fluorescence imaging HUBRECHT IMAGING CENTER Hubrecht Imaging Center. The Hubrecht Imaging Center ensures high performance and optimal use of the advanced imaging equipment at the Hubrecht Institute by testing periodically and optimizing all systems, training of new researchers and providing support to advanced imaging experiments. New microscope users should contact microscopy manager KOPS GROUP - HUBRECHT INSTITUTE Geert Kops. Geert Kops is group leader at the Hubrecht Institute, professor of Molecular Tumor Cell Biology at the University Medical Center Utrecht and Scientific Director of Oncode Institute. His group is interested in the processes that ensure correct chromosome segregation during cell division.CLEVERS GROUP
Hans Clevers. Hans Clevers is group leader at the Hubrecht Institute for Developmental Biology and Stem Cell Research and at the Princess Máxima Center for Pediatric Oncology. He is also University Professor at the University Utrecht and Oncode Investigator.RABOUILLE GROUP
Catherine Rabouille. Catherine Rabouille is group leader at the Hubrecht Institute and Professor of Cell Biology at the University Medical Center Groningen, and is also affiliated with the University Medical Center Utrecht. After studying the early secretory pathway in Drosophila melanogaster, her group now focuses on how nutrient stress(serum
SIGNALING PROTEINS IN PACEMAKER CELLS REGULATE CARDIAC Signaling proteins in pacemaker cells regulate cardiac rhythm. A signaling process with which cells pass on signals during cardiac development, called Wnt/ß-catenin-signaling, influences the control of the autonomic nervous system on heart rate in zebrafish. That is the conclusion of Silja Burkhard, one of the Hubrecht researchers ofthe
SCIENTISTS START BIOBANK WITH LIVING BREAST CANCER CELLS Therefore, there is a need for personalized treatments. Scientists, led by prof. dr. Hans Clevers (Hubrecht Institute) and prof. dr. Edwin Cuppen (UMC Utrecht), started a biobank with organoids of more than 100 different breast cancers. These organoids are cultivated from live tumor cells that have been harvested from breast cancer patients THESIS DEFENSE ELSE DRIEHUIS: ORGANOIDS AS A TOOL FOR Else Driehuis from the Clevers group successfully defended her thesis “Organoids as a tool for fundamental and translational oncology research” on the 1 st of October. LLAMATAGS: A VERSATILE TOOL TO IMAGE TRANSCRIPTION FACTOR Resource LlamaTags: A Versatile Tool to Image Transcription Factor Dynamics in Live Embryos Jacques P. Bothma,1 Matthew R. Norstad,1 Simon Alamos,4 and Hernan G. Garcia1,2,3,5,6,* 1Department of Molecular & Cell Biology, UC Berkeley, Berkeley, CA 94720, USA 2Department of Physics, UC Berkeley, Berkeley, CA 94720, USA 3Biophysics Graduate Group, UC Berkeley, Berkeley, CA 94720, USA HUBRECHT INSTITUTEABOUT USRESEARCH GROUPSFACILITIESNEWSSOCIETYFRIENDS The institute encompasses 23 research groups that perform fundamental, multidisciplinary research on healthy and diseased cells, tissues andorganisms.
TANENBAUM GROUP
Marvin Tanenbaum is group leader at the Hubrecht Institute. His group studies the molecular mechanisms of gene expression control at the single cell level and aims to understand how control of gene expression affects important cellular decisions. The Tanenbaum group has developed several new techniques, including the SunTag fluorescence imaging HUBRECHT IMAGING CENTER Hubrecht Imaging Center. The Hubrecht Imaging Center ensures high performance and optimal use of the advanced imaging equipment at the Hubrecht Institute by testing periodically and optimizing all systems, training of new researchers and providing support to advanced imaging experiments. New microscope users should contact microscopy manager KOPS GROUP - HUBRECHT INSTITUTE Geert Kops. Geert Kops is group leader at the Hubrecht Institute, professor of Molecular Tumor Cell Biology at the University Medical Center Utrecht and Scientific Director of Oncode Institute. His group is interested in the processes that ensure correct chromosome segregation during cell division.CLEVERS GROUP
Hans Clevers. Hans Clevers is group leader at the Hubrecht Institute for Developmental Biology and Stem Cell Research and at the Princess Máxima Center for Pediatric Oncology. He is also University Professor at the University Utrecht and Oncode Investigator.RABOUILLE GROUP
Catherine Rabouille. Catherine Rabouille is group leader at the Hubrecht Institute and Professor of Cell Biology at the University Medical Center Groningen, and is also affiliated with the University Medical Center Utrecht. After studying the early secretory pathway in Drosophila melanogaster, her group now focuses on how nutrient stress(serum
SIGNALING PROTEINS IN PACEMAKER CELLS REGULATE CARDIAC Signaling proteins in pacemaker cells regulate cardiac rhythm. A signaling process with which cells pass on signals during cardiac development, called Wnt/ß-catenin-signaling, influences the control of the autonomic nervous system on heart rate in zebrafish. That is the conclusion of Silja Burkhard, one of the Hubrecht researchers ofthe
SCIENTISTS START BIOBANK WITH LIVING BREAST CANCER CELLS Therefore, there is a need for personalized treatments. Scientists, led by prof. dr. Hans Clevers (Hubrecht Institute) and prof. dr. Edwin Cuppen (UMC Utrecht), started a biobank with organoids of more than 100 different breast cancers. These organoids are cultivated from live tumor cells that have been harvested from breast cancer patients THESIS DEFENSE ELSE DRIEHUIS: ORGANOIDS AS A TOOL FOR Else Driehuis from the Clevers group successfully defended her thesis “Organoids as a tool for fundamental and translational oncology research” on the 1 st of October. LLAMATAGS: A VERSATILE TOOL TO IMAGE TRANSCRIPTION FACTOR Resource LlamaTags: A Versatile Tool to Image Transcription Factor Dynamics in Live Embryos Jacques P. Bothma,1 Matthew R. Norstad,1 Simon Alamos,4 and Hernan G. Garcia1,2,3,5,6,* 1Department of Molecular & Cell Biology, UC Berkeley, Berkeley, CA 94720, USA 2Department of Physics, UC Berkeley, Berkeley, CA 94720, USA 3Biophysics Graduate Group, UC Berkeley, Berkeley, CA 94720, USA PI3K PATHWAY CONTROLS SURVIVAL OF BLOOD STEM CELLS IN The PTEN-gene is a so-called tumor suppressor gene.It prevents unrestricted cell division, a process that underlies cancer. PTEN controls various signaling pathways that stimulate cell division, including the Phosphatidylinositol-3 kinase (PI3K) pathway.When mutations in PTEN occur, the PI3K pathway goes in overdrive, thereby increasing cell division. CURRICULUM VITAE NAME EDUCATION SCIENTIFIC TRAINING/POSITIONS Curriculum vitae J.C. Clevers - page 3 2016 - 2020 Member of the Scientific Advisory Board of Kallyope, New York 2016 - present Member of the Scientific Advisory Board of the Francis Crick Institute,London
THE LIFE AND DEATH OF A SINGLE MRNA MOLECULE A cellular system to get rid of faulty mRNAs was studied for the first time at the single molecule level. Researchers of the Tanenbaum group at the Hubrecht Institute used a new method to study this cellular quality control system, called nonsense-mediated mRNA decay, for individual mRNA molecules under the microscope in living cells. Their study was published in the scientific journalRABOUILLE GROUP
Catherine Rabouille. Catherine Rabouille is group leader at the Hubrecht Institute and Professor of Cell Biology at the University Medical Center Groningen, and is also affiliated with the University Medical Center Utrecht. After studying the early secretory pathway in Drosophila melanogaster, her group now focuses on how nutrient stress(serum
BARTSCHERER GROUP
Kerstin Bartscherer is a group leader at the Hubrecht Institute. Using both excellent invertebrate (planarian flatworms) and mammalian regenerators (African spiny mice) as experimental models, in combination with comparative approaches, the group aimsCOJOCARU GROUP
Cojocaru: In Silico Biomolecular Structure and Dynamics. Back to research groups. We use computational approaches to understand the structure and dynamics of biomolecules at or near atomic resolution, with a special focus on biomolecular recognition. In particular, we are interested in how a special class of proteins known astranscription
KORSWAGEN GROUP
Rik Korswagen. Rik Korswagen is a group leader at the Hubrecht Institute and professor of Molecular Developmental Genetics at Utrecht University. He has a long standing interest in signal transduction mechanisms and has been focusing on the role of Wnt signaling in the development of the model organism C. elegans. SCIENTISTS START BIOBANK WITH LIVING BREAST CANCER CELLS Living tumor cells Scientists, led by prof. dr. Hans Clevers (Hubrecht Institute) and prof. dr. Edwin Cuppen (UMC Utrecht), started a biobank with organoids of more than 100 different breast cancers. These organoids are cultivated from live tumor cells that have been ROBIN: HEMATOPOIESIS AND STEM CELLS DURING EMBRYONIC Hematopoietic Stem Cells (HSCs) are self-renewing multipotent cells that produce all blood cell types during the entire life of an individual. They are the key cell type in transplantation protocols for patients with hematological malignancies. Adult HSCs are initially generated during embryonic development. We recently developed a novel experimental imaging set-up to visualize the mousePAUL SCHALING
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