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STEM CELLS PORTAL
Activin A-derived human embryonic stem cells show increased competence to differentiate into primordial germ cell-like cells Swati Mishra, et al., STEM CELLS Robust differentiation of human primordial germ cell-like cells (hPGCLCs) starting from human STEM CELL-BASED VACCINE OFFERS A NEW APPROACH THAT MAY STANFORD, CA (US), May 2021 — New research by Joseph Wu, Edgar Engelman and colleagues at Stanford University has advanced an old concept to develop a new strategy to train the immune system of mice to recognize cancer cells. This work is based on the recent understanding that induced pluripotent stem cells (iPSCs), which are stem cells generated from skin or blood cells COMBINED CELL THERAPY AS AN ENHANCED TREATMENT FOR Review of “ Combination therapy with Treg and MSC enhances potency and attenuation of inflammation after traumatic brain injury compared to monotherapy ” from STEM CELLS by Stuart P. Atkinson Research led by Scott D. Olson and Charles S. Cox, Jr. (University of Texas Health Science Center at Houston, Houston, Texas, USA) into cell therapies for traumatic brain injury has highlighted A QUICK AND EFFICIENT PROTOCOL FOR RBC PRODUCTION FROM This quick and efficient feeder- and serum-free defined protocol represents a grand step towards the clinical application of hPSC-derived erythrocytes. However, this improved methodology also provides researchers a tractable system to pull apart the regulatory mechanisms that control the various stages of hematopoiesis anderythropoiesis.
MESC SHOWDOWN: 2I VS. SERUM Embryonic stem cells (ESCs) maintained in serum are often morphologically heterogeneous and also express pluripotency associated transcription factors in a heterogeneous manner (Toyooka et al) perhaps suggesting that the pluripotent state in unstable. However, the derivation and maintenance of mESCs in serum-free conditions through the use of two small molecule kinase (Mek and YAMANAKA FACTORS, VERSION 2.0 Yamanaka Factors, Version 2.0. Advances in pluripotent stem cell biology have been fast and furious ever since the production of mouse induced pluripotent stem cells (iPSCs) were first described by ectopic expression of Oct3/4, Sox2, Klf4, and c-Myc, commonly referred to as the “Yamanaka Factors” (Takahashi and Yamanaka 2006). THE SOFTER, THE BETTER The Softer, the Better - How Niche Stiffness Affects Aging Stem Cells. Review of “ Niche stiffness underlies the ageing of central nervous system progenitor cells ” from Nature by Stuart P. Atkinson. While studies have indicated that the loss of function of adult stem cell and progenitor cell populations causes a decline in tissue THAILAND SEEKS TO CONTROL STEM CELL THERAPY SERVICES The Public Health Ministry is working on a bill to stop unverified commercial stem cell therapy services being advertised after finding some clinics making exaggerated claims, according to a report in the Bangkok Post.Spearheaded by the Department of Health Service Support (HSS), the bill will conform to the Medical Council of Thailand's (MCT) regulations on medical ethics, LITHIUM PRECONDITIONING BOOSTS STROKE TREATMENT BY MSC Review of "Lithium modulates miR-1906 levels of MSC-derived extracellular vesicles contributing to post-stroke neuroprotection by toll-like receptor 4 regulation" from STEM CELLS Translational Medicine by Stuart P. AtkinsonWhile lithium has a well-recognized function as a mood stabilizer, a wide range of research now supports a neuroprotective role for lithium in conditions such as cerebral MFAT VS. BMAC: MESENCHYMAL STEM CELL THERAPY SHOWDOWN FOR Review of “Functional Outcomes Following Microfragmented Adipose Tissue Versus Bone Marrow Aspirate Concentrate Injections for Symptomatic Knee Osteoarthritis” from STEM CELLS Translational Medicine by Stuart P. Atkinson Osteoarthritis, a chronic degenerative disease of the articular cartilage, currently affects an estimated 30 million U.S. adults and costs over $185 billion aSTEM CELLS PORTAL
Activin A-derived human embryonic stem cells show increased competence to differentiate into primordial germ cell-like cells Swati Mishra, et al., STEM CELLS Robust differentiation of human primordial germ cell-like cells (hPGCLCs) starting from human STEM CELL-BASED VACCINE OFFERS A NEW APPROACH THAT MAY STANFORD, CA (US), May 2021 — New research by Joseph Wu, Edgar Engelman and colleagues at Stanford University has advanced an old concept to develop a new strategy to train the immune system of mice to recognize cancer cells. This work is based on the recent understanding that induced pluripotent stem cells (iPSCs), which are stem cells generated from skin or blood cells COMBINED CELL THERAPY AS AN ENHANCED TREATMENT FOR Review of “ Combination therapy with Treg and MSC enhances potency and attenuation of inflammation after traumatic brain injury compared to monotherapy ” from STEM CELLS by Stuart P. Atkinson Research led by Scott D. Olson and Charles S. Cox, Jr. (University of Texas Health Science Center at Houston, Houston, Texas, USA) into cell therapies for traumatic brain injury has highlighted A QUICK AND EFFICIENT PROTOCOL FOR RBC PRODUCTION FROM This quick and efficient feeder- and serum-free defined protocol represents a grand step towards the clinical application of hPSC-derived erythrocytes. However, this improved methodology also provides researchers a tractable system to pull apart the regulatory mechanisms that control the various stages of hematopoiesis anderythropoiesis.
MESC SHOWDOWN: 2I VS. SERUM Embryonic stem cells (ESCs) maintained in serum are often morphologically heterogeneous and also express pluripotency associated transcription factors in a heterogeneous manner (Toyooka et al) perhaps suggesting that the pluripotent state in unstable. However, the derivation and maintenance of mESCs in serum-free conditions through the use of two small molecule kinase (Mek and YAMANAKA FACTORS, VERSION 2.0 Yamanaka Factors, Version 2.0. Advances in pluripotent stem cell biology have been fast and furious ever since the production of mouse induced pluripotent stem cells (iPSCs) were first described by ectopic expression of Oct3/4, Sox2, Klf4, and c-Myc, commonly referred to as the “Yamanaka Factors” (Takahashi and Yamanaka 2006). THE SOFTER, THE BETTER The Softer, the Better - How Niche Stiffness Affects Aging Stem Cells. Review of “ Niche stiffness underlies the ageing of central nervous system progenitor cells ” from Nature by Stuart P. Atkinson. While studies have indicated that the loss of function of adult stem cell and progenitor cell populations causes a decline in tissue THAILAND SEEKS TO CONTROL STEM CELL THERAPY SERVICES The Public Health Ministry is working on a bill to stop unverified commercial stem cell therapy services being advertised after finding some clinics making exaggerated claims, according to a report in the Bangkok Post.Spearheaded by the Department of Health Service Support (HSS), the bill will conform to the Medical Council of Thailand's (MCT) regulations on medical ethics, LITHIUM PRECONDITIONING BOOSTS STROKE TREATMENT BY MSC Review of "Lithium modulates miR-1906 levels of MSC-derived extracellular vesicles contributing to post-stroke neuroprotection by toll-like receptor 4 regulation" from STEM CELLS Translational Medicine by Stuart P. AtkinsonWhile lithium has a well-recognized function as a mood stabilizer, a wide range of research now supports a neuroprotective role for lithium in conditions such as cerebral MFAT VS. BMAC: MESENCHYMAL STEM CELL THERAPY SHOWDOWN FOR Review of “Functional Outcomes Following Microfragmented Adipose Tissue Versus Bone Marrow Aspirate Concentrate Injections for Symptomatic Knee Osteoarthritis” from STEM CELLS Translational Medicine by Stuart P. Atkinson Osteoarthritis, a chronic degenerative disease of the articular cartilage, currently affects an estimated 30 million U.S. adults and costs over $185 billion a NEWS | STEM CELLS PORTAL Heart attack recovery aided by injecting heart muscle cells that overexpress cyclin D2. BIRMINGHAM, AL (US), May 2021 — University of Alabama Birmingham (UAB) researchers have shown that heart attack recovery is aided by injection of heart muscle cells derived from human induced pluripotent stem cells (hiPSCs) that overexpress cyclinD2.
STEM CELL-BASED VACCINE OFFERS A NEW APPROACH THAT MAY STANFORD, CA (US), May 2021 — New research by Joseph Wu, Edgar Engelman and colleagues at Stanford University has advanced an old concept to develop a new strategy to train the immune system of mice to recognize cancer cells. This work is based on the recent understanding that induced pluripotent stem cells (iPSCs), which are stem cells generated from skin or blood cells CLINICAL TRIAL LAUNCHED FOLLOWING DISCOVERY THAT AMSTERDAM (NL), June 2021 — Researchers in The Netherlands have discovered a way to boost the fitness of healthy stem cells in the gut to prevent the development of bowel cancer. The findings have led to the initiation of a clinical trial to find out if a commonly used psychiatric drug could be used to prevent bowel cancer in people. The trial will recruit patients with a NON-ALTERED BIRTH CORD CELLS BOOST SURVIVAL OF CRITICALLY Durham, NC ( June 8, 2021 ) - Critically ill COVID-19 patients treated with non-altered stem cells from umbilical cord connective tissue were more than twice as likely to survive as those who did not have the treatment, according to a study published today in STEM CELLS Translational Medicine.The clinical trial, carried out at four hospitals in Jakarta, Indonesia, also showed A2AR AND BDNF IN ADULT NEUROGENESIS In a recent STEM CELLS article, researchers led by Sara Xapelli (Universidade de Lisboa, Lisbon, Portugal) report that adenosine A 2A receptor (A 2A R) activation enhances postnatal and adult hippocampal neurogenesis. Ribeiro et al. demonstrated that this was made possible through the increased self-renewal capacity of Type 1 and Type 2 cells and neuronal committed cell protection GENETIC BASE EDITING TREATS SICKLE CELL DISEASE IN MICE CAMBRIDGE, MA (US), June 2021 — Sickle cell disease (SCD) is the most common deadly genetic disorder, affecting more than 300,000 newborns worldwide each year. It leads to chronic pain, organ failure and early death in patients. A team led by researchers at the Broad Institute of MIT and Harvard and St. Jude Children's Research Hospital has now demonstrated a base editing approach that TINY IMPLANT CURES DIABETES IN MICE WITHOUT TRIGGERING ST. LOUIS, MO (US), June 2021 — A team of researchers led by diabetes specialists and biomedical engineers at Washington University School of Medicine in St. Louis and Cornell University has demonstrated that, using a miniscule device, they can implant insulin-secreting cells into diabetic mice. Once implanted, the cells secrete insulin in response to blood sugar, reversing diabetes without MESENCHYMAL NICHE SUPPORTS ALVEOLAR EPITHELIAL STEM CELLS The Stem Cells Portal is a shared platform for the STEM CELLS and STEM CELLS Translational Medicine sister journals, providing up-to-the-minute coverage of the latest research from bench science and developments to clinical applications.STEM CELLS and STEM CELLS Translational Medicine sister journals, providing up-to-the-minute coverage of the latest DECODING THE SECRETOME OF CARDIOPOIETIC CELLS In a new STEM CELLS Translational Medicine article, researchers led by Andre Terzic (Mayo Clinic, Rochester, MN, USA) report the decoding of the secretome of clinical trial-biobanked cardiopoietic cells. Arrell et al. reported the echoing of the mined (cardiomyo)vasculogenic systems signature in the response of cell recipients demonstratingdisease rescue.
ZBTB46 INDUCES ESC-DERIVED HEMATOPOIETIC PROGENITORS While the transcription factor Zbtb46 is a hallmark of dendritic cells, the exact function of this protein remains poorly characterized. In a new STEM CELLS article, researchers led by Istvan Szatmari (University of Debrecen, Hungary) probed the function of Zbtb46 in embryonic stem cell (ESC)-derived blood cell progenitors using chemically inducible transgenic cell lines.STEM CELLS PORTAL
Activin A-derived human embryonic stem cells show increased competence to differentiate into primordial germ cell-like cells Swati Mishra, et al., STEM CELLS Robust differentiation of human primordial germ cell-like cells (hPGCLCs) starting from human embryonic stem cells (hESCs) is currently hampered by the inherent heterogeneous nature of different hESC lines. STEM CELL-BASED VACCINE OFFERS A NEW APPROACH THAT MAY STANFORD, CA (US), May 2021 — New research by Joseph Wu, Edgar Engelman and colleagues at Stanford University has advanced an old concept to develop a new strategy to train the immune system of mice to recognize cancer cells. This work is based on the recent understanding that induced pluripotent stem cells (iPSCs), which are stem cells generated from skin or blood cells CLINICAL TRIALS: STEM CELLS AND REGENERATIVE MEDICINE There are over 5,000 registered clinical trials involving stem cells research on ClinicalTrials.gov, with new clinical trials in this field being offered every day. To help readers navigate through this information, STEM CELLS Translational Medicine has created a clinical trial listing based on the presenting clinical condition categorieslisted below.
A QUICK AND EFFICIENT PROTOCOL FOR RBC PRODUCTION FROM This quick and efficient feeder- and serum-free defined protocol represents a grand step towards the clinical application of hPSC-derived erythrocytes. However, this improved methodology also provides researchers a tractable system to pull apart the regulatory mechanisms that control the various stages of hematopoiesis anderythropoiesis.
GENE-MODIFIED ORGANOIDS AID THE DEVELOPMENT OF RETINAL Review of “ NRL-/- gene edited human embryonic stem cells (ESCs) generate rod-deficient retinal organoids enriched in S-cone-like photoreceptors ” from STEM CELLS by Stuart P. Atkinson The generation of retinal organoids from human pluripotent stem cells recapitulates many of the typical features of retinogenesis, including an organized multilayered tissue structure and long human STEM CELL THERAPY FURTHERS RESEARCH FOR INFANTS WITH ROCHESTER, MN (US), July 2019 ― A phase I clinical trial is the first research monitored by the Food and Drug Administration that demonstrates the potential of regenerative therapy for hypoplastic left heart syndrome (HLHS) through collecting, processing and injecting an infant's own stem cells directly into the heart at thetime of surgery.
MESC SHOWDOWN: 2I VS. SERUM Embryonic stem cells (ESCs) maintained in serum are often morphologically heterogeneous and also express pluripotency associated transcription factors in a heterogeneous manner (Toyooka et al) perhaps suggesting that the pluripotent state in unstable. However, the derivation and maintenance of mESCs in serum-free conditions through the use of two small molecule kinase (Mek and THE SOFTER, THE BETTER The Softer, the Better - How Niche Stiffness Affects Aging Stem Cells. Review of “ Niche stiffness underlies the ageing of central nervous system progenitor cells ” from Nature by Stuart P. Atkinson. While studies have indicated that the loss of function of adult stem cell and progenitor cell populations causes a decline in tissue IMPROVED PANCREATIC DIFFERENTIATION VIA CYTOSKELETAL Review of “Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells” from Nature Biotechnology by Stuart P. Atkinson The differentiation of large numbers of fully functional pancreatic β cells from cultures of human pluripotent stem cells (hPSCs) remains a difficult task; however, researchers from the laboratory of Jeffrey R. Millman (Washington HAIR FOLLICLE REGENERATION While hair loss affects a growing number of people worldwide, the limited efficacy and side effects suffered following current treatment approaches have fostered the search for alternative therapeutic solutions. Much hope lies in hair follicle bioengineering (the development of functional hair follicles from an expanded population of hair‐inductive cells); however, humanSTEM CELLS PORTAL
Activin A-derived human embryonic stem cells show increased competence to differentiate into primordial germ cell-like cells Swati Mishra, et al., STEM CELLS Robust differentiation of human primordial germ cell-like cells (hPGCLCs) starting from human embryonic stem cells (hESCs) is currently hampered by the inherent heterogeneous nature of different hESC lines. STEM CELL-BASED VACCINE OFFERS A NEW APPROACH THAT MAY STANFORD, CA (US), May 2021 — New research by Joseph Wu, Edgar Engelman and colleagues at Stanford University has advanced an old concept to develop a new strategy to train the immune system of mice to recognize cancer cells. This work is based on the recent understanding that induced pluripotent stem cells (iPSCs), which are stem cells generated from skin or blood cells CLINICAL TRIALS: STEM CELLS AND REGENERATIVE MEDICINE There are over 5,000 registered clinical trials involving stem cells research on ClinicalTrials.gov, with new clinical trials in this field being offered every day. To help readers navigate through this information, STEM CELLS Translational Medicine has created a clinical trial listing based on the presenting clinical condition categorieslisted below.
A QUICK AND EFFICIENT PROTOCOL FOR RBC PRODUCTION FROM This quick and efficient feeder- and serum-free defined protocol represents a grand step towards the clinical application of hPSC-derived erythrocytes. However, this improved methodology also provides researchers a tractable system to pull apart the regulatory mechanisms that control the various stages of hematopoiesis anderythropoiesis.
GENE-MODIFIED ORGANOIDS AID THE DEVELOPMENT OF RETINAL Review of “ NRL-/- gene edited human embryonic stem cells (ESCs) generate rod-deficient retinal organoids enriched in S-cone-like photoreceptors ” from STEM CELLS by Stuart P. Atkinson The generation of retinal organoids from human pluripotent stem cells recapitulates many of the typical features of retinogenesis, including an organized multilayered tissue structure and long human STEM CELL THERAPY FURTHERS RESEARCH FOR INFANTS WITH ROCHESTER, MN (US), July 2019 ― A phase I clinical trial is the first research monitored by the Food and Drug Administration that demonstrates the potential of regenerative therapy for hypoplastic left heart syndrome (HLHS) through collecting, processing and injecting an infant's own stem cells directly into the heart at thetime of surgery.
MESC SHOWDOWN: 2I VS. SERUM Embryonic stem cells (ESCs) maintained in serum are often morphologically heterogeneous and also express pluripotency associated transcription factors in a heterogeneous manner (Toyooka et al) perhaps suggesting that the pluripotent state in unstable. However, the derivation and maintenance of mESCs in serum-free conditions through the use of two small molecule kinase (Mek and THE SOFTER, THE BETTER The Softer, the Better - How Niche Stiffness Affects Aging Stem Cells. Review of “ Niche stiffness underlies the ageing of central nervous system progenitor cells ” from Nature by Stuart P. Atkinson. While studies have indicated that the loss of function of adult stem cell and progenitor cell populations causes a decline in tissue IMPROVED PANCREATIC DIFFERENTIATION VIA CYTOSKELETAL Review of “Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells” from Nature Biotechnology by Stuart P. Atkinson The differentiation of large numbers of fully functional pancreatic β cells from cultures of human pluripotent stem cells (hPSCs) remains a difficult task; however, researchers from the laboratory of Jeffrey R. Millman (Washington HAIR FOLLICLE REGENERATION While hair loss affects a growing number of people worldwide, the limited efficacy and side effects suffered following current treatment approaches have fostered the search for alternative therapeutic solutions. Much hope lies in hair follicle bioengineering (the development of functional hair follicles from an expanded population of hair‐inductive cells); however, human CLINICAL TRIALS: STROKE AND RELATED The Stem Cells Portal is a shared platform for the STEM CELLS and STEM CELLS Translational Medicine sister journals, providing up-to-the-minute coverage of the latest research from bench science and developments to clinical applications. NON-ALTERED BIRTH CORD CELLS BOOST SURVIVAL OF CRITICALLY Durham, NC ( June 8, 2021 ) - Critically ill COVID-19 patients treated with non-altered stem cells from umbilical cord connective tissue were more than twice as likely to survive as those who did not have the treatment, according to a study published today in STEM CELLS Translational Medicine.The clinical trial, carried out at four hospitals in Jakarta, Indonesia, also showed A2AR AND BDNF IN ADULT NEUROGENESIS In a recent STEM CELLS article, researchers led by Sara Xapelli (Universidade de Lisboa, Lisbon, Portugal) report that adenosine A 2A receptor (A 2A R) activation enhances postnatal and adult hippocampal neurogenesis. Ribeiro et al. demonstrated that this was made possible through the increased self-renewal capacity of Type 1 and Type 2 cells and neuronal committed cell protection GENETIC BASE EDITING TREATS SICKLE CELL DISEASE IN MICE CAMBRIDGE, MA (US), June 2021 — Sickle cell disease (SCD) is the most common deadly genetic disorder, affecting more than 300,000 newborns worldwide each year. It leads to chronic pain, organ failure and early death in patients. A team led by researchers at the Broad Institute of MIT and Harvard and St. Jude Children's Research Hospital has now demonstrated a base editing approach that TINY IMPLANT CURES DIABETES IN MICE WITHOUT TRIGGERING ST. LOUIS, MO (US), June 2021 — A team of researchers led by diabetes specialists and biomedical engineers at Washington University School of Medicine in St. Louis and Cornell University has demonstrated that, using a miniscule device, they can implant insulin-secreting cells into diabetic mice. Once implanted, the cells secrete insulin in response to blood sugar, reversing diabetes without TINIEST OF MOMENTS PROVES KEY FOR BABY’S HEALTHY BRAIN CHARLOTTESVILLE, VA (US), May 2021 — University of Virginia School of Medicine researchers have shed new light on how our brains develop, revealing that the very last step in cell division is crucial for the brain to reach its proper size and function. The new findings identify a potential contributor to microcephaly, a birth defect in which the head is underdeveloped and QUANTITY AND CONTROL CULTURE OF DIABETIC STEM CELLS BOOSTS Review of “ Ex vivo conditioning of peripheral blood mononuclear cells of diabetic patients promotes vasculogenic wound healing ” from STEM CELLS Translational Medicine by Stuart P. Atkinson The use of endothelial progenitor cells (EPCs) isolated from diabetic patients in clinical vascular regenerative therapies requires optimized and simplified isolation and culture techniques to MESENCHYMAL NICHE SUPPORTS ALVEOLAR EPITHELIAL STEM CELLS The Stem Cells Portal is a shared platform for the STEM CELLS and STEM CELLS Translational Medicine sister journals, providing up-to-the-minute coverage of the latest research from bench science and developments to clinical applications.STEM CELLS and STEM CELLS Translational Medicine sister journals, providing up-to-the-minute coverage of the latest NICHE-DERIVED FACTORS MODULATE INHIBITORY RESPONSES OF Review of “ Niche‐dependent inhibition of neural stem cell proliferation and oligodendrogenesis is mediated by the presence of myelin basic protein ” from STEM CELLS by Stuart P. Atkinson While on the search for factors that regulate the behavior of neural stem cells (NSCs) in response to injury or disease, researchers led by Nishanth Lakshman and Cindi M. Morshead (University of Toronto CHAPERONE-MEDIATED AUTOPHAGY TAKES THE STRESS OFF HSCS Review of “ Chaperone-mediated autophagy sustains haematopoietic stem-cell function ” from Nature by Stuart P. Atkinson A recent study from researchers led by Britta Will and Ana Maria Cuervo (Albert Einstein College of Medicine, New York, NY, USA) explored the relevance of chaperone-mediated autophagy, a selective form of lysosomal protein degradation , to the maintenance and functionSTEM CELLS PORTAL
Activin A-derived human embryonic stem cells show increased competence to differentiate into primordial germ cell-like cells Swati Mishra, et al., STEM CELLS Robust differentiation of human primordial germ cell-like cells (hPGCLCs) starting from human embryonic stem cells (hESCs) is currently hampered by the inherent heterogeneous nature of different hESC lines. STEM CELL-BASED VACCINE OFFERS A NEW APPROACH THAT MAY STANFORD, CA (US), May 2021 — New research by Joseph Wu, Edgar Engelman and colleagues at Stanford University has advanced an old concept to develop a new strategy to train the immune system of mice to recognize cancer cells. This work is based on the recent understanding that induced pluripotent stem cells (iPSCs), which are stem cells generated from skin or blood cells CLINICAL TRIALS: STEM CELLS AND REGENERATIVE MEDICINE There are over 5,000 registered clinical trials involving stem cells research on ClinicalTrials.gov, with new clinical trials in this field being offered every day. To help readers navigate through this information, STEM CELLS Translational Medicine has created a clinical trial listing based on the presenting clinical condition categorieslisted below.
A QUICK AND EFFICIENT PROTOCOL FOR RBC PRODUCTION FROM This quick and efficient feeder- and serum-free defined protocol represents a grand step towards the clinical application of hPSC-derived erythrocytes. However, this improved methodology also provides researchers a tractable system to pull apart the regulatory mechanisms that control the various stages of hematopoiesis anderythropoiesis.
GENE-MODIFIED ORGANOIDS AID THE DEVELOPMENT OF RETINAL Review of “ NRL-/- gene edited human embryonic stem cells (ESCs) generate rod-deficient retinal organoids enriched in S-cone-like photoreceptors ” from STEM CELLS by Stuart P. Atkinson The generation of retinal organoids from human pluripotent stem cells recapitulates many of the typical features of retinogenesis, including an organized multilayered tissue structure and long human STEM CELL THERAPY FURTHERS RESEARCH FOR INFANTS WITH ROCHESTER, MN (US), July 2019 ― A phase I clinical trial is the first research monitored by the Food and Drug Administration that demonstrates the potential of regenerative therapy for hypoplastic left heart syndrome (HLHS) through collecting, processing and injecting an infant's own stem cells directly into the heart at thetime of surgery.
MESC SHOWDOWN: 2I VS. SERUM Embryonic stem cells (ESCs) maintained in serum are often morphologically heterogeneous and also express pluripotency associated transcription factors in a heterogeneous manner (Toyooka et al) perhaps suggesting that the pluripotent state in unstable. However, the derivation and maintenance of mESCs in serum-free conditions through the use of two small molecule kinase (Mek and THE SOFTER, THE BETTER The Softer, the Better - How Niche Stiffness Affects Aging Stem Cells. Review of “ Niche stiffness underlies the ageing of central nervous system progenitor cells ” from Nature by Stuart P. Atkinson. While studies have indicated that the loss of function of adult stem cell and progenitor cell populations causes a decline in tissue IMPROVED PANCREATIC DIFFERENTIATION VIA CYTOSKELETAL Review of “Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells” from Nature Biotechnology by Stuart P. Atkinson The differentiation of large numbers of fully functional pancreatic β cells from cultures of human pluripotent stem cells (hPSCs) remains a difficult task; however, researchers from the laboratory of Jeffrey R. Millman (Washington HAIR FOLLICLE REGENERATION While hair loss affects a growing number of people worldwide, the limited efficacy and side effects suffered following current treatment approaches have fostered the search for alternative therapeutic solutions. Much hope lies in hair follicle bioengineering (the development of functional hair follicles from an expanded population of hair‐inductive cells); however, humanSTEM CELLS PORTAL
Activin A-derived human embryonic stem cells show increased competence to differentiate into primordial germ cell-like cells Swati Mishra, et al., STEM CELLS Robust differentiation of human primordial germ cell-like cells (hPGCLCs) starting from human embryonic stem cells (hESCs) is currently hampered by the inherent heterogeneous nature of different hESC lines. STEM CELL-BASED VACCINE OFFERS A NEW APPROACH THAT MAY STANFORD, CA (US), May 2021 — New research by Joseph Wu, Edgar Engelman and colleagues at Stanford University has advanced an old concept to develop a new strategy to train the immune system of mice to recognize cancer cells. This work is based on the recent understanding that induced pluripotent stem cells (iPSCs), which are stem cells generated from skin or blood cells CLINICAL TRIALS: STEM CELLS AND REGENERATIVE MEDICINE There are over 5,000 registered clinical trials involving stem cells research on ClinicalTrials.gov, with new clinical trials in this field being offered every day. To help readers navigate through this information, STEM CELLS Translational Medicine has created a clinical trial listing based on the presenting clinical condition categorieslisted below.
A QUICK AND EFFICIENT PROTOCOL FOR RBC PRODUCTION FROM This quick and efficient feeder- and serum-free defined protocol represents a grand step towards the clinical application of hPSC-derived erythrocytes. However, this improved methodology also provides researchers a tractable system to pull apart the regulatory mechanisms that control the various stages of hematopoiesis anderythropoiesis.
GENE-MODIFIED ORGANOIDS AID THE DEVELOPMENT OF RETINAL Review of “ NRL-/- gene edited human embryonic stem cells (ESCs) generate rod-deficient retinal organoids enriched in S-cone-like photoreceptors ” from STEM CELLS by Stuart P. Atkinson The generation of retinal organoids from human pluripotent stem cells recapitulates many of the typical features of retinogenesis, including an organized multilayered tissue structure and long human STEM CELL THERAPY FURTHERS RESEARCH FOR INFANTS WITH ROCHESTER, MN (US), July 2019 ― A phase I clinical trial is the first research monitored by the Food and Drug Administration that demonstrates the potential of regenerative therapy for hypoplastic left heart syndrome (HLHS) through collecting, processing and injecting an infant's own stem cells directly into the heart at thetime of surgery.
MESC SHOWDOWN: 2I VS. SERUM Embryonic stem cells (ESCs) maintained in serum are often morphologically heterogeneous and also express pluripotency associated transcription factors in a heterogeneous manner (Toyooka et al) perhaps suggesting that the pluripotent state in unstable. However, the derivation and maintenance of mESCs in serum-free conditions through the use of two small molecule kinase (Mek and THE SOFTER, THE BETTER The Softer, the Better - How Niche Stiffness Affects Aging Stem Cells. Review of “ Niche stiffness underlies the ageing of central nervous system progenitor cells ” from Nature by Stuart P. Atkinson. While studies have indicated that the loss of function of adult stem cell and progenitor cell populations causes a decline in tissue IMPROVED PANCREATIC DIFFERENTIATION VIA CYTOSKELETAL Review of “Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells” from Nature Biotechnology by Stuart P. Atkinson The differentiation of large numbers of fully functional pancreatic β cells from cultures of human pluripotent stem cells (hPSCs) remains a difficult task; however, researchers from the laboratory of Jeffrey R. Millman (Washington HAIR FOLLICLE REGENERATION While hair loss affects a growing number of people worldwide, the limited efficacy and side effects suffered following current treatment approaches have fostered the search for alternative therapeutic solutions. Much hope lies in hair follicle bioengineering (the development of functional hair follicles from an expanded population of hair‐inductive cells); however, human CLINICAL TRIALS: STROKE AND RELATED The Stem Cells Portal is a shared platform for the STEM CELLS and STEM CELLS Translational Medicine sister journals, providing up-to-the-minute coverage of the latest research from bench science and developments to clinical applications. NON-ALTERED BIRTH CORD CELLS BOOST SURVIVAL OF CRITICALLY Durham, NC ( June 8, 2021 ) - Critically ill COVID-19 patients treated with non-altered stem cells from umbilical cord connective tissue were more than twice as likely to survive as those who did not have the treatment, according to a study published today in STEM CELLS Translational Medicine.The clinical trial, carried out at four hospitals in Jakarta, Indonesia, also showed A2AR AND BDNF IN ADULT NEUROGENESIS In a recent STEM CELLS article, researchers led by Sara Xapelli (Universidade de Lisboa, Lisbon, Portugal) report that adenosine A 2A receptor (A 2A R) activation enhances postnatal and adult hippocampal neurogenesis. Ribeiro et al. demonstrated that this was made possible through the increased self-renewal capacity of Type 1 and Type 2 cells and neuronal committed cell protection GENETIC BASE EDITING TREATS SICKLE CELL DISEASE IN MICE CAMBRIDGE, MA (US), June 2021 — Sickle cell disease (SCD) is the most common deadly genetic disorder, affecting more than 300,000 newborns worldwide each year. It leads to chronic pain, organ failure and early death in patients. A team led by researchers at the Broad Institute of MIT and Harvard and St. Jude Children's Research Hospital has now demonstrated a base editing approach that TINY IMPLANT CURES DIABETES IN MICE WITHOUT TRIGGERING ST. LOUIS, MO (US), June 2021 — A team of researchers led by diabetes specialists and biomedical engineers at Washington University School of Medicine in St. Louis and Cornell University has demonstrated that, using a miniscule device, they can implant insulin-secreting cells into diabetic mice. Once implanted, the cells secrete insulin in response to blood sugar, reversing diabetes without TINIEST OF MOMENTS PROVES KEY FOR BABY’S HEALTHY BRAIN CHARLOTTESVILLE, VA (US), May 2021 — University of Virginia School of Medicine researchers have shed new light on how our brains develop, revealing that the very last step in cell division is crucial for the brain to reach its proper size and function. The new findings identify a potential contributor to microcephaly, a birth defect in which the head is underdeveloped and HAIR FOLLICLE REGENERATION While hair loss affects a growing number of people worldwide, the limited efficacy and side effects suffered following current treatment approaches have fostered the search for alternative therapeutic solutions. Much hope lies in hair follicle bioengineering (the development of functional hair follicles from an expanded population of hair‐inductive cells); however, human QUANTITY AND CONTROL CULTURE OF DIABETIC STEM CELLS BOOSTS Review of “ Ex vivo conditioning of peripheral blood mononuclear cells of diabetic patients promotes vasculogenic wound healing ” from STEM CELLS Translational Medicine by Stuart P. Atkinson The use of endothelial progenitor cells (EPCs) isolated from diabetic patients in clinical vascular regenerative therapies requires optimized and simplified isolation and culture techniques to NICHE-DERIVED FACTORS MODULATE INHIBITORY RESPONSES OF Review of “ Niche‐dependent inhibition of neural stem cell proliferation and oligodendrogenesis is mediated by the presence of myelin basic protein ” from STEM CELLS by Stuart P. Atkinson While on the search for factors that regulate the behavior of neural stem cells (NSCs) in response to injury or disease, researchers led by Nishanth Lakshman and Cindi M. Morshead (University of Toronto CHAPERONE-MEDIATED AUTOPHAGY TAKES THE STRESS OFF HSCS Review of “ Chaperone-mediated autophagy sustains haematopoietic stem-cell function ” from Nature by Stuart P. Atkinson A recent study from researchers led by Britta Will and Ana Maria Cuervo (Albert Einstein College of Medicine, New York, NY, USA) explored the relevance of chaperone-mediated autophagy, a selective form of lysosomal protein degradation , to the maintenance and functionSTEM CELLS PORTAL
Activin A-derived human embryonic stem cells show increased competence to differentiate into primordial germ cell-like cells Swati Mishra, et al., STEM CELLS Robust differentiation of human primordial germ cell-like cells (hPGCLCs) starting from human embryonic stem cells (hESCs) is currently hampered by the inherent heterogeneous nature of different hESC lines. STEM CELL-BASED VACCINE OFFERS A NEW APPROACH THAT MAY STANFORD, CA (US), May 2021 — New research by Joseph Wu, Edgar Engelman and colleagues at Stanford University has advanced an old concept to develop a new strategy to train the immune system of mice to recognize cancer cells. This work is based on the recent understanding that induced pluripotent stem cells (iPSCs), which are stem cells generated from skin or blood cells CLINICAL TRIALS: STEM CELLS AND REGENERATIVE MEDICINESTEM CELLS RESEARCHWHY ARE STEM CELLS SPECIALSTEM CELL CENTERS PORTALSTEM CELL CENTERS PORTALSTEM STUDENT PORTALSTEM STUDENT PORTAL There are over 5,000 registered clinical trials involving stem cells research on ClinicalTrials.gov, with new clinical trials in this field being offered every day. To help readers navigate through this information, STEM CELLS Translational Medicine has created a clinical trial listing based on the presenting clinical condition categorieslisted below.
A QUICK AND EFFICIENT PROTOCOL FOR RBC PRODUCTION FROM This quick and efficient feeder- and serum-free defined protocol represents a grand step towards the clinical application of hPSC-derived erythrocytes. However, this improved methodology also provides researchers a tractable system to pull apart the regulatory mechanisms that control the various stages of hematopoiesis anderythropoiesis.
GENE-MODIFIED ORGANOIDS AID THE DEVELOPMENT OF RETINAL Review of “ NRL-/- gene edited human embryonic stem cells (ESCs) generate rod-deficient retinal organoids enriched in S-cone-like photoreceptors ” from STEM CELLS by Stuart P. Atkinson The generation of retinal organoids from human pluripotent stem cells recapitulates many of the typical features of retinogenesis, including an organized multilayered tissue structure and long human STEM CELL THERAPY FURTHERS RESEARCH FOR INFANTS WITH ROCHESTER, MN (US), July 2019 ― A phase I clinical trial is the first research monitored by the Food and Drug Administration that demonstrates the potential of regenerative therapy for hypoplastic left heart syndrome (HLHS) through collecting, processing and injecting an infant's own stem cells directly into the heart at thetime of surgery.
MESC SHOWDOWN: 2I VS. SERUM Embryonic stem cells (ESCs) maintained in serum are often morphologically heterogeneous and also express pluripotency associated transcription factors in a heterogeneous manner (Toyooka et al) perhaps suggesting that the pluripotent state in unstable. However, the derivation and maintenance of mESCs in serum-free conditions through the use of two small molecule kinase (Mek and THE SOFTER, THE BETTER The Softer, the Better - How Niche Stiffness Affects Aging Stem Cells. Review of “ Niche stiffness underlies the ageing of central nervous system progenitor cells ” from Nature by Stuart P. Atkinson. While studies have indicated that the loss of function of adult stem cell and progenitor cell populations causes a decline in tissue IMPROVED PANCREATIC DIFFERENTIATION VIA CYTOSKELETAL Review of “Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells” from Nature Biotechnology by Stuart P. Atkinson The differentiation of large numbers of fully functional pancreatic β cells from cultures of human pluripotent stem cells (hPSCs) remains a difficult task; however, researchers from the laboratory of Jeffrey R. Millman (Washington HAIR FOLLICLE REGENERATION While hair loss affects a growing number of people worldwide, the limited efficacy and side effects suffered following current treatment approaches have fostered the search for alternative therapeutic solutions. Much hope lies in hair follicle bioengineering (the development of functional hair follicles from an expanded population of hair‐inductive cells); however, humanSTEM CELLS PORTAL
Activin A-derived human embryonic stem cells show increased competence to differentiate into primordial germ cell-like cells Swati Mishra, et al., STEM CELLS Robust differentiation of human primordial germ cell-like cells (hPGCLCs) starting from human embryonic stem cells (hESCs) is currently hampered by the inherent heterogeneous nature of different hESC lines. STEM CELL-BASED VACCINE OFFERS A NEW APPROACH THAT MAY STANFORD, CA (US), May 2021 — New research by Joseph Wu, Edgar Engelman and colleagues at Stanford University has advanced an old concept to develop a new strategy to train the immune system of mice to recognize cancer cells. This work is based on the recent understanding that induced pluripotent stem cells (iPSCs), which are stem cells generated from skin or blood cells CLINICAL TRIALS: STEM CELLS AND REGENERATIVE MEDICINESTEM CELLS RESEARCHWHY ARE STEM CELLS SPECIALSTEM CELL CENTERS PORTALSTEM CELL CENTERS PORTALSTEM STUDENT PORTALSTEM STUDENT PORTAL There are over 5,000 registered clinical trials involving stem cells research on ClinicalTrials.gov, with new clinical trials in this field being offered every day. To help readers navigate through this information, STEM CELLS Translational Medicine has created a clinical trial listing based on the presenting clinical condition categorieslisted below.
A QUICK AND EFFICIENT PROTOCOL FOR RBC PRODUCTION FROM This quick and efficient feeder- and serum-free defined protocol represents a grand step towards the clinical application of hPSC-derived erythrocytes. However, this improved methodology also provides researchers a tractable system to pull apart the regulatory mechanisms that control the various stages of hematopoiesis anderythropoiesis.
GENE-MODIFIED ORGANOIDS AID THE DEVELOPMENT OF RETINAL Review of “ NRL-/- gene edited human embryonic stem cells (ESCs) generate rod-deficient retinal organoids enriched in S-cone-like photoreceptors ” from STEM CELLS by Stuart P. Atkinson The generation of retinal organoids from human pluripotent stem cells recapitulates many of the typical features of retinogenesis, including an organized multilayered tissue structure and long human STEM CELL THERAPY FURTHERS RESEARCH FOR INFANTS WITH ROCHESTER, MN (US), July 2019 ― A phase I clinical trial is the first research monitored by the Food and Drug Administration that demonstrates the potential of regenerative therapy for hypoplastic left heart syndrome (HLHS) through collecting, processing and injecting an infant's own stem cells directly into the heart at thetime of surgery.
MESC SHOWDOWN: 2I VS. SERUM Embryonic stem cells (ESCs) maintained in serum are often morphologically heterogeneous and also express pluripotency associated transcription factors in a heterogeneous manner (Toyooka et al) perhaps suggesting that the pluripotent state in unstable. However, the derivation and maintenance of mESCs in serum-free conditions through the use of two small molecule kinase (Mek and THE SOFTER, THE BETTER The Softer, the Better - How Niche Stiffness Affects Aging Stem Cells. Review of “ Niche stiffness underlies the ageing of central nervous system progenitor cells ” from Nature by Stuart P. Atkinson. While studies have indicated that the loss of function of adult stem cell and progenitor cell populations causes a decline in tissue IMPROVED PANCREATIC DIFFERENTIATION VIA CYTOSKELETAL Review of “Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells” from Nature Biotechnology by Stuart P. Atkinson The differentiation of large numbers of fully functional pancreatic β cells from cultures of human pluripotent stem cells (hPSCs) remains a difficult task; however, researchers from the laboratory of Jeffrey R. Millman (Washington HAIR FOLLICLE REGENERATION While hair loss affects a growing number of people worldwide, the limited efficacy and side effects suffered following current treatment approaches have fostered the search for alternative therapeutic solutions. Much hope lies in hair follicle bioengineering (the development of functional hair follicles from an expanded population of hair‐inductive cells); however, human CLINICAL TRIALS: STROKE AND RELATED The Stem Cells Portal is a shared platform for the STEM CELLS and STEM CELLS Translational Medicine sister journals, providing up-to-the-minute coverage of the latest research from bench science and developments to clinical applications. NON-ALTERED BIRTH CORD CELLS BOOST SURVIVAL OF CRITICALLY Durham, NC ( June 8, 2021 ) - Critically ill COVID-19 patients treated with non-altered stem cells from umbilical cord connective tissue were more than twice as likely to survive as those who did not have the treatment, according to a study published today in STEM CELLS Translational Medicine.The clinical trial, carried out at four hospitals in Jakarta, Indonesia, also showed A2AR AND BDNF IN ADULT NEUROGENESIS In a recent STEM CELLS article, researchers led by Sara Xapelli (Universidade de Lisboa, Lisbon, Portugal) report that adenosine A 2A receptor (A 2A R) activation enhances postnatal and adult hippocampal neurogenesis. Ribeiro et al. demonstrated that this was made possible through the increased self-renewal capacity of Type 1 and Type 2 cells and neuronal committed cell protection GENETIC BASE EDITING TREATS SICKLE CELL DISEASE IN MICE CAMBRIDGE, MA (US), June 2021 — Sickle cell disease (SCD) is the most common deadly genetic disorder, affecting more than 300,000 newborns worldwide each year. It leads to chronic pain, organ failure and early death in patients. A team led by researchers at the Broad Institute of MIT and Harvard and St. Jude Children's Research Hospital has now demonstrated a base editing approach that TINY IMPLANT CURES DIABETES IN MICE WITHOUT TRIGGERING ST. LOUIS, MO (US), June 2021 — A team of researchers led by diabetes specialists and biomedical engineers at Washington University School of Medicine in St. Louis and Cornell University has demonstrated that, using a miniscule device, they can implant insulin-secreting cells into diabetic mice. Once implanted, the cells secrete insulin in response to blood sugar, reversing diabetes without TINIEST OF MOMENTS PROVES KEY FOR BABY’S HEALTHY BRAIN CHARLOTTESVILLE, VA (US), May 2021 — University of Virginia School of Medicine researchers have shed new light on how our brains develop, revealing that the very last step in cell division is crucial for the brain to reach its proper size and function. The new findings identify a potential contributor to microcephaly, a birth defect in which the head is underdeveloped and HAIR FOLLICLE REGENERATION While hair loss affects a growing number of people worldwide, the limited efficacy and side effects suffered following current treatment approaches have fostered the search for alternative therapeutic solutions. Much hope lies in hair follicle bioengineering (the development of functional hair follicles from an expanded population of hair‐inductive cells); however, human QUANTITY AND CONTROL CULTURE OF DIABETIC STEM CELLS BOOSTS Review of “ Ex vivo conditioning of peripheral blood mononuclear cells of diabetic patients promotes vasculogenic wound healing ” from STEM CELLS Translational Medicine by Stuart P. Atkinson The use of endothelial progenitor cells (EPCs) isolated from diabetic patients in clinical vascular regenerative therapies requires optimized and simplified isolation and culture techniques to NICHE-DERIVED FACTORS MODULATE INHIBITORY RESPONSES OF Review of “ Niche‐dependent inhibition of neural stem cell proliferation and oligodendrogenesis is mediated by the presence of myelin basic protein ” from STEM CELLS by Stuart P. Atkinson While on the search for factors that regulate the behavior of neural stem cells (NSCs) in response to injury or disease, researchers led by Nishanth Lakshman and Cindi M. Morshead (University of Toronto CHAPERONE-MEDIATED AUTOPHAGY TAKES THE STRESS OFF HSCS Review of “ Chaperone-mediated autophagy sustains haematopoietic stem-cell function ” from Nature by Stuart P. Atkinson A recent study from researchers led by Britta Will and Ana Maria Cuervo (Albert Einstein College of Medicine, New York, NY, USA) explored the relevance of chaperone-mediated autophagy, a selective form of lysosomal protein degradation , to the maintenance and functionJump to navigation
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COVID-19 Announcement3/23/2020
In response to the COVID-19 outbreak, we at AlphaMed Press are following the CDC recommendations by having our staff work remotely. Our team is working diligently to ensure our operations continue to run smoothly. We realize that as members of the global medical community, you may have additional responsibilities, both on the front lines and at home, and we are thankful for the sacrifices you are making as we struggle with this health crisis. We hope everyone stays safe and healthy in these uncertain times.FEATURED ARTICLES
ADULT TISSUE–DERIVED NEURAL CREST-LIKE STEM CELLS: SOURCES, REGULATORY NETWORKS, AND TRANSLATIONAL POTENTIAL Pihu Mehrotra, et al., _STEM CELLS_ Translational Medicine This concise review reports the advantages of using neural crest for the treatment of demyelinating disorders and spinal cord injury over other cell sources such as induced pluripotent stem cells and embryonic stem cells. This technology can also be used for disease modeling and drug testing, making way for personalized therapeutics for neurological disorders. ------------------------- RECAPITULATING HUMAN TISSUE DAMAGE, REPAIR AND FIBROSIS WITH HPSC-DERIVED ORGANOIDS: CONCISE REVIEW Maria F. Sobral‐Reyes, et al., _STEM CELLS_ As new applications for drug-screening and tissue replacement therapies emerge, there is a need to examine the mechanisms of tissue injury and fibrosis in human pluripotent stem cell‐derived mini organs in order to determine how well organoid tissues recapitulate the mechanisms of tissue damage and regeneration observed in vivo.ARTICLE SCANS
PATIENT-SPECIFIC IPSCS AID THE DEVELOPMENT OF NEW AGE-RELATED MACULARDEGENERATION MODEL
Researchers report on a new age‐related macular degeneration model that more faithfully mimics the interaction of RPE and Bruch's membrane under disease conditions DECIPHERING THE ROLE OF LONG NON-CODING RNAS IN ESC DIFFERENTIATION Researchers report how a large intergenic non-coding RNA inhibits the early stage of mouse embryonic stem cell differentiation by regulatingLIF/STAT3 signaling
TREATING SPINAL CORD INJURY WITH POTENTIATED IPSC-DERIVED NEURALPROGENITOR CELLS
Neural progenitor cells pretreated with an inactive tissue-type plasminogen activator represents a safe and effective means to promote motor function improvements in a spinal cord injury rat modelRECENTLY PUBLISHED
March 24, 2020
ROLE OF EPIGENETICS IN KIDNEY PROGENITOR CELLSMarch 24, 2020
PROPAGATION OF HUMAN PROSTATE TISSUE FROM IPSCSMarch 24, 2020
INCREASED PH LIMITS FORMATION OF WPB IN HIPSC-ECSMarch 24, 2020
CYST EPITHELIAL-DERIVED IPSCS FROM ADPKD PATIENTS* Home
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A recap on last week: two gut wrenching studies More at cirmresearch.blogspot.com/ The Stem Cells Portal is a shared platform for the _STEM CELLS_ and _STEM CELLS TRANSLATIONAL MEDICINE_ sister journals, providing up-to-the-minute coverage of the latest research from bench science and developments to clinical applications.NEWS
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