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RESEARCH HIGHLIGHTS
Research Highlights. This section briefly describes several ongoing major studies as well as recently completed investigations. The Scripps Translational Science Institute also sponsors pilot/methodological studies whose potential impact on health care is significant. To learn about these projects, please visit Pilot StudyAwards.
TRANSLATIONAL RESEARCH The power of translational research – from the laboratory bench to the patient’s bedside –is illustrated by Scripps Translational Science Institute scientists’ research on clopidogrel pharmacogenomics.At left, Lauren Ariniello in the lab, and at right, Matthew Price, M.D., in Scripps Green Hospital’s cardiac catheterization patient care facility.DIGITAL MEDICINE
Digital Medicine. In 2012, the Scripps Translational Science Institute (STSI) established a Division of Digital Medicine, which has developed into an internationally recognized leader in all aspects of the clinical implementation of wireless technologies in health andhealthcare.
CLINICAL TRIALS IN DIGITAL MEDICINE The primary objective of the trial is to determine whether screening select individuals in their homes using wearable medical devices can identify people with asymptomatic AFib more efficiently than routine care. The study, launched in November 2015, is a novel multisectoral collaboration between Scripps Translational Science Institute (STSIMATTHEW PRICE, M.D.
Scripps Translational Science Institute 3344 North Torrey Pines Court Suite 300 La Jolla, CA 92037 Map 858-554-5708INFECTIOUS DISEASES
Genetic factors that distinguish potentially lethal MRSA strains. Scripps Translational Science Institute researchers are scrutinizing the DNA sequences of different strains of methicillin-resistant Staphylococcus aureus (MRSA) to identify genetic factors that distinguish the serious but treatable noninvasive form of the disease from the invasive and potentially lethal infections that boreERIC J. TOPOL, M.D.
Eric J. Topol, M.D. Voted as the #1 Most Influential Physician Executive in the United States in 2012 in a national poll conducted by Modern Healthcare, Dr. Topol works on genomic and wireless digital innovative technologies to reshape the future of medicine. He is a practicing cardiologist at Scripps in La Jolla, California and widelycredited
GENES, GENETICS AND GENOMICS, OH MY! activities. See Genetics/Genomics Competencies in Box 2 for a listing of the individual competencies. Implementation of the essential nursing competencies for genetics and ABOUT | SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE About. The Scripps Translational Science Institute (STSI) aims to replace the status-quo of one-size-fits-all-medicine with individualized health care that is based on the known genetic factors influencing health and disease and that takes advantage of advances in digital technology for real-time health monitoring.. Under the leadership of Eric J. Topol, M.D., one of the world’s premier SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE Scripps Translational Science Institute 3344 North Torrey Pines Court Suite 300 La Jolla, CA 92037 Map 858.554.5708RESEARCH HIGHLIGHTS
Research Highlights. This section briefly describes several ongoing major studies as well as recently completed investigations. The Scripps Translational Science Institute also sponsors pilot/methodological studies whose potential impact on health care is significant. To learn about these projects, please visit Pilot StudyAwards.
TRANSLATIONAL RESEARCH The power of translational research – from the laboratory bench to the patient’s bedside –is illustrated by Scripps Translational Science Institute scientists’ research on clopidogrel pharmacogenomics.At left, Lauren Ariniello in the lab, and at right, Matthew Price, M.D., in Scripps Green Hospital’s cardiac catheterization patient care facility.DIGITAL MEDICINE
Digital Medicine. In 2012, the Scripps Translational Science Institute (STSI) established a Division of Digital Medicine, which has developed into an internationally recognized leader in all aspects of the clinical implementation of wireless technologies in health andhealthcare.
CLINICAL TRIALS IN DIGITAL MEDICINE The primary objective of the trial is to determine whether screening select individuals in their homes using wearable medical devices can identify people with asymptomatic AFib more efficiently than routine care. The study, launched in November 2015, is a novel multisectoral collaboration between Scripps Translational Science Institute (STSIMATTHEW PRICE, M.D.
Scripps Translational Science Institute 3344 North Torrey Pines Court Suite 300 La Jolla, CA 92037 Map 858-554-5708INFECTIOUS DISEASES
Genetic factors that distinguish potentially lethal MRSA strains. Scripps Translational Science Institute researchers are scrutinizing the DNA sequences of different strains of methicillin-resistant Staphylococcus aureus (MRSA) to identify genetic factors that distinguish the serious but treatable noninvasive form of the disease from the invasive and potentially lethal infections that boreERIC J. TOPOL, M.D.
Eric J. Topol, M.D. Voted as the #1 Most Influential Physician Executive in the United States in 2012 in a national poll conducted by Modern Healthcare, Dr. Topol works on genomic and wireless digital innovative technologies to reshape the future of medicine. He is a practicing cardiologist at Scripps in La Jolla, California and widelycredited
GENES, GENETICS AND GENOMICS, OH MY! activities. See Genetics/Genomics Competencies in Box 2 for a listing of the individual competencies. Implementation of the essential nursing competencies for genetics and SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE Scripps Study Participant Enters White House Film Contest - Jan 30, 2014. Dr. Daniel Salomon presents President Obama with HOPE Act for signature - Dec 02, 2013. Wireless Sensors Used to Study Meditations Effect on Heart Health - Nov 13, 2013. Scripps Launches “Wired forHealth” Study -
ABOUT | SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE About. The Scripps Translational Science Institute (STSI) aims to replace the status-quo of one-size-fits-all-medicine with individualized health care that is based on the known genetic factors influencing health and disease and that takes advantage of advances in digital technology for real-time health monitoring.. Under the leadership of Eric J. Topol, M.D., one of the world’s premierINFECTIOUS DISEASES
Genetic factors that distinguish potentially lethal MRSA strains. Scripps Translational Science Institute researchers are scrutinizing the DNA sequences of different strains of methicillin-resistant Staphylococcus aureus (MRSA) to identify genetic factors that distinguish the serious but treatable noninvasive form of the disease from the invasive and potentially lethal infections that bore SCRIPPS ADVANCED CLINICAL TRIALS With the infrastructural support provided by the CTSA Consortium, research at STSI is a truly collaborative effort between STSI, Gary & Mary West Wireless Health Institute, Scripps Advanced Clinical Trials, Scripps Genomic Medicine, and external collaborators. Our current research and clinical trials are described for each institute listedbelow.
CONSUMER GENOMICS
Initiated in 2008, the Scripps Genomic Health Initiative (SGHI) is the first large-scale and long-term evaluation of the attitudes and perceptions of consumers who have purchased a commercially available personal genomic risk assessment test. A total of 3,630 consumers, whose ages range from 18 to 85 years, agreed to participate in thestudy.
THE CREATIVE DESTRUCTION OF MEDICINE The Creative Destruction of Medicine is a call to action for doctors and patients alike. We must see our world and our job as doctor and patient very differently. In a profession so uncertain of its future, we need precisely the vision and critical dialog offered here. I suspect that 150 years from now when historians are looking back atthe
HEALTHY AGING
Locating healthy elderly (80 years of age and older) to get DNA samples is challenging, since they don’t spend much time in health care facilities. Scripps currently attracts volunteers by conducting outreach efforts in the community. “The logistics are tricky, but we have to find them,” said Dr. Topol. “We think as people learnabout
PILOT STUDY AWARDEES Faculty Awardees. Identification of biomarkers to predict severity of lassa fever. Brian Sullivan, PhD. Developing preclinical candidates for GI and pancreatic cancer. Matthew Disney, PhD. Discovery of novel small-molecule activators of autophagy for the treatment of Parkinson’s disease. Jeff Kelly, PhD. Pilot study of muscle myosinas
HEALTHY PREGNANCY STUDY The Scripps Translational Science Institute (STSI) has partnered with WebMD to conduct the Healthy Pregnancy Study, a long-term research project designed to improve understanding of pregnancy through the collection of survey and connected device data. Users of WebMD’s popular Pregnancy mobile app are able to participate in the studythrough
TORKAMANI, ALI
Dr. Torkamani’s overall vision is to decipher that code in order to understand and predict interventions that restore diseased individuals to a healthy ground state. He is the Director of Genomics and Genome Informatics at the Scripps Translational Science Institute and an Associate Professor at The Scripps Research Institute – professor ABOUT | SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE About. The Scripps Translational Science Institute (STSI) aims to replace the status-quo of one-size-fits-all-medicine with individualized health care that is based on the known genetic factors influencing health and disease and that takes advantage of advances in digital technology for real-time health monitoring.. Under the leadership of Eric J. Topol, M.D., one of the world’s premier SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE Scripps Translational Science Institute 3344 North Torrey Pines Court Suite 300 La Jolla, CA 92037 Map 858.554.5708RESEARCH HIGHLIGHTS
Research Highlights. This section briefly describes several ongoing major studies as well as recently completed investigations. The Scripps Translational Science Institute also sponsors pilot/methodological studies whose potential impact on health care is significant. To learn about these projects, please visit Pilot StudyAwards.
TRANSLATIONAL RESEARCH The power of translational research – from the laboratory bench to the patient’s bedside –is illustrated by Scripps Translational Science Institute scientists’ research on clopidogrel pharmacogenomics.At left, Lauren Ariniello in the lab, and at right, Matthew Price, M.D., in Scripps Green Hospital’s cardiac catheterization patient care facility.DIGITAL MEDICINE
Digital Medicine. In 2012, the Scripps Translational Science Institute (STSI) established a Division of Digital Medicine, which has developed into an internationally recognized leader in all aspects of the clinical implementation of wireless technologies in health andhealthcare.
CLINICAL TRIALS IN DIGITAL MEDICINE The primary objective of the trial is to determine whether screening select individuals in their homes using wearable medical devices can identify people with asymptomatic AFib more efficiently than routine care. The study, launched in November 2015, is a novel multisectoral collaboration between Scripps Translational Science Institute (STSIMATTHEW PRICE, M.D.
Scripps Translational Science Institute 3344 North Torrey Pines Court Suite 300 La Jolla, CA 92037 Map 858-554-5708INFECTIOUS DISEASES
Genetic factors that distinguish potentially lethal MRSA strains. Scripps Translational Science Institute researchers are scrutinizing the DNA sequences of different strains of methicillin-resistant Staphylococcus aureus (MRSA) to identify genetic factors that distinguish the serious but treatable noninvasive form of the disease from the invasive and potentially lethal infections that boreERIC J. TOPOL, M.D.
Eric J. Topol, M.D. Voted as the #1 Most Influential Physician Executive in the United States in 2012 in a national poll conducted by Modern Healthcare, Dr. Topol works on genomic and wireless digital innovative technologies to reshape the future of medicine. He is a practicing cardiologist at Scripps in La Jolla, California and widelycredited
GENES, GENETICS AND GENOMICS, OH MY! activities. See Genetics/Genomics Competencies in Box 2 for a listing of the individual competencies. Implementation of the essential nursing competencies for genetics and ABOUT | SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE About. The Scripps Translational Science Institute (STSI) aims to replace the status-quo of one-size-fits-all-medicine with individualized health care that is based on the known genetic factors influencing health and disease and that takes advantage of advances in digital technology for real-time health monitoring.. Under the leadership of Eric J. Topol, M.D., one of the world’s premier SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE Scripps Translational Science Institute 3344 North Torrey Pines Court Suite 300 La Jolla, CA 92037 Map 858.554.5708RESEARCH HIGHLIGHTS
Research Highlights. This section briefly describes several ongoing major studies as well as recently completed investigations. The Scripps Translational Science Institute also sponsors pilot/methodological studies whose potential impact on health care is significant. To learn about these projects, please visit Pilot StudyAwards.
TRANSLATIONAL RESEARCH The power of translational research – from the laboratory bench to the patient’s bedside –is illustrated by Scripps Translational Science Institute scientists’ research on clopidogrel pharmacogenomics.At left, Lauren Ariniello in the lab, and at right, Matthew Price, M.D., in Scripps Green Hospital’s cardiac catheterization patient care facility.DIGITAL MEDICINE
Digital Medicine. In 2012, the Scripps Translational Science Institute (STSI) established a Division of Digital Medicine, which has developed into an internationally recognized leader in all aspects of the clinical implementation of wireless technologies in health andhealthcare.
CLINICAL TRIALS IN DIGITAL MEDICINE The primary objective of the trial is to determine whether screening select individuals in their homes using wearable medical devices can identify people with asymptomatic AFib more efficiently than routine care. The study, launched in November 2015, is a novel multisectoral collaboration between Scripps Translational Science Institute (STSIMATTHEW PRICE, M.D.
Scripps Translational Science Institute 3344 North Torrey Pines Court Suite 300 La Jolla, CA 92037 Map 858-554-5708INFECTIOUS DISEASES
Genetic factors that distinguish potentially lethal MRSA strains. Scripps Translational Science Institute researchers are scrutinizing the DNA sequences of different strains of methicillin-resistant Staphylococcus aureus (MRSA) to identify genetic factors that distinguish the serious but treatable noninvasive form of the disease from the invasive and potentially lethal infections that boreERIC J. TOPOL, M.D.
Eric J. Topol, M.D. Voted as the #1 Most Influential Physician Executive in the United States in 2012 in a national poll conducted by Modern Healthcare, Dr. Topol works on genomic and wireless digital innovative technologies to reshape the future of medicine. He is a practicing cardiologist at Scripps in La Jolla, California and widelycredited
GENES, GENETICS AND GENOMICS, OH MY! activities. See Genetics/Genomics Competencies in Box 2 for a listing of the individual competencies. Implementation of the essential nursing competencies for genetics and SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE Scripps Study Participant Enters White House Film Contest - Jan 30, 2014. Dr. Daniel Salomon presents President Obama with HOPE Act for signature - Dec 02, 2013. Wireless Sensors Used to Study Meditations Effect on Heart Health - Nov 13, 2013. Scripps Launches “Wired forHealth” Study -
ABOUT | SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE About. The Scripps Translational Science Institute (STSI) aims to replace the status-quo of one-size-fits-all-medicine with individualized health care that is based on the known genetic factors influencing health and disease and that takes advantage of advances in digital technology for real-time health monitoring.. Under the leadership of Eric J. Topol, M.D., one of the world’s premierINFECTIOUS DISEASES
Genetic factors that distinguish potentially lethal MRSA strains. Scripps Translational Science Institute researchers are scrutinizing the DNA sequences of different strains of methicillin-resistant Staphylococcus aureus (MRSA) to identify genetic factors that distinguish the serious but treatable noninvasive form of the disease from the invasive and potentially lethal infections that bore SCRIPPS ADVANCED CLINICAL TRIALS With the infrastructural support provided by the CTSA Consortium, research at STSI is a truly collaborative effort between STSI, Gary & Mary West Wireless Health Institute, Scripps Advanced Clinical Trials, Scripps Genomic Medicine, and external collaborators. Our current research and clinical trials are described for each institute listedbelow.
CONSUMER GENOMICS
Initiated in 2008, the Scripps Genomic Health Initiative (SGHI) is the first large-scale and long-term evaluation of the attitudes and perceptions of consumers who have purchased a commercially available personal genomic risk assessment test. A total of 3,630 consumers, whose ages range from 18 to 85 years, agreed to participate in thestudy.
THE CREATIVE DESTRUCTION OF MEDICINE The Creative Destruction of Medicine is a call to action for doctors and patients alike. We must see our world and our job as doctor and patient very differently. In a profession so uncertain of its future, we need precisely the vision and critical dialog offered here. I suspect that 150 years from now when historians are looking back atthe
HEALTHY AGING
Locating healthy elderly (80 years of age and older) to get DNA samples is challenging, since they don’t spend much time in health care facilities. Scripps currently attracts volunteers by conducting outreach efforts in the community. “The logistics are tricky, but we have to find them,” said Dr. Topol. “We think as people learnabout
PILOT STUDY AWARDEES Faculty Awardees. Identification of biomarkers to predict severity of lassa fever. Brian Sullivan, PhD. Developing preclinical candidates for GI and pancreatic cancer. Matthew Disney, PhD. Discovery of novel small-molecule activators of autophagy for the treatment of Parkinson’s disease. Jeff Kelly, PhD. Pilot study of muscle myosinas
HEALTHY PREGNANCY STUDY The Scripps Translational Science Institute (STSI) has partnered with WebMD to conduct the Healthy Pregnancy Study, a long-term research project designed to improve understanding of pregnancy through the collection of survey and connected device data. Users of WebMD’s popular Pregnancy mobile app are able to participate in the studythrough
TORKAMANI, ALI
Dr. Torkamani’s overall vision is to decipher that code in order to understand and predict interventions that restore diseased individuals to a healthy ground state. He is the Director of Genomics and Genome Informatics at the Scripps Translational Science Institute and an Associate Professor at The Scripps Research Institute – professor ABOUT | SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE About. The Scripps Translational Science Institute (STSI) aims to replace the status-quo of one-size-fits-all-medicine with individualized health care that is based on the known genetic factors influencing health and disease and that takes advantage of advances in digital technology for real-time health monitoring.. Under the leadership of Eric J. Topol, M.D., one of the world’s premier SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE Scripps Translational Science Institute 3344 North Torrey Pines Court Suite 300 La Jolla, CA 92037 Map 858.554.5708RESEARCH HIGHLIGHTS
Research Highlights. This section briefly describes several ongoing major studies as well as recently completed investigations. The Scripps Translational Science Institute also sponsors pilot/methodological studies whose potential impact on health care is significant. To learn about these projects, please visit Pilot StudyAwards.
TRANSLATIONAL RESEARCH The power of translational research – from the laboratory bench to the patient’s bedside –is illustrated by Scripps Translational Science Institute scientists’ research on clopidogrel pharmacogenomics.At left, Lauren Ariniello in the lab, and at right, Matthew Price, M.D., in Scripps Green Hospital’s cardiac catheterization patient care facility. CLINICAL TRIALS IN DIGITAL MEDICINE The primary objective of the trial is to determine whether screening select individuals in their homes using wearable medical devices can identify people with asymptomatic AFib more efficiently than routine care. The study, launched in November 2015, is a novel multisectoral collaboration between Scripps Translational Science Institute (STSI THE CREATIVE DESTRUCTION OF MEDICINE The Creative Destruction of Medicine is a call to action for doctors and patients alike. We must see our world and our job as doctor and patient very differently. In a profession so uncertain of its future, we need precisely the vision and critical dialog offered here. I suspect that 150 years from now when historians are looking back atthe
INFECTIOUS DISEASES
Genetic factors that distinguish potentially lethal MRSA strains. Scripps Translational Science Institute researchers are scrutinizing the DNA sequences of different strains of methicillin-resistant Staphylococcus aureus (MRSA) to identify genetic factors that distinguish the serious but treatable noninvasive form of the disease from the invasive and potentially lethal infections that boreMATTHEW PRICE, M.D.
Scripps Translational Science Institute 3344 North Torrey Pines Court Suite 300 La Jolla, CA 92037 Map 858-554-5708ERIC J. TOPOL, M.D.
Eric J. Topol, M.D. Voted as the #1 Most Influential Physician Executive in the United States in 2012 in a national poll conducted by Modern Healthcare, Dr. Topol works on genomic and wireless digital innovative technologies to reshape the future of medicine. He is a practicing cardiologist at Scripps in La Jolla, California and widelycredited
TORKAMANI, ALI
Dr. Torkamani’s overall vision is to decipher that code in order to understand and predict interventions that restore diseased individuals to a healthy ground state. He is the Director of Genomics and Genome Informatics at the Scripps Translational Science Institute and an Associate Professor at The Scripps Research Institute – professor ABOUT | SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE About. The Scripps Translational Science Institute (STSI) aims to replace the status-quo of one-size-fits-all-medicine with individualized health care that is based on the known genetic factors influencing health and disease and that takes advantage of advances in digital technology for real-time health monitoring.. Under the leadership of Eric J. Topol, M.D., one of the world’s premier SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE Scripps Translational Science Institute 3344 North Torrey Pines Court Suite 300 La Jolla, CA 92037 Map 858.554.5708RESEARCH HIGHLIGHTS
Research Highlights. This section briefly describes several ongoing major studies as well as recently completed investigations. The Scripps Translational Science Institute also sponsors pilot/methodological studies whose potential impact on health care is significant. To learn about these projects, please visit Pilot StudyAwards.
TRANSLATIONAL RESEARCH The power of translational research – from the laboratory bench to the patient’s bedside –is illustrated by Scripps Translational Science Institute scientists’ research on clopidogrel pharmacogenomics.At left, Lauren Ariniello in the lab, and at right, Matthew Price, M.D., in Scripps Green Hospital’s cardiac catheterization patient care facility. CLINICAL TRIALS IN DIGITAL MEDICINE The primary objective of the trial is to determine whether screening select individuals in their homes using wearable medical devices can identify people with asymptomatic AFib more efficiently than routine care. The study, launched in November 2015, is a novel multisectoral collaboration between Scripps Translational Science Institute (STSI THE CREATIVE DESTRUCTION OF MEDICINE The Creative Destruction of Medicine is a call to action for doctors and patients alike. We must see our world and our job as doctor and patient very differently. In a profession so uncertain of its future, we need precisely the vision and critical dialog offered here. I suspect that 150 years from now when historians are looking back atthe
INFECTIOUS DISEASES
Genetic factors that distinguish potentially lethal MRSA strains. Scripps Translational Science Institute researchers are scrutinizing the DNA sequences of different strains of methicillin-resistant Staphylococcus aureus (MRSA) to identify genetic factors that distinguish the serious but treatable noninvasive form of the disease from the invasive and potentially lethal infections that boreMATTHEW PRICE, M.D.
Scripps Translational Science Institute 3344 North Torrey Pines Court Suite 300 La Jolla, CA 92037 Map 858-554-5708ERIC J. TOPOL, M.D.
Eric J. Topol, M.D. Voted as the #1 Most Influential Physician Executive in the United States in 2012 in a national poll conducted by Modern Healthcare, Dr. Topol works on genomic and wireless digital innovative technologies to reshape the future of medicine. He is a practicing cardiologist at Scripps in La Jolla, California and widelycredited
TORKAMANI, ALI
Dr. Torkamani’s overall vision is to decipher that code in order to understand and predict interventions that restore diseased individuals to a healthy ground state. He is the Director of Genomics and Genome Informatics at the Scripps Translational Science Institute and an Associate Professor at The Scripps Research Institute – professor ABOUT | SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE About. The Scripps Translational Science Institute (STSI) aims to replace the status-quo of one-size-fits-all-medicine with individualized health care that is based on the known genetic factors influencing health and disease and that takes advantage of advances in digital technology for real-time health monitoring.. Under the leadership of Eric J. Topol, M.D., one of the world’s premier SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE Scripps Translational Science Institute 3344 North Torrey Pines Court Suite 300 La Jolla, CA 92037 Map 858.554.5708 SITEMAP | SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE Scripps Translational Science Institute 3344 North Torrey Pines Court Suite 300 La Jolla, CA 92037 Map 858-554-5708 EVENTS | SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE Computational Biology Research Camp June 2017, La Jolla, CA. The Scripps Translational Science Institute is partnering with non-profit organization miRcore to host a computational biology research summer camp for 8th – 12th grade students interested inINFECTIOUS DISEASES
Genetic factors that distinguish potentially lethal MRSA strains. Scripps Translational Science Institute researchers are scrutinizing the DNA sequences of different strains of methicillin-resistant Staphylococcus aureus (MRSA) to identify genetic factors that distinguish the serious but treatable noninvasive form of the disease from the invasive and potentially lethal infections that boreDIGITAL MEDICINE
Digital Medicine. In 2012, the Scripps Translational Science Institute (STSI) established a Division of Digital Medicine, which has developed into an internationally recognized leader in all aspects of the clinical implementation of wireless technologies in health andhealthcare.
HEALTHY AGING
Locating healthy elderly (80 years of age and older) to get DNA samples is challenging, since they don’t spend much time in health care facilities. Scripps currently attracts volunteers by conducting outreach efforts in the community. “The logistics are tricky, but we have to find them,” said Dr. Topol. “We think as people learnabout
HEALTHY PREGNANCY STUDY The Scripps Translational Science Institute (STSI) has partnered with WebMD to conduct the Healthy Pregnancy Study, a long-term research project designed to improve understanding of pregnancy through the collection of survey and connected device data. Users of WebMD’s popular Pregnancy mobile app are able to participate in the studythrough
PRECISION MEDICINE FOR YOUR PRACTICE The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. GENES, GENETICS AND GENOMICS, OH MY! activities. See Genetics/Genomics Competencies in Box 2 for a listing of the individual competencies. Implementation of the essential nursing competencies for genetics and SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE Scripps Translational Science Institute 3344 North Torrey Pines Court Suite 300 La Jolla, CA 92037 Map 858.554.5708RESEARCH HIGHLIGHTS
Research Highlights. This section briefly describes several ongoing major studies as well as recently completed investigations. The Scripps Translational Science Institute also sponsors pilot/methodological studies whose potential impact on health care is significant. To learn about these projects, please visit Pilot StudyAwards.
TRANSLATIONAL RESEARCH The power of translational research – from the laboratory bench to the patient’s bedside –is illustrated by Scripps Translational Science Institute scientists’ research on clopidogrel pharmacogenomics.At left, Lauren Ariniello in the lab, and at right, Matthew Price, M.D., in Scripps Green Hospital’s cardiac catheterization patient care facility.DIGITAL MEDICINE
Digital Medicine. In 2012, the Scripps Translational Science Institute (STSI) established a Division of Digital Medicine, which has developed into an internationally recognized leader in all aspects of the clinical implementation of wireless technologies in health andhealthcare.
THE CREATIVE DESTRUCTION OF MEDICINE The Creative Destruction of Medicine is a call to action for doctors and patients alike. We must see our world and our job as doctor and patient very differently. In a profession so uncertain of its future, we need precisely the vision and critical dialog offered here. I suspect that 150 years from now when historians are looking back atthe
MATTHEW PRICE, M.D.
Scripps Translational Science Institute 3344 North Torrey Pines Court Suite 300 La Jolla, CA 92037 Map 858-554-5708HEALTHY AGING
Locating healthy elderly (80 years of age and older) to get DNA samples is challenging, since they don’t spend much time in health care facilities. Scripps currently attracts volunteers by conducting outreach efforts in the community. “The logistics are tricky, but we have to find them,” said Dr. Topol. “We think as people learnabout
ERIC J. TOPOL, M.D.
Eric J. Topol, M.D. Voted as the #1 Most Influential Physician Executive in the United States in 2012 in a national poll conducted by Modern Healthcare, Dr. Topol works on genomic and wireless digital innovative technologies to reshape the future of medicine. He is a practicing cardiologist at Scripps in La Jolla, California and widelycredited
TORKAMANI, ALI
Dr. Torkamani’s overall vision is to decipher that code in order to understand and predict interventions that restore diseased individuals to a healthy ground state. He is the Director of Genomics and Genome Informatics at the Scripps Translational Science Institute and an Associate Professor at The Scripps Research Institute – professor GENES, GENETICS AND GENOMICS, OH MY! activities. See Genetics/Genomics Competencies in Box 2 for a listing of the individual competencies. Implementation of the essential nursing competencies for genetics and SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE Scripps Translational Science Institute 3344 North Torrey Pines Court Suite 300 La Jolla, CA 92037 Map 858.554.5708RESEARCH HIGHLIGHTS
Research Highlights. This section briefly describes several ongoing major studies as well as recently completed investigations. The Scripps Translational Science Institute also sponsors pilot/methodological studies whose potential impact on health care is significant. To learn about these projects, please visit Pilot StudyAwards.
TRANSLATIONAL RESEARCH The power of translational research – from the laboratory bench to the patient’s bedside –is illustrated by Scripps Translational Science Institute scientists’ research on clopidogrel pharmacogenomics.At left, Lauren Ariniello in the lab, and at right, Matthew Price, M.D., in Scripps Green Hospital’s cardiac catheterization patient care facility.DIGITAL MEDICINE
Digital Medicine. In 2012, the Scripps Translational Science Institute (STSI) established a Division of Digital Medicine, which has developed into an internationally recognized leader in all aspects of the clinical implementation of wireless technologies in health andhealthcare.
THE CREATIVE DESTRUCTION OF MEDICINE The Creative Destruction of Medicine is a call to action for doctors and patients alike. We must see our world and our job as doctor and patient very differently. In a profession so uncertain of its future, we need precisely the vision and critical dialog offered here. I suspect that 150 years from now when historians are looking back atthe
MATTHEW PRICE, M.D.
Scripps Translational Science Institute 3344 North Torrey Pines Court Suite 300 La Jolla, CA 92037 Map 858-554-5708HEALTHY AGING
Locating healthy elderly (80 years of age and older) to get DNA samples is challenging, since they don’t spend much time in health care facilities. Scripps currently attracts volunteers by conducting outreach efforts in the community. “The logistics are tricky, but we have to find them,” said Dr. Topol. “We think as people learnabout
ERIC J. TOPOL, M.D.
Eric J. Topol, M.D. Voted as the #1 Most Influential Physician Executive in the United States in 2012 in a national poll conducted by Modern Healthcare, Dr. Topol works on genomic and wireless digital innovative technologies to reshape the future of medicine. He is a practicing cardiologist at Scripps in La Jolla, California and widelycredited
TORKAMANI, ALI
Dr. Torkamani’s overall vision is to decipher that code in order to understand and predict interventions that restore diseased individuals to a healthy ground state. He is the Director of Genomics and Genome Informatics at the Scripps Translational Science Institute and an Associate Professor at The Scripps Research Institute – professor GENES, GENETICS AND GENOMICS, OH MY! activities. See Genetics/Genomics Competencies in Box 2 for a listing of the individual competencies. Implementation of the essential nursing competencies for genetics and ABOUT | SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE About. The Scripps Translational Science Institute (STSI) aims to replace the status-quo of one-size-fits-all-medicine with individualized health care that is based on the known genetic factors influencing health and disease and that takes advantage of advances in digital technology for real-time health monitoring.. Under the leadership of Eric J. Topol, M.D., one of the world’s premier THE CREATIVE DESTRUCTION OF MEDICINE The Creative Destruction of Medicine is a call to action for doctors and patients alike. We must see our world and our job as doctor and patient very differently. In a profession so uncertain of its future, we need precisely the vision and critical dialog offered here. I suspect that 150 years from now when historians are looking back atthe
CONSUMER GENOMICS
Scripps Genomic Health Initiative. Initiated in 2008, the Scripps Genomic Health Initiative (SGHI) is the first large-scale and long-term evaluation of the attitudes and perceptions of consumers who have purchased a commercially available personal genomic riskassessment test.
HEART DISEASE
Circulating endothelial cells: potential prognostic biomarker for sudden heart attack. If blood levels of circulating endothelial cells are a prognostic biomarker for an impending heart attack or stroke, physicians could more accurately gauge patients’ risk for these life-threatening conditions and initiate therapies to prevent their occurrence, or at least lessen their severity. BEHAVIORAL DISORDERS Autism Spectrum Disorders. Several genes have been linked to autism spectrum disorders (ASD), with one of the most intriguing being MeCP2 (methyl-CpG-binding protein 2), a very complex and multifunctional nuclear protein whose mechanism of action is not yet fully understood.. Learn More CANCER: DISTINGUISHING “DRIVER” FROM “PASSENGER” GENETIC Each cancer is characterized by numerous somatic mutations, of which only a subset contributes to the tumor’s progression. Scientists want to be able to distinguish these “driver” mutations from the preponderance of neutral “passenger” mutations that characterize each cancer, so that they can take advantage of the wealth of data produced by the large-scale tumor resequencing studies PILOT STUDY AWARDEES Faculty Awardees. Identification of biomarkers to predict severity of lassa fever. Brian Sullivan, PhD. Developing preclinical candidates for GI and pancreatic cancer. Matthew Disney, PhD. Discovery of novel small-molecule activators of autophagy for the treatment of Parkinson’s disease. Jeff Kelly, PhD. Pilot study of muscle myosinas
HEALTHY AGING
Locating healthy elderly (80 years of age and older) to get DNA samples is challenging, since they don’t spend much time in health care facilities. Scripps currently attracts volunteers by conducting outreach efforts in the community. “The logistics are tricky, but we have to find them,” said Dr. Topol. “We think as people learnabout
CIRCULATING ENDOTHELIAL CELLS Although genomics has advanced scientific understanding about the underpinnings of disease, much of that progress has occurred in cancer because tissue-specific molecular characteristics, such as somatic mutations, epigenomics and regulatory elements, can be analyzed in tumor tissue obtained through biopsy or surgical resection. DIABETES | SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE Pharmacogenetic approach to type 2 diabetes. Researchers plan to map individuals with type 2 diabetes into disease sub-types, each of which will be based on genetic susceptibility allele profiles. SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE Scripps Translational Science Institute 3344 North Torrey Pines Court Suite 300 La Jolla, CA 92037 Map 858.554.5708RESEARCH HIGHLIGHTS
Research Highlights. This section briefly describes several ongoing major studies as well as recently completed investigations. The Scripps Translational Science Institute also sponsors pilot/methodological studies whose potential impact on health care is significant. To learn about these projects, please visit Pilot StudyAwards.
TRANSLATIONAL RESEARCH The power of translational research – from the laboratory bench to the patient’s bedside –is illustrated by Scripps Translational Science Institute scientists’ research on clopidogrel pharmacogenomics.At left, Lauren Ariniello in the lab, and at right, Matthew Price, M.D., in Scripps Green Hospital’s cardiac catheterization patient care facility.DIGITAL MEDICINE
Digital Medicine. In 2012, the Scripps Translational Science Institute (STSI) established a Division of Digital Medicine, which has developed into an internationally recognized leader in all aspects of the clinical implementation of wireless technologies in health andhealthcare.
THE CREATIVE DESTRUCTION OF MEDICINE The Creative Destruction of Medicine is a call to action for doctors and patients alike. We must see our world and our job as doctor and patient very differently. In a profession so uncertain of its future, we need precisely the vision and critical dialog offered here. I suspect that 150 years from now when historians are looking back atthe
MATTHEW PRICE, M.D.
Scripps Translational Science Institute 3344 North Torrey Pines Court Suite 300 La Jolla, CA 92037 Map 858-554-5708HEALTHY AGING
Locating healthy elderly (80 years of age and older) to get DNA samples is challenging, since they don’t spend much time in health care facilities. Scripps currently attracts volunteers by conducting outreach efforts in the community. “The logistics are tricky, but we have to find them,” said Dr. Topol. “We think as people learnabout
ERIC J. TOPOL, M.D.
Eric J. Topol, M.D. Voted as the #1 Most Influential Physician Executive in the United States in 2012 in a national poll conducted by Modern Healthcare, Dr. Topol works on genomic and wireless digital innovative technologies to reshape the future of medicine. He is a practicing cardiologist at Scripps in La Jolla, California and widelycredited
TORKAMANI, ALI
Dr. Torkamani’s overall vision is to decipher that code in order to understand and predict interventions that restore diseased individuals to a healthy ground state. He is the Director of Genomics and Genome Informatics at the Scripps Translational Science Institute and an Associate Professor at The Scripps Research Institute – professor GENES, GENETICS AND GENOMICS, OH MY! activities. See Genetics/Genomics Competencies in Box 2 for a listing of the individual competencies. Implementation of the essential nursing competencies for genetics and SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE Scripps Translational Science Institute 3344 North Torrey Pines Court Suite 300 La Jolla, CA 92037 Map 858.554.5708RESEARCH HIGHLIGHTS
Research Highlights. This section briefly describes several ongoing major studies as well as recently completed investigations. The Scripps Translational Science Institute also sponsors pilot/methodological studies whose potential impact on health care is significant. To learn about these projects, please visit Pilot StudyAwards.
TRANSLATIONAL RESEARCH The power of translational research – from the laboratory bench to the patient’s bedside –is illustrated by Scripps Translational Science Institute scientists’ research on clopidogrel pharmacogenomics.At left, Lauren Ariniello in the lab, and at right, Matthew Price, M.D., in Scripps Green Hospital’s cardiac catheterization patient care facility.DIGITAL MEDICINE
Digital Medicine. In 2012, the Scripps Translational Science Institute (STSI) established a Division of Digital Medicine, which has developed into an internationally recognized leader in all aspects of the clinical implementation of wireless technologies in health andhealthcare.
THE CREATIVE DESTRUCTION OF MEDICINE The Creative Destruction of Medicine is a call to action for doctors and patients alike. We must see our world and our job as doctor and patient very differently. In a profession so uncertain of its future, we need precisely the vision and critical dialog offered here. I suspect that 150 years from now when historians are looking back atthe
MATTHEW PRICE, M.D.
Scripps Translational Science Institute 3344 North Torrey Pines Court Suite 300 La Jolla, CA 92037 Map 858-554-5708HEALTHY AGING
Locating healthy elderly (80 years of age and older) to get DNA samples is challenging, since they don’t spend much time in health care facilities. Scripps currently attracts volunteers by conducting outreach efforts in the community. “The logistics are tricky, but we have to find them,” said Dr. Topol. “We think as people learnabout
ERIC J. TOPOL, M.D.
Eric J. Topol, M.D. Voted as the #1 Most Influential Physician Executive in the United States in 2012 in a national poll conducted by Modern Healthcare, Dr. Topol works on genomic and wireless digital innovative technologies to reshape the future of medicine. He is a practicing cardiologist at Scripps in La Jolla, California and widelycredited
TORKAMANI, ALI
Dr. Torkamani’s overall vision is to decipher that code in order to understand and predict interventions that restore diseased individuals to a healthy ground state. He is the Director of Genomics and Genome Informatics at the Scripps Translational Science Institute and an Associate Professor at The Scripps Research Institute – professor GENES, GENETICS AND GENOMICS, OH MY! activities. See Genetics/Genomics Competencies in Box 2 for a listing of the individual competencies. Implementation of the essential nursing competencies for genetics and ABOUT | SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE About. The Scripps Translational Science Institute (STSI) aims to replace the status-quo of one-size-fits-all-medicine with individualized health care that is based on the known genetic factors influencing health and disease and that takes advantage of advances in digital technology for real-time health monitoring.. Under the leadership of Eric J. Topol, M.D., one of the world’s premier THE CREATIVE DESTRUCTION OF MEDICINE The Creative Destruction of Medicine is a call to action for doctors and patients alike. We must see our world and our job as doctor and patient very differently. In a profession so uncertain of its future, we need precisely the vision and critical dialog offered here. I suspect that 150 years from now when historians are looking back atthe
CONSUMER GENOMICS
Scripps Genomic Health Initiative. Initiated in 2008, the Scripps Genomic Health Initiative (SGHI) is the first large-scale and long-term evaluation of the attitudes and perceptions of consumers who have purchased a commercially available personal genomic riskassessment test.
HEART DISEASE
Circulating endothelial cells: potential prognostic biomarker for sudden heart attack. If blood levels of circulating endothelial cells are a prognostic biomarker for an impending heart attack or stroke, physicians could more accurately gauge patients’ risk for these life-threatening conditions and initiate therapies to prevent their occurrence, or at least lessen their severity. BEHAVIORAL DISORDERS Autism Spectrum Disorders. Several genes have been linked to autism spectrum disorders (ASD), with one of the most intriguing being MeCP2 (methyl-CpG-binding protein 2), a very complex and multifunctional nuclear protein whose mechanism of action is not yet fully understood.. Learn More CANCER: DISTINGUISHING “DRIVER” FROM “PASSENGER” GENETIC Each cancer is characterized by numerous somatic mutations, of which only a subset contributes to the tumor’s progression. Scientists want to be able to distinguish these “driver” mutations from the preponderance of neutral “passenger” mutations that characterize each cancer, so that they can take advantage of the wealth of data produced by the large-scale tumor resequencing studies PILOT STUDY AWARDEES Faculty Awardees. Identification of biomarkers to predict severity of lassa fever. Brian Sullivan, PhD. Developing preclinical candidates for GI and pancreatic cancer. Matthew Disney, PhD. Discovery of novel small-molecule activators of autophagy for the treatment of Parkinson’s disease. Jeff Kelly, PhD. Pilot study of muscle myosinas
HEALTHY AGING
Locating healthy elderly (80 years of age and older) to get DNA samples is challenging, since they don’t spend much time in health care facilities. Scripps currently attracts volunteers by conducting outreach efforts in the community. “The logistics are tricky, but we have to find them,” said Dr. Topol. “We think as people learnabout
CIRCULATING ENDOTHELIAL CELLS Although genomics has advanced scientific understanding about the underpinnings of disease, much of that progress has occurred in cancer because tissue-specific molecular characteristics, such as somatic mutations, epigenomics and regulatory elements, can be analyzed in tumor tissue obtained through biopsy or surgical resection. DIABETES | SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE Pharmacogenetic approach to type 2 diabetes. Researchers plan to map individuals with type 2 diabetes into disease sub-types, each of which will be based on genetic susceptibility allele profiles. SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE Scripps Translational Science Institute 3344 North Torrey Pines Court Suite 300 La Jolla, CA 92037 Map 858.554.5708RESEARCH HIGHLIGHTS
Research Highlights. This section briefly describes several ongoing major studies as well as recently completed investigations. The Scripps Translational Science Institute also sponsors pilot/methodological studies whose potential impact on health care is significant. To learn about these projects, please visit Pilot StudyAwards.
TRANSLATIONAL RESEARCH The power of translational research – from the laboratory bench to the patient’s bedside –is illustrated by Scripps Translational Science Institute scientists’ research on clopidogrel pharmacogenomics.At left, Lauren Ariniello in the lab, and at right, Matthew Price, M.D., in Scripps Green Hospital’s cardiac catheterization patient care facility.DIGITAL MEDICINE
Digital Medicine. In 2012, the Scripps Translational Science Institute (STSI) established a Division of Digital Medicine, which has developed into an internationally recognized leader in all aspects of the clinical implementation of wireless technologies in health andhealthcare.
THE CREATIVE DESTRUCTION OF MEDICINE The Creative Destruction of Medicine is a call to action for doctors and patients alike. We must see our world and our job as doctor and patient very differently. In a profession so uncertain of its future, we need precisely the vision and critical dialog offered here. I suspect that 150 years from now when historians are looking back atthe
MATTHEW PRICE, M.D.
Scripps Translational Science Institute 3344 North Torrey Pines Court Suite 300 La Jolla, CA 92037 Map 858-554-5708HEALTHY AGING
Locating healthy elderly (80 years of age and older) to get DNA samples is challenging, since they don’t spend much time in health care facilities. Scripps currently attracts volunteers by conducting outreach efforts in the community. “The logistics are tricky, but we have to find them,” said Dr. Topol. “We think as people learnabout
ERIC J. TOPOL, M.D.
Eric J. Topol, M.D. Voted as the #1 Most Influential Physician Executive in the United States in 2012 in a national poll conducted by Modern Healthcare, Dr. Topol works on genomic and wireless digital innovative technologies to reshape the future of medicine. He is a practicing cardiologist at Scripps in La Jolla, California and widelycredited
TORKAMANI, ALI
Dr. Torkamani’s overall vision is to decipher that code in order to understand and predict interventions that restore diseased individuals to a healthy ground state. He is the Director of Genomics and Genome Informatics at the Scripps Translational Science Institute and an Associate Professor at The Scripps Research Institute – professor GENES, GENETICS AND GENOMICS, OH MY! activities. See Genetics/Genomics Competencies in Box 2 for a listing of the individual competencies. Implementation of the essential nursing competencies for genetics and SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE Scripps Translational Science Institute 3344 North Torrey Pines Court Suite 300 La Jolla, CA 92037 Map 858.554.5708RESEARCH HIGHLIGHTS
Research Highlights. This section briefly describes several ongoing major studies as well as recently completed investigations. The Scripps Translational Science Institute also sponsors pilot/methodological studies whose potential impact on health care is significant. To learn about these projects, please visit Pilot StudyAwards.
TRANSLATIONAL RESEARCH The power of translational research – from the laboratory bench to the patient’s bedside –is illustrated by Scripps Translational Science Institute scientists’ research on clopidogrel pharmacogenomics.At left, Lauren Ariniello in the lab, and at right, Matthew Price, M.D., in Scripps Green Hospital’s cardiac catheterization patient care facility.DIGITAL MEDICINE
Digital Medicine. In 2012, the Scripps Translational Science Institute (STSI) established a Division of Digital Medicine, which has developed into an internationally recognized leader in all aspects of the clinical implementation of wireless technologies in health andhealthcare.
THE CREATIVE DESTRUCTION OF MEDICINE The Creative Destruction of Medicine is a call to action for doctors and patients alike. We must see our world and our job as doctor and patient very differently. In a profession so uncertain of its future, we need precisely the vision and critical dialog offered here. I suspect that 150 years from now when historians are looking back atthe
MATTHEW PRICE, M.D.
Scripps Translational Science Institute 3344 North Torrey Pines Court Suite 300 La Jolla, CA 92037 Map 858-554-5708HEALTHY AGING
Locating healthy elderly (80 years of age and older) to get DNA samples is challenging, since they don’t spend much time in health care facilities. Scripps currently attracts volunteers by conducting outreach efforts in the community. “The logistics are tricky, but we have to find them,” said Dr. Topol. “We think as people learnabout
ERIC J. TOPOL, M.D.
Eric J. Topol, M.D. Voted as the #1 Most Influential Physician Executive in the United States in 2012 in a national poll conducted by Modern Healthcare, Dr. Topol works on genomic and wireless digital innovative technologies to reshape the future of medicine. He is a practicing cardiologist at Scripps in La Jolla, California and widelycredited
TORKAMANI, ALI
Dr. Torkamani’s overall vision is to decipher that code in order to understand and predict interventions that restore diseased individuals to a healthy ground state. He is the Director of Genomics and Genome Informatics at the Scripps Translational Science Institute and an Associate Professor at The Scripps Research Institute – professor GENES, GENETICS AND GENOMICS, OH MY! activities. See Genetics/Genomics Competencies in Box 2 for a listing of the individual competencies. Implementation of the essential nursing competencies for genetics and ABOUT | SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE About. The Scripps Translational Science Institute (STSI) aims to replace the status-quo of one-size-fits-all-medicine with individualized health care that is based on the known genetic factors influencing health and disease and that takes advantage of advances in digital technology for real-time health monitoring.. Under the leadership of Eric J. Topol, M.D., one of the world’s premier THE CREATIVE DESTRUCTION OF MEDICINE The Creative Destruction of Medicine is a call to action for doctors and patients alike. We must see our world and our job as doctor and patient very differently. In a profession so uncertain of its future, we need precisely the vision and critical dialog offered here. I suspect that 150 years from now when historians are looking back atthe
CONSUMER GENOMICS
Scripps Genomic Health Initiative. Initiated in 2008, the Scripps Genomic Health Initiative (SGHI) is the first large-scale and long-term evaluation of the attitudes and perceptions of consumers who have purchased a commercially available personal genomic riskassessment test.
HEART DISEASE
Circulating endothelial cells: potential prognostic biomarker for sudden heart attack. If blood levels of circulating endothelial cells are a prognostic biomarker for an impending heart attack or stroke, physicians could more accurately gauge patients’ risk for these life-threatening conditions and initiate therapies to prevent their occurrence, or at least lessen their severity. BEHAVIORAL DISORDERS Autism Spectrum Disorders. Several genes have been linked to autism spectrum disorders (ASD), with one of the most intriguing being MeCP2 (methyl-CpG-binding protein 2), a very complex and multifunctional nuclear protein whose mechanism of action is not yet fully understood.. Learn More CANCER: DISTINGUISHING “DRIVER” FROM “PASSENGER” GENETIC Each cancer is characterized by numerous somatic mutations, of which only a subset contributes to the tumor’s progression. Scientists want to be able to distinguish these “driver” mutations from the preponderance of neutral “passenger” mutations that characterize each cancer, so that they can take advantage of the wealth of data produced by the large-scale tumor resequencing studies PILOT STUDY AWARDEES Faculty Awardees. Identification of biomarkers to predict severity of lassa fever. Brian Sullivan, PhD. Developing preclinical candidates for GI and pancreatic cancer. Matthew Disney, PhD. Discovery of novel small-molecule activators of autophagy for the treatment of Parkinson’s disease. Jeff Kelly, PhD. Pilot study of muscle myosinas
HEALTHY AGING
Locating healthy elderly (80 years of age and older) to get DNA samples is challenging, since they don’t spend much time in health care facilities. Scripps currently attracts volunteers by conducting outreach efforts in the community. “The logistics are tricky, but we have to find them,” said Dr. Topol. “We think as people learnabout
CIRCULATING ENDOTHELIAL CELLS Although genomics has advanced scientific understanding about the underpinnings of disease, much of that progress has occurred in cancer because tissue-specific molecular characteristics, such as somatic mutations, epigenomics and regulatory elements, can be analyzed in tumor tissue obtained through biopsy or surgical resection. DIABETES | SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE Pharmacogenetic approach to type 2 diabetes. Researchers plan to map individuals with type 2 diabetes into disease sub-types, each of which will be based on genetic susceptibility allele profiles.* Home
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* Scripps Launches “Wired for Health” Study- Sep 26, 2013
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* Dr. Steven Steinhubl joins STSI as Director for Digital Medicine- Jul 10, 2013
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