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Scientists worldwide continue their push to develop effective treatments and a vaccine for the highly contagious COVID-19. A press release issued by University of South Florida suggests that existing compounds could block the replication of the virus. And repurposing existing drugs that contain these compounds could be the most effective way to fight the virus. SEE, THAT’S WHAT THE APP IS Thrivous is the human enhancement company. Get nootropics and geroprotectors with the greatest potential to improve your brain andbody.
PULSE 158: WEAR THOSE MASKS Yesterday, our swimming pool reopened after four months. All over the world, COVID-19 lockdown measures are being eased. This is a very goodthing for
CAFFEINE BENEFITS, SIDE EFFECTS, AND AFFECTS ON... If you can’t imagine getting up in the morning without reaching for a cup of coffee, you’re not alone. Namely, over 50% of Americans aged 18 or older drink coffee every day. PULSE 157: DEXAMETHASONE IMPROVES SURVIVAL IN... The low-dose steroid treatment dexamethasone is a major breakthrough in the fight against the deadly virus, COVID-19. This is according to UK experts, as reported by BBC News.. The drug is part of a trial testing existing treatments to see if they also work for coronavirus. Dexamethasone cut the risk of death by a third for patients onventilators.
PULSE 160: REPURPOSING EXISTING DRUGS FOR COVID-19 Scientists worldwide continue their push to develop effective treatments and a vaccine for the highly contagious COVID-19. A press release issued by University of South Florida suggests that existing compounds could block the replication of the virus. And repurposing existing drugs that contain these compounds could be the most effective way to fight the virus. PULSE 159: PRESERVING BIODIVERSITY SAVES LIVES Life-saving drugs, combatting diseases such as cancer, “have been developed from marine organisms and their symbiotic microbiota,” notes a press release from GEOMAR Helmholtz Centre for Ocean Research Kiel (see below). “Fungi, which we isolated from bladder wrack and fermented in optimized laboratory conditions, are an established source of natural anti-cancer agents,” said POWER UP YOUR BIKE RIDE WITH CAFFEINE Thrivous is the human enhancement company. Get nootropics and geroprotectors with the greatest potential to improve your brain andbody.
9 ULTRA-WEALTHY INDIVIDUALS WHO AIM TO DEFEAT... For the first time in all of history, defeating death from aging and extending healthy lifespans seem to be attainable goals. Based on my research, I think we’ll all have the option to choose life extension sometime over the next twenty or thirty years.THRIVOUS.TUMBLR.COM
Scientists worldwide continue their push to develop effective treatments and a vaccine for the highly contagious COVID-19. A press release issued by University of South Florida suggests that existing compounds could block the replication of the virus. And repurposing existing drugs that contain these compounds could be the most effective way to fight the virus. SEE, THAT’S WHAT THE APP IS Thrivous is the human enhancement company. Get nootropics and geroprotectors with the greatest potential to improve your brain andbody.
PULSE 158: WEAR THOSE MASKS Yesterday, our swimming pool reopened after four months. All over the world, COVID-19 lockdown measures are being eased. This is a very goodthing for
CAFFEINE BENEFITS, SIDE EFFECTS, AND AFFECTS ON... If you can’t imagine getting up in the morning without reaching for a cup of coffee, you’re not alone. Namely, over 50% of Americans aged 18 or older drink coffee every day. PULSE 157: DEXAMETHASONE IMPROVES SURVIVAL IN... The low-dose steroid treatment dexamethasone is a major breakthrough in the fight against the deadly virus, COVID-19. This is according to UK experts, as reported by BBC News.. The drug is part of a trial testing existing treatments to see if they also work for coronavirus. Dexamethasone cut the risk of death by a third for patients onventilators.
PULSE 160: REPURPOSING EXISTING DRUGS FOR COVID-19 Scientists worldwide continue their push to develop effective treatments and a vaccine for the highly contagious COVID-19. A press release issued by University of South Florida suggests that existing compounds could block the replication of the virus. And repurposing existing drugs that contain these compounds could be the most effective way to fight the virus. PULSE 159: PRESERVING BIODIVERSITY SAVES LIVES Life-saving drugs, combatting diseases such as cancer, “have been developed from marine organisms and their symbiotic microbiota,” notes a press release from GEOMAR Helmholtz Centre for Ocean Research Kiel (see below). “Fungi, which we isolated from bladder wrack and fermented in optimized laboratory conditions, are an established source of natural anti-cancer agents,” said POWER UP YOUR BIKE RIDE WITH CAFFEINE Thrivous is the human enhancement company. Get nootropics and geroprotectors with the greatest potential to improve your brain andbody.
9 ULTRA-WEALTHY INDIVIDUALS WHO AIM TO DEFEAT... For the first time in all of history, defeating death from aging and extending healthy lifespans seem to be attainable goals. Based on my research, I think we’ll all have the option to choose life extension sometime over the next twenty or thirty years.THRIVOUS.TUMBLR.COM
Life-saving drugs, combatting diseases such as cancer, “have been developed from marine organisms and their symbiotic microbiota,” notes a press release from GEOMAR Helmholtz Centre for Ocean Research Kiel (see below). “Fungi, which we isolated from bladder wrack and fermented in optimized laboratory conditions, are an established source of natural anti-cancer agents,” said research SEE, THAT’S WHAT THE APP IS Thrivous is the human enhancement company. Get nootropics and geroprotectors with the greatest potential to improve your brain andbody.
PULSE 158: WEAR THOSE MASKS Yesterday, our swimming pool reopened after four months. All over the world, COVID-19 lockdown measures are being eased. This is a very goodthing for
CAFFEINE BENEFITS, SIDE EFFECTS, AND AFFECTS ON... If you can’t imagine getting up in the morning without reaching for a cup of coffee, you’re not alone. Namely, over 50% of Americans aged 18 or older drink coffee every day. PULSE 157: DEXAMETHASONE IMPROVES SURVIVAL IN... The low-dose steroid treatment dexamethasone is a major breakthrough in the fight against the deadly virus, COVID-19. This is according to UK experts, as reported by BBC News.. The drug is part of a trial testing existing treatments to see if they also work for coronavirus. Dexamethasone cut the risk of death by a third for patients onventilators.
PULSE 160: REPURPOSING EXISTING DRUGS FOR COVID-19 Scientists worldwide continue their push to develop effective treatments and a vaccine for the highly contagious COVID-19. A press release issued by University of South Florida suggests that existing compounds could block the replication of the virus. And repurposing existing drugs that contain these compounds could be the most effective way to fight the virus. PULSE 159: PRESERVING BIODIVERSITY SAVES LIVES Life-saving drugs, combatting diseases such as cancer, “have been developed from marine organisms and their symbiotic microbiota,” notes a press release from GEOMAR Helmholtz Centre for Ocean Research Kiel (see below). “Fungi, which we isolated from bladder wrack and fermented in optimized laboratory conditions, are an established source of natural anti-cancer agents,” said POWER UP YOUR BIKE RIDE WITH CAFFEINE Thrivous is the human enhancement company. Get nootropics and geroprotectors with the greatest potential to improve your brain andbody.
9 ULTRA-WEALTHY INDIVIDUALS WHO AIM TO DEFEAT... For the first time in all of history, defeating death from aging and extending healthy lifespans seem to be attainable goals. Based on my research, I think we’ll all have the option to choose life extension sometime over the next twenty or thirty years.1.5M ratings
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SEE, THAT’S WHAT THE APP IS PERFECT FOR. Sounds perfect Wahhhh, I don’t wannaTHRIVOUS
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PULSE 114: ANTI-AGING FROM WORM EXPERIMENTS TO HUMAN THERAPIES A protein known as LIN-53 has been found to play an important role in healthy aging (see below), in nematode worms. LIN-53 affects muscle development through the molecular complex NuRD, while it affects lifespan through a separate complex, Sin3. The fact that these are distinct pathways, but both involving LIN-53, is particularly intriguing and strongly suggests the importance of LIN-53 as a link between healthspan and lifespan. Since the protein is very similar to human protein RBBP4/7, the insights gained from worm studies could, one day, find clinical applications in human patients. “It is such a small organism and yet still resembles human tissues, pathways and gene regulation, so we are able to transfer results from the nematode to humans,” said lead researcher Stefanie Müthel. I guess Müthel means something like “we might eventually be able to transfer …” In fact, the road from lab experiments with worms to working anti-aging therapies for humans is likely to be long. Yet, this and similar research results are encouraging. PROTEIN HAS POWERFUL ANTI-AGING EFFECTS IN WORMS. Researchers at the Max Delbrueck Center for Molecular Medicine (MDC) have identified an epigenetic mechanism that appears to strongly influence healthyaging. A study
published in _Aging Cell_ reveals that the protein LIN-53, which controls muscle integrity, lifespan and levels of an essential sugar, plays an important anti-aging role in worms, ensuring muscle development and longer life. NEW DRUG COULD IMPROVE CHEMOTHERAPY FOR PANCREATIC CANCER. Scientists at Columbia University have suggested that a new drug, able to penetrate the protective barrier around pancreatic cancers and accumulate in malignant cells, might improve current chemotherapy. The drug, an experimental compound called PTC596, is known to have antitumor activity in mouse and human pancreatic cancer cells. The scientists have tested PTC596 in combination with gemcitabine (a first-line drug for pancreatic cancer) in genetically engineered mice with an aggressive form of pancreatic cancer that is generally resistant to chemotherapy. The results, described in a study published in _Clinical Cancer Research_, are encouraging. DNA METHYLATION PRESERVES MOLECULAR MEMORY IN FISH. University of Otago researchers have found that molecular memory, in the form of “DNA methylation,” is preserved between generations of fish, in contrast to humans where it is almost entirely erased. DNA methylation encodes additional information passed from parents to their offspring, which we are only starting to understand. In humans and other mammals, DNA methylation is erased at each generation. But the new research results, outlinedin a study
published in _Nature Communications_, show that global erasure of DNA methylation memory does not occur in fish. BIODEGRADABLE IMPLANTS FOR PRECISE, CONTROLLED RELEASE OF PAINKILLERS. EPFL researchers have developed biodegradable microresonators, described in a study published in _Advanced Functional Materials_, which can be heated locally with a wireless system. The device could be used in implants to control the release of painkillers within tissue. Such an implant would enable release of controlled amounts of anesthetic in a specific location over several days. After that, the implant will degrade safely inside the body. TOWARD CANCER THERAPIES WITH MINIMAL SIDE EFFECTS. Scientists at Oregon State University, University of Central Florida, and New York University, have advanced toward new cancer therapies that don’t have the side effects that often accompany many current cancer treatments by identifying a protein modification that specifically supports survival of tumor cells. The research results,
published in _Journal of Biological Chemistry_, outline a new therapeutic strategy for the treatment of tumors of the nervous system, with minimal to no side effects on normal tissues. NANO-VACCINE EFFECTIVE AGAINST MELANOMA IN LABORATORY MICE. Researchers at Tel Aviv University have developed a novel nano-vaccine for melanoma, the most aggressive type of skin cancer. Their approach, described in a research paper published in _Nature Nanotechnology_, has so far proven effective in preventing the development of melanoma in mouse models and in treating primary tumors and metastases that result from melanoma. IMMUNOTHERAPY FOR TREATMENT-RESISTANT LYMPHOMA. Mount Sinai researchers have developed a way to use immunotherapy drugs against treatment-resistant non-Hodgkin’s lymphomas for the first time by combining them with stem cell transplantation. According to the researchers this approach, described in a paper published in _Cancer Discovery_, could also dramatically increase the success of the drugs in treatment of melanoma and lung cancer. Originally published at thrivous.com on August 12, 2019 at 09:26AM.Aug 12th, 2019
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PULSE 113: FUTURE NANOTECHNOLOGY FOR NEURODEGENERATIVE DISEASE “Perhaps have discovered a new target for someday intervening in neurodegenerative diseases with novel therapeutics,” says Johns Hopkins Medicine professor Jeffrey Rothstein, commenting on successful preliminary experiments to deliver corrective proteins via nanoparticles to replace missing proteins needed for repairing defective neural connections (see below). The prospect to fix brain defects by supplying needed proteins via nanoparticles sounds awesome, but of course this research work will need time to move from the lab to clinical practice. So, someday we may have a cure for neurodegenerative diseases like Alzheimer’s, but you shouldn’t hold your breath. In the meantime, if you are prone to depression, maybe try red wine and chocolate. A new study has revealed that the plant compound resveratrol, which is found in red wine, displays anti-stress effects by blocking the expression of an enzyme related to the control of stress in the brain. Similarly, eating dark chocolate may positively affect mood and relieve depressive symptoms, a new study looking at whether different types of chocolate are associated with mood disorders has found. NANOPARTICLES DELIVER CORRECTIVE PROTEINS TO REPAIR DEFECTIVE NEURAL CONNECTIONS. Johns Hopkins Medicine researchers have conducted proof-of-concept experiments that show they could deliver corrective proteins via nanoparticles to replace missing proteins needed for repairing defective neural connections. In a paper published in _Nature Neuroscience_, the researchers describe experiments with lab mice and show that a protein produced by some brain cells, which plays a specific role in directing the formation of connections among neurons needed for learning and forming new memories, can be reproduced by injecting nanoparticles if missing. The researchers repeated these experiments with human neurons too. DETECTING NEURAL SIGNALS THROUGHOUT THE BRAIN. Scientists at Howard Hughes Medical Institute have developed a new way to track neural activity. The new technique, called Voltron, described in a study published in _Science_, lets researchers track neuron activity in living animals more precisely and for far longer time periods than was once possible. The scientists used a specially engineered protein that changes intensity when specific neurons switch on, allowing researchers to detect neural signals throughout the brain. That kind of data makes it easier to study the complex ways neurons coordinatebehavior.
MOLECULAR SWITCH TURNS ON ANTI-INFLAMMATORY FUNCTION IN IMMUNE CELLS. Researchers at University of Illinois at Chicago have identified a molecular switch that causes immune cells known as macrophages to clean up cellular debris caused by infections. The findings, published in PNAS, indicate that a molecule called Gas6 induces macrophages to perform an anti-inflammatory role, which could serve as a potential drug target for drug makers. According to the researchers, harnessing the anti-inflammatory function of macrophages using the Gas6 switch holds great potential for treating diseases ranging from heart disease to cancer to rheumatoid arthritis, where inflammation is a keyunderlying feature.
ENGINEERED BACTERIA PRODUCE NANOWIRES FOR BIOLOGICAL SENSORS. Microbiologists at University of Massachusetts at Amherst have reported advances in the quest to develop electrically conductive protein nanowires in the bacterium Geobacter sulfurreducens for use as chemical and biological sensors. In a study published in _ACS Synthetic Biology_, the microbiologists describe how they built a strain of G. sulfurreducens that made synthetic nanowires that could be controlled by introducing a genetic circuit. ZOOMING ON THE GENETIC MECHANISMS FOR LIMB REGENERATION IN FISH. Michigan State University scientists have argued that gar, a freshwater fish able to regenerate its limbs, could reveal genetic blueprints for limb regeneration in people. In a research paper published in _PNAS_, the scientists pinpointed the genes and the mechanisms that drive limb regrowth in gar. The genes responsible for this action in fish also are largely present in humans, but the genetic mechanisms that activate these genes are missing in humans. Searching for ways to trigger similar genetic mechanisms in humans could, according to the scientists, lead to revolutionary medicaladvances.
ENHANCING THE IMMUNE SYSTEM TO FIGHT LEUKEMIA. Researchers at Case Western Reserve University have developed a new combination treatment regimen that enhances the immune system’s ability to kill leukemias that do not respond to standard treatments. The regimen, described in a study published in _Cancer Immunology Research_, includes a therapeutic antibody designed to act like a bridge connecting cancer cells to natural killer cells, drawing natural killer immune cells tocancer cells.
Originally published at thrivous.com on August 05, 2019 at 09:44AM.Aug 5th, 2019
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PULSE 112: FIRST CRISPR CLINICAL TRIAL TO EDIT DNA IN THE HUMAN BODY Biotech companies Allergan and Editas Medicine have announcedthat
the Brilliance Phase ½ clinical trial of AGN-151587 (EDIT-101) is open for patient enrollment. The clinical trial will be the world’s first in vivo study of a CRISPR-based genome editing medicine, where the editing takes place inside the human body. “Beginning patient enrollment in the AGN-151587 clinical trial with our partners at Editas is an important step toward our goal of developing a game-changing, transformative, CRISPR-based medicine,” said Allergen researcher David Nicholson. AGN-151587 is an experimental medicine under development for the treatment of Leber congenital amaurosis 10 (LCA10), an inherited form of blindness caused by mutations in the CEP290 gene. _SingularityHub_ emphasizes that, while CRISPR-based medicine has been tested in humans, this is the first study to use CRISPR to edit DNA inside the human body. The clinical trial patients will have the treatment,
which was approved by the FDA in December, injected behind their retinas. The hope is that the patients’ DNA will repair itself in a way that restores normal protein function, ultimately fixing their photoreceptor cells and letting them see. HIGH-ENERGY PARTICLE BEAMS TARGET TUMORS PRECISELY. Researchers led by scientists at the University of Strathclyde have proposed a new way of concentrating radiotherapy doses in tumors, while minimizing damage to healthy cells. In a study published in _Scientific Reports_, the researchers suggest that focusing high-energy particle beams on a small spot deep inside the body could potentially enable clinicians to target cancerous tumors precisely, while reducing the dose to surrounding tissue. ADVANCES TOWARD DRUGS ABLE TO REMOVE AGING CELLS. Researchers at University of Southern California have advanced toward an understanding of how the aging process works. In a study published in _Journal of Biological Chemistry_, the researchers show that aging senescent cells stop producing a class of chemicals called nucleotides, which are the building blocks of DNA. The research results could find applications in the emerging field of senolytics, the development of drugs that may be able to eliminate aging cells, and open the door to better cancer treatments and revolutionary new drugs for aging patients. LASER-GUIDED MICROROBOTS PRECISELY DELIVER CANCER DRUGS. Caltech researchers are working on an entirely new form of treatment: microrobots that can deliver drugs to specific spots inside the body while being monitored and controlled from outside the body. Once the microrobots, described in aresearch paper
published in _Science Robotics_, arrive in the vicinity of a tumor, a near-infrared laser beam is used to activate them. Because the microrobots absorb the infrared light strongly, they briefly heat up. At that point, the microrobots’ bubble jets activate, and the microrobots swarm and deliver their medication payload. 3D-PRINTED PILL PROFILES BACTERIA IN THE GUT. Researchers led by Tufts University engineers have developed a 3D-printed pill, described in a study published in _Advanced Intelligent Systems_, which samples bacteria found in the gut, known as the microbiome, as it passes through the gastrointestinal tract (GI). The ability to profile bacterial species throughout the GI tract could have important implications for the diagnosis and treatment of diseases and conditions that are affectedby the microbiome.
TRACKING AND KILLING CANCER CELLS THAT ESCAPE SURGERY. Biomedical engineers at Vanderbilt University have discovered a method to track down and kill escaping cancer cells during tumor removal surgeries. In a research paper published in _Science Advances_, the scientists report that nanoparticles injected during and after tumor removal kill all cancer cells loosed as a result. The method, which uses the body’s own defenses in the form of modified lipid nanoparticles adhered to white blood cells, could also help patients who already suffer frommetastatic cancer.
PROTEIN SENSOR FINDS DAMAGED DNA AND OVERSEES REPAIR. Scientists at University of Pittsburgh have advanced toward an understanding how one protein in particular keeps DNA damage in check. The protein, called UV-DDB, which stands for ultraviolet-damaged DNA-binding, is useful beyond safeguarding against the sun. New evidence, described in a study published in _Nature Structural and Molecular Biology_, points to UV-DDB being a scout for general DNA damage and an overseer of the molecular repair crew that fixes it. Originally published at thrivous.com on July 29, 2019 at 09:09AM.Jul 29th, 2019
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ENHANCE PHYSICAL PERFORMANCE AND RECOVERY WITH THESE 3 SUPPLEMENTS One day, when I showed up to work at a skilled nursing home, a young college student I work with declared, “I’ve decided I’m never getting old!” I pointed out that working in an environment where people come when they need help with daily tasks or to recuperate after surgery was probably skewing her view of aging. I started sending her links to videos like the 103-year-old woman who won the gold medal at the Senior Olympics in the 50- and 100-meter dash,
and the Senior Monster dance group in Tokyo.
A lot of factors come into play in aging, including genetics, but many people are able to maintain their body function into “old age.” BOSWELLIA MAY ENHANCE JOINT FUNCTION. A pilot, randomized, double-blind, placebo-controlled trial to assess the safety and efficacy of a novel Boswellia serrata extract in the management of osteoarthritis of the knee.
This study recruited 48 people with knee joint degeneration to take a placebo or 338.66 mg of boswellia extract (30% AKBA) for 4 months. After 4 months the group that took the boswellia supplement experienced decreased pain on 3 different pain scales, reduced stiffness, traveled further on a 6 minute walk, and had improved quality-of-life scores. X-ray data showed improved gap size in the knee joints and decreased spurs. Decreased CRP values suggested overall inflammation was decreased by the supplement. After 4 months of boswellia supplementation, the participants felt less pain and gained mobility in their knees. CURCUMIN MAY ENHANCE MUSCLE RECOVERY. Effective Timing of Curcumin Ingestion to Attenuate Eccentric Exercise-Induced Muscle Soreness inMen
.
This study involved 24 young adult men. These men performed 30 maximal isokinetic eccentric contractions of the elbow flexors to induce muscle damage. Participants were assigned to take 180 mg/day of oral curcumin for the 7 days before the exercise event, 180 mg/day of oral curcumin for the 4 days after the exercise, or nothing before the exercise and a placebo for the 4 days after the exercise as a control group. Although there were no differences in torque or serum creatine kinase, the group that took the curcumin supplement for the 4 days after the exercise event had a greater range of motion and less muscle soreness than the control or pre-exercise-supplement group. The researchers concluded that curcumin ingestion after eccentric exercise was effective in reducing muscle soreness and may “contribute to improvement of performance after eccentric exercise-induced muscledamage”
CAFFEINE MAY ENHANCE PHYSICAL PERFORMANCE. Effect of caffeinated gum on a battery of rugby-specific tests in trained university-standard male rugby union players.
This study involved 17 male university rugby players who received a placebo or 200 mg caffeine (between 2.1 to 2.7 mg/kg bodyweight) in gum form before performing three countermovement jumps, an Illinois agility test, 6 × 30 m repeated sprints, and the Yo-Yo IR-2 test (20 m shuttle runs that gradually increased in speed until the player could no longer beat the timer), separated by short rest periods. While there was no difference on the agility test, the group of players that received caffeine experienced an enhanced countermovement jump, greater resistance to fatigue during the 6 × 30 m repeated sprint test, and better performance on the Yo-Yo IR2. The researchers concluded that caffeine may enhance performance in rugby matches.EDITOR NOTE
Thrivous Tenacity Arthroprotector provides clinical doses of Boswellia and Curcumin. And Surge AcuteNootropic
provides convenient doses of Caffeine, coupled with Theanine for evenbetter results.
Originally published at thrivous.com on July 27, 2019 at 07:43AM.Jul 27th, 2019
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PULSE 111: NEURALINK BRAIN INTERFACES FOR ARTIFICIAL TELEPATHY In a much hoped and awaited for presentation, which was live-streamed and now is available on YouTube,
Elon Musk unveiled his plans for Neuralink.
In a preprint published in bioRxiv, Musk describes the Neuralink technology platform as “an integrated brain-machine interface platform with thousands of channels.”
The abstract of the paper characterizes Neuralink as an experimental scalable high-bandwidth Brain-Machine Interface (BMI) system for clinical applications including the restoration of sensory and motor function and the treatment of neurological disorders, but Musk isaiming higher:
“ clinical devices that will derive from this platform will be fully implantable … and have on-board signal compression, reduced power consumption, wireless power transmission, and data telemetry through the skin without percutaneous leads.” In other words, someday in the near future you could have a Neuralink interface implanted in your brain with a short and painless procedure (like LASIK eye surgery), and become able to stream your thoughts wirelessly to the cloud. Ultimately, Neuralink could make people fullytelepathic.
The Nauralink launch event has been covered by nearly all major news outlets, with a lot of hype (of course) but also ferocious criticism (of course). In my opinion, while some enthusiasts are indulging in wishful thinking, some critics are falling into (equally naive) reverse wishful thinking. It seems possible and even plausible that, in a future not as close as enthusiasts hope but not as remote as naysayers think, Neuralink-like technology could find momentous applications, perhaps exceeding Elon Musk’s wildest dreams. POWERFUL, SAFE, AND INEXPENSIVE OXIDATION CATALYSTS CLEAN WATER IN MINUTES. Scientists at Carnegie Mellon University have advanced toward environmentally sustainable chemistry by unveiling powerful, safe, and inexpensive oxidation catalysts inspired by biological processes that break down even the most stubborn micropollutants. In astudy
published in _ACS Catalysis_, the scientists report the “record-setting” performances of these improved catalysts, called NewTAMLs (TAML stands for tetra-amido macrocyclic ligands). Testing has shown that infinitesimal amounts of these catalysts activate hydrogen peroxide to eliminate the pharmaceutical and common persistent micropollutant propranolol from water in less than fiveminutes.
STEALTHY DELIVERY SYSTEM DISGUISES ANTI-CANCER DRUGS AS FAT. Researchers at Northwestern University have developed a stealthy new drug-delivery system that disguises chemotherapeutics as fat in order to outsmart, penetrate, and destroy tumors. Thinking the drugs are tasty fats, tumors invite the drug inside. Once there, the targeted drug activates, immediately suppressing tumor growth. As described in a study published in _Journal of the American Chemical Society_, the researchers used the drug delivery system to carry a common, FDA-approved chemotherapy drug, paclitaxel, into tumors in animals. Disguised as fat, the drug entered and completely eliminated the tumors in three types of cancer: bone, pancreatic, and colon. TOWARD HUMAN-LIKE BRAINS-ON-A-CHIP. Engineers at RMIT University havemimicked
the human brain with an electronic chip that uses light to create and modify memories. The chip, inspired by optogenetics and described in apaper
published in _Advanced Functional Materials_, is based on an ultra-thin material that changes electrical resistance in response to different wavelengths of light, enabling it to mimic the way that neurons work to store and delete information in the brain. According to the engineers, this is an important step toward a bionic brain-on-a-chip that can learn from its environment just like humansdo.
PROTEIN PROMOTES EFFICIENT REPAIR OF DNA. Researchers at Tufts University have found that a transcription factor (transcription factors are proteins that bind to DNA) called Slug contributes to breast cell fitness by promoting efficient repair of DNA damage. In a research paper published in _Cell Reports_, the scientists show that Slug promotes both stem cell activity and efficient DNA damage repair, and the absence of Slug leads to unresolved DNA damage and accelerated agingof breast cells.
PET YOUR STRESS AWAY. Scientists at Washington State University havedemonstrated
that interacting with cats and dogs produces a significant reduction in cortisol, a major stress hormone. In a study with a sample of college students, published in _AERA Open_, the scientists report that students who interact directly with pets show significantly less cortisol in their saliva after the interaction. DOUBLE-STRANDED RNA FOR SKIN REJUVENATION. Researchers at Johns Hopkins Medicine have discovered that two skin rejuvenation methods - laser treatments and the drug retinoic acid, used to treat acne, wrinkles, and sunspots - share a common molecular pathway. In a research paper published in _Nature Communications_, the researchers report that the genes involved in sensing double-stranded RNA (dsRNA), and the genes involved in producing the skin’s natural retinoic acid, were all expressed at higher levels after the laser treatment. Next, the researchers treated isolated human skin cells with loose dsRNA, mimicking the effect of the laser treatment. The amount of retinoic acid inside the cells increased by more than tenfold. Originally published at thrivous.com on July 22, 2019 at 02:01PM.Jul 22nd, 2019
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PULSE 110: CRISPR ADVANCES IN THE LAB AND HUMAN TRIALS The first two news summaries below show, once again, that CRISPR gene editing technology is advancing fast in the lab. There are also more and more indications that CRISPR trials in humans are inevitable andare coming soon.
Five Russian couples, who are deaf, want to try the CRISPR gene-editing technique so they can have a biological child who can hear, biologist Denis Rebrikov has told _New Scientist_.
He plans to apply to the relevant Russian authorities for permission. “It is clear and understandable to ordinary people,” said the scientist. “Each new baby for this pair would be deaf without gene mutation editing.” Rebrikov’s highly controversial plans have been recently covered by_Nature
_
and _MIT Technology Review_.
See also Pulse 109
,
106
,
90
,
89
.
NANOPARTICLES PRECISELY DELIVER CRISPR GENE EDITING PAYLOADS TO CELLS. Researchers at Tufts University and the Chinese Academy of Scienceshave developed
a significantly improved delivery mechanism for the CRISPR/Cas9 gene editing method in the liver. The delivery method, described in aresearch paper
published in _Advanced Materials_, uses biodegradable synthetic lipid nanoparticles that carry the molecular editing tools into the cell to precisely alter the cells’ genetic code with as much as 90 percent efficiency. According to the researchers, the nanoparticles could help overcome technical hurdles to enable gene editing in a broad range of clinical therapeutic applications. CRISPR-ENGINEERED T CELLS ACT LIKE NATURAL IMMUNE CELLS. Scientists at Technical University of Munich (TUM) have engineered T cells that are very similar to physiological immune cells, asreported in a study
published in _Nature Biomedical Engineering_. Until now, modified T cells have not been as effective as natural T cells and have only been of limited clinical value. The scientists used CRISPR-Cas9 gene scissors, which can be used to snip out and replace targeted segments of the genome, to generate modified T cells that are very similar to their natural counterparts and could solve some of those problems. NANOTHERANOSTIC SYSTEM BASED ON HARMONIC NANOPARTICLES. Chemical engineers at EPFL have developed a novel nanotheranostic system that uses tunable light to activate or image nanoparticles, thus opening a new path for nanotheranostics, a cutting-edge field of medicine that uses nanoparticles to simultaneously diagnose and treat diseases. The new system, describedin a study
published in _ACS Applied Materials and Interfaces_, uses “harmonic nanoparticles” (HNPs), a family of metal-oxide nanocrystals, and can be easily activated with near-infrared light and imaged at longer wavelength for both detection and drug release processes. COMMON COLD VIRUSES TARGET, INFECT, AND DESTROY CANCER CELLS. Scientists at University of Surrey and Royal Surrey County Hospitalhave investigated
the safety and tolerability of exposure to the oncolytic (cancer-killing) virus coxsackievirus (CVA21), a naturally occurring strain of the common cold, in fifteen patients with non-muscle invasive bladder cancer (NMIBC). In a research paper published in _Clinical Cancer Research_, the scientists report that the virus is able to target, infect, and destroy cancer cells in patients with bladder cancer. No trace of the cancer was found in one patient following treatment with the virus. ENGINEERED BACTERIA DELIVER CANCER IMMUNOTHERAPY, KILL CANCER CELLS. Researchers at Columbia University have engineered a strain of non-pathogenic bacteria that can colonize solid tumors in mice and safely deliver potent immunotherapies, acting as a Trojan Horse that treats tumors from within. A study published in _Nature Medicine_ describes how the researchers achieved not only complete tumor regression in a mouse model of lymphoma, but also significant control of distant, uninjected tumor lesions. NANOPROBE ARRAYS RECORD THE ELECTRICAL ACTIVITY OF CARDIAC CELLS AND NEURONS. Scientists at University of Surrey and Harvard Universityhave built
scalable nanoprobe arrays small enough to record the inner workings of human cardiac cells and primary neurons. In a paper published in _Nature Nanotechnology_, the scientists detail how they produced an array of the ultra-small U-shaped nanowire field-effect transistor probes for intracellular recording. The ability to read electrical activity from cells is the foundation of many biomedical procedures, such as brain activity mapping, neural prosthetics, and Brain-Computer interfaces (BCI). COMPUTER MODEL OF CANCER CELLS ASSISTS THERAPY. Researchers at University of Luxembourg have developed a computer model that simulates the metabolism of cancer cells. Astudy
published in _EBioMedicine_ describes how the researchers used the program to investigate how combinations of drugs could be used more effectively to stop tumor growth. A BACTERIUM SEEMS TO REDUCE CARDIOVASCULAR RISKS. Scientists at Université Catholique de Louvain have found that the bacterium Akkermansia limits the increase of several risk factors for cardiovascular diseases, moderates the progression of pre-diabetes, and reduces cholesterol levels in humans. The researchresults
,
published in _Nature Medicine_, are important because one in two individuals is overweight and has cardiovascular risk factors. The scientists are planning larger-scale tests and the commercializationof the bacteria.
Originally published at thrivous.com on July 15, 2019 at 11:02AM.Jul 15th, 2019
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DO YOU KNOW WHAT'S IN YOUR SUPPLEMENT? IS IT TESTED? DOES IT WORK? One important thing to look for in a supplement is a detailedingredient list.
My husband once ordered a mixed-ingredient nootropic supplement that a friend recommended. The friend had been impressed by a representative of the company who she had met at a professional meeting. While examining the bottle of the new supplement, he called me over. He was concerned with the term “proprietary blend” listed in the ingredient list. He had no idea of the amount of any single plant or compound he would be ingesting. A trustworthy supplement company will disclose the contents of its supplements. Their labels will list the amount of each plant used, and the concentration of the active compound of interest. And they will provide evidence of quality assurance testing to verify their ingredients are pure and up to standard. CARNITINE, VITAMIN B COMPLEX, AND ZINC MAY ENHANCE GENERAL WELL-BEING AND SKIN ELASTICITY FOR BETTER AGING. Daily oral supplementation with collagen peptides combined with vitamins and other bioactive compounds improves skin elasticity and has a beneficial effect on joint andgeneral wellbeing
.
This study involved a mixed-ingredient supplement that included L-carnitine, niacin, vitamin B6, biotin, zinc, and black pepper among other ingredients. 120 adult participants took a placebo or the mixed-ingredient supplement for 90 days. The supplemented group saw improvement in skin elasticity, reduction in skin photo-aging, and an improvement in general wellbeing. 83% of the supplemented subjects claimed to have more energy and 93% claimed to be willing to continuethe supplement.
MELATONIN MAY IMPROVE MOOD AND FACILITATE GLUCOSE METABOLISM. Effects of melatonin administration on mental health parameters, metabolic and genetic profiles in women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial.
Polycystic ovary syndrome (PCOS) is a condition often characterized by irregular menstruation, altered lipid profiles, depression, anxiety, and disrupted sleep. Many symptoms seem to be rooted in insulin resistance. This study involved 58 women with PCOS who took a placebo or 10 mg of melatonin one hour before bed for 12 weeks. Melatonin supplementation had favorable effects on depression, anxiety, sleep quality, insulin concentrations, and insulin resistance. The melatonin supplement also upregulated gene expression of the PPARγ gene, which facilitates insulin sensitization and enhances glucose metabolism, and the LDLR gene, which codes for the receptor that removes LDL particles from the blood. In their discussion of the results, the researchers mentioned previous studies that showed similar desired effects of melatonin supplementation in other populations. VITAMIN B6 MAY PROTECT OVERALL HEALTH. Prospective cohort studies of dietary vitamin B6 intake and risk of cause-specific mortality.
This study took a broader look at vitamin B6. Sometimes research gets so focused on an individual cell or organ that it helps to step back and see if the nutrient has an impact on the big picture goals. Acknowledging that vitamin B6 plays an important role in chronic disease, researchers looked at data from 134,480 participants of the Shanghai Men’s Health Study (2002-2014) and the Shanghai Women’s Health Study (1997-2014). They looked at the relationship between vitamin B6 and the risk of various causes of mortality. They found that higher levels of dietary intake of vitamin B6 were associated with lower risk of all-cause mortality and cardiovascular disease mortality. The benefit of vitamin B6 intake was independent of the overall diet quality and protective from health-related death.EDITOR NOTE
Thrivous provides premium quality open-source supplements, with full disclosure of all ingredients, doses, and quality test results – no hiding behind secretive proprietary blends. Clarity Daily Nootropic provides evidence-based doses of Vitamin B Complex (including Vitamin B6) and bioavailable Zinc. Serenity Nightly Nootropic is an excellent source of Melatonin. And Alpha Neuroprotector provides a clinical dose of Acetyl L Carnitine. Originally published at thrivous.com on July 12, 2019 at 12:58PM.Jul 12th, 2019
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YOU’RE PROBABLY NOT GETTING ENOUGH CHOLINE FOR BRAIN AND LIVERHEALTH
You’re probably not getting enough choline, according to a 2018 review of the scientific literature. Published in _Nutrition Today_, the review essay combined the efforts of researchers at four different universities and three NGOs. It grew out of discussions at the 2018 Choline Science Summit in Washington, D.C. in February 2018. Choline is an essential nutrient that plays a role in cell repair and proper function of the muscles, liver, and brain. Our bodies produce a small amount of choline, but in order to prevent deficiency we also need some from our food. Choline deficiency can cause liver damage and inhibit children’s brain development. The National Academies of Medicine (NAM) usually sets its dietary guidelines by simply observing the intake of a nutrient in normal, healthy adults. That’s not a very scientifically rigorous way to set guidelines! Fortunately, the recommendations for choline were set based on actual experimental evidence. Back in 1991, scientists deprived a group of men of choline and then gradually brought their choline intake back up until the symptoms of deficiency went away. From there, the NAM extrapolated recommendations for women and children and for different body weights. Pregnant and breastfeeding women need extra choline because they secrete it for their infants. The NAM guidelines are a little dated, but they’re better than most of the nutritional guidelines out there. So how much choline do you need? Approximately 7 milligrams per kilogram of bodyweight, or about 425 milligrams per day for an average woman and 550 milligrams per day for an average man. Pregnant women need about 450 milligrams per day, and breastfeeding women need about 550 milligrams per day. However, most preteens, teens, and adults fall far short of these adequate intake levels. The average intake for an American adult is about 300 milligrams per day. Only about 10% of adults and 8% of pregnant women get their adequate daily choline intake. The problem is worse for vegetarians, because most choline-rich foods are animal products. Vegetarians consume an average of 192 milligrams per day. Recent research on choline mostly validates the NAM guidelines, though there are some genetic and hormonal factors we’re only now beginningto understand.
Researchers have confirmed that choline deficiency causes fatty liver disease in about half of premenopausal women, although the other half are protected by their higher levels of natural choline production due to their genetic makeup. Pregnant women produce somewhat more natural choline due to higher estrogen levels during pregnancy, although they still need a lot of choline in their diet. Choline deficiency during pregnancy can cause birth defects like cleft palate and spina bifida, especially for mothers with certain genes. It can also cause placental inflammation and may increase the likelihood of the child developing stress-related diseases later in life. Adequate choline intake, meanwhile, promotes brain health in both children and adults. Children whose mothers take choline supplements exhibit faster reaction times and better attention, memory, and problem-solving at 4 and 7 years old. Human studies haven’t yet looked at whether these benefits persist later in life, but in animal studies the effects have been shown to be life-long. In adults, adequate choline intake improves hand-eye coordination and memory, and it may help stave off age-related cognitive decline. So how can you get more choline in your diet? Liver, salmon, and eggs are among the richest sources of choline, with one egg providing 147 milligrams. For vegetarians, half a cup of soybeans contains choline levels similar to a chicken breast or steak—about 107 milligrams—and smaller amounts of choline can be found in shiitake mushrooms, red potatoes, kidney beans, and quinoa. A red baked potato nets you about 57 milligrams, but only if you eat theskin.
Choline is tough to find as a supplement, because choline salts are bulky. However, one powerful alternative is alpha-GPC. This supplement increases your body’s own ability to produce choline, and significantly increases levels of choline in the blood for about a 6-hour period. Alpha-GPC has been shown to be a powerful nootropic, and much of its effect may be due to its promotion of choline. Don’t overdo it, of course. The body can tolerate a lot of choline—about 3500 milligrams per day—but megadoses larger than that can be toxic. Abnormally high choline intake may also be a risk factor for cardiovascular diseases, though the evidence of this is weak. Consume choline in the recommended amounts, as part of a well-balanced diet, and in conjunction with exercise. As always, consult with a doctor before making radical dietary changes or takingnew supplements.
REFERENCES
Wallace TC, et al. (2018). Choline: The Underconsumed and Underappreciated Essential Nutrient. Nutr Today, 53(6):240-253. doi: 10.10997/NT.0000000000000302. Gatti G, et al. (1992). A comparative study of free plasma choline levels following intramuscular administration of L-alpha-glycerylphosphorylcholine and citicoline in normal volunteers. Int J Clin Pharmacol Ther Toxicol, 30(9):331-335.EDITOR NOTE
Thrivous Alpha Neuroprotector is an excellent source of choline. It provides 300 mg of highly neuroavailable Alpha GPC (from 600 mg of 50% material) in each serving. Beware vendors who claim to provide 300 mg Alpha GPC per serving without indicating whether the 300 mg quantity represents the Alpha GPC or the material by which it’s delivered. Many vendors deceptively list the amount of material, which means they’re delivering only half of the amount of Alpha GPC that they’re leading their customers to believe. In contrast, Thrivous transparently publishes all formula and testing details, so you know exactly whatyou get each time.
Originally published at thrivous.com on July 03, 2019 at 09:03AM.Jul 3rd, 2019
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ENHANCE ATTENTION WITH CAFFEINE AND L THEANINE _Psychology Today_ describesattention
as “a spotlight that focuses an individual’s awareness on a particular facet of their environment, or on the thoughts in their head.“ And they point out that "the ability to pay attention to important things — and to ignore the rest — likely helped early humans survive and evolve.” Although humans today are rarely in the position of having to focus to survive a life-or-death situation, attention is still beneficial to our work and our relationships. And, in turn, our work and relationships help to stabilize society. When I can’t focus my attention, it hurts my productivity. It strains my relationships with friends and family members. And it inhibits meaningful interactions with people I come into contact with in the community. The first study below addresses attention specifically, and the other two address related topics of memory and overall cognitivefunction.
CAFFEINE AND L THEANINE MAY ENHANCE ATTENTION AND ATTENTION-SWITCHING ABILITY. Effects of a Multi-Ingredient Energy Supplement on Cognitive Performance and Cerebral-Cortical Activation.
Researchers recruited 24 adults, aged 18-35, to wear a scalp EEG apparatus and complete a computer-guided test that measured attention-switching ability. The computer test was taken on three different days, 30 minutes after consuming a placebo, a single serving of a mixed ingredient supplement, or two servings of a mixed ingredient supplement. This supplement included folate, niacin, caffeine (150 mg), and L-theanine (50 mg) along with other components. Researchers found that the supplement increased cerebral-cortical activation, which suggests the supplement helped to focus attention during the attention-demanding task. This finding was supported by the improved performance on the computer test after supplementation. The effects were greater with the larger dose of the supplement. The authors attributed much of the success of the supplement to synergies between caffeine and L-theanine. BLUEBERRY MAY ENHANCE MEMORY. The effect of blueberry interventions on cognitive performance and mood: A systematic review of randomizedcontrolled trials
.
The researchers compared the data from 12 studies on blueberry products to make more general conclusions about the benefit of blueberry supplements. The data varied in length from 6 weeks to 6 months and in anthocyanin content from 1.55 mg/d to 387 mg/d. The effect on mood was only addressed in 4 studies and the mood effects were inconclusive overall. The effect of blueberry products on cognition, specifically short- and long-term memory and spatial memory, showed improvement in the longer-term studies over 3 months. OMEGA 3 AND ZINC MAY ENHANCE COGNITIVE FUNCTION. Unsaturated Fatty Acid Intakes During Midlife Are Positively Associated with Later Cognitive Function in Older Adults with Modulating Effects of Antioxidant Supplementation.
This study looked back at previously collected data and analyzed it with new eyes. They took data from the SU.VI.MAX (Supplementation with Antioxidant Vitamins and Minerals) study, that was conducted during 1994-2002 with a follow-up in 2007-2009, and included 6,850 French participants aged 35-60. Research participants were randomly assigned to take an antioxidant supplement or placebo during the study period. The original study found better cognitive outcomes after 8 years of the antioxidant supplement. The new study used the supplementation status, cognitive test results, and the dietary information collected. Researchers found that those who consumed more monounsaturated fats and polyunsaturated fats (including omega-3) had better cognitive function at the follow-up. It appears that omega-3 may have enabled further cognitive enhancement from the antioxidant vitamins and minerals, including zinc. EDITOR NOTE: Thrivous Surge Acute Nootropic provides a combination of 100 mg Caffeine and 200 mg L Theanine per serving. Vitality Geroprotector is an excellent source of Blueberry extract, standardized at 25% Anthocyanin and dosed at 1400 mg per serving. Omega Cardioprotector provides 500 mg Omega 3 per serving. And each serving of Clarity DailyNootropic
provides 11 mg Zinc Picolinate, which is a particularly bioavailableform of zinc.
Originally published at thrivous.com on June 28, 2019 at 03:37PM.Jul 2nd, 2019
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PULSE 109: HUMAN GENE EDITING VIA CRISPR IS COMING The cut-and-paste gene editing technology CRISPR continues to be on the front page news. CRISPR has been used to treat US cancer patients for the first time, and now a Russian scientist wants to repeat the CRISPR experiment in China to create humans resistant to HIV (see Pulse 106),
_MIT Technology Review_ reports. Most CRISPR researchers think it’s too soon for experiments like these. “The technology is not ready,” says CRISPR pioneer Jennifer Doudna, as reported by _Nature_.
This seems a reasonable position, and Doudna doesn’t seem to be ruling out ambitious CRISPR experiments in humans once the technology is ready. But it can be argued that such experiments could help CRISPR technology reach clinical maturity. In the meantime, SingularityHub notes that “the Pandora’s box of human gene editing has been opened,” and _Nature_ elaborates on “what it would take to make the technique safe and acceptable.” GUT BACTERIA AS BIOSENSORS. Researchers at Wyss Institute for Biologically Inspired Engineering at Harvard University and Harvard Medical School have created an effective, non-invasive way to quickly identify new bacterial biosensors. A synthetic circuit, which has been integrated into the genomes of bacteria, can be activated by specific health issues, as shown by experiments with laboratory mice. The technique, described ina paper
published in _mSystems_, can recognize and report the presence of various disease triggers in the gut, helping set the stage for a new frontier of digestive health monitoring and treatment. 3D BODY MAPPING TO MONITOR THE PERFORMANCE OF ENGINEERED TISSUES. Scientists at Purdue University have developed a 3D mapping technology to monitor and track the behavior of engineered cells and tissues used to replace natural cells and tissues damaged by cancer, cardiovascular disease and other medical issues. The technology, described in a study published in _ACS Nano_, could improve the success rate for patients who have already faced a debilitating disease. NANOPARTICLE CLUSTERS PERMIT HEATING CANCER CELLS TO DEATH. Researchers at Oregon State University have developed an improved technique for using magnetic nanoparticles to kill hard-to-reach tumors. The research results,
published in _ACS Nano_, indicate that nanoclusters, multiatom collections of oxide nanoparticles doped with cobalt and manganese and loaded into biodegradable nanocarriers, accumulate in a tumor well enough to allow alternating magnetic fields to heat cancer cells todeath.
MONITORING AND RECORDING CELL COMMUNICATIONS. Scientists at University of Connecticut have found a way to record cells communicating in real time. Using a combination of microfluidics and computer modeling, described in a study published in _PNAS_, the scientists created a platform to record cell messages in depth, uncovering the precise ways in which the words and messages are arranged in these intercellular conversations. According to the scientists, the findings could open the door to new developments in cell therapy and other areas within cell biology. BACTERIA ENHANCE PHYSICAL PERFORMANCE. Researchers at Joslin Diabetes Center have identified a type of bacteria found in the microbiomes of elite athletes that contributes to improved capacity for exercise. These bacteria, members of the genus Veillonella, are not found in the guts of sedentary people. A research paper published in _Nature Medicine_ indicates that Veillonella metabolizes lactic acid produced by exercise and converts it into propionate, a short chain fatty acid. The human body then utilizes that propionate to improve exercise capacity. In future clinical applications, probiotic capsules containing Veillonella could give people with metabolic disorders, who are not able to exercise, the boost they need for effective exercise. NANOGEL DELIVERS DRUGS THROUGH THE SKIN. MIT chemical engineers havedevised
a new way to create nanoemulsions, very tiny droplets of one liquid suspended within another. The engineers have also developed a way, described in a study published in _Nature Communications_, to easily convert nanoemulsions to a gel when they reach body temperature, which could be useful for developing materials that can deliver medication when rubbed on skin or injected into the body. Originally published at thrivous.com on July 01, 2019 at 09:17AM.Jul 2nd, 2019
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