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THE PUBLIC
Virology Down Under Facts, data, info, expert opinion and a reasonable, occasionally grumpy, voice on viruses: what they are, how they tick and the illnesses they may cause. A COLD VIRUS IN THE BLOOD... Sometimes, viruses jump – or leak – from where we think they belong, turning up in an unexpected body compartment. We saw it with Ebola virus – it’s now known to have an unquantified but non-zero risk of sexual transmission via the semen ; we saw it with Zika virus – it is now known to cross into maternal and foetal tissues and sometimes cause congenital Zika syndrome and other ABOUT ME - VIROLOGY DOWN UNDER Thanks for visiting! My name is Ian M. Mackay, a working Scientist and an adjunct Associate Professor (University of Queensland). I have a PhD in virology, also from UQ. This blog is not affiliated withALUMINIUM AND YOU
Aluminium (aluminum if you’re from North America) is the most abundant metal in the earth’s crust and th e third most abundant element of the planet. Compounds containing aluminium are also widespread.Humans – neonates, babies, infants, children, adults – are exposed to chemical compounds containing aluminium in many ways. During the first 400 days of life, we are also KITS AND REAGENTS AND VIRUSES YES, PCR TESTS CAN DETECT "THE COVID VIRUS" I was asked to write some comments for a fact check article about some of the myths going around about PCR-based testing and whether PCR tests can detect “the COVID virus”. SIGH, YES, THE 'COVID VIRUS' IS REAL RHINOVIRUS RAMPANT OR TESTING TRIUMPHANT? THE "FALSE-POSITIVE PCR" PROBLEM IS NOT A PROBLEMSEE MORE ON VIROLOGYDOWNUNDER.COM THERE ARE PLENTY OF PLACEBO-CONTROLLED VACCINE TRIALSSEE MORE ON VIROLOGYDOWNUNDER.COM VIROLOGY DOWN UNDERABOUT MEEBOLA INDEXMERS NUMBERSPAST TIME TO TELLTHE PUBLIC
Virology Down Under Facts, data, info, expert opinion and a reasonable, occasionally grumpy, voice on viruses: what they are, how they tick and the illnesses they may cause. A COLD VIRUS IN THE BLOOD... Sometimes, viruses jump – or leak – from where we think they belong, turning up in an unexpected body compartment. We saw it with Ebola virus – it’s now known to have an unquantified but non-zero risk of sexual transmission via the semen ; we saw it with Zika virus – it is now known to cross into maternal and foetal tissues and sometimes cause congenital Zika syndrome and other ABOUT ME - VIROLOGY DOWN UNDER Thanks for visiting! My name is Ian M. Mackay, a working Scientist and an adjunct Associate Professor (University of Queensland). I have a PhD in virology, also from UQ. This blog is not affiliated withALUMINIUM AND YOU
Aluminium (aluminum if you’re from North America) is the most abundant metal in the earth’s crust and th e third most abundant element of the planet. Compounds containing aluminium are also widespread.Humans – neonates, babies, infants, children, adults – are exposed to chemical compounds containing aluminium in many ways. During the first 400 days of life, we are also KITS AND REAGENTS AND VIRUSES YES, PCR TESTS CAN DETECT "THE COVID VIRUS" I was asked to write some comments for a fact check article about some of the myths going around about PCR-based testing and whether PCR tests can detect “the COVID virus”. SIGH, YES, THE 'COVID VIRUS' IS REAL RHINOVIRUS RAMPANT OR TESTING TRIUMPHANT? THE "FALSE-POSITIVE PCR" PROBLEM IS NOT A PROBLEMSEE MORE ON VIROLOGYDOWNUNDER.COM THERE ARE PLENTY OF PLACEBO-CONTROLLED VACCINE TRIALSSEE MORE ON VIROLOGYDOWNUNDER.COM SIGH, YES, THE 'COVID VIRUS' IS REAL Whole-genome sequencing (WGS) was used to identify the unique genetic sequence of the cultured virus and a specific real-time reverse transcription-polymerase chain reaction (RT-rPCR) designed to allow screening of more sensitive and rapid screening of more samples.The RT-rPCR was tested against human endemic CoVs (229E, OC43, HKU1) as well as MERS-CoV, SARS-CoV and others, PCR PRIMERS...A PRIMER! The polymerase chain reaction (PCR, described here) works mainly because of two components – a heat-stable DNA polymerase enzyme (adds new nucleotides to a chain of nucleotides) and a pair of DNA PCR primers. The PCR aims to detect the presence of a section of genetic material; usually only a small part of a greater whole. THE STRUCTURE OF DNA... A PRIMER The naming system, 5′ to 3′ is used to describe the order of the nucleotides in the DNA strand. Think of the system as being similar to the way European people are taught to read and write – from the left side of a page to the right side. FLIGHT OF THE AEROSOL Understanding what we mean when we discuss airborne virus infection risk. An article collaboratively written by (alphabetically).. Dr. Katherine ArdenA former postdoctoral researcher with interests in the detection, culture, characterization and epidemiology of respiratory viruses.Dr Graham JohnsonA post-doctoral scientist with extensive WHO TO NEW PCR USERS: READ THE DAMNED MANUAL! The World Health Organization (WHO) recently published (14th Dec 2020, then updated 20th Jan 2021) a piece of advice for laboratories testing for SARS-CoV-2 using PCR. The advice boils down: new to PCR? Read the THE SWISS CHEESE INFOGRAPHIC THAT WENT VIRAL A visual representation of how to prevent transmission of SARS-CoV-2 struck a chord with many in 2020. I won’t rehash all that has already been written about the Swiss cheese infographic but this is a small timeline, some links and some of the thinking that went on. WE DON’T YET KNOW THE ORIGIN STORY FOR SARS-COV-2 By Katherine E Arden, PhD & Ian M Mackay, PhD. The existence of a coronavirus related to severe acute respiratory syndrome coronavirus (SARS-CoV) was first hinted at by a researcher from the Wuhan University School of Medicine. A coronavirus pathogen was confirmed a week later, and its genetic sequence made public days after that. It was later called SARS-CoV-2. WHAT DOES A POSITIVE PCR RESULT MEAN...OR NOT MEAN The polymerase chain reaction (PCR) has remained a hugely important laboratory tool for decades. Subtle changes to the enzymes and drastic changes to the detection of a result have occurred in that span, but the tool and its reliability have remained remarkably consistent. NO, THEY DIDN'T RENAME POLIO Yes, they did rename polio. Polio has diverse symptoms, diverse degrees of expression. Many different diagnoses possible. Polio vax only came along at the end of polio’s natural infectious cycle, but medics were quick to credit all success to vax when in fact better nutrition, sanitation and related measures actually did the heavylifting.
COVID-19 IS NOT A VIRUS, BUT SARS-COV-2 IS I suggest it helps memory to recall COVID-19, the disease, contains the D for disease, ergo, COVID-19. As the ICTV points out on its homepage, “For an outbreak of a new viral disease, there are three names to be decided: the disease, the virus and thespecies.
VIROLOGY DOWN UNDERABOUT MEEBOLA INDEXMERS NUMBERSPAST TIME TO TELLTHE PUBLIC
The mechanics of the polymerase chain reaction (PCR)a primer. The polymerase chain reaction (PCR) is a technique for copying a piece of DNA a billion-fold. As the name suggests, the process creates a chain of many pieces, in this Read More . ABOUT ME - VIROLOGY DOWN UNDER My name is Ian M. Mackay, a working Scientist and an adjunct Associate Professor (University of Queensland). I have a PhD in virology, also from UQ. This blog is not affiliated with any Organisation and contains cited facts and some personal opinions. Enough about me – get over to here for the actual blog, Virology Down Under (VDU)! A COLD VIRUS IN THE BLOOD... RVs disappeared from the blood between 14 to 51 days later in 29 (52%) of the 56 viraemic cases. Most of the cases of viraemia occurred among children aged 1-2 years (a quarter of all viraemic people) and those with RV-C viraemia also had a significantly higher swab viral load. 15% of the 375 casesDetails
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